Click here to switch to the map view.

The map label for this gene is nadC [H]

Identifier: 114797685

GI number: 114797685

Start: 699469

End: 700326

Strand: Reverse

Name: nadC [H]

Synonym: HNE_0689

Alternate gene names: 114797685

Gene position: 700326-699469 (Counterclockwise)

Preceding gene: 114800426

Following gene: 114798485

Centisome position: 18.9

GC content: 64.22

Gene sequence:

>858_bases
ATGACGACCTATATTCCCCCGCTTTCCCCGATCATCCTTGATCCGATTGTCCGCCTGGCGCTGGCCGAGGATCTGGGCCG
GGCGGGCGACCTGACGACTGACGCTACCATTCCGCCGGAGACACAGCTTTCGGTGGTGATCGCCGCGCGCAAGCCCGGCG
TGATTGCGGGGCTGGACGTGGCGGCCTATTCGGCAAGCCTTGTGGACCCGGCACTGAAGCTGGAAATCGAAAAGCCCGAT
GGCAGCGCGCTGACGCCCGGCGATGTGGTGGCGCGGCTTTCGGGATCGGCGCGGTCGATCCTGACGGCGGAGCGCACGAT
GCTGAACTTTCTGGGGCGGCTTTCGGGCGTCGCGAGCCTGACGCGGCAGTATGTGGACGCGGTGGCCCACACGAAAACAC
GCATCGTCTGCACCCGGAAGACAACGCCGGGGCACCGGGCGCTGGAGAAGCGGGCGGTCCGCTGTGGCGGGGGAACGTCG
CACCGCTATGGGCTGGATGACGCGATCCTGATCAAGGACAATCACATTGCCGCCTGCGGCGGGTCGATTGAAGCTACGCT
GGAGCGGGCGAAAGCCTATGCCGGGCATCTGCGGATGATCGAAATTGAGGTGGATACGCTGGCCCAGCTTGAAGAAGCGC
TGAAATATGGTCCGCATGCGATCCTTCTGGACAATATGAGCCTGGAGCAATTGCGCGAAGCGGTCACCATTACCGGCGGG
CGCGTGCCGCTCGAAGCCTCGGGCGGGGTGACGCTGACTTCCGTAGCGGCAATTGCTGAGACGGGGGTGGACTTCATTTC
CTCGGGCGCGCTGACCCATTCGGCGCCCAATCTTGACCTTGGCCTCGATGTGGTCTGA

Upstream 100 bases:

>100_bases
GCGCCGAAAGCCGCGGCGGACATTTCCGGTCCGACTATCCCGACACCGGCGCGCCCGAGCGCCAGTTCCTGTTCCACACA
AGCCGCGAGGCGCTTGTCAT

Downstream 100 bases:

>100_bases
CAGTCTCTGCCAGAGACGCTGACACAGTCAGTGAAAGATACTGGCGGAGGAAAACATGGCAGGCGCAAACGGCCGCAAGG
CGATTTTCATCACGGGAGCC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MTTYIPPLSPIILDPIVRLALAEDLGRAGDLTTDATIPPETQLSVVIAARKPGVIAGLDVAAYSASLVDPALKLEIEKPD
GSALTPGDVVARLSGSARSILTAERTMLNFLGRLSGVASLTRQYVDAVAHTKTRIVCTRKTTPGHRALEKRAVRCGGGTS
HRYGLDDAILIKDNHIAACGGSIEATLERAKAYAGHLRMIEIEVDTLAQLEEALKYGPHAILLDNMSLEQLREAVTITGG
RVPLEASGGVTLTSVAAIAETGVDFISSGALTHSAPNLDLGLDVV

Sequences:

>Translated_285_residues
MTTYIPPLSPIILDPIVRLALAEDLGRAGDLTTDATIPPETQLSVVIAARKPGVIAGLDVAAYSASLVDPALKLEIEKPD
GSALTPGDVVARLSGSARSILTAERTMLNFLGRLSGVASLTRQYVDAVAHTKTRIVCTRKTTPGHRALEKRAVRCGGGTS
HRYGLDDAILIKDNHIAACGGSIEATLERAKAYAGHLRMIEIEVDTLAQLEEALKYGPHAILLDNMSLEQLREAVTITGG
RVPLEASGGVTLTSVAAIAETGVDFISSGALTHSAPNLDLGLDVV
>Mature_284_residues
TTYIPPLSPIILDPIVRLALAEDLGRAGDLTTDATIPPETQLSVVIAARKPGVIAGLDVAAYSASLVDPALKLEIEKPDG
SALTPGDVVARLSGSARSILTAERTMLNFLGRLSGVASLTRQYVDAVAHTKTRIVCTRKTTPGHRALEKRAVRCGGGTSH
RYGLDDAILIKDNHIAACGGSIEATLERAKAYAGHLRMIEIEVDTLAQLEEALKYGPHAILLDNMSLEQLREAVTITGGR
VPLEASGGVTLTSVAAIAETGVDFISSGALTHSAPNLDLGLDVV

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=283, Percent_Identity=33.9222614840989, Blast_Score=133, Evalue=2e-31,
Organism=Escherichia coli, GI1786299, Length=267, Percent_Identity=43.0711610486891, Blast_Score=168, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6321162, Length=250, Percent_Identity=32.4, Blast_Score=116, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 29871; Mature: 29739

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTYIPPLSPIILDPIVRLALAEDLGRAGDLTTDATIPPETQLSVVIAARKPGVIAGLDV
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEECHH
AAYSASLVDPALKLEIEKPDGSALTPGDVVARLSGSARSILTAERTMLNFLGRLSGVASL
HHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TRQYVDAVAHTKTRIVCTRKTTPGHRALEKRAVRCGGGTSHRYGLDDAILIKDNHIAACG
HHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCEEEEEC
GSIEATLERAKAYAGHLRMIEIEVDTLAQLEEALKYGPHAILLDNMSLEQLREAVTITGG
CCHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHEECCC
RVPLEASGGVTLTSVAAIAETGVDFISSGALTHSAPNLDLGLDVV
CEEEECCCCEEHHHHHHHHHHCHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTYIPPLSPIILDPIVRLALAEDLGRAGDLTTDATIPPETQLSVVIAARKPGVIAGLDV
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEECHH
AAYSASLVDPALKLEIEKPDGSALTPGDVVARLSGSARSILTAERTMLNFLGRLSGVASL
HHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TRQYVDAVAHTKTRIVCTRKTTPGHRALEKRAVRCGGGTSHRYGLDDAILIKDNHIAACG
HHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCEEEEEC
GSIEATLERAKAYAGHLRMIEIEVDTLAQLEEALKYGPHAILLDNMSLEQLREAVTITGG
CCHHHHHHHHHHHHCCEEEEEEEHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHEECCC
RVPLEASGGVTLTSVAAIAETGVDFISSGALTHSAPNLDLGLDVV
CEEEECCCCEEHHHHHHHHHHCHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]