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The map label for this gene is cusR [H]

Identifier: 114797880

GI number: 114797880

Start: 1345454

End: 1346161

Strand: Reverse

Name: cusR [H]

Synonym: HNE_1312

Alternate gene names: 114797880

Gene position: 1346161-1345454 (Counterclockwise)

Preceding gene: 114798730

Following gene: 114799948

Centisome position: 36.33

GC content: 62.99

Gene sequence:

>708_bases
ATGGTCGAAACAGAATCCACGACATCGCTGAAAGTCCTCGTCATCGAGGACGACACTGAAATGGCAAGCTTCATCGAGAA
GGTGCTGCTTGACGCTGGACACAAGGTGGAGCGCGCCAGCGATGGCGCTTCCGGTCTGGCAATGGCGCGGGCGTCTGAAT
ATGACGCCCTCATCGTTGACCGGATGCTTCCGGAAAAGGACGGCCTCACCCTGTTGCAGGAATTCCGCGCAGCCGGTGGC
ACAACGCCCGCCCTCTTCCTCTCCGCCCTCGGAGACGTTCAGAACAAGGTGCAGGGCCTTCGCGCCGGCGCTGAGGACTA
TCTGGGCAAGCCCTTTGCCCCGGCAGAACTCGCCGCCCGCGTCGAAGCCCTCGGCCGCCGCCAGACGAATGCCGAGCCGC
CGGTCACGGTGCTCAAGGCAGGCGACCTGGAAATGAACCTCCTGACCCGCAAGGTCACCCGCGCCGGCAAGAAGATCGAC
CTTCAGCCCCGCGAGTTCCGCCTGCTGGAATATCTGATGCGCCATGCCGGCCAGGTCGTGACGCGCACGATGCTGCTGGA
AAAGGTGTGGGACTATAACTTCGATCCCCAGACCAATGTGATCGACGTTCACATCTCCCGCCTGCGCGCAAAGATCGACA
AGGAGTTCGCCGAACCGCTGCTCCAGACCGTTCGCGGCGCCGGATACCGCCTGCAGAGCCAGGGCTAG

Upstream 100 bases:

>100_bases
AAATCCTTCTGGCCGTCCGCGTCGGTCAGACCACCATTTACCGCACTGTAGATTTGCCGGCAGGCTGAAGGAGCCAACCA
TGACGTTGATGGAGACCGAT

Downstream 100 bases:

>100_bases
ACCTTTTGGAGCGGCGCTGGCACCTAGCGCGAGATGAAAACGCCGCTCCAACTTCCCGCATGGCTGGCCCCTCGGGTGCC
TGACAGGACCCAGCTCCTGA

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MVETESTTSLKVLVIEDDTEMASFIEKVLLDAGHKVERASDGASGLAMARASEYDALIVDRMLPEKDGLTLLQEFRAAGG
TTPALFLSALGDVQNKVQGLRAGAEDYLGKPFAPAELAARVEALGRRQTNAEPPVTVLKAGDLEMNLLTRKVTRAGKKID
LQPREFRLLEYLMRHAGQVVTRTMLLEKVWDYNFDPQTNVIDVHISRLRAKIDKEFAEPLLQTVRGAGYRLQSQG

Sequences:

>Translated_235_residues
MVETESTTSLKVLVIEDDTEMASFIEKVLLDAGHKVERASDGASGLAMARASEYDALIVDRMLPEKDGLTLLQEFRAAGG
TTPALFLSALGDVQNKVQGLRAGAEDYLGKPFAPAELAARVEALGRRQTNAEPPVTVLKAGDLEMNLLTRKVTRAGKKID
LQPREFRLLEYLMRHAGQVVTRTMLLEKVWDYNFDPQTNVIDVHISRLRAKIDKEFAEPLLQTVRGAGYRLQSQG
>Mature_235_residues
MVETESTTSLKVLVIEDDTEMASFIEKVLLDAGHKVERASDGASGLAMARASEYDALIVDRMLPEKDGLTLLQEFRAAGG
TTPALFLSALGDVQNKVQGLRAGAEDYLGKPFAPAELAARVEALGRRQTNAEPPVTVLKAGDLEMNLLTRKVTRAGKKID
LQPREFRLLEYLMRHAGQVVTRTMLLEKVWDYNFDPQTNVIDVHISRLRAKIDKEFAEPLLQTVRGAGYRLQSQG

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=44.3946188340807, Blast_Score=199, Evalue=1e-52,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=40, Blast_Score=163, Evalue=9e-42,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=39.1891891891892, Blast_Score=149, Evalue=1e-37,
Organism=Escherichia coli, GI1790552, Length=227, Percent_Identity=37.4449339207048, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1786599, Length=229, Percent_Identity=31.4410480349345, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1789809, Length=233, Percent_Identity=30.9012875536481, Blast_Score=124, Evalue=4e-30,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=33.3333333333333, Blast_Score=123, Evalue=9e-30,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=33.6363636363636, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=33.0357142857143, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=35.2173913043478, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1788394, Length=234, Percent_Identity=31.6239316239316, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=31.8965517241379, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=28.0701754385965, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=25.1101321585903, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1790437, Length=128, Percent_Identity=31.25, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=28.9719626168224, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788191, Length=118, Percent_Identity=33.8983050847458, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25966; Mature: 25966

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVETESTTSLKVLVIEDDTEMASFIEKVLLDAGHKVERASDGASGLAMARASEYDALIVD
CCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHCCCHHHHHH
RMLPEKDGLTLLQEFRAAGGTTPALFLSALGDVQNKVQGLRAGAEDYLGKPFAPAELAAR
HHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHH
VEALGRRQTNAEPPVTVLKAGDLEMNLLTRKVTRAGKKIDLQPREFRLLEYLMRHAGQVV
HHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
TRTMLLEKVWDYNFDPQTNVIDVHISRLRAKIDKEFAEPLLQTVRGAGYRLQSQG
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCC
>Mature Secondary Structure
MVETESTTSLKVLVIEDDTEMASFIEKVLLDAGHKVERASDGASGLAMARASEYDALIVD
CCCCCCCCCEEEEEEECCHHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHCCCHHHHHH
RMLPEKDGLTLLQEFRAAGGTTPALFLSALGDVQNKVQGLRAGAEDYLGKPFAPAELAAR
HHCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHH
VEALGRRQTNAEPPVTVLKAGDLEMNLLTRKVTRAGKKIDLQPREFRLLEYLMRHAGQVV
HHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
TRTMLLEKVWDYNFDPQTNVIDVHISRLRAKIDKEFAEPLLQTVRGAGYRLQSQG
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]