Click here to switch to the map view.

The map label for this gene is degP [H]

Identifier: 114798730

GI number: 114798730

Start: 1346194

End: 1347732

Strand: Reverse

Name: degP [H]

Synonym: HNE_1313

Alternate gene names: 114798730

Gene position: 1347732-1346194 (Counterclockwise)

Preceding gene: 114799452

Following gene: 114797880

Centisome position: 36.38

GC content: 63.35

Gene sequence:

>1539_bases
ATGCGCAAAATCGGGATTTCGGCTCAGGCACTCGTCGCTGCTGCCTTCGGAGCTGTGATCATGGGAGGCGCGATCTCGGT
ACCGAAACTTATCGCGCCCGAGGCAGGGGCTCAGCCCATTGCCATTCAGGCGCCCCCCGGCGCGCCCCTCAGCTTTGCAG
ACCTCATCGAGAAGGTCGAACCAGCCGTCGTCAGCGTCAACGTTATTGCCACCCAGGAAGTCGGCAGCGTTCCGGGTATT
GAAGAATTCTTTGAACAGTTTCGGGGCGCCCCCGGCATGGAAGAATTCTTCCAGCAACGCCCCGCCCCGCAGGAAACACC
CCGCCAGCGCGAATCGCGCTCACTGGGCTCGGGCTTCTTCATCTCCGAAGACGGCCTCGTCGTCACCAACCATCACGTCA
TCGACCGCGCCACTCAGATCCAGATCGTCACCTCCGACGGCAAGGAACTTGAGGCCGAGCTTGTCGGCACCGACCGCCAG
ACAGACCTCGCTGTCGTTCGCGTGAAGGAAAAGGGCAAATATCCCCACGTCGAATTCGGCTCGTCGGAGAATGTCCGCAA
GGGTGACTGGGTCGTCGCGCTCGGCAACCCCTTCGGCCTTGGCGGCACGGCAACGGCCGGCATCCTCTCGGCCAATGGCC
GCGAGCTTGGCGCCGGAAGCCCGTATACGGACTTTATCCAGATCGACGCCCCGATTAACCGCGGCAACTCCGGCGGCCCG
ACCTTTGACCTCAGAGGCAACGTCATCGGCGTAAACTCGCAGATCCTCTCGCCCACCGGCGGCTCGGTCGGCATCGGCTT
TGCCATTCCCTCGGAACTGGCCAAGGAAGTCACCGATACGCTGATCAAGGACGGCCGCGTCTCCCGCGGCTGGCTCGGCG
TGCAGATCGCAGACCTCACCCCTGAATTTGCCGAAGCCCTCGGCATCGCAGACACCAAGGGGTCGCTGATCGCAGACGTA
ACGGTCGGCAGCCCGGCTGAGAAAGCCGGCCTGCGCCGCAACGACATCATCCTCTCGGTCAACGGCCAGAAGGTCACCGA
CGCAACCTCCACCACCCGCATCGTTGGCCGCCTCATCGCCAACACCGCAAACAAGTTCGACATCATCCGCGAAGGCAAGC
GCCAGACCATCAACGTCACCGTCGGCGAACGCCCCGAAGATCCGTATGCAACGCCAGGCAATCCGGGATCGCCTGACGCT
GGCCCCGGCGACCAGTCCTCCGGTGTCCCCGGCGCACTGCTGGACGATCTCGGTGTCCGCCTCGTGCCGATGACGGAAGA
AATTCGTGAACGGCTCGCGCTGCGCCCCGGTGATACCGGCCTGGCCATCACGGAAGTGACGCCCGACAGCGTGTTCGCAA
AAGCTGGCTTCGAAAGCGGCCTCGTCATTCTGGAATCCAACGGTCAACCCGTCCCGAGTGTCGCGGCGTTTGAGAAAACG
GTGAGCGAAGCCCGCGCGGCCAACCGGTCGAAAATCCTTCTGGCCGTCCGCGTCGGTCAGACCACCATTTACCGCACTGT
AGATTTGCCGGCAGGCTGA

Upstream 100 bases:

>100_bases
GATTACACCTAACTGTCTTTTAATGCCCACTCTGGCTGTGGCATGTTTATGTTTTGGCTCAACGTCATACTGGCGTAAAA
TCAGCGATCTGGAGAATTAG

Downstream 100 bases:

>100_bases
AGGAGCCAACCATGACGTTGATGGAGACCGATATGGTCGAAACAGAATCCACGACATCGCTGAAAGTCCTCGTCATCGAG
GACGACACTGAAATGGCAAG

Product: Do family protease

Products: NA

Alternate protein names: Antigen htrA [H]

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MRKIGISAQALVAAAFGAVIMGGAISVPKLIAPEAGAQPIAIQAPPGAPLSFADLIEKVEPAVVSVNVIATQEVGSVPGI
EEFFEQFRGAPGMEEFFQQRPAPQETPRQRESRSLGSGFFISEDGLVVTNHHVIDRATQIQIVTSDGKELEAELVGTDRQ
TDLAVVRVKEKGKYPHVEFGSSENVRKGDWVVALGNPFGLGGTATAGILSANGRELGAGSPYTDFIQIDAPINRGNSGGP
TFDLRGNVIGVNSQILSPTGGSVGIGFAIPSELAKEVTDTLIKDGRVSRGWLGVQIADLTPEFAEALGIADTKGSLIADV
TVGSPAEKAGLRRNDIILSVNGQKVTDATSTTRIVGRLIANTANKFDIIREGKRQTINVTVGERPEDPYATPGNPGSPDA
GPGDQSSGVPGALLDDLGVRLVPMTEEIRERLALRPGDTGLAITEVTPDSVFAKAGFESGLVILESNGQPVPSVAAFEKT
VSEARAANRSKILLAVRVGQTTIYRTVDLPAG

Sequences:

>Translated_512_residues
MRKIGISAQALVAAAFGAVIMGGAISVPKLIAPEAGAQPIAIQAPPGAPLSFADLIEKVEPAVVSVNVIATQEVGSVPGI
EEFFEQFRGAPGMEEFFQQRPAPQETPRQRESRSLGSGFFISEDGLVVTNHHVIDRATQIQIVTSDGKELEAELVGTDRQ
TDLAVVRVKEKGKYPHVEFGSSENVRKGDWVVALGNPFGLGGTATAGILSANGRELGAGSPYTDFIQIDAPINRGNSGGP
TFDLRGNVIGVNSQILSPTGGSVGIGFAIPSELAKEVTDTLIKDGRVSRGWLGVQIADLTPEFAEALGIADTKGSLIADV
TVGSPAEKAGLRRNDIILSVNGQKVTDATSTTRIVGRLIANTANKFDIIREGKRQTINVTVGERPEDPYATPGNPGSPDA
GPGDQSSGVPGALLDDLGVRLVPMTEEIRERLALRPGDTGLAITEVTPDSVFAKAGFESGLVILESNGQPVPSVAAFEKT
VSEARAANRSKILLAVRVGQTTIYRTVDLPAG
>Mature_512_residues
MRKIGISAQALVAAAFGAVIMGGAISVPKLIAPEAGAQPIAIQAPPGAPLSFADLIEKVEPAVVSVNVIATQEVGSVPGI
EEFFEQFRGAPGMEEFFQQRPAPQETPRQRESRSLGSGFFISEDGLVVTNHHVIDRATQIQIVTSDGKELEAELVGTDRQ
TDLAVVRVKEKGKYPHVEFGSSENVRKGDWVVALGNPFGLGGTATAGILSANGRELGAGSPYTDFIQIDAPINRGNSGGP
TFDLRGNVIGVNSQILSPTGGSVGIGFAIPSELAKEVTDTLIKDGRVSRGWLGVQIADLTPEFAEALGIADTKGSLIADV
TVGSPAEKAGLRRNDIILSVNGQKVTDATSTTRIVGRLIANTANKFDIIREGKRQTINVTVGERPEDPYATPGNPGSPDA
GPGDQSSGVPGALLDDLGVRLVPMTEEIRERLALRPGDTGLAITEVTPDSVFAKAGFESGLVILESNGQPVPSVAAFEKT
VSEARAANRSKILLAVRVGQTTIYRTVDLPAG

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=351, Percent_Identity=33.6182336182336, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI24308541, Length=252, Percent_Identity=38.4920634920635, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI22129776, Length=339, Percent_Identity=31.858407079646, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI7019477, Length=356, Percent_Identity=30.6179775280899, Blast_Score=145, Evalue=1e-34,
Organism=Escherichia coli, GI1786356, Length=487, Percent_Identity=33.4702258726899, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI1789629, Length=468, Percent_Identity=35.6837606837607, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1789630, Length=301, Percent_Identity=36.5448504983389, Blast_Score=187, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24646839, Length=296, Percent_Identity=33.445945945946, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 53518; Mature: 53518

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKIGISAQALVAAAFGAVIMGGAISVPKLIAPEAGAQPIAIQAPPGAPLSFADLIEKVE
CCCCCCCHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCEEEECCCCCCCCHHHHHHHCC
PAVVSVNVIATQEVGSVPGIEEFFEQFRGAPGMEEFFQQRPAPQETPRQRESRSLGSGFF
CEEEEEEEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHCCCCCEE
ISEDGLVVTNHHVIDRATQIQIVTSDGKELEAELVGTDRQTDLAVVRVKEKGKYPHVEFG
ECCCCEEEECCCEECCCEEEEEEECCCCEEEEEEECCCCCCCEEEEEEECCCCCCCEEEC
SSENVRKGDWVVALGNPFGLGGTATAGILSANGRELGAGSPYTDFIQIDAPINRGNSGGP
CCCCCCCCCEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCC
TFDLRGNVIGVNSQILSPTGGSVGIGFAIPSELAKEVTDTLIKDGRVSRGWLGVQIADLT
EEEECCCEEECCCEEECCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCC
PEFAEALGIADTKGSLIADVTVGSPAEKAGLRRNDIILSVNGQKVTDATSTTRIVGRLIA
HHHHHHHCCCCCCCCEEEEEECCCCHHHHCCCCCCEEEEECCCEEECCHHHHHHHHHHHH
NTANKFDIIREGKRQTINVTVGERPEDPYATPGNPGSPDAGPGDQSSGVPGALLDDLGVR
CCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCE
LVPMTEEIRERLALRPGDTGLAITEVTPDSVFAKAGFESGLVILESNGQPVPSVAAFEKT
EEECHHHHHHHHCCCCCCCCEEEEEECCCHHHHHCCCCCCEEEEECCCCCCCHHHHHHHH
VSEARAANRSKILLAVRVGQTTIYRTVDLPAG
HHHHHHCCCCEEEEEEEECCEEEEEEEECCCC
>Mature Secondary Structure
MRKIGISAQALVAAAFGAVIMGGAISVPKLIAPEAGAQPIAIQAPPGAPLSFADLIEKVE
CCCCCCCHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCEEEECCCCCCCCHHHHHHHCC
PAVVSVNVIATQEVGSVPGIEEFFEQFRGAPGMEEFFQQRPAPQETPRQRESRSLGSGFF
CEEEEEEEEEECCCCCCCCHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHCCCCCEE
ISEDGLVVTNHHVIDRATQIQIVTSDGKELEAELVGTDRQTDLAVVRVKEKGKYPHVEFG
ECCCCEEEECCCEECCCEEEEEEECCCCEEEEEEECCCCCCCEEEEEEECCCCCCCEEEC
SSENVRKGDWVVALGNPFGLGGTATAGILSANGRELGAGSPYTDFIQIDAPINRGNSGGP
CCCCCCCCCEEEECCCCCCCCCCCCCEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCCC
TFDLRGNVIGVNSQILSPTGGSVGIGFAIPSELAKEVTDTLIKDGRVSRGWLGVQIADLT
EEEECCCEEECCCEEECCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEEEECCC
PEFAEALGIADTKGSLIADVTVGSPAEKAGLRRNDIILSVNGQKVTDATSTTRIVGRLIA
HHHHHHHCCCCCCCCEEEEEECCCCHHHHCCCCCCEEEEECCCEEECCHHHHHHHHHHHH
NTANKFDIIREGKRQTINVTVGERPEDPYATPGNPGSPDAGPGDQSSGVPGALLDDLGVR
CCCHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCE
LVPMTEEIRERLALRPGDTGLAITEVTPDSVFAKAGFESGLVILESNGQPVPSVAAFEKT
EEECHHHHHHHHCCCCCCCCEEEEEECCCHHHHHCCCCCCEEEEECCCCCCCHHHHHHHH
VSEARAANRSKILLAVRVGQTTIYRTVDLPAG
HHHHHHCCCCEEEEEEEECCEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8027347 [H]