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The map label for this gene is hisN [H]

Identifier: 114797506

GI number: 114797506

Start: 218407

End: 219219

Strand: Reverse

Name: hisN [H]

Synonym: HNE_0226

Alternate gene names: 114797506

Gene position: 219219-218407 (Counterclockwise)

Preceding gene: 114798925

Following gene: 114799501

Centisome position: 5.92

GC content: 66.54

Gene sequence:

>813_bases
ATGACCTCTATCCGAAATATCGCAGACGACATCGCCCTCGCCCGCCGGCTCGCTGATGCCGCATGGGCCGCCATCCGCCC
GCATTTCCGGAATCTGGACGCCGTCGATCATAAATCCGGCACGGAAAAATCCGGCTTCGACCCCGTGACTGAAGCAGACC
GCGCCGCCGAACTGGCGATGCGCGCTCTCATTTCCACGCAGCGCCCGGATGACGGCGTCACGGGCGAGGAATTCCCGGAA
ACCGCCTCAACCAGCGGCTGGCGCTGGTATTTTGACCCAATCGACGGCACGCGCGCCTTCGTCGCCGGCCTGCCTGTCTG
GACCACGCTCATTGCCCTCGTGAACCCCGAGGGCGTTCCGGTGATCGGCGTTATCGACCAGCCTGTGGTGGGCGAGCGCT
ATCTCGGCTGGCCCGGCGGCGCAGAGATGCAAACTCCAGAGGGCACGTTCCCGATCAGAGTTTCAGGCAATCCCGACCTG
CGCACCGCCACCATCGCGACAACCGATCCCTTCATCTTCACCCCGCCCGAACAGGGCGCATGGAACCATCTGCGCGCCAC
CGCGCGGATCGCCCGCTACGGGCTTGATGCCTATGCCTACGCCCGCATTGCCGGGGGCACGCTGGATCTGGTCGCCGAGT
CGGGCCTCAAGGCCTGGGATGTGGCCGCGCTTATCCCTGTTGTTCGTGGCGCGGGCGGCCTTGCTACAAACTGGCGAGGC
GAACCACCAGCGCTCGGCGGGCAGATCGTCTGCGCCGCCAGCCAGGGCATTCTCGCTCAGGCGCTGCTCGCCCTGCGCCG
CGCGGCAGACTGA

Upstream 100 bases:

>100_bases
CGCGCCGCCGCCTGCTGGAGCTTGCCAAAGCCCTGGAGCAGGACACTTCCAGCACCGGCGCTGCTTGACCTGATCTCATG
GGCGGGGCATCGCCTCGCCC

Downstream 100 bases:

>100_bases
GCGGCCTTACGGCCCCTCGACCGTATAACCCTCGTCGCGCAGCATCTTGATGACACTGTCTTCACCGGCCAGGTGGCCCG
CGCCAACGGCAATCAGGATC

Product: inositol monophosphatase family protein

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MTSIRNIADDIALARRLADAAWAAIRPHFRNLDAVDHKSGTEKSGFDPVTEADRAAELAMRALISTQRPDDGVTGEEFPE
TASTSGWRWYFDPIDGTRAFVAGLPVWTTLIALVNPEGVPVIGVIDQPVVGERYLGWPGGAEMQTPEGTFPIRVSGNPDL
RTATIATTDPFIFTPPEQGAWNHLRATARIARYGLDAYAYARIAGGTLDLVAESGLKAWDVAALIPVVRGAGGLATNWRG
EPPALGGQIVCAASQGILAQALLALRRAAD

Sequences:

>Translated_270_residues
MTSIRNIADDIALARRLADAAWAAIRPHFRNLDAVDHKSGTEKSGFDPVTEADRAAELAMRALISTQRPDDGVTGEEFPE
TASTSGWRWYFDPIDGTRAFVAGLPVWTTLIALVNPEGVPVIGVIDQPVVGERYLGWPGGAEMQTPEGTFPIRVSGNPDL
RTATIATTDPFIFTPPEQGAWNHLRATARIARYGLDAYAYARIAGGTLDLVAESGLKAWDVAALIPVVRGAGGLATNWRG
EPPALGGQIVCAASQGILAQALLALRRAAD
>Mature_269_residues
TSIRNIADDIALARRLADAAWAAIRPHFRNLDAVDHKSGTEKSGFDPVTEADRAAELAMRALISTQRPDDGVTGEEFPET
ASTSGWRWYFDPIDGTRAFVAGLPVWTTLIALVNPEGVPVIGVIDQPVVGERYLGWPGGAEMQTPEGTFPIRVSGNPDLR
TATIATTDPFIFTPPEQGAWNHLRATARIARYGLDAYAYARIAGGTLDLVAESGLKAWDVAALIPVVRGAGGLATNWRGE
PPALGGQIVCAASQGILAQALLALRRAAD

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Escherichia coli, GI1788882, Length=267, Percent_Identity=29.5880149812734, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI193202572, Length=256, Percent_Identity=27.34375, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193202570, Length=259, Percent_Identity=27.4131274131274, Blast_Score=78, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 28752; Mature: 28621

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSIRNIADDIALARRLADAAWAAIRPHFRNLDAVDHKSGTEKSGFDPVTEADRAAELAM
CCCHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
RALISTQRPDDGVTGEEFPETASTSGWRWYFDPIDGTRAFVAGLPVWTTLIALVNPEGVP
HHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHCCHHHHHHHHHCCCCCCE
VIGVIDQPVVGERYLGWPGGAEMQTPEGTFPIRVSGNPDLRTATIATTDPFIFTPPEQGA
EEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEEECCCEEEECCCCCC
WNHLRATARIARYGLDAYAYARIAGGTLDLVAESGLKAWDVAALIPVVRGAGGLATNWRG
HHHHHHHHHHHHHCCCHHHHHHHCCCHHEEHHHCCCCHHHHHHHHHHHHCCCCCCCCCCC
EPPALGGQIVCAASQGILAQALLALRRAAD
CCCCCCCEEEEECCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSIRNIADDIALARRLADAAWAAIRPHFRNLDAVDHKSGTEKSGFDPVTEADRAAELAM
CCHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
RALISTQRPDDGVTGEEFPETASTSGWRWYFDPIDGTRAFVAGLPVWTTLIALVNPEGVP
HHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHCCHHHHHHHHHCCCCCCE
VIGVIDQPVVGERYLGWPGGAEMQTPEGTFPIRVSGNPDLRTATIATTDPFIFTPPEQGA
EEEECCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEEECCCEEEECCCCCC
WNHLRATARIARYGLDAYAYARIAGGTLDLVAESGLKAWDVAALIPVVRGAGGLATNWRG
HHHHHHHHHHHHHCCCHHHHHHHCCCHHEEHHHCCCCHHHHHHHHHHHHCCCCCCCCCCC
EPPALGGQIVCAASQGILAQALLALRRAAD
CCCCCCCEEEEECCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]