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The map label for this gene is serA [H]

Identifier: 114797371

GI number: 114797371

Start: 1502482

End: 1503495

Strand: Reverse

Name: serA [H]

Synonym: HNE_1475

Alternate gene names: 114797371

Gene position: 1503495-1502482 (Counterclockwise)

Preceding gene: 114800104

Following gene: 114798151

Centisome position: 40.58

GC content: 61.54

Gene sequence:

>1014_bases
ATGAAAAAGCCTCCCCGGAGGGTGGTCGTCACTCAGAAATTCTTCGATGATGCGGCCATCGCCTTTCTGCAGGACAGGAA
TATTGAGGTCATCCTCCCGAACCTGCCTGAAGGCAAAGGCGAGGGCGATCTGAATGTGGAGGACATCCGCCTGCTTCTGG
AGGGCGCAGGCGGCTGGGTTGTCGGGCATGCGCGCATTACCCGCGCAGTATTTGAGGCCCTTCCCGATCTGGCTGTCATC
TCCCGGCGGGGAGTGGGTTATGAAAAGGTAGACGTCGAGGCGGCCAGAGACCTTGGCCGGGTTGTGGCGATTGCCGCGGG
CGGGAATGATGCCTCGGTGGCCGATCAGGTAATCGGCATGATGATCTCCATCGGCCGCCGCTTCCAGGAAGCCCAGAGCG
CGATGAAGGCCGGCAAATGGAACATCCTTGTCGGGACAGAACTCTACCGCCGCAAGGTCGGCATCGTCGGCTTCGGCCGT
ATCGGGCGCAGCCTCGCCAGACGCCTCAGCGGGTTTGAGGCTGAAATCCTGGTGTGCGCCCCACGCCTCGCCAGCGAAGA
CATCGAAACATTCGGCCTGCGCCATGTGGCTTTTGAAACGCTGCTGAAAGAGGCGGACTATATCTCGGTCCACGCCCCTC
TGACGCCGGAAACACGCCATATGTTCAACGCGGCTGCCTTCGGCAGAATGAAACCCTCTGCCGTACTCATTAATTCCGCC
CGCGGTGGCCTTGTGGATGATACCGCGCTGCTGGCCGCGCTGGAAAGCGGGCAGATCCTCGGCGCCGGACTCGACGTCTA
TGAAAGCGAAAGCGATCCGTCAAAACAGCCTGTCACCGACGCGCTGATCGCACGGCATGATGTCATCGCCGCCCCTCATG
CCGGCGCCTCCACGCATGAAGCCCTCGCCCGTACGAACAGGATCGCTGCTCTGTGTGCGGCAGAAGTCATTGATGGCGGA
AATCCGCCCGCTGCCTGCATAGTCGCCGATGGACGCTCAGCGCCTGGAAGCTGA

Upstream 100 bases:

>100_bases
CGGGATGACGCTACAGTGGCGCACTGAGATCGAAACCTTCCAATCCCGCTATCTGGGCGCGCGCGCCTGGCTGGCCTGAC
AACACGCAAGGACACTCCCG

Downstream 100 bases:

>100_bases
TCAGGGAAACCCCAGACAGCTGCCTTAGGCTCCGCCAGGAGGGCTTAAGGCCCTTATCTGGCCCCTCGCTACACATGCCG
AGACAGACGGCCCGGCCTGC

Product: D-isomer specific 2-hydroxyacid dehydrogenase family protein

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MKKPPRRVVVTQKFFDDAAIAFLQDRNIEVILPNLPEGKGEGDLNVEDIRLLLEGAGGWVVGHARITRAVFEALPDLAVI
SRRGVGYEKVDVEAARDLGRVVAIAAGGNDASVADQVIGMMISIGRRFQEAQSAMKAGKWNILVGTELYRRKVGIVGFGR
IGRSLARRLSGFEAEILVCAPRLASEDIETFGLRHVAFETLLKEADYISVHAPLTPETRHMFNAAAFGRMKPSAVLINSA
RGGLVDDTALLAALESGQILGAGLDVYESESDPSKQPVTDALIARHDVIAAPHAGASTHEALARTNRIAALCAAEVIDGG
NPPAACIVADGRSAPGS

Sequences:

>Translated_337_residues
MKKPPRRVVVTQKFFDDAAIAFLQDRNIEVILPNLPEGKGEGDLNVEDIRLLLEGAGGWVVGHARITRAVFEALPDLAVI
SRRGVGYEKVDVEAARDLGRVVAIAAGGNDASVADQVIGMMISIGRRFQEAQSAMKAGKWNILVGTELYRRKVGIVGFGR
IGRSLARRLSGFEAEILVCAPRLASEDIETFGLRHVAFETLLKEADYISVHAPLTPETRHMFNAAAFGRMKPSAVLINSA
RGGLVDDTALLAALESGQILGAGLDVYESESDPSKQPVTDALIARHDVIAAPHAGASTHEALARTNRIAALCAAEVIDGG
NPPAACIVADGRSAPGS
>Mature_337_residues
MKKPPRRVVVTQKFFDDAAIAFLQDRNIEVILPNLPEGKGEGDLNVEDIRLLLEGAGGWVVGHARITRAVFEALPDLAVI
SRRGVGYEKVDVEAARDLGRVVAIAAGGNDASVADQVIGMMISIGRRFQEAQSAMKAGKWNILVGTELYRRKVGIVGFGR
IGRSLARRLSGFEAEILVCAPRLASEDIETFGLRHVAFETLLKEADYISVHAPLTPETRHMFNAAAFGRMKPSAVLINSA
RGGLVDDTALLAALESGQILGAGLDVYESESDPSKQPVTDALIARHDVIAAPHAGASTHEALARTNRIAALCAAEVIDGG
NPPAACIVADGRSAPGS

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=317, Percent_Identity=34.384858044164, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI61743967, Length=298, Percent_Identity=29.1946308724832, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI4557497, Length=298, Percent_Identity=29.1946308724832, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI145580578, Length=263, Percent_Identity=31.5589353612167, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI4557499, Length=263, Percent_Identity=31.5589353612167, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI6912396, Length=251, Percent_Identity=32.2709163346614, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI145580575, Length=263, Percent_Identity=31.5589353612167, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI87082289, Length=292, Percent_Identity=36.3013698630137, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1787645, Length=250, Percent_Identity=34.4, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1789279, Length=246, Percent_Identity=34.5528455284553, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788660, Length=223, Percent_Identity=30.9417040358744, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87081824, Length=268, Percent_Identity=26.1194029850746, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=230, Percent_Identity=34.3478260869565, Blast_Score=137, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI25147481, Length=272, Percent_Identity=28.6764705882353, Blast_Score=101, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6324055, Length=258, Percent_Identity=33.3333333333333, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322116, Length=275, Percent_Identity=30.5454545454545, Blast_Score=118, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320925, Length=275, Percent_Identity=30.5454545454545, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6324964, Length=233, Percent_Identity=27.0386266094421, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6325144, Length=178, Percent_Identity=27.5280898876405, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321253, Length=180, Percent_Identity=30.5555555555556, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19921140, Length=231, Percent_Identity=38.0952380952381, Blast_Score=157, Evalue=7e-39,
Organism=Drosophila melanogaster, GI28574286, Length=254, Percent_Identity=36.2204724409449, Blast_Score=151, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24585514, Length=261, Percent_Identity=35.632183908046, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI28574282, Length=261, Percent_Identity=35.632183908046, Blast_Score=149, Evalue=3e-36,
Organism=Drosophila melanogaster, GI45552429, Length=261, Percent_Identity=35.632183908046, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI28574284, Length=261, Percent_Identity=35.632183908046, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI45551003, Length=261, Percent_Identity=35.632183908046, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI28571528, Length=253, Percent_Identity=35.5731225296443, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24585516, Length=249, Percent_Identity=34.5381526104418, Blast_Score=141, Evalue=7e-34,
Organism=Drosophila melanogaster, GI62472511, Length=257, Percent_Identity=31.9066147859922, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646446, Length=285, Percent_Identity=30.5263157894737, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646448, Length=285, Percent_Identity=30.5263157894737, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646452, Length=285, Percent_Identity=30.5263157894737, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646450, Length=285, Percent_Identity=30.5263157894737, Blast_Score=116, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 35770; Mature: 35770

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKPPRRVVVTQKFFDDAAIAFLQDRNIEVILPNLPEGKGEGDLNVEDIRLLLEGAGGWV
CCCCCCEEEEEHHHHHHHHEEEEECCCEEEEECCCCCCCCCCCCCHHHHHHEEECCCCEE
VGHARITRAVFEALPDLAVISRRGVGYEKVDVEAARDLGRVVAIAAGGNDASVADQVIGM
EEHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHH
MISIGRRFQEAQSAMKAGKWNILVGTELYRRKVGIVGFGRIGRSLARRLSGFEAEILVCA
HHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHCCEEEHHHHHHHHHHHHCCCCEEEEEEC
PRLASEDIETFGLRHVAFETLLKEADYISVHAPLTPETRHMFNAAAFGRMKPSAVLINSA
CCHHHCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECC
RGGLVDDTALLAALESGQILGAGLDVYESESDPSKQPVTDALIARHDVIAAPHAGASTHE
CCCCCCHHHHHHHHCCCCEEECCCEEECCCCCCCCCCHHHHHHHHHHEEECCCCCCHHHH
ALARTNRIAALCAAEVIDGGNPPAACIVADGRSAPGS
HHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MKKPPRRVVVTQKFFDDAAIAFLQDRNIEVILPNLPEGKGEGDLNVEDIRLLLEGAGGWV
CCCCCCEEEEEHHHHHHHHEEEEECCCEEEEECCCCCCCCCCCCCHHHHHHEEECCCCEE
VGHARITRAVFEALPDLAVISRRGVGYEKVDVEAARDLGRVVAIAAGGNDASVADQVIGM
EEHHHHHHHHHHHCCCHHHHHHCCCCCCHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHH
MISIGRRFQEAQSAMKAGKWNILVGTELYRRKVGIVGFGRIGRSLARRLSGFEAEILVCA
HHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHCCEEEHHHHHHHHHHHHCCCCEEEEEEC
PRLASEDIETFGLRHVAFETLLKEADYISVHAPLTPETRHMFNAAAFGRMKPSAVLINSA
CCHHHCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECC
RGGLVDDTALLAALESGQILGAGLDVYESESDPSKQPVTDALIARHDVIAAPHAGASTHE
CCCCCCHHHHHHHHCCCCEEECCCEEECCCCCCCCCCHHHHHHHHHHEEECCCCCCHHHH
ALARTNRIAALCAAEVIDGGNPPAACIVADGRSAPGS
HHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]