Click here to switch to the map view.

The map label for this gene is ccmE

Identifier: 114797067

GI number: 114797067

Start: 1341563

End: 1341988

Strand: Direct

Name: ccmE

Synonym: HNE_1309

Alternate gene names: 114797067

Gene position: 1341563-1341988 (Clockwise)

Preceding gene: 114799426

Following gene: 114797201

Centisome position: 36.21

GC content: 64.79

Gene sequence:

>426_bases
ATGCGCGCACGGACCCGACGGCTTTATACTTTTGGCATTGCGGCCGCCCTGATTGTTGCGGCGGCGGCGCTGGCGTTCTT
TGCGCTGCGCGAGAATGCCAATCTCTTCTACACGCCTGAAGTTCTTGCCGAAAAAGGCCTGCCTCGCGAGGGGCGGGAGG
TGAAGGTGGGCGGCTGGGTGGAGCCCGGATCGCTGACCTATGCCGATGGCGGGGCGACGATGCGGTTTACCGTGATCGAC
AACAGCCCGAGCACCATTACCGTGAGCTTCAATGGCGTGGCGCCCGACCTGTTCCGCGAGGGGCAGGGCGTTGTGGCGAC
CGGCACATTTACGCCGGAGGGCGAGTTCACTGCGCGCCAGCTGCTGGCCAAGCATGACGAGAATTACCAGCCGCGCGAGC
TGAAGCCGCTCGAGGCGGGCGGATGA

Upstream 100 bases:

>100_bases
GGCCGATGATCGAGGCGATTGGGCAGGCGCCGGCTGAGCCGGAATAGCGCTGTATCTGCCGCACTCCCCAAGGGGGGCGG
GGCAGCTTATAACCTGACCC

Downstream 100 bases:

>100_bases
TCGAACTCGGCCATTTTGCCGCCTTCCTCGCACTGGGGCTGGCTTTGGCGCAGACGGTGCTGGGGCTGAAGGGCGAGCGG
CGCCTGGCGGGGCTGGCGGC

Product: cytochrome c-type biogenesis protein CcmE

Products: NA

Alternate protein names: Cytochrome c maturation protein E; Heme chaperone CcmE

Number of amino acids: Translated: 141; Mature: 141

Protein sequence:

>141_residues
MRARTRRLYTFGIAAALIVAAAALAFFALRENANLFYTPEVLAEKGLPREGREVKVGGWVEPGSLTYADGGATMRFTVID
NSPSTITVSFNGVAPDLFREGQGVVATGTFTPEGEFTARQLLAKHDENYQPRELKPLEAGG

Sequences:

>Translated_141_residues
MRARTRRLYTFGIAAALIVAAAALAFFALRENANLFYTPEVLAEKGLPREGREVKVGGWVEPGSLTYADGGATMRFTVID
NSPSTITVSFNGVAPDLFREGQGVVATGTFTPEGEFTARQLLAKHDENYQPRELKPLEAGG
>Mature_141_residues
MRARTRRLYTFGIAAALIVAAAALAFFALRENANLFYTPEVLAEKGLPREGREVKVGGWVEPGSLTYADGGATMRFTVID
NSPSTITVSFNGVAPDLFREGQGVVATGTFTPEGEFTARQLLAKHDENYQPRELKPLEAGG

Specific function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

COG id: COG2332

COG function: function code O; Cytochrome c-type biogenesis protein CcmE

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmE/CycJ family

Homologues:

Organism=Escherichia coli, GI1788525, Length=142, Percent_Identity=40.8450704225352, Blast_Score=100, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCME_HYPNA (Q0C2L6)

Other databases:

- EMBL:   CP000158
- RefSeq:   YP_760027.1
- ProteinModelPortal:   Q0C2L6
- SMR:   Q0C2L6
- STRING:   Q0C2L6
- GeneID:   4287035
- GenomeReviews:   CP000158_GR
- KEGG:   hne:HNE_1309
- NMPDR:   fig|228405.5.peg.1273
- TIGR:   HNE_1309
- eggNOG:   COG2332
- HOGENOM:   HBG296631
- OMA:   HVEFAVH
- PhylomeDB:   Q0C2L6
- BioCyc:   HNEP81032:HNE_1309-MONOMER
- HAMAP:   MF_01959
- InterPro:   IPR004329
- InterPro:   IPR012340
- Gene3D:   G3DSA:2.40.50.140

Pfam domain/function: PF03100 CcmE; SSF82093 Pyrv/PenolPyrv_Kinase_cat

EC number: NA

Molecular weight: Translated: 15236; Mature: 15236

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: BINDING 125-125

Signals:

None

Transmembrane regions:

HASH(0x126cdf5c)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRARTRRLYTFGIAAALIVAAAALAFFALRENANLFYTPEVLAEKGLPREGREVKVGGWV
CCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHCCCCCCCCEEEECCEE
EPGSLTYADGGATMRFTVIDNSPSTITVSFNGVAPDLFREGQGVVATGTFTPEGEFTARQ
CCCCEEEECCCCEEEEEEEECCCCEEEEEECCCCHHHHHCCCCEEEECCCCCCCCHHHHH
LLAKHDENYQPRELKPLEAGG
HHHHCCCCCCCCCCCCCCCCH
>Mature Secondary Structure
MRARTRRLYTFGIAAALIVAAAALAFFALRENANLFYTPEVLAEKGLPREGREVKVGGWV
CCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHCCCCCCCCEEEECCEE
EPGSLTYADGGATMRFTVIDNSPSTITVSFNGVAPDLFREGQGVVATGTFTPEGEFTARQ
CCCCEEEECCCCEEEEEEEECCCCEEEEEECCCCHHHHHCCCCEEEECCCCCCCCHHHHH
LLAKHDENYQPRELKPLEAGG
HHHHCCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA