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The map label for this gene is ctaC [H]

Identifier: 114332352

GI number: 114332352

Start: 2509074

End: 2509916

Strand: Reverse

Name: ctaC [H]

Synonym: Neut_2395

Alternate gene names: 114332352

Gene position: 2509916-2509074 (Counterclockwise)

Preceding gene: 114332358

Following gene: 114332351

Centisome position: 94.32

GC content: 43.53

Gene sequence:

>843_bases
ATGAAGGGTAGTAAGTTGATGGCGTTGCTATCAAGTTTTGTAGTTCTTGGTTCTTATTCAGGGCTGGCGATATCAAGCAA
GTATAACCTGCCTGAACCACAGACTCCGATTGCACAGGAGATATATGATCAGCACATAATGGCTTTATGGATCTGTCTGA
TAATATTTGTCGGTGTATTCGGTGTGATGGGTTATTCCATTGTCAAGCACCGTAAATCGGTTGGCTATAAAGCAGCAAAT
TTTCATCACAGCACGGTTGTTGAGCTGGTGTGGACAGCTATTCCTGTATTGATCTTAATCGCAATATCATGGCCAGCAAC
CAAAACAGTTATTGCAATGAAAGATACAAGTGAAGCAGACATTACCATCAAGGCTACCGGATATCAGTGGATGTGGGGAT
ATGACTACATTCAAGGAGAAGGTGAGGGAATCAGTTTTTACAGTCAGTTAGCTACTTCTCAGGATCAGATCCGTAACCAG
GCACCTAAGGGGGAAAATTATTTGCTGGAAGTGGATAATCGTGTGGTAGTACCGACTGGCAAGAAAATTAGAGTACTCAT
GACAGCCAATGATGTCATCCATGCTTGGTGGGTACCTGCGCTTGGCGTAAAGCAAGACGCTATACCTGGATTTATTCGTG
ATGCATGGTTTAAAGTCGAAAAGCCAGGTATCTATCGTGGCCAGTGTGCTGAGCTTTGTGGTAAGGAACATGGATTTATG
CCGGTAGTCGTAGAGGTAATGGAACAGGAAAAATACAGTCAGTGGGTTGCGGAGAGACAAAAAACCGCATCAGCTGCAGT
TGTGAATACAGCTCTCGTTAAAAATGAGGCGAGTAAAAACTGA

Upstream 100 bases:

>100_bases
CAAATATTCTTATGAGCAGCTAATTGTGAGGCGTGGAGATGCTACAGGATCACAGGCGAGCTGCTGAAATTGATTTGGTA
ATTAATGTGGGGGGTAAGAT

Downstream 100 bases:

>100_bases
TATATCCAGATACGGTTAGTCGGGATATAGATCAAATTAGATTAAAAAAGGAGAAGATAATGGCGGTAATACAAGATGTA
CATGGCCATACACATGATCA

Product: cytochrome c oxidase, subunit II

Products: NA

Alternate protein names: Cytochrome aa3 subunit 2; Cytochrome c oxidase polypeptide II [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MKGSKLMALLSSFVVLGSYSGLAISSKYNLPEPQTPIAQEIYDQHIMALWICLIIFVGVFGVMGYSIVKHRKSVGYKAAN
FHHSTVVELVWTAIPVLILIAISWPATKTVIAMKDTSEADITIKATGYQWMWGYDYIQGEGEGISFYSQLATSQDQIRNQ
APKGENYLLEVDNRVVVPTGKKIRVLMTANDVIHAWWVPALGVKQDAIPGFIRDAWFKVEKPGIYRGQCAELCGKEHGFM
PVVVEVMEQEKYSQWVAERQKTASAAVVNTALVKNEASKN

Sequences:

>Translated_280_residues
MKGSKLMALLSSFVVLGSYSGLAISSKYNLPEPQTPIAQEIYDQHIMALWICLIIFVGVFGVMGYSIVKHRKSVGYKAAN
FHHSTVVELVWTAIPVLILIAISWPATKTVIAMKDTSEADITIKATGYQWMWGYDYIQGEGEGISFYSQLATSQDQIRNQ
APKGENYLLEVDNRVVVPTGKKIRVLMTANDVIHAWWVPALGVKQDAIPGFIRDAWFKVEKPGIYRGQCAELCGKEHGFM
PVVVEVMEQEKYSQWVAERQKTASAAVVNTALVKNEASKN
>Mature_280_residues
MKGSKLMALLSSFVVLGSYSGLAISSKYNLPEPQTPIAQEIYDQHIMALWICLIIFVGVFGVMGYSIVKHRKSVGYKAAN
FHHSTVVELVWTAIPVLILIAISWPATKTVIAMKDTSEADITIKATGYQWMWGYDYIQGEGEGISFYSQLATSQDQIRNQ
APKGENYLLEVDNRVVVPTGKKIRVLMTANDVIHAWWVPALGVKQDAIPGFIRDAWFKVEKPGIYRGQCAELCGKEHGFM
PVVVEVMEQEKYSQWVAERQKTASAAVVNTALVKNEASKN

Specific function: Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) [H]

COG id: COG1622

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 2

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RPE1 insert domain [H]

Homologues:

Organism=Homo sapiens, GI251831110, Length=231, Percent_Identity=34.1991341991342, Blast_Score=143, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6226540, Length=230, Percent_Identity=33.0434782608696, Blast_Score=135, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001505
- InterPro:   IPR008972
- InterPro:   IPR014222
- InterPro:   IPR015964
- InterPro:   IPR002429
- InterPro:   IPR011759
- InterPro:   IPR005728 [H]

Pfam domain/function: PF00116 COX2; PF02790 COX2_TM [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 31175; Mature: 31175

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: PS00078 COX2 ; PS50999 COX2_TM ; PS50857 COX2_CUA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGSKLMALLSSFVVLGSYSGLAISSKYNLPEPQTPIAQEIYDQHIMALWICLIIFVGVF
CCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GVMGYSIVKHRKSVGYKAANFHHSTVVELVWTAIPVLILIAISWPATKTVIAMKDTSEAD
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCC
ITIKATGYQWMWGYDYIQGEGEGISFYSQLATSQDQIRNQAPKGENYLLEVDNRVVVPTG
EEEEECCEEEEECCCEEECCCCCHHHHHHHHCCHHHHHHCCCCCCCEEEEECCEEEECCC
KKIRVLMTANDVIHAWWVPALGVKQDAIPGFIRDAWFKVEKPGIYRGQCAELCGKEHGFM
CEEEEEEECCCEEHHHHCCCCCCCCCCCCHHHHHHHEEECCCCCCCCHHHHHCCCCCCCH
PVVVEVMEQEKYSQWVAERQKTASAAVVNTALVKNEASKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKGSKLMALLSSFVVLGSYSGLAISSKYNLPEPQTPIAQEIYDQHIMALWICLIIFVGVF
CCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GVMGYSIVKHRKSVGYKAANFHHSTVVELVWTAIPVLILIAISWPATKTVIAMKDTSEAD
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCC
ITIKATGYQWMWGYDYIQGEGEGISFYSQLATSQDQIRNQAPKGENYLLEVDNRVVVPTG
EEEEECCEEEEECCCEEECCCCCHHHHHHHHCCHHHHHHCCCCCCCEEEEECCEEEECCC
KKIRVLMTANDVIHAWWVPALGVKQDAIPGFIRDAWFKVEKPGIYRGQCAELCGKEHGFM
CEEEEEEECCCEEHHHHCCCCCCCCCCCCHHHHHHHEEECCCCCCCCHHHHHCCCCCCCH
PVVVEVMEQEKYSQWVAERQKTASAAVVNTALVKNEASKN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9823893; 11030655 [H]