Click here to switch to the map view.

The map label for this gene is nhaA [H]

Identifier: 114332358

GI number: 114332358

Start: 2515966

End: 2516919

Strand: Reverse

Name: nhaA [H]

Synonym: Neut_2402

Alternate gene names: 114332358

Gene position: 2516919-2515966 (Counterclockwise)

Preceding gene: 114332359

Following gene: 114332352

Centisome position: 94.58

GC content: 45.39

Gene sequence:

>954_bases
ATGGCTGATACAGAAAATACCAACAAGGAAAAATGGGAGAGAGAAACACTGCGGGATTTGGTGTTTTCCTCTCTGAAGGA
GCAGAAAAAAGCACGCAACTGGGGTATTTTTTTCCGCTTGCTAACCTTTTCTTATTTATTTACGCTACTTTTTTGGGGGT
TAGGTTGGTTAGATACCGAAGCAACAGGTGGTTTTGGCAAGCACACTGCACTGGTTGATTTGCGCGGTGAAATTACTGCG
GATGGTTTAAACAGCGCAGAAAATATTAATACCGGACTGAAAAAAGCATTTGAAGATAAAAATACAGCTGCTGTGATATT
ACGGATTAATAGCCCTGGTGGCAGCCCGGTTCAGGCTGGCTCTATTAACGATGAAATTCATCGGTTGCGTACACAGCATC
CTGATATTCCCTTATATGCCGTAGTTGAAGATATTTGCGCTTCGGGAGGTTATTACATCGCTGTTGCAGCGGACAAAATT
TTCGTAGATAAGGCCAGTATCGTAGGATCAATTGGCGTACTCATGGATGGATTCGGATTTACCGGGACGCTTGAAAAATT
GGGGATAGAGCGTCGCTTGTTGACAGCTGGAGAAAACAAGGGGTTTCTTGATCCTTTCTCGCCTTCCGACCCTGGACAGA
GAGAACACGCCAAGAAAATGCTGGTGGAAATTCATCAGCAATTTATCCAGGTCGTTCAGGATGGCAGAGGGGATCGCTTG
AAAGACAATCCTGAGATTTTTAGCGGTATGGTCTGGACAGGAGCTAGAAGTATAGAGTTGGGTCTGGCCGATGCCTTAGG
CAGTATGGATTATGTTGCTCGCGAAGTGATTCAGGCAGAACGTATCGTTGATTATACCGTTCAGGAAGGGATTACAGAAC
GCTTTGCCAAGCGGTTTGGTCGGGTCGCAACAGATTTACTGACCGATACTAGATTTGCGTGGCTTATCCGCTGA

Upstream 100 bases:

>100_bases
CGCCGCAGGTCGAGCAAGAAATCGCAGGGTAGAGATCTACGTTTCGGAAACACGGGGTGGATCAGTTCAATAAATTGACC
GGGGTGAGTGACTAATATTT

Downstream 100 bases:

>100_bases
GTGCTGGTTTTACTGTGAGTAAATTTCACTTAGCATACGAGTCACTCCGGTTTGCCAGTGTGGGAGATAGAGATTGAAAG
TATTGCGCAACTTATCTGTA

Product: peptidase S49

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MADTENTNKEKWERETLRDLVFSSLKEQKKARNWGIFFRLLTFSYLFTLLFWGLGWLDTEATGGFGKHTALVDLRGEITA
DGLNSAENINTGLKKAFEDKNTAAVILRINSPGGSPVQAGSINDEIHRLRTQHPDIPLYAVVEDICASGGYYIAVAADKI
FVDKASIVGSIGVLMDGFGFTGTLEKLGIERRLLTAGENKGFLDPFSPSDPGQREHAKKMLVEIHQQFIQVVQDGRGDRL
KDNPEIFSGMVWTGARSIELGLADALGSMDYVAREVIQAERIVDYTVQEGITERFAKRFGRVATDLLTDTRFAWLIR

Sequences:

>Translated_317_residues
MADTENTNKEKWERETLRDLVFSSLKEQKKARNWGIFFRLLTFSYLFTLLFWGLGWLDTEATGGFGKHTALVDLRGEITA
DGLNSAENINTGLKKAFEDKNTAAVILRINSPGGSPVQAGSINDEIHRLRTQHPDIPLYAVVEDICASGGYYIAVAADKI
FVDKASIVGSIGVLMDGFGFTGTLEKLGIERRLLTAGENKGFLDPFSPSDPGQREHAKKMLVEIHQQFIQVVQDGRGDRL
KDNPEIFSGMVWTGARSIELGLADALGSMDYVAREVIQAERIVDYTVQEGITERFAKRFGRVATDLLTDTRFAWLIR
>Mature_316_residues
ADTENTNKEKWERETLRDLVFSSLKEQKKARNWGIFFRLLTFSYLFTLLFWGLGWLDTEATGGFGKHTALVDLRGEITAD
GLNSAENINTGLKKAFEDKNTAAVILRINSPGGSPVQAGSINDEIHRLRTQHPDIPLYAVVEDICASGGYYIAVAADKIF
VDKASIVGSIGVLMDGFGFTGTLEKLGIERRLLTAGENKGFLDPFSPSDPGQREHAKKMLVEIHQQFIQVVQDGRGDRLK
DNPEIFSGMVWTGARSIELGLADALGSMDYVAREVIQAERIVDYTVQEGITERFAKRFGRVATDLLTDTRFAWLIR

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=239, Percent_Identity=31.3807531380753, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788064, Length=204, Percent_Identity=27.4509803921569, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 35281; Mature: 35149

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTENTNKEKWERETLRDLVFSSLKEQKKARNWGIFFRLLTFSYLFTLLFWGLGWLDTE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ATGGFGKHTALVDLRGEITADGLNSAENINTGLKKAFEDKNTAAVILRINSPGGSPVQAG
CCCCCCCCEEEEEECCCEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCC
SINDEIHRLRTQHPDIPLYAVVEDICASGGYYIAVAADKIFVDKASIVGSIGVLMDGFGF
CCHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCC
TGTLEKLGIERRLLTAGENKGFLDPFSPSDPGQREHAKKMLVEIHQQFIQVVQDGRGDRL
CHHHHHHCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
KDNPEIFSGMVWTGARSIELGLADALGSMDYVAREVIQAERIVDYTVQEGITERFAKRFG
CCCHHHHHCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVATDLLTDTRFAWLIR
HHHHHHHHHCHHHEEEC
>Mature Secondary Structure 
ADTENTNKEKWERETLRDLVFSSLKEQKKARNWGIFFRLLTFSYLFTLLFWGLGWLDTE
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ATGGFGKHTALVDLRGEITADGLNSAENINTGLKKAFEDKNTAAVILRINSPGGSPVQAG
CCCCCCCCEEEEEECCCEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCC
SINDEIHRLRTQHPDIPLYAVVEDICASGGYYIAVAADKIFVDKASIVGSIGVLMDGFGF
CCHHHHHHHHHCCCCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCC
TGTLEKLGIERRLLTAGENKGFLDPFSPSDPGQREHAKKMLVEIHQQFIQVVQDGRGDRL
CHHHHHHCHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
KDNPEIFSGMVWTGARSIELGLADALGSMDYVAREVIQAERIVDYTVQEGITERFAKRFG
CCCHHHHHCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVATDLLTDTRFAWLIR
HHHHHHHHHCHHHEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA