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The map label for this gene is ctaD [H]

Identifier: 114332351

GI number: 114332351

Start: 2507437

End: 2509014

Strand: Reverse

Name: ctaD [H]

Synonym: Neut_2394

Alternate gene names: 114332351

Gene position: 2509014-2507437 (Counterclockwise)

Preceding gene: 114332352

Following gene: 114332350

Centisome position: 94.29

GC content: 43.47

Gene sequence:

>1578_bases
ATGGCGGTAATACAAGATGTACATGGCCATACACATGATCATCCGACCGGTATAATGCGTTGGCTAACCACTACCAACCA
TAAAGATATCGGAACGCTTTATTTGTGTTTTAGTCTGGCTATGTTGTTTGTTGGTGGTTTTTTGGCCATGGGTATCAGAG
CAGAACTTTTTATGCCTGGTATTCAGATATTGGAGCCTGAAGTATTTAATTCATTTACCACATTGCATGGCCTGATCATG
GTATTTGGTGCCGTAATGCCAGCATGGGTGGGATTTGCGAATTGGCAGATACCATTAATGATAGGTGCTCCAGATATGGC
TTTTGCTCGTCTGAATAACTGGAGTTTCTGGTTATTGCCGATTGCAGCATTGCTATTAATAACTTCATTTTTTGTGCCCG
GCGGGGCGGCGGCCGGTGGCTGGACATTCTACCCACCACTATCCACACAAGGTGGTATGGGGACAGACATGATGTTGTTT
GCAGTGCATGTCTTTGGAATGTCTTCAATTATGGGTTCTATCAACATCATTACAACCATCTTGAATATGCGCGCACCAGG
CATGACATTGATGAAGATGCCAATGTTCGTGTGGAGCTGGTTAATTACTGCATACCTACTTGTATTGGTAATGCCGGTAT
TGGCTGGAGCTGTGACAATGGTCCTTACAGATCGTAACTTTGGTACAAGCTTCTTCAATGCTGCTGGCGGCGGTGACCCG
GTTATGTTTCAACACATCTTCTGGTTCTTCGGACACCCGGAGGTATACATCATGATATTACCGGCGTTTGGTGTGGTTTC
CGAGGTTATTACAACATTTTCACGTAAACCTTTGTTTGGTTATACATCAATGGTTTATGCGATTGCCGCAATTGCATTGT
TATCTTGCTTTGTATGGGCACATCACATGTTTACCGTTGGTATGCCTGTTACTGGACAACTGTTCTTCATGTACGCAACG
ATGTTGATTGCTGTACCAACCGGCGTTAAGGTCTTTAACTGGACCGCAACCATGTGGCGAGGTTCTTTGACCTTTGAAAC
ACCGATGTTGTTTTCAATAGGGTTTATCGTTCTGTTCGTTATTGGTGGATTCAGCGGTGTTGTTTGCGCAATAGTCCCAA
TCGATGTGCAAGTACAAGATACCTACTATGTCATTGCGCACTTCCATTACGTGTTGGTTTCGGGGGCATTGTTTGCATTA
TTCTCAGGTGCATACTACTGGTTACCAAAATGGACTGGTCATATGTACAACGAAACATTGGGTAAGTGGCATTTCTGGCT
GTCAATGATTTTCTTTAATGTAGCATTCTTTGTTCAGCATTTCCTTGGATTAGCTGGTATGCCTCGTAGAATTCCGGATT
ATGCACTCCAGTTTGCTGACTTCAATATGATTTCCAGTATCGGTGCATTTGGATTCGGATTGACACAGTTGCTGTTTGTA
TACATTGTTATTAAATGTGTACGTGGTGGAGAAAAGGCTGCAGATAAAACATGGGAAGGGGCACATACTCTGGAATGGAC
GCATTTGCCTTCACCAGCTCCATACCATAGTTTTGAAACACCACCTGTCGTTAAATAA

Upstream 100 bases:

>100_bases
TGAATACAGCTCTCGTTAAAAATGAGGCGAGTAAAAACTGATATATCCAGATACGGTTAGTCGGGATATAGATCAAATTA
GATTAAAAAAGGAGAAGATA

Downstream 100 bases:

>100_bases
GCAGGTATAGAAATGACTGAAAATAAGGATACAGAATTACAACGCAGAAAATTACGTACTGCATCAATTCTAGTTATCTT
GGTAATAGTAGTTTTTATAG

Product: cytochrome-c oxidase

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I [H]

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MAVIQDVHGHTHDHPTGIMRWLTTTNHKDIGTLYLCFSLAMLFVGGFLAMGIRAELFMPGIQILEPEVFNSFTTLHGLIM
VFGAVMPAWVGFANWQIPLMIGAPDMAFARLNNWSFWLLPIAALLLITSFFVPGGAAAGGWTFYPPLSTQGGMGTDMMLF
AVHVFGMSSIMGSINIITTILNMRAPGMTLMKMPMFVWSWLITAYLLVLVMPVLAGAVTMVLTDRNFGTSFFNAAGGGDP
VMFQHIFWFFGHPEVYIMILPAFGVVSEVITTFSRKPLFGYTSMVYAIAAIALLSCFVWAHHMFTVGMPVTGQLFFMYAT
MLIAVPTGVKVFNWTATMWRGSLTFETPMLFSIGFIVLFVIGGFSGVVCAIVPIDVQVQDTYYVIAHFHYVLVSGALFAL
FSGAYYWLPKWTGHMYNETLGKWHFWLSMIFFNVAFFVQHFLGLAGMPRRIPDYALQFADFNMISSIGAFGFGLTQLLFV
YIVIKCVRGGEKAADKTWEGAHTLEWTHLPSPAPYHSFETPPVVK

Sequences:

>Translated_525_residues
MAVIQDVHGHTHDHPTGIMRWLTTTNHKDIGTLYLCFSLAMLFVGGFLAMGIRAELFMPGIQILEPEVFNSFTTLHGLIM
VFGAVMPAWVGFANWQIPLMIGAPDMAFARLNNWSFWLLPIAALLLITSFFVPGGAAAGGWTFYPPLSTQGGMGTDMMLF
AVHVFGMSSIMGSINIITTILNMRAPGMTLMKMPMFVWSWLITAYLLVLVMPVLAGAVTMVLTDRNFGTSFFNAAGGGDP
VMFQHIFWFFGHPEVYIMILPAFGVVSEVITTFSRKPLFGYTSMVYAIAAIALLSCFVWAHHMFTVGMPVTGQLFFMYAT
MLIAVPTGVKVFNWTATMWRGSLTFETPMLFSIGFIVLFVIGGFSGVVCAIVPIDVQVQDTYYVIAHFHYVLVSGALFAL
FSGAYYWLPKWTGHMYNETLGKWHFWLSMIFFNVAFFVQHFLGLAGMPRRIPDYALQFADFNMISSIGAFGFGLTQLLFV
YIVIKCVRGGEKAADKTWEGAHTLEWTHLPSPAPYHSFETPPVVK
>Mature_524_residues
AVIQDVHGHTHDHPTGIMRWLTTTNHKDIGTLYLCFSLAMLFVGGFLAMGIRAELFMPGIQILEPEVFNSFTTLHGLIMV
FGAVMPAWVGFANWQIPLMIGAPDMAFARLNNWSFWLLPIAALLLITSFFVPGGAAAGGWTFYPPLSTQGGMGTDMMLFA
VHVFGMSSIMGSINIITTILNMRAPGMTLMKMPMFVWSWLITAYLLVLVMPVLAGAVTMVLTDRNFGTSFFNAAGGGDPV
MFQHIFWFFGHPEVYIMILPAFGVVSEVITTFSRKPLFGYTSMVYAIAAIALLSCFVWAHHMFTVGMPVTGQLFFMYATM
LIAVPTGVKVFNWTATMWRGSLTFETPMLFSIGFIVLFVIGGFSGVVCAIVPIDVQVQDTYYVIAHFHYVLVSGALFALF
SGAYYWLPKWTGHMYNETLGKWHFWLSMIFFNVAFFVQHFLGLAGMPRRIPDYALQFADFNMISSIGAFGFGLTQLLFVY
IVIKCVRGGEKAADKTWEGAHTLEWTHLPSPAPYHSFETPPVVK

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=511, Percent_Identity=49.5107632093933, Blast_Score=452, Evalue=1e-127,
Organism=Escherichia coli, GI1786634, Length=514, Percent_Identity=41.2451361867704, Blast_Score=360, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6226519, Length=532, Percent_Identity=48.1203007518797, Blast_Score=475, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6226524, Length=323, Percent_Identity=50.4643962848297, Blast_Score=322, Evalue=7e-89,
Organism=Saccharomyces cerevisiae, GI6226523, Length=248, Percent_Identity=47.1774193548387, Blast_Score=207, Evalue=4e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 58439; Mature: 58308

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
6.5 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
6.3 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVIQDVHGHTHDHPTGIMRWLTTTNHKDIGTLYLCFSLAMLFVGGFLAMGIRAELFMPG
CCCEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
IQILEPEVFNSFTTLHGLIMVFGAVMPAWVGFANWQIPLMIGAPDMAFARLNNWSFWLLP
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHCCCCCCHHHH
IAALLLITSFFVPGGAAAGGWTFYPPLSTQGGMGTDMMLFAVHVFGMSSIMGSINIITTI
HHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LNMRAPGMTLMKMPMFVWSWLITAYLLVLVMPVLAGAVTMVLTDRNFGTSFFNAAGGGDP
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHCCCCCCCH
VMFQHIFWFFGHPEVYIMILPAFGVVSEVITTFSRKPLFGYTSMVYAIAAIALLSCFVWA
HHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
HHMFTVGMPVTGQLFFMYATMLIAVPTGVKVFNWTATMWRGSLTFETPMLFSIGFIVLFV
HHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCEECCHHHHHHHHHHHHH
IGGFSGVVCAIVPIDVQVQDTYYVIAHFHYVLVSGALFALFSGAYYWLPKWTGHMYNETL
HHCCCCCEEEEEEEEEEECCCEEHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHH
GKWHFWLSMIFFNVAFFVQHFLGLAGMPRRIPDYALQFADFNMISSIGAFGFGLTQLLFV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YIVIKCVRGGEKAADKTWEGAHTLEWTHLPSPAPYHSFETPPVVK
HHHHHHHCCCCHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AVIQDVHGHTHDHPTGIMRWLTTTNHKDIGTLYLCFSLAMLFVGGFLAMGIRAELFMPG
CCEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
IQILEPEVFNSFTTLHGLIMVFGAVMPAWVGFANWQIPLMIGAPDMAFARLNNWSFWLLP
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHCCCCCCHHHH
IAALLLITSFFVPGGAAAGGWTFYPPLSTQGGMGTDMMLFAVHVFGMSSIMGSINIITTI
HHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LNMRAPGMTLMKMPMFVWSWLITAYLLVLVMPVLAGAVTMVLTDRNFGTSFFNAAGGGDP
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHCCCCCCCH
VMFQHIFWFFGHPEVYIMILPAFGVVSEVITTFSRKPLFGYTSMVYAIAAIALLSCFVWA
HHHHHHHHHCCCCEEEEEEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
HHMFTVGMPVTGQLFFMYATMLIAVPTGVKVFNWTATMWRGSLTFETPMLFSIGFIVLFV
HHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCEECCHHHHHHHHHHHHH
IGGFSGVVCAIVPIDVQVQDTYYVIAHFHYVLVSGALFALFSGAYYWLPKWTGHMYNETL
HHCCCCCEEEEEEEEEEECCCEEHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHH
GKWHFWLSMIFFNVAFFVQHFLGLAGMPRRIPDYALQFADFNMISSIGAFGFGLTQLLFV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YIVIKCVRGGEKAADKTWEGAHTLEWTHLPSPAPYHSFETPPVVK
HHHHHHHCCCCHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2172930; 1965217; 12597275 [H]