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The map label for this gene is zwf [H]

Identifier: 114332108

GI number: 114332108

Start: 2271368

End: 2272843

Strand: Reverse

Name: zwf [H]

Synonym: Neut_2143

Alternate gene names: 114332108

Gene position: 2272843-2271368 (Counterclockwise)

Preceding gene: 114332109

Following gene: 114332103

Centisome position: 85.41

GC content: 46.0

Gene sequence:

>1476_bases
ATGGATCAATCCCAAAATTTACCTTGCTCGTTTGTTATTTTTGGAGCAACAGGGGATCTTGCCGCACATAAATTGTTACC
AGCCTTGTTTGATCTGGAGCATGCCGGTCGCTTGGCTGATAACCTTTCCATCATTGCTATTTCACGGCGGGAATGGACAA
CGGACGATTGGCTTGAATACGTACGTTCGATACTAAAAAACAAACTTGATCAGCCGTCTTGCCAAGCGTTACTGGAACGT
TTTCTGGCGCGCTTTCGTTACTTGCGAGGGGATCTTAAAGAGGTAGATTCCTATCACGCACTTGCTGCGGACATAGCACC
TGGATCAGCCTGTTCTCGCACAGTGTTTTATCTGGCAATCCGTCCAGCTGATTTTGTAACGGTAATTAAAAATCTCAAAG
TTGCTGGTTTGAATGAGCCACGCGGTATGAACCGGGTGGTCATCGAAAAACCATTTGGGGAAGATCTGGAATCGGCACAA
GTGCTTAACCGTGTATTACACCAGTATTTTGATGAAGAACAGATTTATCGTATTGATCATTTTCTGGGTAAGGAAACAGT
ACAAAATCTGCTGGTTTTCCGGTTTGCCAATACAATAATCGAGCCATTGTGGAATCGCAATTTTATTGACCATGTACAAA
TTACGGTTGCAGAGTCAATCGGTATTGAAAAACGCGCAGGCTATTATGATCGCGCAGGAGCATTGCGTGATATGTTGCAG
AATCATCTCATGCAACTGTTAACTGTGGTAGCGATGGAACCTCCACCTGCTCTGGAAGCGGATGCGTTGCGTGATGAAAA
GGTCAAGGTGTTGCGGTCGATTCGCCCGATTGCTAAACGCGCAGTGCATGCACATGCAGTGCGCGCACAATATACACATG
GCAATATTGACGGGCAGTCGGTGGTGGGTTACCAACAGGAAGAAAACGTTGAGTCAGATTCGATTACTGAAACTTTTGCT
GCAGCTAAATTCTATATTGATAATTGGCGTTGGCGCGGTGTTCCGTTTTATCTACGAACGGGAAAACGTATGCCCAGGCG
GCATTCGATGATTGCGATTCGTTTCAAACACCCTCCGCAGCAACTTTTCCGCGAAACACCACTGGAGTCAATCGACCCTA
ACTGGGTATTGTTGTCGATTCAACCGGAAGAATCCATGCATATGGAAATTCACGTTAAACAACCGGGCTTGGATATGAAT
ACCCGCGTAATACAAATGAATGCAAGTTTCCTCAGGACGGATGAGCAAACGTTGGGTGCTTATGAAACCTTGCTGCTGGA
TGTAATTGAAGGCGATCGTTCATTGTTTATTCGCTTTGATGAGGCTGAATGGGCGTGGCGAGTCATTGATCCAATCTTGA
AATTCTGGACGGTTGAGCGTGAATATATCGCAACTTATCCTGCCGGCAGCTGGGGGCCGGCTGAAGCCAACCGATTGTTT
GACAGTGATGATCAGGTTTGGCGTAATGAGCTTTAA

Upstream 100 bases:

>100_bases
ACAGGGGAAAAATGATTATGCCGCTAAAATGCTAGCAAAAATGCGTCATGGCTTTGGCGGCCATGCTGTTAAAAAGGACT
AAATAATGGGTGGTGCAAAA

Downstream 100 bases:

>100_bases
CCTGATCATTTTTTATGCGCCATCGTGCATGGATTGTGGATAAAGATGTTCTGCTGAAGCTGGTTCAGACTCGGTTACCT
GATTGACTGGCATTTTATGT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MDQSQNLPCSFVIFGATGDLAAHKLLPALFDLEHAGRLADNLSIIAISRREWTTDDWLEYVRSILKNKLDQPSCQALLER
FLARFRYLRGDLKEVDSYHALAADIAPGSACSRTVFYLAIRPADFVTVIKNLKVAGLNEPRGMNRVVIEKPFGEDLESAQ
VLNRVLHQYFDEEQIYRIDHFLGKETVQNLLVFRFANTIIEPLWNRNFIDHVQITVAESIGIEKRAGYYDRAGALRDMLQ
NHLMQLLTVVAMEPPPALEADALRDEKVKVLRSIRPIAKRAVHAHAVRAQYTHGNIDGQSVVGYQQEENVESDSITETFA
AAKFYIDNWRWRGVPFYLRTGKRMPRRHSMIAIRFKHPPQQLFRETPLESIDPNWVLLSIQPEESMHMEIHVKQPGLDMN
TRVIQMNASFLRTDEQTLGAYETLLLDVIEGDRSLFIRFDEAEWAWRVIDPILKFWTVEREYIATYPAGSWGPAEANRLF
DSDDQVWRNEL

Sequences:

>Translated_491_residues
MDQSQNLPCSFVIFGATGDLAAHKLLPALFDLEHAGRLADNLSIIAISRREWTTDDWLEYVRSILKNKLDQPSCQALLER
FLARFRYLRGDLKEVDSYHALAADIAPGSACSRTVFYLAIRPADFVTVIKNLKVAGLNEPRGMNRVVIEKPFGEDLESAQ
VLNRVLHQYFDEEQIYRIDHFLGKETVQNLLVFRFANTIIEPLWNRNFIDHVQITVAESIGIEKRAGYYDRAGALRDMLQ
NHLMQLLTVVAMEPPPALEADALRDEKVKVLRSIRPIAKRAVHAHAVRAQYTHGNIDGQSVVGYQQEENVESDSITETFA
AAKFYIDNWRWRGVPFYLRTGKRMPRRHSMIAIRFKHPPQQLFRETPLESIDPNWVLLSIQPEESMHMEIHVKQPGLDMN
TRVIQMNASFLRTDEQTLGAYETLLLDVIEGDRSLFIRFDEAEWAWRVIDPILKFWTVEREYIATYPAGSWGPAEANRLF
DSDDQVWRNEL
>Mature_491_residues
MDQSQNLPCSFVIFGATGDLAAHKLLPALFDLEHAGRLADNLSIIAISRREWTTDDWLEYVRSILKNKLDQPSCQALLER
FLARFRYLRGDLKEVDSYHALAADIAPGSACSRTVFYLAIRPADFVTVIKNLKVAGLNEPRGMNRVVIEKPFGEDLESAQ
VLNRVLHQYFDEEQIYRIDHFLGKETVQNLLVFRFANTIIEPLWNRNFIDHVQITVAESIGIEKRAGYYDRAGALRDMLQ
NHLMQLLTVVAMEPPPALEADALRDEKVKVLRSIRPIAKRAVHAHAVRAQYTHGNIDGQSVVGYQQEENVESDSITETFA
AAKFYIDNWRWRGVPFYLRTGKRMPRRHSMIAIRFKHPPQQLFRETPLESIDPNWVLLSIQPEESMHMEIHVKQPGLDMN
TRVIQMNASFLRTDEQTLGAYETLLLDVIEGDRSLFIRFDEAEWAWRVIDPILKFWTVEREYIATYPAGSWGPAEANRLF
DSDDQVWRNEL

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI109389365, Length=476, Percent_Identity=37.8151260504202, Blast_Score=305, Evalue=4e-83,
Organism=Homo sapiens, GI108773793, Length=476, Percent_Identity=37.8151260504202, Blast_Score=305, Evalue=6e-83,
Organism=Homo sapiens, GI52145310, Length=507, Percent_Identity=30.3747534516765, Blast_Score=181, Evalue=2e-45,
Organism=Escherichia coli, GI1788158, Length=483, Percent_Identity=42.4430641821946, Blast_Score=394, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17538218, Length=482, Percent_Identity=36.3070539419087, Blast_Score=305, Evalue=2e-83,
Organism=Saccharomyces cerevisiae, GI6324088, Length=474, Percent_Identity=36.4978902953587, Blast_Score=289, Evalue=7e-79,
Organism=Drosophila melanogaster, GI24643352, Length=487, Percent_Identity=37.1663244353183, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24643350, Length=487, Percent_Identity=37.1663244353183, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI221513548, Length=490, Percent_Identity=31.0204081632653, Blast_Score=206, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 56636; Mature: 56636

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00014 ER_TARGET

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQSQNLPCSFVIFGATGDLAAHKLLPALFDLEHAGRLADNLSIIAISRREWTTDDWLEY
CCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHH
VRSILKNKLDQPSCQALLERFLARFRYLRGDLKEVDSYHALAADIAPGSACSRTVFYLAI
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
RPADFVTVIKNLKVAGLNEPRGMNRVVIEKPFGEDLESAQVLNRVLHQYFDEEQIYRIDH
CCHHHHHHHHCCEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
FLGKETVQNLLVFRFANTIIEPLWNRNFIDHVQITVAESIGIEKRAGYYDRAGALRDMLQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEHHHCCCHHCCCCHHHHHHHHHHHH
NHLMQLLTVVAMEPPPALEADALRDEKVKVLRSIRPIAKRAVHAHAVRAQYTHGNIDGQS
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCE
VVGYQQEENVESDSITETFAAAKFYIDNWRWRGVPFYLRTGKRMPRRHSMIAIRFKHPPQ
EECCCHHCCCCCHHHHHHHHHHHHEECCEEECCCCEEEECCCCCCCCCCEEEEEECCCHH
QLFRETPLESIDPNWVLLSIQPEESMHMEIHVKQPGLDMNTRVIQMNASFLRTDEQTLGA
HHHHHCCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCEEEEECHHHHHCCHHHHHH
YETLLLDVIEGDRSLFIRFDEAEWAWRVIDPILKFWTVEREYIATYPAGSWGPAEANRLF
HHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCHHHEEECCCCCCCCHHHHHCC
DSDDQVWRNEL
CCCHHHHHCCC
>Mature Secondary Structure
MDQSQNLPCSFVIFGATGDLAAHKLLPALFDLEHAGRLADNLSIIAISRREWTTDDWLEY
CCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHH
VRSILKNKLDQPSCQALLERFLARFRYLRGDLKEVDSYHALAADIAPGSACSRTVFYLAI
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEE
RPADFVTVIKNLKVAGLNEPRGMNRVVIEKPFGEDLESAQVLNRVLHQYFDEEQIYRIDH
CCHHHHHHHHCCEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHHH
FLGKETVQNLLVFRFANTIIEPLWNRNFIDHVQITVAESIGIEKRAGYYDRAGALRDMLQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEHHHCCCHHCCCCHHHHHHHHHHHH
NHLMQLLTVVAMEPPPALEADALRDEKVKVLRSIRPIAKRAVHAHAVRAQYTHGNIDGQS
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCE
VVGYQQEENVESDSITETFAAAKFYIDNWRWRGVPFYLRTGKRMPRRHSMIAIRFKHPPQ
EECCCHHCCCCCHHHHHHHHHHHHEECCEEECCCCEEEECCCCCCCCCCEEEEEECCCHH
QLFRETPLESIDPNWVLLSIQPEESMHMEIHVKQPGLDMNTRVIQMNASFLRTDEQTLGA
HHHHHCCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCCCEEEEECHHHHHCCHHHHHH
YETLLLDVIEGDRSLFIRFDEAEWAWRVIDPILKFWTVEREYIATYPAGSWGPAEANRLF
HHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCCHHHEEECCCCCCCCHHHHHCC
DSDDQVWRNEL
CCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]