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The map label for this gene is yqeC [H]

Identifier: 114332109

GI number: 114332109

Start: 2272862

End: 2273770

Strand: Reverse

Name: yqeC [H]

Synonym: Neut_2144

Alternate gene names: 114332109

Gene position: 2273770-2272862 (Counterclockwise)

Preceding gene: 114332110

Following gene: 114332108

Centisome position: 85.45

GC content: 52.04

Gene sequence:

>909_bases
ATGGAATTCGGTATAGTGGGTTTAGGGCGAATGGGTGGCAACATGGCACGCCGTCTCGCCGAGAAAGATAAAAAAATTGC
AATAACGAATCGCAGCTTTAATGTAACCGAAGCATTGGCCAGAGACACGGGACACACGGCGTGCAAAAGTTATGCTGACC
TGGTTGCTTCACTTGAAAAGCCCCGCATCATCTGGCTGATGCTGCCAGCGGGCGAAGTAACTGAAACAGCACTTTCTGCA
TTGTTGCCGTTGCTATCGGCAGGTGATCTGATTGTGGATGGTGCCAATACGCACTGGCAAGATGATATTCCCCGTGCAGC
ACGTTGTGCAGAGCAAGGTATTGAATTTGCTGATGCGGGGGTTTCTGGGGGGGTATGGGGGCTGGAAAACGGCTATTGCA
TCATGTTTGGTGGATCAAATGCCGCCGCGGCACGCCTGAAACCCTATATGGAAGCATTGGCGCCAACCCCGATGACCGGC
TGGCTACATACTGGGCCGGTTGGATCGGGGCATTACGTGAAGATGGTACATAATGGAATCGAATACGGCATGATGCAAGC
CTTGGCCGAAGGGTTTGCGCTGATGAAGGACAAACCTGGATTTGATCTTGACCTTGCTGCAATCGCCGAATTGTGGCGGC
ATGGCAGCGTGGTGCGTTCGTGGCTACTTGATTTGTCTGCGGACTTCTTGGCGGAAGATCAGGCGCTTGATGATATTGCT
CCTTTCGTGGCGGATTCCGGTGAAGGGCGTTGGACGACACTTGCTTCCCTGGAGCAAGGAATTCCTGTGCCCGTGATCAC
GCTTGCACTGATGATGCGTTTTGCCTCACAGGGGAAAAATGATTATGCCGCTAAAATGCTAGCAAAAATGCGTCATGGCT
TTGGCGGCCATGCTGTTAAAAAGGACTAA

Upstream 100 bases:

>100_bases
GGAACTTGCAGCTATGGCGGGTTCAGCCTGAGACTGGTGTTCTTGATTCCGTATCTGATAGGCCAGTATTCCTGATTGTA
TCTGCTCAAAGGAGAAAAAT

Downstream 100 bases:

>100_bases
ATAATGGGTGGTGCAAAAATGGATCAATCCCAAAATTTACCTTGCTCGTTTGTTATTTTTGGAGCAACAGGGGATCTTGC
CGCACATAAATTGTTACCAG

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MEFGIVGLGRMGGNMARRLAEKDKKIAITNRSFNVTEALARDTGHTACKSYADLVASLEKPRIIWLMLPAGEVTETALSA
LLPLLSAGDLIVDGANTHWQDDIPRAARCAEQGIEFADAGVSGGVWGLENGYCIMFGGSNAAAARLKPYMEALAPTPMTG
WLHTGPVGSGHYVKMVHNGIEYGMMQALAEGFALMKDKPGFDLDLAAIAELWRHGSVVRSWLLDLSADFLAEDQALDDIA
PFVADSGEGRWTTLASLEQGIPVPVITLALMMRFASQGKNDYAAKMLAKMRHGFGGHAVKKD

Sequences:

>Translated_302_residues
MEFGIVGLGRMGGNMARRLAEKDKKIAITNRSFNVTEALARDTGHTACKSYADLVASLEKPRIIWLMLPAGEVTETALSA
LLPLLSAGDLIVDGANTHWQDDIPRAARCAEQGIEFADAGVSGGVWGLENGYCIMFGGSNAAAARLKPYMEALAPTPMTG
WLHTGPVGSGHYVKMVHNGIEYGMMQALAEGFALMKDKPGFDLDLAAIAELWRHGSVVRSWLLDLSADFLAEDQALDDIA
PFVADSGEGRWTTLASLEQGIPVPVITLALMMRFASQGKNDYAAKMLAKMRHGFGGHAVKKD
>Mature_302_residues
MEFGIVGLGRMGGNMARRLAEKDKKIAITNRSFNVTEALARDTGHTACKSYADLVASLEKPRIIWLMLPAGEVTETALSA
LLPLLSAGDLIVDGANTHWQDDIPRAARCAEQGIEFADAGVSGGVWGLENGYCIMFGGSNAAAARLKPYMEALAPTPMTG
WLHTGPVGSGHYVKMVHNGIEYGMMQALAEGFALMKDKPGFDLDLAAIAELWRHGSVVRSWLLDLSADFLAEDQALDDIA
PFVADSGEGRWTTLASLEQGIPVPVITLALMMRFASQGKNDYAAKMLAKMRHGFGGHAVKKD

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=295, Percent_Identity=33.2203389830508, Blast_Score=140, Evalue=1e-33,
Organism=Escherichia coli, GI1788341, Length=298, Percent_Identity=36.9127516778523, Blast_Score=171, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17542558, Length=304, Percent_Identity=32.2368421052632, Blast_Score=151, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6321695, Length=303, Percent_Identity=35.6435643564356, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6321977, Length=302, Percent_Identity=33.112582781457, Blast_Score=147, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24639279, Length=292, Percent_Identity=34.2465753424658, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 32421; Mature: 32421

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFGIVGLGRMGGNMARRLAEKDKKIAITNRSFNVTEALARDTGHTACKSYADLVASLEK
CCCCEEEHHHCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHCCC
PRIIWLMLPAGEVTETALSALLPLLSAGDLIVDGANTHWQDDIPRAARCAEQGIEFADAG
CEEEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHCCCHHCCC
VSGGVWGLENGYCIMFGGSNAAAARLKPYMEALAPTPMTGWLHTGPVGSGHYVKMVHNGI
CCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCHHHHHHHH
EYGMMQALAEGFALMKDKPGFDLDLAAIAELWRHGSVVRSWLLDLSADFLAEDQALDDIA
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PFVADSGEGRWTTLASLEQGIPVPVITLALMMRFASQGKNDYAAKMLAKMRHGFGGHAVK
HHHHCCCCCCEEEHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCC
KD
CC
>Mature Secondary Structure
MEFGIVGLGRMGGNMARRLAEKDKKIAITNRSFNVTEALARDTGHTACKSYADLVASLEK
CCCCEEEHHHCCHHHHHHHHHCCCEEEEECCCCCHHHHHHHCCCHHHHHHHHHHHHHCCC
PRIIWLMLPAGEVTETALSALLPLLSAGDLIVDGANTHWQDDIPRAARCAEQGIEFADAG
CEEEEEEECCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHCCCHHCCC
VSGGVWGLENGYCIMFGGSNAAAARLKPYMEALAPTPMTGWLHTGPVGSGHYVKMVHNGI
CCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCHHHHHHHH
EYGMMQALAEGFALMKDKPGFDLDLAAIAELWRHGSVVRSWLLDLSADFLAEDQALDDIA
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PFVADSGEGRWTTLASLEQGIPVPVITLALMMRFASQGKNDYAAKMLAKMRHGFGGHAVK
HHHHCCCCCCEEEHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCC
KD
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]