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The map label for this gene is uppS [H]

Identifier: 114331997

GI number: 114331997

Start: 2147175

End: 2147966

Strand: Reverse

Name: uppS [H]

Synonym: Neut_2031

Alternate gene names: 114331997

Gene position: 2147966-2147175 (Counterclockwise)

Preceding gene: 114331998

Following gene: 114331996

Centisome position: 80.72

GC content: 46.09

Gene sequence:

>792_bases
ATGCCTTCAATATTGAGTTCAACTCGTGGAATCCCGGAAACCGGGATGATACCCAAGCATATCGCTATTATCATGGATGG
TAATGGCCGGTGGGCAAAGCAGCGTTATCTGCCACGAATAGCAGGACATACTCAGGGTGTTGAGGCGGTACGAGGTACGA
TTAAAGCCTGCATTGAAAGAGGCGTTCCGTATCTGACAGTTTTTGCGTTCAGTAGTGAAAACTGGCGAAGACCTGCGGAA
GAGGTCAAGCTGCTGATGCAACTGTTTCTCGCTGCGCTTGAACGGGAGGTTACCAGCTTGCATGAAAATGGAGTCCGATT
CCGGGTGATTGGTGATCTTTCGAAATTTGATCCCAGAGTAATCGAATGTGTTCGGCATGGTGAGATGCTTACTGCCGGAA
ATACTCGTTTGCATTTTACGGTGGCTGCAAATTACGGAGGACGCTGGGATATCATGCAAGCTGTACGCAAAATGATCGCC
CAACGCTCTGATTCAACTATGGATTTTAATGAATCTGATCTTTCTAGATACCTGACTATGGCGGATGCTCCCGAGCCAGA
TTTATTCATTCGCACCGGAGGAGAATGTCGGATCAGTAATTTTCTGCTCTGGCAACTTGCGTATACCGAACTATATTTTA
CCGATACCTTGTGGCCAGATTTCAATGTATCAACTCTTGACAAGGCTATCCTTTCCTATCAGAAACGTGAGCGCAGATTT
GGTCAAACAAGTGAGCAGCTTGCAAGTCGGCAGGAAATCAAGGATACGATCTTGAACGAAAATAAAGTTTAA

Upstream 100 bases:

>100_bases
CCGTGCGCAGGATGATATCCAGAAACTGACAGACCGATATATTGCCGAGGTAGACAAGCTGCTGCAAGCCAAAGAAGCAG
AATTGATGGCTGTCTGATAT

Downstream 100 bases:

>100_bases
CCATCATTGTTCAATTAACGGGACTCACCCGTTCATGCTTAGCACCCGACTCTTTACCGCACTCATATTATTGACCGCCT
TTCTGGCGGCATTATTTTAT

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MPSILSSTRGIPETGMIPKHIAIIMDGNGRWAKQRYLPRIAGHTQGVEAVRGTIKACIERGVPYLTVFAFSSENWRRPAE
EVKLLMQLFLAALEREVTSLHENGVRFRVIGDLSKFDPRVIECVRHGEMLTAGNTRLHFTVAANYGGRWDIMQAVRKMIA
QRSDSTMDFNESDLSRYLTMADAPEPDLFIRTGGECRISNFLLWQLAYTELYFTDTLWPDFNVSTLDKAILSYQKRERRF
GQTSEQLASRQEIKDTILNENKV

Sequences:

>Translated_263_residues
MPSILSSTRGIPETGMIPKHIAIIMDGNGRWAKQRYLPRIAGHTQGVEAVRGTIKACIERGVPYLTVFAFSSENWRRPAE
EVKLLMQLFLAALEREVTSLHENGVRFRVIGDLSKFDPRVIECVRHGEMLTAGNTRLHFTVAANYGGRWDIMQAVRKMIA
QRSDSTMDFNESDLSRYLTMADAPEPDLFIRTGGECRISNFLLWQLAYTELYFTDTLWPDFNVSTLDKAILSYQKRERRF
GQTSEQLASRQEIKDTILNENKV
>Mature_262_residues
PSILSSTRGIPETGMIPKHIAIIMDGNGRWAKQRYLPRIAGHTQGVEAVRGTIKACIERGVPYLTVFAFSSENWRRPAEE
VKLLMQLFLAALEREVTSLHENGVRFRVIGDLSKFDPRVIECVRHGEMLTAGNTRLHFTVAANYGGRWDIMQAVRKMIAQ
RSDSTMDFNESDLSRYLTMADAPEPDLFIRTGGECRISNFLLWQLAYTELYFTDTLWPDFNVSTLDKAILSYQKRERRFG
QTSEQLASRQEIKDTILNENKV

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=231, Percent_Identity=37.6623376623377, Blast_Score=151, Evalue=6e-37,
Organism=Homo sapiens, GI45580738, Length=231, Percent_Identity=37.6623376623377, Blast_Score=151, Evalue=6e-37,
Organism=Escherichia coli, GI1786371, Length=247, Percent_Identity=49.7975708502024, Blast_Score=247, Evalue=5e-67,
Organism=Caenorhabditis elegans, GI71993029, Length=229, Percent_Identity=35.8078602620087, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6319474, Length=220, Percent_Identity=35.9090909090909, Blast_Score=124, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323748, Length=228, Percent_Identity=29.8245614035088, Blast_Score=112, Evalue=6e-26,
Organism=Drosophila melanogaster, GI18857969, Length=234, Percent_Identity=36.3247863247863, Blast_Score=154, Evalue=8e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 30081; Mature: 29950

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSILSSTRGIPETGMIPKHIAIIMDGNGRWAKQRYLPRIAGHTQGVEAVRGTIKACIER
CCCHHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
GVPYLTVFAFSSENWRRPAEEVKLLMQLFLAALEREVTSLHENGVRFRVIGDLSKFDPRV
CCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHCCHHH
IECVRHGEMLTAGNTRLHFTVAANYGGRWDIMQAVRKMIAQRSDSTMDFNESDLSRYLTM
HHHHHCCCEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
ADAPEPDLFIRTGGECRISNFLLWQLAYTELYFTDTLWPDFNVSTLDKAILSYQKRERRF
CCCCCCCEEEEECCCEEHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHC
GQTSEQLASRQEIKDTILNENKV
CCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PSILSSTRGIPETGMIPKHIAIIMDGNGRWAKQRYLPRIAGHTQGVEAVRGTIKACIER
CCHHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
GVPYLTVFAFSSENWRRPAEEVKLLMQLFLAALEREVTSLHENGVRFRVIGDLSKFDPRV
CCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHCCHHH
IECVRHGEMLTAGNTRLHFTVAANYGGRWDIMQAVRKMIAQRSDSTMDFNESDLSRYLTM
HHHHHCCCEEECCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
ADAPEPDLFIRTGGECRISNFLLWQLAYTELYFTDTLWPDFNVSTLDKAILSYQKRERRF
CCCCCCCEEEEECCCEEHHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHC
GQTSEQLASRQEIKDTILNENKV
CCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12700255 [H]