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The map label for this gene is dxr

Identifier: 114331995

GI number: 114331995

Start: 2145075

End: 2146316

Strand: Reverse

Name: dxr

Synonym: Neut_2029

Alternate gene names: 114331995

Gene position: 2146316-2145075 (Counterclockwise)

Preceding gene: 114331996

Following gene: 114331994

Centisome position: 80.66

GC content: 48.87

Gene sequence:

>1242_bases
ATGACTCCAATCCGTCATCTGACCATCTTGGGCTCGACCGGCAGCATTGGGGAAAGCACATTGGACGTGGTAGCCAGACA
TCCCGACCGGTTTCAGGCGGTTGCCCTGACTGCCGACAAGAATGTTGAAAAAATGTTTGAGCAGTGCAAACGATTTTACC
CGTCGTACGCTGTGATGCTCAACGCTCAGAGTGCCGAGCAACTGGAAGCTAAATTGCGTGTGGCAGGCTTGGGTACCATG
GTGCTTTCAGGTATCGAATCACTGGAAAAAGTAGCATCTTTACCAGAAATCGATACGGTTATGGCAGCGATTGTTGGCGC
GGCAGGTATTCGTCCGACACTCTCGGCTGCGCAGGCGGGCAAACATATTCTTCTGGCTAACAAGGAGACGCTGGTGATGG
CTGGACGTATCTTTATGGATACGATCAGACAATATCATGCAACGTTATTACCGATAGACAGCGAACACAATGCGATTTTT
CAGTCATTGCCACAACATTACAATGGAGATCTGATTAGTTCTGGGGTGCGCCGGATATTGCTTACTGCCTCGGGAGGACC
TTTCCATAAAGCAGATTTGCAGACCCTGTCAACCGTTACGCCGGAGCAAGCTTGTGCTCATCCCAATTGGGTAATGGGCA
GAAAAATATCGGTTGATTCAGCTACCATGATGAATAAAGGGCTGGAAGTCATTGAGGCGCACTGGCTGTTTAATGTGGAA
CCCGAAAAAATCCAGGTGGTTGTTCATCCGCAAAGCGTCATTCATTCTATGGTTGAATATATTGATGGCTCGGTGCTTGC
CCAACTCGGTAATCCGGATATGCGCACACCGATAGCGCATGCGTTGGGTTATCCCGAGAGAATAGAAAGTGGTGTGCAAT
CCATGGATATTTTCAAAATTGCACAATTGAATTTTGAGGCTCCGGATTTCGAGCGATTCCCCTGTCTCAGGCTTGCATAT
GAAGCCCTTTCAAAGGGAGGTAATATGCCCGCCGTACTGAATGCCGCCAATGAAGTTGCGGTTGAAGTTTTTCTGGCTGG
TAAAATACCTTTCACGGTAATCCCTGCGATCATCGAGCATGTAATGGAATCAATAGACAGGCAGGAAATTACAGACCTGG
AAGATGTGCTTGCTGCTGATTTACGGGCGCGTGAGACAGCTCGCAAGTGGTTGGATACTCAGGCTTGGCAAAGAGGACAG
TCCGGAGCTCCGTTATTTCGTGCCGAGCAGTGGAATGGATAA

Upstream 100 bases:

>100_bases
TTCTGCCAGGTCACGGCGGTATACTGGATCGTATTGATGCGTTGATCCCAGTTTTACCTGTTGCTGCGCTATCGGCCATC
TTATTTTATTCGACTGAATT

Downstream 100 bases:

>100_bases
TTTTTGCAGATCTTTAATATGACACTGCTCTCAACTATTTTTGCATTCGTAATTGCACTGGGTCTACTGATCACTTTTCA
CGAATTTGGCCATTATCTGG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MTPIRHLTILGSTGSIGESTLDVVARHPDRFQAVALTADKNVEKMFEQCKRFYPSYAVMLNAQSAEQLEAKLRVAGLGTM
VLSGIESLEKVASLPEIDTVMAAIVGAAGIRPTLSAAQAGKHILLANKETLVMAGRIFMDTIRQYHATLLPIDSEHNAIF
QSLPQHYNGDLISSGVRRILLTASGGPFHKADLQTLSTVTPEQACAHPNWVMGRKISVDSATMMNKGLEVIEAHWLFNVE
PEKIQVVVHPQSVIHSMVEYIDGSVLAQLGNPDMRTPIAHALGYPERIESGVQSMDIFKIAQLNFEAPDFERFPCLRLAY
EALSKGGNMPAVLNAANEVAVEVFLAGKIPFTVIPAIIEHVMESIDRQEITDLEDVLAADLRARETARKWLDTQAWQRGQ
SGAPLFRAEQWNG

Sequences:

>Translated_413_residues
MTPIRHLTILGSTGSIGESTLDVVARHPDRFQAVALTADKNVEKMFEQCKRFYPSYAVMLNAQSAEQLEAKLRVAGLGTM
VLSGIESLEKVASLPEIDTVMAAIVGAAGIRPTLSAAQAGKHILLANKETLVMAGRIFMDTIRQYHATLLPIDSEHNAIF
QSLPQHYNGDLISSGVRRILLTASGGPFHKADLQTLSTVTPEQACAHPNWVMGRKISVDSATMMNKGLEVIEAHWLFNVE
PEKIQVVVHPQSVIHSMVEYIDGSVLAQLGNPDMRTPIAHALGYPERIESGVQSMDIFKIAQLNFEAPDFERFPCLRLAY
EALSKGGNMPAVLNAANEVAVEVFLAGKIPFTVIPAIIEHVMESIDRQEITDLEDVLAADLRARETARKWLDTQAWQRGQ
SGAPLFRAEQWNG
>Mature_412_residues
TPIRHLTILGSTGSIGESTLDVVARHPDRFQAVALTADKNVEKMFEQCKRFYPSYAVMLNAQSAEQLEAKLRVAGLGTMV
LSGIESLEKVASLPEIDTVMAAIVGAAGIRPTLSAAQAGKHILLANKETLVMAGRIFMDTIRQYHATLLPIDSEHNAIFQ
SLPQHYNGDLISSGVRRILLTASGGPFHKADLQTLSTVTPEQACAHPNWVMGRKISVDSATMMNKGLEVIEAHWLFNVEP
EKIQVVVHPQSVIHSMVEYIDGSVLAQLGNPDMRTPIAHALGYPERIESGVQSMDIFKIAQLNFEAPDFERFPCLRLAYE
ALSKGGNMPAVLNAANEVAVEVFLAGKIPFTVIPAIIEHVMESIDRQEITDLEDVLAADLRARETARKWLDTQAWQRGQS
GAPLFRAEQWNG

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=391, Percent_Identity=58.8235294117647, Blast_Score=445, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_NITEC (Q0AEI0)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_748217.1
- ProteinModelPortal:   Q0AEI0
- SMR:   Q0AEI0
- STRING:   Q0AEI0
- GeneID:   4273241
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_2029
- NMPDR:   fig|335283.3.peg.2490
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- PhylomeDB:   Q0AEI0
- ProtClustDB:   PRK05447
- BioCyc:   NEUT335283:NEUT_2029-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 45323; Mature: 45191

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: BINDING 128-128 BINDING 155-155 BINDING 184-184 BINDING 207-207 BINDING 229-229

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPIRHLTILGSTGSIGESTLDVVARHPDRFQAVALTADKNVEKMFEQCKRFYPSYAVML
CCCCEEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEE
NAQSAEQLEAKLRVAGLGTMVLSGIESLEKVASLPEIDTVMAAIVGAAGIRPTLSAAQAG
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHCC
KHILLANKETLVMAGRIFMDTIRQYHATLLPIDSEHNAIFQSLPQHYNGDLISSGVRRIL
CEEEEECCCEEEHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHCCCHHHHHHHHEEE
LTASGGPFHKADLQTLSTVTPEQACAHPNWVMGRKISVDSATMMNKGLEVIEAHWLFNVE
EECCCCCCCHHHHHHHHHCCCHHHHCCCCCCCCCEECCCHHHHHHHCHHHEEHHEEEECC
PEKIQVVVHPQSVIHSMVEYIDGSVLAQLGNPDMRTPIAHALGYPERIESGVQSMDIFKI
CCEEEEEECCHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHH
AQLNFEAPDFERFPCLRLAYEALSKGGNMPAVLNAANEVAVEVFLAGKIPFTVIPAIIEH
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHCCHHHHEEEEEEECCCCHHHHHHHHHH
VMESIDRQEITDLEDVLAADLRARETARKWLDTQAWQRGQSGAPLFRAEQWNG
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TPIRHLTILGSTGSIGESTLDVVARHPDRFQAVALTADKNVEKMFEQCKRFYPSYAVML
CCCEEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHCCCEEEEE
NAQSAEQLEAKLRVAGLGTMVLSGIESLEKVASLPEIDTVMAAIVGAAGIRPTLSAAQAG
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHCC
KHILLANKETLVMAGRIFMDTIRQYHATLLPIDSEHNAIFQSLPQHYNGDLISSGVRRIL
CEEEEECCCEEEHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHCCCHHHHHHHHEEE
LTASGGPFHKADLQTLSTVTPEQACAHPNWVMGRKISVDSATMMNKGLEVIEAHWLFNVE
EECCCCCCCHHHHHHHHHCCCHHHHCCCCCCCCCEECCCHHHHHHHCHHHEEHHEEEECC
PEKIQVVVHPQSVIHSMVEYIDGSVLAQLGNPDMRTPIAHALGYPERIESGVQSMDIFKI
CCEEEEEECCHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHH
AQLNFEAPDFERFPCLRLAYEALSKGGNMPAVLNAANEVAVEVFLAGKIPFTVIPAIIEH
HHCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHCCHHHHEEEEEEECCCCHHHHHHHHHH
VMESIDRQEITDLEDVLAADLRARETARKWLDTQAWQRGQSGAPLFRAEQWNG
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA