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The map label for this gene is trpB

Identifier: 114331150

GI number: 114331150

Start: 1191925

End: 1193124

Strand: Direct

Name: trpB

Synonym: Neut_1152

Alternate gene names: 114331150

Gene position: 1191925-1193124 (Clockwise)

Preceding gene: 114331149

Following gene: 114331151

Centisome position: 44.79

GC content: 49.25

Gene sequence:

>1200_bases
GTGAAAATGTATGATCTTCCCGATAAACGTGGCCATTTTGGTCCGTACGGTGGTACGTTCGTGGCTGAAACCCTGATTTC
AGCCTTGGATGAGCTTTGTAAGCAATATGAGTATTATCGTGGTGATGCCGAATTTCAAACGGAATTCTTTCGTGAGCTTA
AACATTATGTTGGCCGCCCCAGTCCCATTTATCATGCCAGACGTTGGTCGGATCATCTGGGTGGTGCACAGATTCTACTG
AAGCGTGAAGATCTTAACCATACAGGTGCACATAAAATTAACAATACGGTTGGCCAGGCGTTGCTTGCAAGGCGTATGGG
GAAAAGTCGTATCATCGCTGAAACGGGTGCCGGTCAGCATGGAGTAGCCAGTGCCACTGTGGCCGCCCGCTATGGTATGG
AATGTGTCGTGTACATGGGTTCCGAGGATGTCAAGCGACAGGCAACCAATGTTTATCGTATGAAGTTGCTTGGGGCCACA
GTCATACCGGTTGATTCAGGTTCGCGCACACTTAAAGATGCATTGAATGAAGCCATGCGTGACTGGGTGACCAATGTTGG
TAACACCTACTATATTATTGGTACTGTTGCGGGACCGCATCCTTATCCGATGATGGTCAGGGATTTTCAGGCGGTAATCG
GGAATGAAGCCAGGCAACAGATGCAGGAAGAATATGGTAGACAACCAGATGCTCTGATTGCATGTGTAGGCGGCGGTTCA
AATGCCATTGGCCTGTTTTATCCTTATATTGGGGAAGAAAACGTTCGAATGATTGGTGTAGAAGCCGCGGGCAAGGGAAT
CGATACGCAGAAACATGCTGCCACCCTGGTAACGGGCAGGCCGGGTGTTTTACATGGTAATCGTACCTATCTGATTCAGG
ATGAAAATGGCCAGATCATCGAAACACATTCAATTTCTGCTGGCCTGGATTACCCGGGAGTAGGACCGGAGCATGCATGG
CTTAAGGACTGCGGTCGTGCCGAATATGTCGCTATAACAGATGGTGAGGCTTTGGCTGCATTTCATGCTTTATGTCGCTT
CGAAGGGATCATGCCGGCTTTGGAATCCAGCCACGCTCTGGCTTATGCAGCCAAACTTGCGCCAACACTGAGAAAAGATC
AGCTCCTCCTGGTGAACCTGTCAGGTCGCGGGGACAAGGATATGGCAACAGTGGCACAGCAATCAGGTATTTCGCTTTAA

Upstream 100 bases:

>100_bases
ACTCGTCCATTGGCAATTGACGTTTCAAGCGGGGTTGAAATTGCTAATGGCATAAAAGACGCAGACAAAATTTCTGTTTT
CATGCAAGGAGTAAGATCTT

Downstream 100 bases:

>100_bases
CCGAATGTCTGATAGATCTCATTATATTTTGATTTTTCGGATTATCTGTTAAATGAATCGTATTGAATCTGTTTTTTCCC
GGCTCAAGTCACAAGATAAA

Product: tryptophan synthase subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MKMYDLPDKRGHFGPYGGTFVAETLISALDELCKQYEYYRGDAEFQTEFFRELKHYVGRPSPIYHARRWSDHLGGAQILL
KREDLNHTGAHKINNTVGQALLARRMGKSRIIAETGAGQHGVASATVAARYGMECVVYMGSEDVKRQATNVYRMKLLGAT
VIPVDSGSRTLKDALNEAMRDWVTNVGNTYYIIGTVAGPHPYPMMVRDFQAVIGNEARQQMQEEYGRQPDALIACVGGGS
NAIGLFYPYIGEENVRMIGVEAAGKGIDTQKHAATLVTGRPGVLHGNRTYLIQDENGQIIETHSISAGLDYPGVGPEHAW
LKDCGRAEYVAITDGEALAAFHALCRFEGIMPALESSHALAYAAKLAPTLRKDQLLLVNLSGRGDKDMATVAQQSGISL

Sequences:

>Translated_399_residues
MKMYDLPDKRGHFGPYGGTFVAETLISALDELCKQYEYYRGDAEFQTEFFRELKHYVGRPSPIYHARRWSDHLGGAQILL
KREDLNHTGAHKINNTVGQALLARRMGKSRIIAETGAGQHGVASATVAARYGMECVVYMGSEDVKRQATNVYRMKLLGAT
VIPVDSGSRTLKDALNEAMRDWVTNVGNTYYIIGTVAGPHPYPMMVRDFQAVIGNEARQQMQEEYGRQPDALIACVGGGS
NAIGLFYPYIGEENVRMIGVEAAGKGIDTQKHAATLVTGRPGVLHGNRTYLIQDENGQIIETHSISAGLDYPGVGPEHAW
LKDCGRAEYVAITDGEALAAFHALCRFEGIMPALESSHALAYAAKLAPTLRKDQLLLVNLSGRGDKDMATVAQQSGISL
>Mature_399_residues
MKMYDLPDKRGHFGPYGGTFVAETLISALDELCKQYEYYRGDAEFQTEFFRELKHYVGRPSPIYHARRWSDHLGGAQILL
KREDLNHTGAHKINNTVGQALLARRMGKSRIIAETGAGQHGVASATVAARYGMECVVYMGSEDVKRQATNVYRMKLLGAT
VIPVDSGSRTLKDALNEAMRDWVTNVGNTYYIIGTVAGPHPYPMMVRDFQAVIGNEARQQMQEEYGRQPDALIACVGGGS
NAIGLFYPYIGEENVRMIGVEAAGKGIDTQKHAATLVTGRPGVLHGNRTYLIQDENGQIIETHSISAGLDYPGVGPEHAW
LKDCGRAEYVAITDGEALAAFHALCRFEGIMPALESSHALAYAAKLAPTLRKDQLLLVNLSGRGDKDMATVAQQSGISL

Specific function: The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine

COG id: COG0133

COG function: function code E; Tryptophan synthase beta chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpB family

Homologues:

Organism=Escherichia coli, GI1787515, Length=381, Percent_Identity=56.1679790026247, Blast_Score=428, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6321412, Length=382, Percent_Identity=55.7591623036649, Blast_Score=461, Evalue=1e-130,

Paralogues:

None

Copy number: 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 5,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPB_NITEC (Q0AGX5)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_747372.1
- ProteinModelPortal:   Q0AGX5
- SMR:   Q0AGX5
- STRING:   Q0AGX5
- GeneID:   4273555
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_1152
- NMPDR:   fig|335283.3.peg.965
- eggNOG:   COG0133
- HOGENOM:   HBG303148
- OMA:   LKREDLC
- PhylomeDB:   Q0AGX5
- ProtClustDB:   PRK04346
- BioCyc:   NEUT335283:NEUT_1152-MONOMER
- HAMAP:   MF_00133
- InterPro:   IPR001926
- InterPro:   IPR006653
- InterPro:   IPR006654
- InterPro:   IPR023026
- TIGRFAMs:   TIGR00263

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =4.2.1.20

Molecular weight: Translated: 43637; Mature: 43637

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS00168 TRP_SYNTHASE_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMYDLPDKRGHFGPYGGTFVAETLISALDELCKQYEYYRGDAEFQTEFFRELKHYVGRP
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
SPIYHARRWSDHLGGAQILLKREDLNHTGAHKINNTVGQALLARRMGKSRIIAETGAGQH
CCCHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
GVASATVAARYGMECVVYMGSEDVKRQATNVYRMKLLGATVIPVDSGSRTLKDALNEAMR
CCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHH
DWVTNVGNTYYIIGTVAGPHPYPMMVRDFQAVIGNEARQQMQEEYGRQPDALIACVGGGS
HHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHCCCCCCEEEEECCCC
NAIGLFYPYIGEENVRMIGVEAAGKGIDTQKHAATLVTGRPGVLHGNRTYLIQDENGQII
CEEEEEEECCCCCCEEEEEEECCCCCCCCCHHHEEEEECCCCEEECCEEEEEECCCCCEE
ETHSISAGLDYPGVGPEHAWLKDCGRAEYVAITDGEALAAFHALCRFEGIMPALESSHAL
EEECCCCCCCCCCCCCCHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCHHHHCCCHH
AYAAKLAPTLRKDQLLLVNLSGRGDKDMATVAQQSGISL
HHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MKMYDLPDKRGHFGPYGGTFVAETLISALDELCKQYEYYRGDAEFQTEFFRELKHYVGRP
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCC
SPIYHARRWSDHLGGAQILLKREDLNHTGAHKINNTVGQALLARRMGKSRIIAETGAGQH
CCCHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCC
GVASATVAARYGMECVVYMGSEDVKRQATNVYRMKLLGATVIPVDSGSRTLKDALNEAMR
CCHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHH
DWVTNVGNTYYIIGTVAGPHPYPMMVRDFQAVIGNEARQQMQEEYGRQPDALIACVGGGS
HHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHCCCCCCEEEEECCCC
NAIGLFYPYIGEENVRMIGVEAAGKGIDTQKHAATLVTGRPGVLHGNRTYLIQDENGQII
CEEEEEEECCCCCCEEEEEEECCCCCCCCCHHHEEEEECCCCEEECCEEEEEECCCCCEE
ETHSISAGLDYPGVGPEHAWLKDCGRAEYVAITDGEALAAFHALCRFEGIMPALESSHAL
EEECCCCCCCCCCCCCCHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHCCHHHHCCCHH
AYAAKLAPTLRKDQLLLVNLSGRGDKDMATVAQQSGISL
HHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA