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The map label for this gene is trpF

Identifier: 114331149

GI number: 114331149

Start: 1191312

End: 1191938

Strand: Direct

Name: trpF

Synonym: Neut_1151

Alternate gene names: 114331149

Gene position: 1191312-1191938 (Clockwise)

Preceding gene: 114331148

Following gene: 114331150

Centisome position: 44.77

GC content: 45.77

Gene sequence:

>627_bases
GTGCGTATTCGTGTAAAAATATGCGGCATTACCCGGTTAGAAGATGCAATGACGGCTGTACACCATGGGGTGGATGCTAT
CGGCTTTATTTTATGGCCTCAGAGTGAACGATATATTTCACCAGAGGAAGCTGGTCAGATTGTGAGATACCTGCCTCCAT
TTGTGCAGGCTGTAGGGGTATTTGTAAACCCTGATAAATCCTGGGTAGAAGTGGCCAGTGCAGCAGCTGGACTTGATCTT
TTGCAGTTTCATGGTGATGAATCGCCGGATTTCTGCAGTCAGTTTCATTTGCCGTATATCAAGGCTGTTCGTGTCCGGGA
CGGATTGGATTTGTTACAATACGCGCAGTGTTATGAAGGATCCAAAGGACTGCTACTAGATGCTTATGCTGAGGGAAAAC
CCGGTGGAACAGGTCACATATTCGACTGGAAGCTGATTCCCTCGGGGTTGTCGTTACCCTGGATACTCTCAGGGGGTCTT
CATTCAGACAATGTTGTCGATGCAATTGAACAGACTCGTCCATTGGCAATTGACGTTTCAAGCGGGGTTGAAATTGCTAA
TGGCATAAAAGACGCAGACAAAATTTCTGTTTTCATGCAAGGAGTAAGATCTTGTGAAAATGTATGA

Upstream 100 bases:

>100_bases
TGCCTACTTTTAACGTAATCCGGCCAGAGAATGTTATAAATATGATTGCAAGCTTTAAATATTCACAGAATTGGGCTGGT
TTGCGTTAAAAGGAGATCTG

Downstream 100 bases:

>100_bases
TCTTCCCGATAAACGTGGCCATTTTGGTCCGTACGGTGGTACGTTCGTGGCTGAAACCCTGATTTCAGCCTTGGATGAGC
TTTGTAAGCAATATGAGTAT

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MRIRVKICGITRLEDAMTAVHHGVDAIGFILWPQSERYISPEEAGQIVRYLPPFVQAVGVFVNPDKSWVEVASAAAGLDL
LQFHGDESPDFCSQFHLPYIKAVRVRDGLDLLQYAQCYEGSKGLLLDAYAEGKPGGTGHIFDWKLIPSGLSLPWILSGGL
HSDNVVDAIEQTRPLAIDVSSGVEIANGIKDADKISVFMQGVRSCENV

Sequences:

>Translated_208_residues
MRIRVKICGITRLEDAMTAVHHGVDAIGFILWPQSERYISPEEAGQIVRYLPPFVQAVGVFVNPDKSWVEVASAAAGLDL
LQFHGDESPDFCSQFHLPYIKAVRVRDGLDLLQYAQCYEGSKGLLLDAYAEGKPGGTGHIFDWKLIPSGLSLPWILSGGL
HSDNVVDAIEQTRPLAIDVSSGVEIANGIKDADKISVFMQGVRSCENV
>Mature_208_residues
MRIRVKICGITRLEDAMTAVHHGVDAIGFILWPQSERYISPEEAGQIVRYLPPFVQAVGVFVNPDKSWVEVASAAAGLDL
LQFHGDESPDFCSQFHLPYIKAVRVRDGLDLLQYAQCYEGSKGLLLDAYAEGKPGGTGHIFDWKLIPSGLSLPWILSGGL
HSDNVVDAIEQTRPLAIDVSSGVEIANGIKDADKISVFMQGVRSCENV

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=207, Percent_Identity=32.3671497584541, Blast_Score=80, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320210, Length=215, Percent_Identity=35.3488372093023, Blast_Score=93, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_NITEC (Q0AGX6)

Other databases:

- EMBL:   CP000450
- RefSeq:   YP_747371.1
- ProteinModelPortal:   Q0AGX6
- SMR:   Q0AGX6
- STRING:   Q0AGX6
- GeneID:   4273554
- GenomeReviews:   CP000450_GR
- KEGG:   net:Neut_1151
- NMPDR:   fig|335283.3.peg.966
- eggNOG:   COG0135
- HOGENOM:   HBG554803
- OMA:   SKICGIT
- PhylomeDB:   Q0AGX6
- ProtClustDB:   PRK01222
- BioCyc:   NEUT335283:NEUT_1151-MONOMER
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 22708; Mature: 22708

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIRVKICGITRLEDAMTAVHHGVDAIGFILWPQSERYISPEEAGQIVRYLPPFVQAVGV
CEEEEEECCCHHHHHHHHHHHHCHHEEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHCCE
FVNPDKSWVEVASAAAGLDLLQFHGDESPDFCSQFHLPYIKAVRVRDGLDLLQYAQCYEG
EECCCHHHHHHHHHHHCHHHHHHCCCCCCHHHHHCCCCHHEEEHHHCCHHHHHHHHHHCC
SKGLLLDAYAEGKPGGTGHIFDWKLIPSGLSLPWILSGGLHSDNVVDAIEQTRPLAIDVS
CCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCEEEECCCCCCHHHHHHHHCCCEEEECC
SGVEIANGIKDADKISVFMQGVRSCENV
CCCHHHHCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRIRVKICGITRLEDAMTAVHHGVDAIGFILWPQSERYISPEEAGQIVRYLPPFVQAVGV
CEEEEEECCCHHHHHHHHHHHHCHHEEEEEECCCCCCCCCHHHHHHHHHHCCHHHHHCCE
FVNPDKSWVEVASAAAGLDLLQFHGDESPDFCSQFHLPYIKAVRVRDGLDLLQYAQCYEG
EECCCHHHHHHHHHHHCHHHHHHCCCCCCHHHHHCCCCHHEEEHHHCCHHHHHHHHHHCC
SKGLLLDAYAEGKPGGTGHIFDWKLIPSGLSLPWILSGGLHSDNVVDAIEQTRPLAIDVS
CCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCEEEECCCCCCHHHHHHHHCCCEEEECC
SGVEIANGIKDADKISVFMQGVRSCENV
CCCHHHHCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA