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The map label for this gene is asd [H]

Identifier: 114331146

GI number: 114331146

Start: 1186716

End: 1187840

Strand: Direct

Name: asd [H]

Synonym: Neut_1148

Alternate gene names: 114331146

Gene position: 1186716-1187840 (Clockwise)

Preceding gene: 114331145

Following gene: 114331147

Centisome position: 44.6

GC content: 46.84

Gene sequence:

>1125_bases
ATGAAACGGGTCGGGTTTGTCGGGTGGCGGGGTATGGTGGGTTCCGTGCTTATGCAACGGATGCGCGAGGAAGATGATTT
TTCATTAATTGAACCTGTATTTTTTTCAACCTCCCAGGCAGGTGGGGAAGGTCCGGATATTGGCGGGAATACAGGGCCAC
TCAAAGATGCTTATGATATTGCTGCGCTGCAGGAAATGGACATTATAATTTCCTGTCAAGGGGGGGATTATACCAACAAT
GTCTTTAAGAAACTTCGTGACTCAGGCTGGCGGGGTTACTGGATTGATGCTGCTTCTGCTCTCAGGATGGATGATGATGC
CGTTATTATTCTTGATCCTGTCAATCGTTCGGTTATCGATGAAGCGCTAAACAAAGGTGTTAAAAACTATATTGGTGGTA
ATTGTACGGTCAGCCTGATGTTAATGGCTGTGGGTGGCTTGTTTGATCAGGACATGGTTGAGTGGGCGAGCATTATGACC
TATCAGGCAGCATCGGGTGCCGGTGCTCAAAATATGCGCGAGCTGTTGCAGCAGATGGGAGAAACCCACAATGTTGCAAA
AGATTTACTGGATGATCCTACTTCCAGCATTTTGGATATTGATCGTAAAGTTGTTGAAAAAATGCGTAATGAAGAATTTC
CCGCTCAGAATTTTGGTGTTCCGTTGGCAGGCAGTCTTATTCCCTGGATTGATCGCGAGGTGGCATACGGACAAAGTCGG
GAAGAATGGAAAGGGCAGGCTGAAACCAATAAAATTCTCGGGCATGCTGATCACCCGGTGCCAGTCGATGGAATTTGTGT
ACGCGTTGGAGCCATGCGCTGCCATAGTCAGGCGCTAACGATCAAACTGAAAAAGGACATTCCTCTGGAAAGAATTAAGG
AAGTAATTGCTGGATCCAATGAATGGGTGCGAGTCATCCCAAATGAAAGGGAGGCTACTACCAAAGAACTTACCCCAGTG
GCGGTAACCGGAAAATTGGATATACATGTCGGACGCATACGCAAATTGAATATGGGGAATGAATATCTTTCTGTTTTTAC
TGTAGGAGATCAGTTATTATGGGGCGCCGCAGAGCCACTGCGCCGGATGTTGCGTATTCTGATCGAAGAAGACAAGGCTG
CATAG

Upstream 100 bases:

>100_bases
TTACTTTTTTCTTCTGATTTTTGGATAATACGCCGGGTAGCAAGCTGTCGAGTACAGTGCAATATTAAAACTATTTTTTG
TAAAAGGCTAAGTGAATTAC

Downstream 100 bases:

>100_bases
AATACTAAGAATTTCATATTTTTCTCAATCTCGGACCGTCTTGCTATAGACAAGATGACCTTCGCTTTCTGATATCGATT
GCCATCCATATTTTGTATCA

Product: aspartate-semialdehyde dehydrogenase

Products: NA

Alternate protein names: ASA dehydrogenase; ASADH [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MKRVGFVGWRGMVGSVLMQRMREEDDFSLIEPVFFSTSQAGGEGPDIGGNTGPLKDAYDIAALQEMDIIISCQGGDYTNN
VFKKLRDSGWRGYWIDAASALRMDDDAVIILDPVNRSVIDEALNKGVKNYIGGNCTVSLMLMAVGGLFDQDMVEWASIMT
YQAASGAGAQNMRELLQQMGETHNVAKDLLDDPTSSILDIDRKVVEKMRNEEFPAQNFGVPLAGSLIPWIDREVAYGQSR
EEWKGQAETNKILGHADHPVPVDGICVRVGAMRCHSQALTIKLKKDIPLERIKEVIAGSNEWVRVIPNEREATTKELTPV
AVTGKLDIHVGRIRKLNMGNEYLSVFTVGDQLLWGAAEPLRRMLRILIEEDKAA

Sequences:

>Translated_374_residues
MKRVGFVGWRGMVGSVLMQRMREEDDFSLIEPVFFSTSQAGGEGPDIGGNTGPLKDAYDIAALQEMDIIISCQGGDYTNN
VFKKLRDSGWRGYWIDAASALRMDDDAVIILDPVNRSVIDEALNKGVKNYIGGNCTVSLMLMAVGGLFDQDMVEWASIMT
YQAASGAGAQNMRELLQQMGETHNVAKDLLDDPTSSILDIDRKVVEKMRNEEFPAQNFGVPLAGSLIPWIDREVAYGQSR
EEWKGQAETNKILGHADHPVPVDGICVRVGAMRCHSQALTIKLKKDIPLERIKEVIAGSNEWVRVIPNEREATTKELTPV
AVTGKLDIHVGRIRKLNMGNEYLSVFTVGDQLLWGAAEPLRRMLRILIEEDKAA
>Mature_374_residues
MKRVGFVGWRGMVGSVLMQRMREEDDFSLIEPVFFSTSQAGGEGPDIGGNTGPLKDAYDIAALQEMDIIISCQGGDYTNN
VFKKLRDSGWRGYWIDAASALRMDDDAVIILDPVNRSVIDEALNKGVKNYIGGNCTVSLMLMAVGGLFDQDMVEWASIMT
YQAASGAGAQNMRELLQQMGETHNVAKDLLDDPTSSILDIDRKVVEKMRNEEFPAQNFGVPLAGSLIPWIDREVAYGQSR
EEWKGQAETNKILGHADHPVPVDGICVRVGAMRCHSQALTIKLKKDIPLERIKEVIAGSNEWVRVIPNEREATTKELTPV
AVTGKLDIHVGRIRKLNMGNEYLSVFTVGDQLLWGAAEPLRRMLRILIEEDKAA

Specific function: Second step in the common biosynthetic pathway leading from Asp to the cell wall precursor meso-diaminopimelate, to Lys, to Met, to Ile and to Thr. [C]

COG id: COG0136

COG function: function code E; Aspartate-semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartate-semialdehyde dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789841, Length=367, Percent_Identity=66.4850136239782, Blast_Score=525, Evalue=1e-150,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000319
- InterPro:   IPR011534
- InterPro:   IPR012080
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280 [H]

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC [H]

EC number: =1.2.1.11 [H]

Molecular weight: Translated: 41408; Mature: 41408

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS01103 ASD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVGFVGWRGMVGSVLMQRMREEDDFSLIEPVFFSTSQAGGEGPDIGGNTGPLKDAYDI
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHH
AALQEMDIIISCQGGDYTNNVFKKLRDSGWRGYWIDAASALRMDDDAVIILDPVNRSVID
HHHHHCCEEEEECCCCCHHHHHHHHHHCCCCEEEECCHHHEEECCCCEEEECCCCHHHHH
EALNKGVKNYIGGNCTVSLMLMAVGGLFDQDMVEWASIMTYQAASGAGAQNMRELLQQMG
HHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
ETHNVAKDLLDDPTSSILDIDRKVVEKMRNEEFPAQNFGVPLAGSLIPWIDREVAYGQSR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCH
EEWKGQAETNKILGHADHPVPVDGICVRVGAMRCHSQALTIKLKKDIPLERIKEVIAGSN
HHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCC
EWVRVIPNEREATTKELTPVAVTGKLDIHVGRIRKLNMGNEYLSVFTVGDQLLWGAAEPL
CEEEECCCCCCCHHHHCCCEEEEEEEEEEECCEEEECCCCCEEEEEEECCHHHHCCHHHH
RRMLRILIEEDKAA
HHHHHHHHHHCCCC
>Mature Secondary Structure
MKRVGFVGWRGMVGSVLMQRMREEDDFSLIEPVFFSTSQAGGEGPDIGGNTGPLKDAYDI
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHH
AALQEMDIIISCQGGDYTNNVFKKLRDSGWRGYWIDAASALRMDDDAVIILDPVNRSVID
HHHHHCCEEEEECCCCCHHHHHHHHHHCCCCEEEECCHHHEEECCCCEEEECCCCHHHHH
EALNKGVKNYIGGNCTVSLMLMAVGGLFDQDMVEWASIMTYQAASGAGAQNMRELLQQMG
HHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
ETHNVAKDLLDDPTSSILDIDRKVVEKMRNEEFPAQNFGVPLAGSLIPWIDREVAYGQSR
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCH
EEWKGQAETNKILGHADHPVPVDGICVRVGAMRCHSQALTIKLKKDIPLERIKEVIAGSN
HHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCC
EWVRVIPNEREATTKELTPVAVTGKLDIHVGRIRKLNMGNEYLSVFTVGDQLLWGAAEPL
CEEEECCCCCCCHHHHCCCEEEEEEEEEEECCEEEECCCCCEEEEEEECCHHHHCCHHHH
RRMLRILIEEDKAA
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9084174; 10984043 [H]