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The map label for this gene is hflK [H]

Identifier: 114330966

GI number: 114330966

Start: 993579

End: 994769

Strand: Direct

Name: hflK [H]

Synonym: Neut_0963

Alternate gene names: 114330966

Gene position: 993579-994769 (Clockwise)

Preceding gene: 114330965

Following gene: 114330967

Centisome position: 37.34

GC content: 45.51

Gene sequence:

>1191_bases
ATGGGCTTGAATGATCCGCAATGGGGGAAAAGGAGAGGTAATTCCGGTCCTCCTGATCTTGAAGAAGTTATGCGCAGCTT
TAATCAAAAAATAAATGAGCTTTTTGGTCGGAAGGGCAGAGGCGATAGTAACGGGGATTCTGATGGGAAGGATCCCGATG
GACCAAGTAGTACAGGTATTGGAATCATTGGGTTCCTGCTCTTGGTCGCGTGGGCGGGAAGCGGATTCTACATCGTTGAT
GAAGGCCATCGAGGAGTCGTGCTGCGATTTGGTAAACATGTAGAAACAACGCAGCCTGGGCTGCGCTGGCATGTTCCTTC
ACCAATTGAATCTGTTGAGGATGTCAATATAGCTCAGGTGCGTACAGTAGAAATTGGATATCGTAATAATGTACGCAGCA
AGGTGCTAAAGGAATCATTAATTCTTACAGATGACGAGAATATCGTTGATATTCAGTTTGCTGTGCAATATATACTTAAT
AGTCCCGAAGATTTTCTGTTCACTAATCGCGAGCCGGAAGACAGCGTTTTGCAGGTAGCGGAAACAGCTATTCGAGAAGT
GATTGGTACCAGTAAAATGGACTTTGTCCTTTATGAAGGACGTGAAGAGGTGGCTGCTAGAACGACTGTATTAATGCAAA
AAATTCTTGATCGTTATCAGATTGGTATTTCTATCAACAGGGTAACTATGCAGAATGCACAGCCACCTGAGCAGGTGCAG
GCAGCTTTTGATGATGCGGTCAAAGCCAATCAGGATAGAGAACGGCAAAGAAACGAGGGACAGGCCTATGCAAATGACGT
GATTCCGAGAGCCAGAGGTGCTGCAGCCCGTTTATTAGAGGAAGCCGAAGGATATAAACAAAGGGTAATCACAGCCTCAG
AGGGTGATGCCAGTCGTTTTGAACAGGTGCTGGTGGAATATGCCAAGGCGCCGGAAGTAACACGTGAGCGTATGTATATT
GATACGGTTCAGCACGTATTATCTAGTACCAGCAAAATCCTGATTGATCAGGAAAAAGGAGGAGGGAATCTGCTTTATCT
GCCATTGGACAAATTGATTCAGGCTGATTCTGGGGTGGCGAAATCATCTACGGGGACAATTAAACAACAAAACGAAAATC
AAGATTTTTCCTCAGATATAAGCTCGCGCTCGCGTGAGTCTTTTCGCAGTCGTGAACGGGAGGTGAGATAA

Upstream 100 bases:

>100_bases
ATCAAAACTTGAATAAATTAAGCAGCATTCAGCAACATCCGTAAGCATGAACGACAATGTCCGTGCCACTTCTATAAATA
ATGAAAAGGACTAAATCAAC

Downstream 100 bases:

>100_bases
TGAAAGCGATTTCATCTATATTTGCTGTACTTTTGCTGGTTTTGGCAGTTGTGGGTAGTTCTGCTGTTTATATTGTTGAT
CAACGTGAACAGGCATTGTT

Product: HflK protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MGLNDPQWGKRRGNSGPPDLEEVMRSFNQKINELFGRKGRGDSNGDSDGKDPDGPSSTGIGIIGFLLLVAWAGSGFYIVD
EGHRGVVLRFGKHVETTQPGLRWHVPSPIESVEDVNIAQVRTVEIGYRNNVRSKVLKESLILTDDENIVDIQFAVQYILN
SPEDFLFTNREPEDSVLQVAETAIREVIGTSKMDFVLYEGREEVAARTTVLMQKILDRYQIGISINRVTMQNAQPPEQVQ
AAFDDAVKANQDRERQRNEGQAYANDVIPRARGAAARLLEEAEGYKQRVITASEGDASRFEQVLVEYAKAPEVTRERMYI
DTVQHVLSSTSKILIDQEKGGGNLLYLPLDKLIQADSGVAKSSTGTIKQQNENQDFSSDISSRSRESFRSREREVR

Sequences:

>Translated_396_residues
MGLNDPQWGKRRGNSGPPDLEEVMRSFNQKINELFGRKGRGDSNGDSDGKDPDGPSSTGIGIIGFLLLVAWAGSGFYIVD
EGHRGVVLRFGKHVETTQPGLRWHVPSPIESVEDVNIAQVRTVEIGYRNNVRSKVLKESLILTDDENIVDIQFAVQYILN
SPEDFLFTNREPEDSVLQVAETAIREVIGTSKMDFVLYEGREEVAARTTVLMQKILDRYQIGISINRVTMQNAQPPEQVQ
AAFDDAVKANQDRERQRNEGQAYANDVIPRARGAAARLLEEAEGYKQRVITASEGDASRFEQVLVEYAKAPEVTRERMYI
DTVQHVLSSTSKILIDQEKGGGNLLYLPLDKLIQADSGVAKSSTGTIKQQNENQDFSSDISSRSRESFRSREREVR
>Mature_395_residues
GLNDPQWGKRRGNSGPPDLEEVMRSFNQKINELFGRKGRGDSNGDSDGKDPDGPSSTGIGIIGFLLLVAWAGSGFYIVDE
GHRGVVLRFGKHVETTQPGLRWHVPSPIESVEDVNIAQVRTVEIGYRNNVRSKVLKESLILTDDENIVDIQFAVQYILNS
PEDFLFTNREPEDSVLQVAETAIREVIGTSKMDFVLYEGREEVAARTTVLMQKILDRYQIGISINRVTMQNAQPPEQVQA
AFDDAVKANQDRERQRNEGQAYANDVIPRARGAAARLLEEAEGYKQRVITASEGDASRFEQVLVEYAKAPEVTRERMYID
TVQHVLSSTSKILIDQEKGGGNLLYLPLDKLIQADSGVAKSSTGTIKQQNENQDFSSDISSRSRESFRSREREVR

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=294, Percent_Identity=40.8163265306122, Blast_Score=234, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 44262; Mature: 44131

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLNDPQWGKRRGNSGPPDLEEVMRSFNQKINELFGRKGRGDSNGDSDGKDPDGPSSTGI
CCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCH
GIIGFLLLVAWAGSGFYIVDEGHRGVVLRFGKHVETTQPGLRWHVPSPIESVEDVNIAQV
HHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCCCCCEEECCCCHHHHCCCCEEEE
RTVEIGYRNNVRSKVLKESLILTDDENIVDIQFAVQYILNSPEDFLFTNREPEDSVLQVA
EEEEECCCCCHHHHHHHHHHEEECCCCEEHHHHHHHHHHCCCHHHEECCCCCHHHHHHHH
ETAIREVIGTSKMDFVLYEGREEVAARTTVLMQKILDRYQIGISINRVTMQNAQPPEQVQ
HHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCHHHHH
AAFDDAVKANQDRERQRNEGQAYANDVIPRARGAAARLLEEAEGYKQRVITASEGDASRF
HHHHHHHHCCCHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEECCCCCHHHH
EQVLVEYAKAPEVTRERMYIDTVQHVLSSTSKILIDQEKGGGNLLYLPLDKLIQADSGVA
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECHHHHHHCCCCCC
KSSTGTIKQQNENQDFSSDISSRSRESFRSREREVR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GLNDPQWGKRRGNSGPPDLEEVMRSFNQKINELFGRKGRGDSNGDSDGKDPDGPSSTGI
CCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCH
GIIGFLLLVAWAGSGFYIVDEGHRGVVLRFGKHVETTQPGLRWHVPSPIESVEDVNIAQV
HHHHHHHHHHHCCCCEEEEECCCCEEEEEECCCCCCCCCCCEEECCCCHHHHCCCCEEEE
RTVEIGYRNNVRSKVLKESLILTDDENIVDIQFAVQYILNSPEDFLFTNREPEDSVLQVA
EEEEECCCCCHHHHHHHHHHEEECCCCEEHHHHHHHHHHCCCHHHEECCCCCHHHHHHHH
ETAIREVIGTSKMDFVLYEGREEVAARTTVLMQKILDRYQIGISINRVTMQNAQPPEQVQ
HHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCCHHHHH
AAFDDAVKANQDRERQRNEGQAYANDVIPRARGAAARLLEEAEGYKQRVITASEGDASRF
HHHHHHHHCCCHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEECCCCCHHHH
EQVLVEYAKAPEVTRERMYIDTVQHVLSSTSKILIDQEKGGGNLLYLPLDKLIQADSGVA
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECHHHHHHCCCCCC
KSSTGTIKQQNENQDFSSDISSRSRESFRSREREVR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]