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The map label for this gene is hflC [H]

Identifier: 114330967

GI number: 114330967

Start: 994769

End: 995647

Strand: Direct

Name: hflC [H]

Synonym: Neut_0964

Alternate gene names: 114330967

Gene position: 994769-995647 (Clockwise)

Preceding gene: 114330966

Following gene: 114330968

Centisome position: 37.38

GC content: 41.98

Gene sequence:

>879_bases
ATGAAAGCGATTTCATCTATATTTGCTGTACTTTTGCTGGTTTTGGCAGTTGTGGGTAGTTCTGCTGTTTATATTGTTGA
TCAACGTGAACAGGCATTGTTATTTCAGCTGGGGGAGGTTGTAGGGGTAAAAACATCTCCTGGTTTATATTTAAAAATAC
CTTTTGTCCAGAATGTTCGTTTTTTTGATTCACGTATTTTGACGATGGATTCAGAAGAACCTGAACGTTATATCACTTCA
GAGAAGAAAAACGTTCTAGTGGATCTATTCGTCAAATGGCGTATTGTAGATGTAAAGCAGTACTACGTTAGTGTGCAGGG
GGATGAAACGTTAGCACGAGTACGTCTTGCACAAACAATAAATTCTAGTATGCGTGATGAATTTGGTAATCGGACGGTGC
ATGATGTGGTTTCTGGCGAACGTGACAAGATCATGGAGGTCATGCGCCAGAAAGCAAACACAGATGCAGAAAAGATTGGT
GTAGAGGTTGTGGATGTACGGCTTAAGCGCGTGGATCTTCCTCAGGAAGTCAGTGAATCTGTTTATCGCAGAATGGAGGC
AGAGCGTAAGCGAGTGGCAAACCAACTGCGATCAACAGGTTTTGCGGAATCTGAGAAAATACGGGCAGATGCTGATCGTC
AGCACGAGGTAATTTTGGCTGAGGCCTATCGTGACGCACAAAAAATCATGGGGGAGGGTGATGCTCAAGCTACGGCAATT
TATGCTGAAGCTTTCCAGAAGGATGCAAAATTCTATGGATTTTACCGCAGCTTGGATGCGTATGAAAAATCCTTTAGAAG
TAAGGAAGATATTCTTGTTGTGGAGCCAAACTCGGAGTTTTTTAAATATATGAAAGATCCGACAGGCCATAAAAAATAA

Upstream 100 bases:

>100_bases
CGGGGACAATTAAACAACAAAACGAAAATCAAGATTTTTCCTCAGATATAAGCTCGCGCTCGCGTGAGTCTTTTCGCAGT
CGTGAACGGGAGGTGAGATA

Downstream 100 bases:

>100_bases
AAATGGAAGCAAAGCTATACCTTGAGTTGAAATATCATGCTAAAAATCAGCATTTCAGGTATTGGAGGATGGCTGATATA
AATAGTTGTTTATATAGAAT

Product: HflC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MKAISSIFAVLLLVLAVVGSSAVYIVDQREQALLFQLGEVVGVKTSPGLYLKIPFVQNVRFFDSRILTMDSEEPERYITS
EKKNVLVDLFVKWRIVDVKQYYVSVQGDETLARVRLAQTINSSMRDEFGNRTVHDVVSGERDKIMEVMRQKANTDAEKIG
VEVVDVRLKRVDLPQEVSESVYRRMEAERKRVANQLRSTGFAESEKIRADADRQHEVILAEAYRDAQKIMGEGDAQATAI
YAEAFQKDAKFYGFYRSLDAYEKSFRSKEDILVVEPNSEFFKYMKDPTGHKK

Sequences:

>Translated_292_residues
MKAISSIFAVLLLVLAVVGSSAVYIVDQREQALLFQLGEVVGVKTSPGLYLKIPFVQNVRFFDSRILTMDSEEPERYITS
EKKNVLVDLFVKWRIVDVKQYYVSVQGDETLARVRLAQTINSSMRDEFGNRTVHDVVSGERDKIMEVMRQKANTDAEKIG
VEVVDVRLKRVDLPQEVSESVYRRMEAERKRVANQLRSTGFAESEKIRADADRQHEVILAEAYRDAQKIMGEGDAQATAI
YAEAFQKDAKFYGFYRSLDAYEKSFRSKEDILVVEPNSEFFKYMKDPTGHKK
>Mature_292_residues
MKAISSIFAVLLLVLAVVGSSAVYIVDQREQALLFQLGEVVGVKTSPGLYLKIPFVQNVRFFDSRILTMDSEEPERYITS
EKKNVLVDLFVKWRIVDVKQYYVSVQGDETLARVRLAQTINSSMRDEFGNRTVHDVVSGERDKIMEVMRQKANTDAEKIG
VEVVDVRLKRVDLPQEVSESVYRRMEAERKRVANQLRSTGFAESEKIRADADRQHEVILAEAYRDAQKIMGEGDAQATAI
YAEAFQKDAKFYGFYRSLDAYEKSFRSKEDILVVEPNSEFFKYMKDPTGHKK

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=313, Percent_Identity=37.3801916932907, Blast_Score=213, Evalue=8e-57,
Organism=Escherichia coli, GI1786697, Length=249, Percent_Identity=25.7028112449799, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32564147, Length=231, Percent_Identity=25.1082251082251, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 33462; Mature: 33462

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAISSIFAVLLLVLAVVGSSAVYIVDQREQALLFQLGEVVGVKTSPGLYLKIPFVQNVR
CHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCCCCEEEEECHHHCHH
FFDSRILTMDSEEPERYITSEKKNVLVDLFVKWRIVDVKQYYVSVQGDETLARVRLAQTI
HHCCEEEECCCCCCHHHHHCCHHHHEEEEEEHHEEEEEEHEEEEECCCHHHHHHHHHHHH
NSSMRDEFGNRTVHDVVSGERDKIMEVMRQKANTDAEKIGVEVVDVRLKRVDLPQEVSES
HHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHCCCCHHHHCHHHEEHHHHHCCCHHHHHHH
VYRRMEAERKRVANQLRSTGFAESEKIRADADRQHEVILAEAYRDAQKIMGEGDAQATAI
HHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
YAEAFQKDAKFYGFYRSLDAYEKSFRSKEDILVVEPNSEFFKYMKDPTGHKK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKAISSIFAVLLLVLAVVGSSAVYIVDQREQALLFQLGEVVGVKTSPGLYLKIPFVQNVR
CHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCCCCCCCEEEEECHHHCHH
FFDSRILTMDSEEPERYITSEKKNVLVDLFVKWRIVDVKQYYVSVQGDETLARVRLAQTI
HHCCEEEECCCCCCHHHHHCCHHHHEEEEEEHHEEEEEEHEEEEECCCHHHHHHHHHHHH
NSSMRDEFGNRTVHDVVSGERDKIMEVMRQKANTDAEKIGVEVVDVRLKRVDLPQEVSES
HHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHCCCCHHHHCHHHEEHHHHHCCCHHHHHHH
VYRRMEAERKRVANQLRSTGFAESEKIRADADRQHEVILAEAYRDAQKIMGEGDAQATAI
HHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
YAEAFQKDAKFYGFYRSLDAYEKSFRSKEDILVVEPNSEFFKYMKDPTGHKK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]