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The map label for this gene is sucC [H]

Identifier: 114330621

GI number: 114330621

Start: 615127

End: 616299

Strand: Reverse

Name: sucC [H]

Synonym: Neut_0606

Alternate gene names: 114330621

Gene position: 616299-615127 (Counterclockwise)

Preceding gene: 114330622

Following gene: 114330620

Centisome position: 23.16

GC content: 52.51

Gene sequence:

>1173_bases
TTGGATATTCATGAATATCAGGCCAAGGAAATTCTGGCTGAATACGGTATCAAACTGGCTGAAGGCGGATTGGCGTATTC
GGTGGAAGAGGCTGTGCAACGCAGCCGGGAAATTGGTAGTAACGTCTGGGTAGTCAAAGCACAAATTCATTCCGGGGCAC
GTGGCAAGGCAGGTGCTATCAAGATATGCAGATCACACCAGGAAATCGAAACAGCAGCTGAATCCCTGCTGGGCAAGAAA
CTGGTTACGCATCAAACCGGTCCGACAGGCAAGCTCTGCTCGAAGTTATATATTGAAGCGGGCACAGACATTGCCCGGGA
AGTGTATCTCGCGCTCATGATTGATCGCAGCCATGAACGTATCGTCATGGTTGGCTCCGCTCAGGGAGGAATGGACATTG
AAACGCTGGCTGTCACAAATCCAGGTGCTATCAAGAAAATTCATATTGAACCGGCTGTCGGTTTGCAGGATTTTCAGGCA
AGAACCATGGCTTTTTCCCTGGGATTGGATGGCGAGCTACTCAATCACGCCATCAAAACCATCAGGGGTTGCTATCGTGC
CTTGCGTGATCTGGACGCCAATATTCTCGAAATCAATCCGCTGGTTGTCACACGGAATAATGAGCTGATCGCACTGGATG
CAAAAATGAGTTTCGATGAAAACGCACTGTTCCGGCGTCACCGGGTTTCTGAGTTGCGCGATAACACACAGATTGATCCG
CGCGAAGTTGCAGCAGCAGAGGCCGGCCTCAGTTATGTTGGACTGGATGGAGATATTGGCTGCATGATCAATGGTGCCGG
ACTTGCCATGGCCACCATGGACATGATCAAACTGGCCGGTGGCGAGCCTGCCAATTTCCTGGATGTGGGTGGTGGCGCCT
CCGCCGAGCGGACTGAAAAAGCATTCCGGCTGGTGCTGGCAGACAGCAATGTAAAGGCCATGCTGGTCAACATCTTCGCT
GGTATTAACCGCTGTGACTGGATTGCCGAGGGCGTAGTCCAGGCGGTGCGGAATATCGGAACAACTGTTCCTCTGGTTGT
ACGTTTGTCCGGCACTAATGTGGAAGAAGGCCGCCGCATTATCGCCGATAGCGGTCTGCCCATTATCACCGCAGAAACTC
TGGCCGAAGCAGCCGAGAAAGCAGTACACGCACGCAACCAGGTCGTAGCCTGA

Upstream 100 bases:

>100_bases
GCTTTTTAGCTGATTTCGCTTTATCTGGCTATCACTCGCACTCTTTTTCAGAGTTTCCCTTAAACCCAACCATTTCATAA
AATTCAAGGGAGAAGCTATA

Downstream 100 bases:

>100_bases
ATAACCGAAACCAGAAAGGGGAACAAAAAGTGGCAATTCTCATTAATGAGCGGACGCGGATCATCGTACAAGGTTTTACC
GGCCGGATTGGCACCTTCCA

Product: malate--CoA ligase subunit beta

Products: NA

Alternate protein names: MTK-beta; Malate thiokinase; Malyl-CoA synthetase [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MDIHEYQAKEILAEYGIKLAEGGLAYSVEEAVQRSREIGSNVWVVKAQIHSGARGKAGAIKICRSHQEIETAAESLLGKK
LVTHQTGPTGKLCSKLYIEAGTDIAREVYLALMIDRSHERIVMVGSAQGGMDIETLAVTNPGAIKKIHIEPAVGLQDFQA
RTMAFSLGLDGELLNHAIKTIRGCYRALRDLDANILEINPLVVTRNNELIALDAKMSFDENALFRRHRVSELRDNTQIDP
REVAAAEAGLSYVGLDGDIGCMINGAGLAMATMDMIKLAGGEPANFLDVGGGASAERTEKAFRLVLADSNVKAMLVNIFA
GINRCDWIAEGVVQAVRNIGTTVPLVVRLSGTNVEEGRRIIADSGLPIITAETLAEAAEKAVHARNQVVA

Sequences:

>Translated_390_residues
MDIHEYQAKEILAEYGIKLAEGGLAYSVEEAVQRSREIGSNVWVVKAQIHSGARGKAGAIKICRSHQEIETAAESLLGKK
LVTHQTGPTGKLCSKLYIEAGTDIAREVYLALMIDRSHERIVMVGSAQGGMDIETLAVTNPGAIKKIHIEPAVGLQDFQA
RTMAFSLGLDGELLNHAIKTIRGCYRALRDLDANILEINPLVVTRNNELIALDAKMSFDENALFRRHRVSELRDNTQIDP
REVAAAEAGLSYVGLDGDIGCMINGAGLAMATMDMIKLAGGEPANFLDVGGGASAERTEKAFRLVLADSNVKAMLVNIFA
GINRCDWIAEGVVQAVRNIGTTVPLVVRLSGTNVEEGRRIIADSGLPIITAETLAEAAEKAVHARNQVVA
>Mature_390_residues
MDIHEYQAKEILAEYGIKLAEGGLAYSVEEAVQRSREIGSNVWVVKAQIHSGARGKAGAIKICRSHQEIETAAESLLGKK
LVTHQTGPTGKLCSKLYIEAGTDIAREVYLALMIDRSHERIVMVGSAQGGMDIETLAVTNPGAIKKIHIEPAVGLQDFQA
RTMAFSLGLDGELLNHAIKTIRGCYRALRDLDANILEINPLVVTRNNELIALDAKMSFDENALFRRHRVSELRDNTQIDP
REVAAAEAGLSYVGLDGDIGCMINGAGLAMATMDMIKLAGGEPANFLDVGGGASAERTEKAFRLVLADSNVKAMLVNIFA
GINRCDWIAEGVVQAVRNIGTTVPLVVRLSGTNVEEGRRIIADSGLPIITAETLAEAAEKAVHARNQVVA

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0045

COG function: function code C; Succinyl-CoA synthetase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI11321583, Length=389, Percent_Identity=42.159383033419, Blast_Score=324, Evalue=1e-88,
Organism=Homo sapiens, GI157779135, Length=378, Percent_Identity=41.005291005291, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI294862256, Length=363, Percent_Identity=40.2203856749311, Blast_Score=278, Evalue=5e-75,
Organism=Escherichia coli, GI1786948, Length=384, Percent_Identity=49.4791666666667, Blast_Score=379, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17567829, Length=394, Percent_Identity=41.6243654822335, Blast_Score=310, Evalue=9e-85,
Organism=Caenorhabditis elegans, GI17539378, Length=393, Percent_Identity=42.7480916030534, Blast_Score=308, Evalue=3e-84,
Organism=Saccharomyces cerevisiae, GI6321683, Length=392, Percent_Identity=43.3673469387755, Blast_Score=329, Evalue=4e-91,
Organism=Drosophila melanogaster, GI21356231, Length=394, Percent_Identity=40.6091370558376, Blast_Score=303, Evalue=9e-83,
Organism=Drosophila melanogaster, GI161078106, Length=390, Percent_Identity=41.025641025641, Blast_Score=298, Evalue=4e-81,
Organism=Drosophila melanogaster, GI24645208, Length=390, Percent_Identity=41.025641025641, Blast_Score=298, Evalue=4e-81,
Organism=Drosophila melanogaster, GI281361397, Length=391, Percent_Identity=40.920716112532, Blast_Score=294, Evalue=6e-80,
Organism=Drosophila melanogaster, GI281361395, Length=391, Percent_Identity=40.920716112532, Blast_Score=294, Evalue=6e-80,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2361 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013650
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR005811
- InterPro:   IPR017866
- InterPro:   IPR005809
- InterPro:   IPR016102 [H]

Pfam domain/function: PF08442 ATP-grasp_2; PF00549 Ligase_CoA [H]

EC number: =6.2.1.9 [H]

Molecular weight: Translated: 41917; Mature: 41917

Theoretical pI: Translated: 5.87; Mature: 5.87

Prosite motif: PS01217 SUCCINYL_COA_LIG_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIHEYQAKEILAEYGIKLAEGGLAYSVEEAVQRSREIGSNVWVVKAQIHSGARGKAGAI
CCCHHHHHHHHHHHCCCEEECCCCEEHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHH
KICRSHQEIETAAESLLGKKLVTHQTGPTGKLCSKLYIEAGTDIAREVYLALMIDRSHER
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHEEECCCCE
IVMVGSAQGGMDIETLAVTNPGAIKKIHIEPAVGLQDFQARTMAFSLGLDGELLNHAIKT
EEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHEEEECCCCHHHHHHHHHH
IRGCYRALRDLDANILEINPLVVTRNNELIALDAKMSFDENALFRRHRVSELRDNTQIDP
HHHHHHHHHHCCCCEEEECEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCH
REVAAAEAGLSYVGLDGDIGCMINGAGLAMATMDMIKLAGGEPANFLDVGGGASAERTEK
HHHHHHHCCCEEEECCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHH
AFRLVLADSNVKAMLVNIFAGINRCDWIAEGVVQAVRNIGTTVPLVVRLSGTNVEEGRRI
HEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHCCEE
IADSGLPIITAETLAEAAEKAVHARNQVVA
EECCCCCEEEHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDIHEYQAKEILAEYGIKLAEGGLAYSVEEAVQRSREIGSNVWVVKAQIHSGARGKAGAI
CCCHHHHHHHHHHHCCCEEECCCCEEHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHH
KICRSHQEIETAAESLLGKKLVTHQTGPTGKLCSKLYIEAGTDIAREVYLALMIDRSHER
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHEEECCCCE
IVMVGSAQGGMDIETLAVTNPGAIKKIHIEPAVGLQDFQARTMAFSLGLDGELLNHAIKT
EEEEECCCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHEEEECCCCHHHHHHHHHH
IRGCYRALRDLDANILEINPLVVTRNNELIALDAKMSFDENALFRRHRVSELRDNTQIDP
HHHHHHHHHHCCCCEEEECEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCH
REVAAAEAGLSYVGLDGDIGCMINGAGLAMATMDMIKLAGGEPANFLDVGGGASAERTEK
HHHHHHHCCCEEEECCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHH
AFRLVLADSNVKAMLVNIFAGINRCDWIAEGVVQAVRNIGTTVPLVVRLSGTNVEEGRRI
HEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHCCEE
IADSGLPIITAETLAEAAEKAVHARNQVVA
EECCCCCEEEHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]