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The map label for this gene is mcl1 [H]

Identifier: 114330622

GI number: 114330622

Start: 616473

End: 617423

Strand: Reverse

Name: mcl1 [H]

Synonym: Neut_0607

Alternate gene names: 114330622

Gene position: 617423-616473 (Counterclockwise)

Preceding gene: 114330623

Following gene: 114330621

Centisome position: 23.2

GC content: 52.16

Gene sequence:

>951_bases
ATGAGTCATACCTTGTATGAAAGCAAAACACCGCGTGTACAACGCTGCGAGCTGGCCGTCCCCGGTTCCCGCCCTGAAAT
GTTTGAAAAAGCACTGAAAAGCGGAGCGGATTTCATATTTCTGGATCTGGAAGATGCAGTTGCACCGGATGACAAGCTCC
AGGCAAGAAAAAATATCATCCAGGCCATCAATGATCTGGATTGGAAAAGCCATGGTGTCACTCTTTCTGTACGTATCAAT
GGGTTGGATACTCAGTATATGGTGCGCGATGTGGTTGATCTGGTTGAGCAGGCCGGGCACAAGATTGATACGCTGCTGAT
CCCCAAAGTCGGAGTTTATGAAGATGTCTACATGGTGGAAGCCATGCTCAATCAGCTCGAAATGCAGCAGGGGTTGAAAA
ACCGGATTGGGGTGGAAGCACTGATTGAAACCGCGCTGGGAATGGCCAATGTTGAAGATATCGCTCGCAAGGGAACTGCG
GGACGTCTGGAAGCACTGCATTTTGGCGTAGCTGATTACGCCGCCAGCAATCGTGCCCGCACCACCAATATCGGTGGACT
CAACCCGGACTACCCAGGTGATCAATGGCATGCTGCCATCAGCAGAATGACCGTTGCCTGCCGCGCATTTGGTCTGCGGC
CGATCGATGGCCCCTTTGGAGACATTCAGGATCCGGAAGGGTTCAAGCTGGCCGCCAGGCGAGCCGCTGCATTGGGTTGT
GAAGGAAAATGGGCTATTCATCCTTCCCAGGTTGTGCTGGCTAATGAGGTCTTTACCCCGCCAGCAGCTGAGATTGACAA
GGCCAAGCGGATACTGGCGGCAATGAAAGAAGCTGCTGCTCAAGGAAAAGGTGCAGCAGCACTGGATGGCAAGCTGATCG
ATGCTGCCTCGGAAAGAATGGCAAACAACATCGTCAAAATGGCAGAAGCGATTGCTGCCAAAAGCAAATAA

Upstream 100 bases:

>100_bases
CACCTGGCAATCCTTTATGGACAGCTGTGACGTTTGCGCACAGCGCACCATGCATTTCGATATTCACACATAACATCGTA
TTTAATCTGTTGGAGGAAGA

Downstream 100 bases:

>100_bases
GTATTCAAGGAACCTCTGAAAAATAACTGCACTGAAATCAGACTAAGAATGCTCAGTTACCTGTGTAAATTGTGCTTTTT
AGCTGATTTCGCTTTATCTG

Product: Citryl-CoA lyase

Products: NA

Alternate protein names: (3S)-malyl-CoA/beta-methylmalyl-CoA lyase; L-malyl-CoA/beta-methylmalyl-CoA lyase [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MSHTLYESKTPRVQRCELAVPGSRPEMFEKALKSGADFIFLDLEDAVAPDDKLQARKNIIQAINDLDWKSHGVTLSVRIN
GLDTQYMVRDVVDLVEQAGHKIDTLLIPKVGVYEDVYMVEAMLNQLEMQQGLKNRIGVEALIETALGMANVEDIARKGTA
GRLEALHFGVADYAASNRARTTNIGGLNPDYPGDQWHAAISRMTVACRAFGLRPIDGPFGDIQDPEGFKLAARRAAALGC
EGKWAIHPSQVVLANEVFTPPAAEIDKAKRILAAMKEAAAQGKGAAALDGKLIDAASERMANNIVKMAEAIAAKSK

Sequences:

>Translated_316_residues
MSHTLYESKTPRVQRCELAVPGSRPEMFEKALKSGADFIFLDLEDAVAPDDKLQARKNIIQAINDLDWKSHGVTLSVRIN
GLDTQYMVRDVVDLVEQAGHKIDTLLIPKVGVYEDVYMVEAMLNQLEMQQGLKNRIGVEALIETALGMANVEDIARKGTA
GRLEALHFGVADYAASNRARTTNIGGLNPDYPGDQWHAAISRMTVACRAFGLRPIDGPFGDIQDPEGFKLAARRAAALGC
EGKWAIHPSQVVLANEVFTPPAAEIDKAKRILAAMKEAAAQGKGAAALDGKLIDAASERMANNIVKMAEAIAAKSK
>Mature_315_residues
SHTLYESKTPRVQRCELAVPGSRPEMFEKALKSGADFIFLDLEDAVAPDDKLQARKNIIQAINDLDWKSHGVTLSVRING
LDTQYMVRDVVDLVEQAGHKIDTLLIPKVGVYEDVYMVEAMLNQLEMQQGLKNRIGVEALIETALGMANVEDIARKGTAG
RLEALHFGVADYAASNRARTTNIGGLNPDYPGDQWHAAISRMTVACRAFGLRPIDGPFGDIQDPEGFKLAARRAAALGCE
GKWAIHPSQVVLANEVFTPPAAEIDKAKRILAAMKEAAAQGKGAAALDGKLIDAASERMANNIVKMAEAIAAKSK

Specific function: Catalyzes the reversible condensation of glyoxylate and acetyl-CoA to L-malyl-CoA and the reversible condensation of glyoxylate and propionyl-CoA to beta-methylmalyl-CoA [H]

COG id: COG2301

COG function: function code G; Citrate lyase beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

Organism=Homo sapiens, GI45545437, Length=319, Percent_Identity=29.4670846394984, Blast_Score=115, Evalue=5e-26,
Organism=Escherichia coli, GI87081764, Length=295, Percent_Identity=29.1525423728814, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17557458, Length=311, Percent_Identity=28.2958199356913, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR011206
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: =4.1.3.24 [H]

Molecular weight: Translated: 34219; Mature: 34087

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHTLYESKTPRVQRCELAVPGSRPEMFEKALKSGADFIFLDLEDAVAPDDKLQARKNII
CCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECHHHCCCCHHHHHHHHHH
QAINDLDWKSHGVTLSVRINGLDTQYMVRDVVDLVEQAGHKIDTLLIPKVGVYEDVYMVE
HHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHH
AMLNQLEMQQGLKNRIGVEALIETALGMANVEDIARKGTAGRLEALHFGVADYAASNRAR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
TTNIGGLNPDYPGDQWHAAISRMTVACRAFGLRPIDGPFGDIQDPEGFKLAARRAAALGC
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
EGKWAIHPSQVVLANEVFTPPAAEIDKAKRILAAMKEAAAQGKGAAALDGKLIDAASERM
CCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHH
ANNIVKMAEAIAAKSK
HHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SHTLYESKTPRVQRCELAVPGSRPEMFEKALKSGADFIFLDLEDAVAPDDKLQARKNII
CCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEECHHHCCCCHHHHHHHHHH
QAINDLDWKSHGVTLSVRINGLDTQYMVRDVVDLVEQAGHKIDTLLIPKVGVYEDVYMVE
HHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHH
AMLNQLEMQQGLKNRIGVEALIETALGMANVEDIARKGTAGRLEALHFGVADYAASNRAR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHCCCCC
TTNIGGLNPDYPGDQWHAAISRMTVACRAFGLRPIDGPFGDIQDPEGFKLAARRAAALGC
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCC
EGKWAIHPSQVVLANEVFTPPAAEIDKAKRILAAMKEAAAQGKGAAALDGKLIDAASERM
CCCEEECCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHH
ANNIVKMAEAIAAKSK
HHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA