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The map label for this gene is metH [H]

Identifier: 114330519

GI number: 114330519

Start: 514706

End: 518419

Strand: Direct

Name: metH [H]

Synonym: Neut_0500

Alternate gene names: 114330519

Gene position: 514706-518419 (Clockwise)

Preceding gene: 114330518

Following gene: 114330520

Centisome position: 19.34

GC content: 51.53

Gene sequence:

>3714_bases
ATGACAATGTCTGATCGTGCTGATTTGCTGAAACAATTACTTGCCGAACGTATCCTGATACTGGATGGTGCCATGGGTAC
GATGATCCAGAGTTATAAGCTGAGTGAGTCGGACTACCGGGGTGAGCGTTTTGCTGATTTCCCGCACGACCTCAAGGGCA
ATAATGATCTGCTTTGCCTGACCAAACCAGAGGTGATCCGTGCTATTCATCGCGCTTATCTTGAAGCCGGATCCGATATT
ATCGAAACCAACACGTTCAATTCAAATGCACCGTCGATGGCGGATTACCACATGCAGGATCTGGTGTATGAGCTGAATGT
GGCAGGTGCACGTCTGGCGTGTGAGGAAGCACGCGCCATGGAAGCAAAACAGCCTGATAAACCCCGCTTTGTTGCCGGCG
TAATCGGGCCTACTACCAAAACAGCTTCGCTTTCACCGGATGTCAATGATCCCGGTTTTCGTGCCATCACATTTGATGAT
CTGGTTGAGAGTTACACCGAATCGGTGAGCGGATTGGTTGACGGCGGGGCCGATATCCTACTGGTCGAAACCATCTTCGA
TACCCTGAACGCTAAGGCTGCACTGTTTGCCATTGAACAGTATTTTGAGACACACGAATTGCGTCTGCCGGTAATGATAT
CGGTCACAATTACTGATGCGTCGGGACGTAATCTTTCCGGACAGACTCCGGAAGCTTTCTGGAATTCGGTGCGACATGCG
CGCCCGCTGTCGGTGGGAATCAACTGCGCACTGGGAGCAGAGCTGATGCGCCCTTATGTGCAAGAGTTGTCAAATGTCTC
CGAGGTTTGTACCAGCGCCCATCCCAATGCTGGTCTGCCCAATCCACTGGCTGAAACCGGTTATGACGAAACTCCGGAAT
ATACTGCCCGGTTGATCAAGGATTTTGCACAATCAGGGTTCGTCAATATTGTTGGCGGGTGTTGCGGTACGACACCGGAA
CATATTGCCGCTATCGTGGAAGCAGTGCAGGACATCCCGCCACGTAAGCTGCCTGATCTTCCTAAGAAGTTGAGGCTCTC
TGGCCTTGAGCCACTCAGCATTGATGAGAGCTCTTTGTTTGTAAACGTGGGAGAACGCACCAATGTTACCGGTTCCAAGG
CATTTGCCCGACTGGTGCTTAGTGGCAATTATGCGGAAGGACTGGTGATTGCGCGCAACCAGGTGGAGAGCGGTGCGCAG
ATCATCGATATCAACATGGATGAAGGTATGCTGGATTCGCAAAAGGCGATGGTGACTTTTCTGAATCTGGTCGCGTCCGA
ACCGGATATCAGTCGCTTGCCAATCATGGTTGATTCCAGCAGGTGGTCAGTGATTGAAGCCGGCCTGAAATGCATCCAAG
GTAAGGCAATCATTAATTCCATCAGTCTTAAGGAAGGTGAAGAGGAATTTCTGCTGCACGCCAAACTGGCGCGCCGTTAT
GGGGCGGCGGTGATTGTCATGGCGTTTGATGAAAGCGGCCAGGCGGATACCTTGCAGCGCAAGGTGGATATTTGCACACG
TAGCTACCATACCCTGATTGAACGGGCTGATTTTCCACCCGAGGATATCATTTTCGATCCGAATATTTTTGCCATTGCCA
CGGGTATCGAGGAACACAGCAACTACGCAGTTGATTTTATTGAAGCCACCCGCCTCATTCGGCAAACGCTGCCTTACGCC
AAGATCAGCGGGGGTGTGTCCAATGTTTCGTTCTCGTTCCGTGGTAACGAACCCATCCGCGAGGCAATTCATACTGCGTT
CTTGTATCATGCGGTCAAGGCCGGCATGACCATGGGGATCGTCAATGCTGGCCAGTTAGGGGTTTATTCGGATATTCCTC
CCGATCTGCTGGAGCGTGTTGAAGATGTGCTGCTCAACCGGCGACCCGATGCAACCGAACGTCTGGTGGAGTTTGCAGAA
AATTTCAAGGGCCAGAAAAAAGAGCAGGCTGAAGATCTTGCCTGGCGGGATGAACCGGTGCGGCAACGCCTGATTCATGC
ACTGGTCAGAGGTATCAATACCTATATTGTTGAGGATACGGAGCTGATCCGGCAGGAAATTGATAGTCAGGGAGGCAAGC
CGATCGAGGTGATCGAAGGCCCGCTGATGGACGGTATGAATGTAGTGGGTGACCTGTTTGGTGCAGGCAAAATGTTTTTG
CCGCAGGTAGTCAAGTCAGCGCGGGTGATGAAGCAGGCGGTTGCCTATCTGTTGCCGTACATCGAGGCAGAAAAAAAGAT
TTCCGGCGACAATAAACCCAAGGGTAAATTGGTTATTGCCACTGTCAAGGGTGATGTGCATGACATCGGCAAAAATATTG
TTTCGGTCGTGCTGCAGTGTAATAACTTTGAGGTTGTCAATCTGGGTGTAATGATTCCCAGTGCGCAAATTCTGGAAACT
GCCCGTCGCGAAAATGCCGATATGATCGGTGTGTCCGGTTTGATTACGCCTTCGCTGGAGGAAATGGCACATGTCGCCAG
AGAAATGGAGCGCGAACAGTTCACCATTCCCTTGCTGATAGGGGGTGCCACCACTTCGCGTGTACATACAGCAGTCAAGA
TAGCACCCCATTACAGCGGGGTGACCATATGGGTACCCGATGCCAGCCGGGCGGTCGGTGTATGCAGCAATCTGATGTCA
CAGGATATGCGCGATGGCTATATCCAGCAGGTCAAAGCCGAGCAGGAAAAGAACCGGGAGCAGCACAAAAACAAGAAAGG
GCCTTCCAAACTGCTGACCTTTGAAGAAGCCCGGGCCAATGCATTCAAAACCGACTGGAACCGTTATACGCCACCTGCTC
CAAGTTTTCTCGGATTACGCACTCTTAACAACTATCCGCTGGAAACACTGGTTCCGTACATTGACTGGACGCCTTTCTTC
CAGGCATGGGAGTTGCATGGGCGCTATCCAGCAATCCTGCAGGATAAGGTCGTCGGAGAAGCGGCCAGCAATCTGTTTCA
TGATGCGCAGGTGATGCTCAGAAAGATTATTGAGCAGAAATGGCTTGCGGCCAACGCTGTTATCGGCCTGTTTCCAGCCA
ATACTGTCAACGGGGATGATATCGAGATTTATGCCGACCGCAGTCGCAGCAAGGTGATCATGACCTGGCATTCCTTGCGG
CAACAGACGACAAAACCTTCGGGACATCCCAATCTGGCACTGGCCGATTTTATTGCACCGCGAGAGACCGGGATAAATGA
CACCATCGGTTTGTTTGCTGTCAGCTCTGGCTTCGGTATTGATGAGCGCGTACGTGCTTTTGAAGCTGAAAATGATGATT
ACAGCGCGATCATATTGAAAGCACTGGCTGATCGTCTGGCTGAAGCGTTTGCAGAACATATGCACGCACGGGTACGACGG
GAATTCTGGGGATATATGAAAGATGAAAGTCTCAACAATGAACAGTTGATCGACGAGCAGTATCTGGGAATCCGCCCGGC
ACCGGGCTATCCTGCCTGCCCTGATCATACCGAGAAGGGGCCATTGTTTGCGGTGCTTGAAGCGGAAAAACGGAGTGGAA
TTATCGTGACGGAATCCTTTGCCATGGTACCGACTGCTGCTGTGTCCGGTTTTTATATTTCCCACCCTGAATCCAAGTAT
TTTGCGGTTGGCAAAATCGGCAAGGACCAGGTTGAAGATTACGCAAGGCGTAAAGGGTGGGCGCTGGAGAAAGCAGAACG
ATGGTTGGCGCCTGCTCTGGCGTATGAGCGCTGA

Upstream 100 bases:

>100_bases
AAACTCTGCACCGTTTGCGTGACCAGCTGGATGCGTTTCCGCAGTAAGCATACAGCTGCCGTATTTATTTTGACTAAAAA
TTCCCGTTTGAAGAGCTGTT

Downstream 100 bases:

>100_bases
TTACTGCTTGTAGCAACATATTTTTACCCTTCCAGGATTATTTCAGAAATGGCGTGTAATCTTTCCCTAAATCTATGAAA
TTTTGCGATGATTATCGGCG

Product: B12-dependent methionine synthase

Products: NA

Alternate protein names: 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12 dependent; MS [H]

Number of amino acids: Translated: 1237; Mature: 1236

Protein sequence:

>1237_residues
MTMSDRADLLKQLLAERILILDGAMGTMIQSYKLSESDYRGERFADFPHDLKGNNDLLCLTKPEVIRAIHRAYLEAGSDI
IETNTFNSNAPSMADYHMQDLVYELNVAGARLACEEARAMEAKQPDKPRFVAGVIGPTTKTASLSPDVNDPGFRAITFDD
LVESYTESVSGLVDGGADILLVETIFDTLNAKAALFAIEQYFETHELRLPVMISVTITDASGRNLSGQTPEAFWNSVRHA
RPLSVGINCALGAELMRPYVQELSNVSEVCTSAHPNAGLPNPLAETGYDETPEYTARLIKDFAQSGFVNIVGGCCGTTPE
HIAAIVEAVQDIPPRKLPDLPKKLRLSGLEPLSIDESSLFVNVGERTNVTGSKAFARLVLSGNYAEGLVIARNQVESGAQ
IIDINMDEGMLDSQKAMVTFLNLVASEPDISRLPIMVDSSRWSVIEAGLKCIQGKAIINSISLKEGEEEFLLHAKLARRY
GAAVIVMAFDESGQADTLQRKVDICTRSYHTLIERADFPPEDIIFDPNIFAIATGIEEHSNYAVDFIEATRLIRQTLPYA
KISGGVSNVSFSFRGNEPIREAIHTAFLYHAVKAGMTMGIVNAGQLGVYSDIPPDLLERVEDVLLNRRPDATERLVEFAE
NFKGQKKEQAEDLAWRDEPVRQRLIHALVRGINTYIVEDTELIRQEIDSQGGKPIEVIEGPLMDGMNVVGDLFGAGKMFL
PQVVKSARVMKQAVAYLLPYIEAEKKISGDNKPKGKLVIATVKGDVHDIGKNIVSVVLQCNNFEVVNLGVMIPSAQILET
ARRENADMIGVSGLITPSLEEMAHVAREMEREQFTIPLLIGGATTSRVHTAVKIAPHYSGVTIWVPDASRAVGVCSNLMS
QDMRDGYIQQVKAEQEKNREQHKNKKGPSKLLTFEEARANAFKTDWNRYTPPAPSFLGLRTLNNYPLETLVPYIDWTPFF
QAWELHGRYPAILQDKVVGEAASNLFHDAQVMLRKIIEQKWLAANAVIGLFPANTVNGDDIEIYADRSRSKVIMTWHSLR
QQTTKPSGHPNLALADFIAPRETGINDTIGLFAVSSGFGIDERVRAFEAENDDYSAIILKALADRLAEAFAEHMHARVRR
EFWGYMKDESLNNEQLIDEQYLGIRPAPGYPACPDHTEKGPLFAVLEAEKRSGIIVTESFAMVPTAAVSGFYISHPESKY
FAVGKIGKDQVEDYARRKGWALEKAERWLAPALAYER

Sequences:

>Translated_1237_residues
MTMSDRADLLKQLLAERILILDGAMGTMIQSYKLSESDYRGERFADFPHDLKGNNDLLCLTKPEVIRAIHRAYLEAGSDI
IETNTFNSNAPSMADYHMQDLVYELNVAGARLACEEARAMEAKQPDKPRFVAGVIGPTTKTASLSPDVNDPGFRAITFDD
LVESYTESVSGLVDGGADILLVETIFDTLNAKAALFAIEQYFETHELRLPVMISVTITDASGRNLSGQTPEAFWNSVRHA
RPLSVGINCALGAELMRPYVQELSNVSEVCTSAHPNAGLPNPLAETGYDETPEYTARLIKDFAQSGFVNIVGGCCGTTPE
HIAAIVEAVQDIPPRKLPDLPKKLRLSGLEPLSIDESSLFVNVGERTNVTGSKAFARLVLSGNYAEGLVIARNQVESGAQ
IIDINMDEGMLDSQKAMVTFLNLVASEPDISRLPIMVDSSRWSVIEAGLKCIQGKAIINSISLKEGEEEFLLHAKLARRY
GAAVIVMAFDESGQADTLQRKVDICTRSYHTLIERADFPPEDIIFDPNIFAIATGIEEHSNYAVDFIEATRLIRQTLPYA
KISGGVSNVSFSFRGNEPIREAIHTAFLYHAVKAGMTMGIVNAGQLGVYSDIPPDLLERVEDVLLNRRPDATERLVEFAE
NFKGQKKEQAEDLAWRDEPVRQRLIHALVRGINTYIVEDTELIRQEIDSQGGKPIEVIEGPLMDGMNVVGDLFGAGKMFL
PQVVKSARVMKQAVAYLLPYIEAEKKISGDNKPKGKLVIATVKGDVHDIGKNIVSVVLQCNNFEVVNLGVMIPSAQILET
ARRENADMIGVSGLITPSLEEMAHVAREMEREQFTIPLLIGGATTSRVHTAVKIAPHYSGVTIWVPDASRAVGVCSNLMS
QDMRDGYIQQVKAEQEKNREQHKNKKGPSKLLTFEEARANAFKTDWNRYTPPAPSFLGLRTLNNYPLETLVPYIDWTPFF
QAWELHGRYPAILQDKVVGEAASNLFHDAQVMLRKIIEQKWLAANAVIGLFPANTVNGDDIEIYADRSRSKVIMTWHSLR
QQTTKPSGHPNLALADFIAPRETGINDTIGLFAVSSGFGIDERVRAFEAENDDYSAIILKALADRLAEAFAEHMHARVRR
EFWGYMKDESLNNEQLIDEQYLGIRPAPGYPACPDHTEKGPLFAVLEAEKRSGIIVTESFAMVPTAAVSGFYISHPESKY
FAVGKIGKDQVEDYARRKGWALEKAERWLAPALAYER
>Mature_1236_residues
TMSDRADLLKQLLAERILILDGAMGTMIQSYKLSESDYRGERFADFPHDLKGNNDLLCLTKPEVIRAIHRAYLEAGSDII
ETNTFNSNAPSMADYHMQDLVYELNVAGARLACEEARAMEAKQPDKPRFVAGVIGPTTKTASLSPDVNDPGFRAITFDDL
VESYTESVSGLVDGGADILLVETIFDTLNAKAALFAIEQYFETHELRLPVMISVTITDASGRNLSGQTPEAFWNSVRHAR
PLSVGINCALGAELMRPYVQELSNVSEVCTSAHPNAGLPNPLAETGYDETPEYTARLIKDFAQSGFVNIVGGCCGTTPEH
IAAIVEAVQDIPPRKLPDLPKKLRLSGLEPLSIDESSLFVNVGERTNVTGSKAFARLVLSGNYAEGLVIARNQVESGAQI
IDINMDEGMLDSQKAMVTFLNLVASEPDISRLPIMVDSSRWSVIEAGLKCIQGKAIINSISLKEGEEEFLLHAKLARRYG
AAVIVMAFDESGQADTLQRKVDICTRSYHTLIERADFPPEDIIFDPNIFAIATGIEEHSNYAVDFIEATRLIRQTLPYAK
ISGGVSNVSFSFRGNEPIREAIHTAFLYHAVKAGMTMGIVNAGQLGVYSDIPPDLLERVEDVLLNRRPDATERLVEFAEN
FKGQKKEQAEDLAWRDEPVRQRLIHALVRGINTYIVEDTELIRQEIDSQGGKPIEVIEGPLMDGMNVVGDLFGAGKMFLP
QVVKSARVMKQAVAYLLPYIEAEKKISGDNKPKGKLVIATVKGDVHDIGKNIVSVVLQCNNFEVVNLGVMIPSAQILETA
RRENADMIGVSGLITPSLEEMAHVAREMEREQFTIPLLIGGATTSRVHTAVKIAPHYSGVTIWVPDASRAVGVCSNLMSQ
DMRDGYIQQVKAEQEKNREQHKNKKGPSKLLTFEEARANAFKTDWNRYTPPAPSFLGLRTLNNYPLETLVPYIDWTPFFQ
AWELHGRYPAILQDKVVGEAASNLFHDAQVMLRKIIEQKWLAANAVIGLFPANTVNGDDIEIYADRSRSKVIMTWHSLRQ
QTTKPSGHPNLALADFIAPRETGINDTIGLFAVSSGFGIDERVRAFEAENDDYSAIILKALADRLAEAFAEHMHARVRRE
FWGYMKDESLNNEQLIDEQYLGIRPAPGYPACPDHTEKGPLFAVLEAEKRSGIIVTESFAMVPTAAVSGFYISHPESKYF
AVGKIGKDQVEDYARRKGWALEKAERWLAPALAYER

Specific function: Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate [H]

COG id: COG1410

COG function: function code E; Methionine synthase I, cobalamin-binding domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Homo sapiens, GI169790923, Length=1250, Percent_Identity=52.56, Blast_Score=1321, Evalue=0.0,
Organism=Escherichia coli, GI1790450, Length=1237, Percent_Identity=62.6515763945028, Blast_Score=1574, Evalue=0.0,
Organism=Escherichia coli, GI1786456, Length=333, Percent_Identity=26.1261261261261, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17535405, Length=1258, Percent_Identity=51.7488076311606, Blast_Score=1274, Evalue=0.0,

Paralogues:

None

Copy number: 513 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 1320 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006158
- InterPro:   IPR011005
- InterPro:   IPR003759
- InterPro:   IPR011822
- InterPro:   IPR000489
- InterPro:   IPR003726
- InterPro:   IPR004223 [H]

Pfam domain/function: PF02310 B12-binding; PF02607 B12-binding_2; PF02965 Met_synt_B12; PF00809 Pterin_bind; PF02574 S-methyl_trans [H]

EC number: =2.1.1.13 [H]

Molecular weight: Translated: 136818; Mature: 136687

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS50974 ADOMET_ACTIVATION ; PS50970 HCY ; PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMSDRADLLKQLLAERILILDGAMGTMIQSYKLSESDYRGERFADFPHDLKGNNDLLCL
CCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEE
TKPEVIRAIHRAYLEAGSDIIETNTFNSNAPSMADYHMQDLVYELNVAGARLACEEARAM
CCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
EAKQPDKPRFVAGVIGPTTKTASLSPDVNDPGFRAITFDDLVESYTESVSGLVDGGADIL
CCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCEE
LVETIFDTLNAKAALFAIEQYFETHELRLPVMISVTITDASGRNLSGQTPEAFWNSVRHA
EHHHHHHHHCCHHHHHHHHHHHHHHCEECEEEEEEEEECCCCCCCCCCCHHHHHHHHHCC
RPLSVGINCALGAELMRPYVQELSNVSEVCTSAHPNAGLPNPLAETGYDETPEYTARLIK
CCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCHHHHHHHHH
DFAQSGFVNIVGGCCGTTPEHIAAIVEAVQDIPPRKLPDLPKKLRLSGLEPLSIDESSLF
HHHHCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCEE
VNVGERTNVTGSKAFARLVLSGNYAEGLVIARNQVESGAQIIDINMDEGMLDSQKAMVTF
EECCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHH
LNLVASEPDISRLPIMVDSSRWSVIEAGLKCIQGKAIINSISLKEGEEEFLLHAKLARRY
HHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHC
GAAVIVMAFDESGQADTLQRKVDICTRSYHTLIERADFPPEDIIFDPNIFAIATGIEEHS
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCEEEEEECCHHHC
NYAVDFIEATRLIRQTLPYAKISGGVSNVSFSFRGNEPIREAIHTAFLYHAVKAGMTMGI
CHHHHHHHHHHHHHHHCCHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEE
VNAGQLGVYSDIPPDLLERVEDVLLNRRPDATERLVEFAENFKGQKKEQAEDLAWRDEPV
ECCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCHHH
RQRLIHALVRGINTYIVEDTELIRQEIDSQGGKPIEVIEGPLMDGMNVVGDLFGAGKMFL
HHHHHHHHHHCCHHEEECCHHHHHHHHHHCCCCEEHHHCCCHHHHHHHHHHHHCCCHHHH
PQVVKSARVMKQAVAYLLPYIEAEKKISGDNKPKGKLVIATVKGDVHDIGKNIVSVVLQC
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCC
NNFEVVNLGVMIPSAQILETARRENADMIGVSGLITPSLEEMAHVAREMEREQFTIPLLI
CCEEEEEEEEECCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHCEEEEEEE
GGATTSRVHTAVKIAPHYSGVTIWVPDASRAVGVCSNLMSQDMRDGYIQQVKAEQEKNRE
CCCCHHHHEEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QHKNKKGPSKLLTFEEARANAFKTDWNRYTPPAPSFLGLRTLNNYPLETLVPYIDWTPFF
HHHCCCCCHHHEEHHHHHCCHHHCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHCCCCHHH
QAWELHGRYPAILQDKVVGEAASNLFHDAQVMLRKIIEQKWLAANAVIGLFPANTVNGDD
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCC
IEIYADRSRSKVIMTWHSLRQQTTKPSGHPNLALADFIAPRETGINDTIGLFAVSSGFGI
EEEEECCCCCEEEEEHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCEEEEEECCCCH
DERVRAFEAENDDYSAIILKALADRLAEAFAEHMHARVRREFWGYMKDESLNNEQLIDEQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
YLGIRPAPGYPACPDHTEKGPLFAVLEAEKRSGIIVTESFAMVPTAAVSGFYISHPESKY
HCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEECCHHHHHHHHHCCEEEECCCCCE
FAVGKIGKDQVEDYARRKGWALEKAERWLAPALAYER
EEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TMSDRADLLKQLLAERILILDGAMGTMIQSYKLSESDYRGERFADFPHDLKGNNDLLCL
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEE
TKPEVIRAIHRAYLEAGSDIIETNTFNSNAPSMADYHMQDLVYELNVAGARLACEEARAM
CCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHH
EAKQPDKPRFVAGVIGPTTKTASLSPDVNDPGFRAITFDDLVESYTESVSGLVDGGADIL
CCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCEE
LVETIFDTLNAKAALFAIEQYFETHELRLPVMISVTITDASGRNLSGQTPEAFWNSVRHA
EHHHHHHHHCCHHHHHHHHHHHHHHCEECEEEEEEEEECCCCCCCCCCCHHHHHHHHHCC
RPLSVGINCALGAELMRPYVQELSNVSEVCTSAHPNAGLPNPLAETGYDETPEYTARLIK
CCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCHHHHHHHHH
DFAQSGFVNIVGGCCGTTPEHIAAIVEAVQDIPPRKLPDLPKKLRLSGLEPLSIDESSLF
HHHHCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCCEE
VNVGERTNVTGSKAFARLVLSGNYAEGLVIARNQVESGAQIIDINMDEGMLDSQKAMVTF
EECCCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHH
LNLVASEPDISRLPIMVDSSRWSVIEAGLKCIQGKAIINSISLKEGEEEFLLHAKLARRY
HHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHHHC
GAAVIVMAFDESGQADTLQRKVDICTRSYHTLIERADFPPEDIIFDPNIFAIATGIEEHS
CCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCEEEEEECCHHHC
NYAVDFIEATRLIRQTLPYAKISGGVSNVSFSFRGNEPIREAIHTAFLYHAVKAGMTMGI
CHHHHHHHHHHHHHHHCCHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEE
VNAGQLGVYSDIPPDLLERVEDVLLNRRPDATERLVEFAENFKGQKKEQAEDLAWRDEPV
ECCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCHHH
RQRLIHALVRGINTYIVEDTELIRQEIDSQGGKPIEVIEGPLMDGMNVVGDLFGAGKMFL
HHHHHHHHHHCCHHEEECCHHHHHHHHHHCCCCEEHHHCCCHHHHHHHHHHHHCCCHHHH
PQVVKSARVMKQAVAYLLPYIEAEKKISGDNKPKGKLVIATVKGDVHDIGKNIVSVVLQC
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCC
NNFEVVNLGVMIPSAQILETARRENADMIGVSGLITPSLEEMAHVAREMEREQFTIPLLI
CCEEEEEEEEECCCHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHCEEEEEEE
GGATTSRVHTAVKIAPHYSGVTIWVPDASRAVGVCSNLMSQDMRDGYIQQVKAEQEKNRE
CCCCHHHHEEEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QHKNKKGPSKLLTFEEARANAFKTDWNRYTPPAPSFLGLRTLNNYPLETLVPYIDWTPFF
HHHCCCCCHHHEEHHHHHCCHHHCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHCCCCHHH
QAWELHGRYPAILQDKVVGEAASNLFHDAQVMLRKIIEQKWLAANAVIGLFPANTVNGDD
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCC
IEIYADRSRSKVIMTWHSLRQQTTKPSGHPNLALADFIAPRETGINDTIGLFAVSSGFGI
EEEEECCCCCEEEEEHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCEEEEEECCCCH
DERVRAFEAENDDYSAIILKALADRLAEAFAEHMHARVRREFWGYMKDESLNNEQLIDEQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
YLGIRPAPGYPACPDHTEKGPLFAVLEAEKRSGIIVTESFAMVPTAAVSGFYISHPESKY
HCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEECCHHHHHHHHHCCEEEECCCCCE
FAVGKIGKDQVEDYARRKGWALEKAERWLAPALAYER
EEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]