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The map label for this gene is bioA [H]

Identifier: 114330237

GI number: 114330237

Start: 213407

End: 214717

Strand: Direct

Name: bioA [H]

Synonym: Neut_0208

Alternate gene names: 114330237

Gene position: 213407-214717 (Clockwise)

Preceding gene: 114330227

Following gene: 114330238

Centisome position: 8.02

GC content: 48.28

Gene sequence:

>1311_bases
GTGAATGATAAAAAAGTAACTTTGCACACCCATCAGAGTGTCTGGCATCCCTGCACCCAGATGAAGCATCACGAAGCATT
TCCCCCGATATTAATCACCAGGGGAGAGGGTGTGTGGCTGTATGGTGCAGATGGTAAGCGTTATCTGGATACAATCAGTT
CATGGTGGGTCAATTTATTTGGGCACTGCAATCCTCGTATCAATGCTGCCATCATTGACCAACTTAGCAAGCTGGAACAC
GCGATGCTGGCTGGATTGATTCATGAGCCAGTAGTAGAGCTGTCAGAACGATTGAGTGCCATAACGCCAGGAAACCTGAG
TCATTGTTTCTATGCCAGCGATGGTTCGTCAGCCAATGAGATTGCGCTGAAAATGAGTTTTCACTACTGGCAGCAATGTG
GTTTCCCCGATAAAACCCAATTCGTTAATCTGCAGAATGGTTATCATGGAGAAACCCTGGGGGCGTTATCGGTCACCGAT
GTCCCGCTTTTTAGACAAATTTATGCACCGCTGTTACGCCCTGCGCATCCGGTACCTACCCCTGATTGGCGTGTTGCTGA
AACTGGAACAACCCCGGAAACTCATGCGCTGAAGGCTGCCGCTGAATTGGAGAGTTATCTCGCACAACATCATGCCAGTA
CAGCGGCTCTGATTCTGGAGCCTCTTATCCAGGGAGCGGGCGGAATGGGAATGTACCACCCGGTTTATCTGCAACGGGCA
CGGGAAATATGCGATACCTACCGGGTTCATTTAATAGCAGATGAGATTGCGGTTGGATTTGGTCGAACAGGCACTCTGTT
TGCATGTGAACAAGCTGGAATCACACCGGATTTTATGTGCCTTGCCAAAGGGTTAAGTGGGGGCTATTTGCCGCTTTCAG
TGGTCATGACTAATGACGCAGTCTATCGTGCGTTTTACCGTGATGAAACTAACCAGGCTTTTCTCCATTCGCACTCCCAT
TCCGGCAATATTCTTGCCTGTCGGGCAGCCCTGGCAACGCTCGATATCATTGAGCAGGATAATGTGATCGAAACAAACCG
TAAAAAAACTGATTTTCTCAATCAATGTTTACAGCCCGTTCGGGAGCACCCGAATGTCAAGAATTTCCGCAACTGCGGTA
TGATTTGGGCGTTTGAAGTGGATAACCCCCAACCGGATTTCACACACCGCTTTGCGCAAAAGGGACTAGAACAACAACTT
CTGATTCGTCCCATGGGCAACTCGGTCTACATCATGCCGCCGTACATTATTAATGAAGAGGAAATGGAATTGATGGCCCG
GGGTATTCTGCACATTCTCAATAGAATATAA

Upstream 100 bases:

>100_bases
GAGTTTCATCAACAATCGCTGAATCTCGTAACAACCTATTATTAGCACTCAACGACGTTGAGTGCTAATAATAGAGGCTA
TTATAAGGAATTTCAAGACA

Downstream 100 bases:

>100_bases
ATACCCATGCAGATTACCTTTCTGGGCGGTGTTGGAGAAGTCACCGGATCATGTTACCTAGTTGAAACGGATGATGTGCG
CTTTCTGGTGGATTGCGGTA

Product: adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MNDKKVTLHTHQSVWHPCTQMKHHEAFPPILITRGEGVWLYGADGKRYLDTISSWWVNLFGHCNPRINAAIIDQLSKLEH
AMLAGLIHEPVVELSERLSAITPGNLSHCFYASDGSSANEIALKMSFHYWQQCGFPDKTQFVNLQNGYHGETLGALSVTD
VPLFRQIYAPLLRPAHPVPTPDWRVAETGTTPETHALKAAAELESYLAQHHASTAALILEPLIQGAGGMGMYHPVYLQRA
REICDTYRVHLIADEIAVGFGRTGTLFACEQAGITPDFMCLAKGLSGGYLPLSVVMTNDAVYRAFYRDETNQAFLHSHSH
SGNILACRAALATLDIIEQDNVIETNRKKTDFLNQCLQPVREHPNVKNFRNCGMIWAFEVDNPQPDFTHRFAQKGLEQQL
LIRPMGNSVYIMPPYIINEEEMELMARGILHILNRI

Sequences:

>Translated_436_residues
MNDKKVTLHTHQSVWHPCTQMKHHEAFPPILITRGEGVWLYGADGKRYLDTISSWWVNLFGHCNPRINAAIIDQLSKLEH
AMLAGLIHEPVVELSERLSAITPGNLSHCFYASDGSSANEIALKMSFHYWQQCGFPDKTQFVNLQNGYHGETLGALSVTD
VPLFRQIYAPLLRPAHPVPTPDWRVAETGTTPETHALKAAAELESYLAQHHASTAALILEPLIQGAGGMGMYHPVYLQRA
REICDTYRVHLIADEIAVGFGRTGTLFACEQAGITPDFMCLAKGLSGGYLPLSVVMTNDAVYRAFYRDETNQAFLHSHSH
SGNILACRAALATLDIIEQDNVIETNRKKTDFLNQCLQPVREHPNVKNFRNCGMIWAFEVDNPQPDFTHRFAQKGLEQQL
LIRPMGNSVYIMPPYIINEEEMELMARGILHILNRI
>Mature_436_residues
MNDKKVTLHTHQSVWHPCTQMKHHEAFPPILITRGEGVWLYGADGKRYLDTISSWWVNLFGHCNPRINAAIIDQLSKLEH
AMLAGLIHEPVVELSERLSAITPGNLSHCFYASDGSSANEIALKMSFHYWQQCGFPDKTQFVNLQNGYHGETLGALSVTD
VPLFRQIYAPLLRPAHPVPTPDWRVAETGTTPETHALKAAAELESYLAQHHASTAALILEPLIQGAGGMGMYHPVYLQRA
REICDTYRVHLIADEIAVGFGRTGTLFACEQAGITPDFMCLAKGLSGGYLPLSVVMTNDAVYRAFYRDETNQAFLHSHSH
SGNILACRAALATLDIIEQDNVIETNRKKTDFLNQCLQPVREHPNVKNFRNCGMIWAFEVDNPQPDFTHRFAQKGLEQQL
LIRPMGNSVYIMPPYIINEEEMELMARGILHILNRI

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=410, Percent_Identity=27.0731707317073, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI37574042, Length=428, Percent_Identity=27.3364485981308, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI13994255, Length=373, Percent_Identity=26.8096514745308, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI226442705, Length=428, Percent_Identity=26.6355140186916, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI226442709, Length=394, Percent_Identity=26.9035532994924, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI284507298, Length=324, Percent_Identity=27.1604938271605, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI24119277, Length=365, Percent_Identity=27.1232876712329, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI1786991, Length=418, Percent_Identity=38.5167464114833, Blast_Score=265, Evalue=5e-72,
Organism=Escherichia coli, GI145693181, Length=395, Percent_Identity=32.4050632911392, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1789759, Length=389, Percent_Identity=29.305912596401, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1789016, Length=421, Percent_Identity=29.4536817102138, Blast_Score=157, Evalue=9e-40,
Organism=Escherichia coli, GI1788044, Length=396, Percent_Identity=29.040404040404, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1787560, Length=401, Percent_Identity=27.6807980049875, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1786349, Length=360, Percent_Identity=26.3888888888889, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI32564660, Length=426, Percent_Identity=26.5258215962441, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI25144271, Length=434, Percent_Identity=26.4976958525346, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI25144274, Length=290, Percent_Identity=27.9310344827586, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71992977, Length=441, Percent_Identity=23.3560090702948, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17541228, Length=466, Percent_Identity=21.244635193133, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6324386, Length=468, Percent_Identity=30.5555555555556, Blast_Score=213, Evalue=5e-56,
Organism=Saccharomyces cerevisiae, GI6324432, Length=404, Percent_Identity=28.7128712871287, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6323470, Length=435, Percent_Identity=26.6666666666667, Blast_Score=118, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6321456, Length=297, Percent_Identity=23.9057239057239, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21357415, Length=398, Percent_Identity=28.643216080402, Blast_Score=154, Evalue=2e-37,
Organism=Drosophila melanogaster, GI28574759, Length=373, Percent_Identity=27.3458445040214, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI161085790, Length=373, Percent_Identity=27.3458445040214, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI21356575, Length=434, Percent_Identity=24.6543778801843, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 48949; Mature: 48949

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDKKVTLHTHQSVWHPCTQMKHHEAFPPILITRGEGVWLYGADGKRYLDTISSWWVNLF
CCCCEEEEEECHHHHHHHHHHHCCCCCCCEEEECCCEEEEECCCCHHHHHHHHHHHHHHH
GHCNPRINAAIIDQLSKLEHAMLAGLIHEPVVELSERLSAITPGNLSHCFYASDGSSANE
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCE
IALKMSFHYWQQCGFPDKTQFVNLQNGYHGETLGALSVTDVPLFRQIYAPLLRPAHPVPT
EEEEEEHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEECCCHHHHHHHHHHHCCCCCCCC
PDWRVAETGTTPETHALKAAAELESYLAQHHASTAALILEPLIQGAGGMGMYHPVYLQRA
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHH
REICDTYRVHLIADEIAVGFGRTGTLFACEQAGITPDFMCLAKGLSGGYLPLSVVMTNDA
HHHHHHHHHEEEEHHHHHCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCEEEEEEEECCH
VYRAFYRDETNQAFLHSHSHSGNILACRAALATLDIIEQDNVIETNRKKTDFLNQCLQPV
HHHHHHHCCCCCCHHCCCCCCCCEEEHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
REHPNVKNFRNCGMIWAFEVDNPQPDFTHRFAQKGLEQQLLIRPMGNSVYIMPPYIINEE
HHCCCCCHHHCCCEEEEEECCCCCCHHHHHHHHCCCCCEEEEEECCCEEEEECCEEECHH
EMELMARGILHILNRI
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNDKKVTLHTHQSVWHPCTQMKHHEAFPPILITRGEGVWLYGADGKRYLDTISSWWVNLF
CCCCEEEEEECHHHHHHHHHHHCCCCCCCEEEECCCEEEEECCCCHHHHHHHHHHHHHHH
GHCNPRINAAIIDQLSKLEHAMLAGLIHEPVVELSERLSAITPGNLSHCFYASDGSSANE
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCE
IALKMSFHYWQQCGFPDKTQFVNLQNGYHGETLGALSVTDVPLFRQIYAPLLRPAHPVPT
EEEEEEHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEECCCHHHHHHHHHHHCCCCCCCC
PDWRVAETGTTPETHALKAAAELESYLAQHHASTAALILEPLIQGAGGMGMYHPVYLQRA
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHHHHH
REICDTYRVHLIADEIAVGFGRTGTLFACEQAGITPDFMCLAKGLSGGYLPLSVVMTNDA
HHHHHHHHHEEEEHHHHHCCCCCCCEEEECCCCCCHHHHHHHHCCCCCCEEEEEEEECCH
VYRAFYRDETNQAFLHSHSHSGNILACRAALATLDIIEQDNVIETNRKKTDFLNQCLQPV
HHHHHHHCCCCCCHHCCCCCCCCEEEHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
REHPNVKNFRNCGMIWAFEVDNPQPDFTHRFAQKGLEQQLLIRPMGNSVYIMPPYIINEE
HHCCCCCHHHCCCEEEEEECCCCCCHHHHHHHHCCCCCEEEEEECCCEEEEECCEEECHH
EMELMARGILHILNRI
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]