Click here to switch to the map view.

The map label for this gene is 114330238

Identifier: 114330238

GI number: 114330238

Start: 214724

End: 216130

Strand: Direct

Name: 114330238

Synonym: Neut_0209

Alternate gene names: NA

Gene position: 214724-216130 (Clockwise)

Preceding gene: 114330237

Following gene: 114330240

Centisome position: 8.07

GC content: 47.62

Gene sequence:

>1407_bases
ATGCAGATTACCTTTCTGGGCGGTGTTGGAGAAGTCACCGGATCATGTTACCTAGTTGAAACGGATGATGTGCGCTTTCT
GGTGGATTGCGGTATGTTCCAGGGCGGGCGGGATGCAAGTCGTAAAAATCATACCGCAATCAATTTTAATCCGGAATCAA
TGGATTTTGTTTTGCTAACACATGCCCATGTGGATCATTCTGGGTTATTGCCGCGCTTGAGTGTGCTCGGATTCAGAGGG
CCTGTCTACATGACCCCGGCCACGGCAGATCTACTTTCAATCATCCTGAAAGATAGTGCTCATATTCAGGAAAAAGAAGC
AGAGTGGCATACAAAAACGGCATTGCGTAATAAACGTTCGCTACGTTATGAAAATGTCCCGCTCTACACTGTTACCCAGG
CAGAAGCATTTCTTAAACAAATGCGAGGTGTCAATTATGACGAAACATGTCAGCCGCATCCATTAGTGCAGTGTCGATTT
CGTGATGCTGGACACATTATTGGATCAGCCATCATTGAGGTCTGGCTGAAGTCCGGTTCCAGGCAGAGAAAAATTGTTTT
CTCGGGTGATCTGGGGCAGCCGGGCCATCCTATCGTGCGCGATCCGACATTTATCAAAGAGGCTGATTATCTGTTGGTTG
AATCCACTTATGGCAACCGTTGCCATCGCAGCATGCAAGACACACGCGATGAAATGGTGGAAATCATTTGTCAGACACTG
ATCCATAAACGCGGCAATATCATCGTACCGGCGTTTACTGTTGGCCGTACTCAGGATTTGTTATTTCTGCTGACGGATCT
GCAGCGTCAGGGGCGCCTGGGAGTGATGGATATTTACGTGGATTCACCTATGGCGTTGGCTGCTACGGAAATCACACTCA
GACATAGAGAATTATTTGATAAGGAAACTATCGATATCATGAACTGGCACAGCCAGCATAATAAGAATCTGCGGATTCAT
TTTGTGCAGGAAGTCGAGGATTCAATCAGGCTCAATCACATACAATCCGGCGCAATCGTTATTTCTGCCAGTGGTATGTG
CGATGCCGGGCGCATTAAATATCACCTGAAATATAACTTGCCCAGACCTGAATGCAGCATTTTGTTTACCGGCTTTCAGG
CTGCGGGTACCTTGGGGCGCAGATTAGTGGATGGTAGTAAAAATGTTCGTGTTTTTGGTGAACAAATTCCTGTGCACGCA
TCTATTCATACGGTTGGCGGGCTTTCTGCCCATGCTGATCAGGAGAATCTGCTTGATTGGTTAAGAGGATTCAGCCAGCC
TCCGCGAAAAACTTTCATCGTGCATGGCGAACCGGGTAGTGCCGAAGCTTTTGCCTGTGCAATCCGGGAACAATTACAGT
GGCCGGTGAGTATTCCTCAGCGCATGGATTCAGAACGACTGGGCTGA

Upstream 100 bases:

>100_bases
CAACTCGGTCTACATCATGCCGCCGTACATTATTAATGAAGAGGAAATGGAATTGATGGCCCGGGGTATTCTGCACATTC
TCAATAGAATATAAATACCC

Downstream 100 bases:

>100_bases
TTCTATTTTCAGCTGAAAGTAGAATCAGCAATTTTCAAACTTCTTCCCGAATCATTATTGCGTTGTATCAACCAGAAAAC
AGCATTAGCAGCAGTCGATT

Product: beta-lactamase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MQITFLGGVGEVTGSCYLVETDDVRFLVDCGMFQGGRDASRKNHTAINFNPESMDFVLLTHAHVDHSGLLPRLSVLGFRG
PVYMTPATADLLSIILKDSAHIQEKEAEWHTKTALRNKRSLRYENVPLYTVTQAEAFLKQMRGVNYDETCQPHPLVQCRF
RDAGHIIGSAIIEVWLKSGSRQRKIVFSGDLGQPGHPIVRDPTFIKEADYLLVESTYGNRCHRSMQDTRDEMVEIICQTL
IHKRGNIIVPAFTVGRTQDLLFLLTDLQRQGRLGVMDIYVDSPMALAATEITLRHRELFDKETIDIMNWHSQHNKNLRIH
FVQEVEDSIRLNHIQSGAIVISASGMCDAGRIKYHLKYNLPRPECSILFTGFQAAGTLGRRLVDGSKNVRVFGEQIPVHA
SIHTVGGLSAHADQENLLDWLRGFSQPPRKTFIVHGEPGSAEAFACAIREQLQWPVSIPQRMDSERLG

Sequences:

>Translated_468_residues
MQITFLGGVGEVTGSCYLVETDDVRFLVDCGMFQGGRDASRKNHTAINFNPESMDFVLLTHAHVDHSGLLPRLSVLGFRG
PVYMTPATADLLSIILKDSAHIQEKEAEWHTKTALRNKRSLRYENVPLYTVTQAEAFLKQMRGVNYDETCQPHPLVQCRF
RDAGHIIGSAIIEVWLKSGSRQRKIVFSGDLGQPGHPIVRDPTFIKEADYLLVESTYGNRCHRSMQDTRDEMVEIICQTL
IHKRGNIIVPAFTVGRTQDLLFLLTDLQRQGRLGVMDIYVDSPMALAATEITLRHRELFDKETIDIMNWHSQHNKNLRIH
FVQEVEDSIRLNHIQSGAIVISASGMCDAGRIKYHLKYNLPRPECSILFTGFQAAGTLGRRLVDGSKNVRVFGEQIPVHA
SIHTVGGLSAHADQENLLDWLRGFSQPPRKTFIVHGEPGSAEAFACAIREQLQWPVSIPQRMDSERLG
>Mature_468_residues
MQITFLGGVGEVTGSCYLVETDDVRFLVDCGMFQGGRDASRKNHTAINFNPESMDFVLLTHAHVDHSGLLPRLSVLGFRG
PVYMTPATADLLSIILKDSAHIQEKEAEWHTKTALRNKRSLRYENVPLYTVTQAEAFLKQMRGVNYDETCQPHPLVQCRF
RDAGHIIGSAIIEVWLKSGSRQRKIVFSGDLGQPGHPIVRDPTFIKEADYLLVESTYGNRCHRSMQDTRDEMVEIICQTL
IHKRGNIIVPAFTVGRTQDLLFLLTDLQRQGRLGVMDIYVDSPMALAATEITLRHRELFDKETIDIMNWHSQHNKNLRIH
FVQEVEDSIRLNHIQSGAIVISASGMCDAGRIKYHLKYNLPRPECSILFTGFQAAGTLGRRLVDGSKNVRVFGEQIPVHA
SIHTVGGLSAHADQENLLDWLRGFSQPPRKTFIVHGEPGSAEAFACAIREQLQWPVSIPQRMDSERLG

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI33300633, Length=476, Percent_Identity=25.2100840336134, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI7706427, Length=459, Percent_Identity=23.9651416122004, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI32564696, Length=486, Percent_Identity=25.1028806584362, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI32566029, Length=483, Percent_Identity=24.0165631469979, Blast_Score=104, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6323307, Length=446, Percent_Identity=21.52466367713, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21358523, Length=476, Percent_Identity=24.1596638655462, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24648013, Length=464, Percent_Identity=23.4913793103448, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 52686; Mature: 52686

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQITFLGGVGEVTGSCYLVETDDVRFLVDCGMFQGGRDASRKNHTAINFNPESMDFVLLT
CEEEEECCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEEEEEE
HAHVDHSGLLPRLSVLGFRGPVYMTPATADLLSIILKDSAHIQEKEAEWHTKTALRNKRS
EEECCCCCCCCHHHHHCCCCCEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
LRYENVPLYTVTQAEAFLKQMRGVNYDETCQPHPLVQCRFRDAGHIIGSAIIEVWLKSGS
CEECCCCEEEEHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCC
RQRKIVFSGDLGQPGHPIVRDPTFIKEADYLLVESTYGNRCHRSMQDTRDEMVEIICQTL
CCEEEEEECCCCCCCCCCCCCCCHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
IHKRGNIIVPAFTVGRTQDLLFLLTDLQRQGRLGVMDIYVDSPMALAATEITLRHRELFD
HHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEHHHHHHHHHHHHC
KETIDIMNWHSQHNKNLRIHFVQEVEDSIRLNHIQSGAIVISASGMCDAGRIKYHLKYNL
CHHHHHEEHHHCCCCCEEEEEEEHHHHHHEEEEECCCEEEEEECCCCCCCEEEEEEEECC
PRPECSILFTGFQAAGTLGRRLVDGSKNVRVFGEQIPVHASIHTVGGLSAHADQENLLDW
CCCCEEEEEECHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCCCCCCHHHHHHH
LRGFSQPPRKTFIVHGEPGSAEAFACAIREQLQWPVSIPQRMDSERLG
HHCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCC
>Mature Secondary Structure
MQITFLGGVGEVTGSCYLVETDDVRFLVDCGMFQGGRDASRKNHTAINFNPESMDFVLLT
CEEEEECCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEEEEEE
HAHVDHSGLLPRLSVLGFRGPVYMTPATADLLSIILKDSAHIQEKEAEWHTKTALRNKRS
EEECCCCCCCCHHHHHCCCCCEEECCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
LRYENVPLYTVTQAEAFLKQMRGVNYDETCQPHPLVQCRFRDAGHIIGSAIIEVWLKSGS
CEECCCCEEEEHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHCCC
RQRKIVFSGDLGQPGHPIVRDPTFIKEADYLLVESTYGNRCHRSMQDTRDEMVEIICQTL
CCEEEEEECCCCCCCCCCCCCCCHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
IHKRGNIIVPAFTVGRTQDLLFLLTDLQRQGRLGVMDIYVDSPMALAATEITLRHRELFD
HHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEEHHHHHHHHHHHHC
KETIDIMNWHSQHNKNLRIHFVQEVEDSIRLNHIQSGAIVISASGMCDAGRIKYHLKYNL
CHHHHHEEHHHCCCCCEEEEEEEHHHHHHEEEEECCCEEEEEECCCCCCCEEEEEEEECC
PRPECSILFTGFQAAGTLGRRLVDGSKNVRVFGEQIPVHASIHTVGGLSAHADQENLLDW
CCCCEEEEEECHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCCCCCCHHHHHHH
LRGFSQPPRKTFIVHGEPGSAEAFACAIREQLQWPVSIPQRMDSERLG
HHCCCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA