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The map label for this gene is tolC [H]

Identifier: 114330227

GI number: 114330227

Start: 198335

End: 199657

Strand: Direct

Name: tolC [H]

Synonym: Neut_0198

Alternate gene names: 114330227

Gene position: 198335-199657 (Clockwise)

Preceding gene: 114330226

Following gene: 114330237

Centisome position: 7.45

GC content: 46.26

Gene sequence:

>1323_bases
ATGATGAAAAGCTTACGAGGTTTAGCGTGTCTATTATGCTTGAGCATGTTTGTTTGTGTTCAGTTAGAAGCTGCCGATCT
GATGCAGATTTACCGTGAAGCGCTGGAAGAGGATGCACAATACGGCGCGGCGCGCGCTGCCTATGTGGCTGCACAAGAAC
GGATGCCTCAGGGAAGGGCAGGGTTATTGCCCGATATTCGCCTGACTGGAGTTGGCCAAAATCAATATATTGAAACAAGT
GGTTTGCCAAGCCGAGAGATCAAAAATCGGGGAATTACCGCGACTCTGACTCAACCGCTCATTCGTTTTGAGAATTTTAT
TATTTATCAGCAATCTAAAAATGAGGTGGCGCAGGCAGATGCGCAATTCGTTATCGCAGCGCAGGATTTGATCTTGCGGG
TTGCACAAACCTATTTTGATATACTCAAGGCAAAAATTGACCTTGAGGTAGTCGAGTCGCAGAAAAAAGCGATTCATGAA
CAGCTAGAACAGGCTAGACGAAATTTTGAAGTTGGTGTTTCGACCATAGTCGATACACACGAAGCCGAAGCGCGTTACGA
TTTAACCTTGTCACAGGAAATCGCTGCCAGAAACAAACTGGAAATTAGTCAGCATGCATTAGAAGTTCTAATCAATCGAC
TCCCGAATGATCTGCAGGATGCAAGCCTGGACAAGATTATCGCCGATCCACTTTCTTTGCCTCACGATGGTATGGATGAG
TGGGTCGGGCTAGCGGAAGAAAAGAATTTCCAGCTGAAAGTACAGCGTATTGCTTACGAGATTTCCGAGCAAGACATTGA
CCGTGCCAAAGCTGGTCACTATCCAACTCTTGATCTGGTTGCACAATATAGTGATCAGCATGGTGTCGGCGGTGCTTTCA
CCGGGCGAGGGCTGGATATCGTCAATAAATCTGTTGGATTACAATTGACGGTTCCTATTTTCCAGGGATTGTCAGTGCAA
TCTCGTGTTAGAGAAGCTTTAGCTAACCGGGACAAGGCTCGTAAAGATATGGAAAATGTGCAGCGCACGATCGCATTGCA
GGTTCGCCAGAATTATCTCAATGTAACTAATGGTATTGCTCAGATCAAAGCGCTGAAGCAGGCATTAACATCCAGCCGCA
GCCAGCTTGATTCAACCACGTTGGGTCAGGAGGTAGGTGTACGGATGGAAATAGATGTACTCAATGCGCAGCAGCAATAT
TTTTCGGCGCGCAGAGATCTTGCTCAGGCCTATTATGATTATCTGATGGCCCGGCTCCAGCTTAAAGCTGAAGTGGGTGA
TCTGGATGAAGATGATTTGCTGGAAATTAATGCATTACTTTGA

Upstream 100 bases:

>100_bases
CCCTGTGTCCGCTAACCGCTTCATAAAAGCCAATGTACTGATAACTTCAGTGGCAATCATCAAACCACGAAAATACGAAG
ATAATGAAATCAGCCGGCTA

Downstream 100 bases:

>100_bases
TTCTTCTTGTTTATTTTTAGTAAAAAAGCCGAAAAATTAGTGTAATCAAGGTAGTAGAAGAATTATTTTTCTGGATGTTC
GCTTGGTCGTTTAGAGGATA

Product: type I secretion outer membrane protein, TolC family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MMKSLRGLACLLCLSMFVCVQLEAADLMQIYREALEEDAQYGAARAAYVAAQERMPQGRAGLLPDIRLTGVGQNQYIETS
GLPSREIKNRGITATLTQPLIRFENFIIYQQSKNEVAQADAQFVIAAQDLILRVAQTYFDILKAKIDLEVVESQKKAIHE
QLEQARRNFEVGVSTIVDTHEAEARYDLTLSQEIAARNKLEISQHALEVLINRLPNDLQDASLDKIIADPLSLPHDGMDE
WVGLAEEKNFQLKVQRIAYEISEQDIDRAKAGHYPTLDLVAQYSDQHGVGGAFTGRGLDIVNKSVGLQLTVPIFQGLSVQ
SRVREALANRDKARKDMENVQRTIALQVRQNYLNVTNGIAQIKALKQALTSSRSQLDSTTLGQEVGVRMEIDVLNAQQQY
FSARRDLAQAYYDYLMARLQLKAEVGDLDEDDLLEINALL

Sequences:

>Translated_440_residues
MMKSLRGLACLLCLSMFVCVQLEAADLMQIYREALEEDAQYGAARAAYVAAQERMPQGRAGLLPDIRLTGVGQNQYIETS
GLPSREIKNRGITATLTQPLIRFENFIIYQQSKNEVAQADAQFVIAAQDLILRVAQTYFDILKAKIDLEVVESQKKAIHE
QLEQARRNFEVGVSTIVDTHEAEARYDLTLSQEIAARNKLEISQHALEVLINRLPNDLQDASLDKIIADPLSLPHDGMDE
WVGLAEEKNFQLKVQRIAYEISEQDIDRAKAGHYPTLDLVAQYSDQHGVGGAFTGRGLDIVNKSVGLQLTVPIFQGLSVQ
SRVREALANRDKARKDMENVQRTIALQVRQNYLNVTNGIAQIKALKQALTSSRSQLDSTTLGQEVGVRMEIDVLNAQQQY
FSARRDLAQAYYDYLMARLQLKAEVGDLDEDDLLEINALL
>Mature_440_residues
MMKSLRGLACLLCLSMFVCVQLEAADLMQIYREALEEDAQYGAARAAYVAAQERMPQGRAGLLPDIRLTGVGQNQYIETS
GLPSREIKNRGITATLTQPLIRFENFIIYQQSKNEVAQADAQFVIAAQDLILRVAQTYFDILKAKIDLEVVESQKKAIHE
QLEQARRNFEVGVSTIVDTHEAEARYDLTLSQEIAARNKLEISQHALEVLINRLPNDLQDASLDKIIADPLSLPHDGMDE
WVGLAEEKNFQLKVQRIAYEISEQDIDRAKAGHYPTLDLVAQYSDQHGVGGAFTGRGLDIVNKSVGLQLTVPIFQGLSVQ
SRVREALANRDKARKDMENVQRTIALQVRQNYLNVTNGIAQIKALKQALTSSRSQLDSTTLGQEVGVRMEIDVLNAQQQY
FSARRDLAQAYYDYLMARLQLKAEVGDLDEDDLLEINALL

Specific function: May be specialized for signal sequence independent, extracellular secretion in Gram-negative bacteria [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI87082199, Length=430, Percent_Identity=31.1627906976744, Blast_Score=186, Evalue=2e-48,

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010130 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 49278; Mature: 49278

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKSLRGLACLLCLSMFVCVQLEAADLMQIYREALEEDAQYGAARAAYVAAQERMPQGRA
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCC
GLLPDIRLTGVGQNQYIETSGLPSREIKNRGITATLTQPLIRFENFIIYQQSKNEVAQAD
CCCCCCEEEECCCCCEEECCCCCHHHHHCCCCCHHHHHHHHHHHHEEEEECCCCHHHHCC
AQFVIAAQDLILRVAQTYFDILKAKIDLEVVESQKKAIHEQLEQARRNFEVGVSTIVDTH
HHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EAEARYDLTLSQEIAARNKLEISQHALEVLINRLPNDLQDASLDKIIADPLSLPHDGMDE
CCCCEECCCHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHH
WVGLAEEKNFQLKVQRIAYEISEQDIDRAKAGHYPTLDLVAQYSDQHGVGGAFTGRGLDI
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCHHH
VNKSVGLQLTVPIFQGLSVQSRVREALANRDKARKDMENVQRTIALQVRQNYLNVTNGIA
HHCCCCCEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QIKALKQALTSSRSQLDSTTLGQEVGVRMEIDVLNAQQQYFSARRDLAQAYYDYLMARLQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKAEVGDLDEDDLLEINALL
HHHHCCCCCCCCHHHHHCCC
>Mature Secondary Structure
MMKSLRGLACLLCLSMFVCVQLEAADLMQIYREALEEDAQYGAARAAYVAAQERMPQGRA
CCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCC
GLLPDIRLTGVGQNQYIETSGLPSREIKNRGITATLTQPLIRFENFIIYQQSKNEVAQAD
CCCCCCEEEECCCCCEEECCCCCHHHHHCCCCCHHHHHHHHHHHHEEEEECCCCHHHHCC
AQFVIAAQDLILRVAQTYFDILKAKIDLEVVESQKKAIHEQLEQARRNFEVGVSTIVDTH
HHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
EAEARYDLTLSQEIAARNKLEISQHALEVLINRLPNDLQDASLDKIIADPLSLPHDGMDE
CCCCEECCCHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHH
WVGLAEEKNFQLKVQRIAYEISEQDIDRAKAGHYPTLDLVAQYSDQHGVGGAFTGRGLDI
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCHHH
VNKSVGLQLTVPIFQGLSVQSRVREALANRDKARKDMENVQRTIALQVRQNYLNVTNGIA
HHCCCCCEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QIKALKQALTSSRSQLDSTTLGQEVGVRMEIDVLNAQQQYFSARRDLAQAYYDYLMARLQ
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKAEVGDLDEDDLLEINALL
HHHHCCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]