Click here to switch to the map view.

The map label for this gene is rmlA [H]

Identifier: 113969662

GI number: 113969662

Start: 1528892

End: 1529767

Strand: Direct

Name: rmlA [H]

Synonym: Shewmr4_1319

Alternate gene names: 113969662

Gene position: 1528892-1529767 (Clockwise)

Preceding gene: 113969661

Following gene: 113969663

Centisome position: 32.49

GC content: 41.1

Gene sequence:

>876_bases
ATGAAAGGAATTATTTTAGCTGGCGGCTCAGGCACACGACTGTATCCCATTACTATGGGCGTATCAAAGCAGTTACTACC
AGTTTACGACAAACCTATGATTTACTACCCTCTTTCGGTGTTAATGCTCGCGGGTATTAAGGATATTTTGATTATCACTA
CCCCAGAAGATTGCGATAGCTTCAAGCGTCTTCTCGGTGACGGATCTCAATTTGGTATTAAGCTCGAATATGCTCTCCAG
CCAAGCCCCGATGGTTTAGCACAAGCATTTATTATTGGCGAAGAGTTTATTGGTAATTCGAGTGTGTGCTTGGTTCTTGG
CGATAATATTTTTTATGGTCAGGGTTTTAGTGCCAAGCTGAAAAAAGCTGTCGAGAAGGCTCAGACTGGAGAAGCTGCGA
CTGTTTTTGGTTACCAAGTTAAAGATCCTGAACGTTTTGGTGTTGTAGAATTTGACCAAAACCAAAAAGCCATTTCTATT
GAGGAAAAACCTGTAAATCCTAAAAGTCACTATGCAGTCACTGGACTCTATTTTTATCCTAATAATGTTGTTGAGATGGC
AAAGCGAGTTAAGCCATCTGAGCGTGGTGAACTTGAAATAACAACTTTAAATGACATGTACCTTAACCAGGGGTATTTGC
ATGTTGAAATGTTGGGACGCGGTTTTGCTTGGTTGGATACAGGTACCCATGAAAGCTTGTTAGAAGCAGCACAGTTTGTT
GAAACGTTAGAAAAACGCCAAGGTTATAAAATCGCCTGTTTAGAAGAGATTGCTTATTTGCAGCATTGGCTAACTGAAGA
GCAGTTAATGGCGCGCGGCGAGTTGATGAGCAAAAACAGTTATGGCCAATATCTGTTAACCTTAGCTAAACCCTAA

Upstream 100 bases:

>100_bases
ACCTATCAGCGAGAGCGTTTAGGCATTTAATCTCTTTAACAACTTTATTTTAAAGTCCTAGTTTTTACCTAGGGCCTATT
TACCTAGGAACTTGATTTAA

Downstream 100 bases:

>100_bases
TCGCTATGATCGATCTTGCGAGTAAAACTAAAAAAGGTCTGCAATGGAGCGCCTTGGAACGATTTTTAACCCAAGGTATT
CAACTCGCAATTACCTTATA

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MKGIILAGGSGTRLYPITMGVSKQLLPVYDKPMIYYPLSVLMLAGIKDILIITTPEDCDSFKRLLGDGSQFGIKLEYALQ
PSPDGLAQAFIIGEEFIGNSSVCLVLGDNIFYGQGFSAKLKKAVEKAQTGEAATVFGYQVKDPERFGVVEFDQNQKAISI
EEKPVNPKSHYAVTGLYFYPNNVVEMAKRVKPSERGELEITTLNDMYLNQGYLHVEMLGRGFAWLDTGTHESLLEAAQFV
ETLEKRQGYKIACLEEIAYLQHWLTEEQLMARGELMSKNSYGQYLLTLAKP

Sequences:

>Translated_291_residues
MKGIILAGGSGTRLYPITMGVSKQLLPVYDKPMIYYPLSVLMLAGIKDILIITTPEDCDSFKRLLGDGSQFGIKLEYALQ
PSPDGLAQAFIIGEEFIGNSSVCLVLGDNIFYGQGFSAKLKKAVEKAQTGEAATVFGYQVKDPERFGVVEFDQNQKAISI
EEKPVNPKSHYAVTGLYFYPNNVVEMAKRVKPSERGELEITTLNDMYLNQGYLHVEMLGRGFAWLDTGTHESLLEAAQFV
ETLEKRQGYKIACLEEIAYLQHWLTEEQLMARGELMSKNSYGQYLLTLAKP
>Mature_291_residues
MKGIILAGGSGTRLYPITMGVSKQLLPVYDKPMIYYPLSVLMLAGIKDILIITTPEDCDSFKRLLGDGSQFGIKLEYALQ
PSPDGLAQAFIIGEEFIGNSSVCLVLGDNIFYGQGFSAKLKKAVEKAQTGEAATVFGYQVKDPERFGVVEFDQNQKAISI
EEKPVNPKSHYAVTGLYFYPNNVVEMAKRVKPSERGELEITTLNDMYLNQGYLHVEMLGRGFAWLDTGTHESLLEAAQFV
ETLEKRQGYKIACLEEIAYLQHWLTEEQLMARGELMSKNSYGQYLLTLAKP

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1790224, Length=293, Percent_Identity=71.6723549488055, Blast_Score=426, Evalue=1e-121,
Organism=Escherichia coli, GI1788351, Length=289, Percent_Identity=65.3979238754325, Blast_Score=395, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI133931050, Length=238, Percent_Identity=26.0504201680672, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6320148, Length=257, Percent_Identity=26.0700389105058, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21355443, Length=253, Percent_Identity=24.5059288537549, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24644084, Length=253, Percent_Identity=24.5059288537549, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32449; Mature: 32449

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGSGTRLYPITMGVSKQLLPVYDKPMIYYPLSVLMLAGIKDILIITTPEDCDS
CCCEEEECCCCCEEEEEEECCCCCCCCCCCCCEEEHHHHHHHHCCCCEEEEEECCCCHHH
FKRLLGDGSQFGIKLEYALQPSPDGLAQAFIIGEEFIGNSSVCLVLGDNIFYGQGFSAKL
HHHHHCCCCCEEEEEEEEECCCCCHHHEEEEEHHHHCCCCCEEEEEECCEEECCCCHHHH
KKAVEKAQTGEAATVFGYQVKDPERFGVVEFDQNQKAISIEEKPVNPKSHYAVTGLYFYP
HHHHHHHHCCCEEEEEEEEECCCCCCCEEEECCCCCEEEEECCCCCCCCCEEEEEEEECC
NNVVEMAKRVKPSERGELEITTLNDMYLNQGYLHVEMLGRGFAWLDTGTHESLLEAAQFV
CHHHHHHHHCCCCCCCCEEEEEECCEECCCCEEEEEEECCCEEEEECCCHHHHHHHHHHH
ETLEKRQGYKIACLEEIAYLQHWLTEEQLMARGELMSKNSYGQYLLTLAKP
HHHHHHCCCEEEHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEECC
>Mature Secondary Structure
MKGIILAGGSGTRLYPITMGVSKQLLPVYDKPMIYYPLSVLMLAGIKDILIITTPEDCDS
CCCEEEECCCCCEEEEEEECCCCCCCCCCCCCEEEHHHHHHHHCCCCEEEEEECCCCHHH
FKRLLGDGSQFGIKLEYALQPSPDGLAQAFIIGEEFIGNSSVCLVLGDNIFYGQGFSAKL
HHHHHCCCCCEEEEEEEEECCCCCHHHEEEEEHHHHCCCCCEEEEEECCEEECCCCHHHH
KKAVEKAQTGEAATVFGYQVKDPERFGVVEFDQNQKAISIEEKPVNPKSHYAVTGLYFYP
HHHHHHHHCCCEEEEEEEEECCCCCCCEEEECCCCCEEEEECCCCCCCCCEEEEEEEECC
NNVVEMAKRVKPSERGELEITTLNDMYLNQGYLHVEMLGRGFAWLDTGTHESLLEAAQFV
CHHHHHHHHCCCCCCCCEEEEEECCEECCCCEEEEEEECCCEEEEECCCHHHHHHHHHHH
ETLEKRQGYKIACLEEIAYLQHWLTEEQLMARGELMSKNSYGQYLLTLAKP
HHHHHHCCCEEEHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7692217 [H]