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The map label for this gene is cynR [H]

Identifier: 113969413

GI number: 113969413

Start: 1251594

End: 1252502

Strand: Direct

Name: cynR [H]

Synonym: Shewmr4_1069

Alternate gene names: 113969413

Gene position: 1251594-1252502 (Clockwise)

Preceding gene: 113969410

Following gene: 113969415

Centisome position: 26.59

GC content: 49.72

Gene sequence:

>909_bases
ATGGAGATGAATGCGATGCTGGAACTTCATTGGTTAAAGACCTTCGTGACCTTAGCCGAGTGTAAGCACTTCGGAAAAGC
GGCAGCAGCGCTGCATATGACGCAGCCTAATGTCAGCTTGCATATCAAACAACTGGAGCAGAATACTCGAGTTAAGTTGA
TTGAGCGCAATCCGTTTAGGCTAACTCAGGCGGGGTTTCGTTTACTCGAGAGTAGCCAGAAGACCTTGATGGAGCTGCAA
GTGTGTCAGGCGGATCTCAATGCCATCAACGATCTCAGTCAAGGCACCTTGACCATAGCAGCCAGCGATATCATTTCGCG
GTTGCTGCTTATTCAGCCATTTCAATTATTTAAAGCGGAATTCCCCGGGATTGATTTTTCCCTGCTCAATACCACGTCTT
CCCAAGCCTCAGAATTAGTGACTAATGCCGAGGCGGATTTAGGCTTTGTGATCGCGCAAAAGGAGAGTCAGCCGCTGCAT
TTTACCGAGTTACAGCAAATCAAATGGTGTGCCCTTGGGGATAATTTGCAGCTGTGGCAGCAAAGCCAAGCCAGCCATGA
TATGCCCCACGCGGAGCGGCCGACTTTGATTCTGCTCGGCCATGATACTCGTACCCGCGAGTTGCTCGATCCCGCATTAC
CGACCTTAAATTTACCCCGTTATCGGATCATGGAAGTCGGTAGTGTGGATGCGCAAATCGATTGGGCCGAGGCGGGCTTT
GGGGTAGCGATTGTGCCTGAGTTTTCAATTTACACTAAGACGCACTTAAAGAGTAAAGTCACGCCATTGCCACAGTTCCC
GAGCACCAGTTTGGGTTACATAGTGCGGCAGAATCAGATCCTATCGAAGGCGATTAAGCAGCTGCTACATTGGGTGAACC
AAGAGATTATCCGTACCCAAGGCAGCTAA

Upstream 100 bases:

>100_bases
GAATTAAGCGATTATGCTAGACCTGCTTAATGAATAAGAGAAATTAATTATAGTTATCGTCGTGATAAGGAAATCATATA
TCATAGGGTGAGCTGAATGG

Downstream 100 bases:

>100_bases
TGGCGGTTTGAAAGGTTACTTAGTGCTAAGCAGTTGTTGATACTGTCCATTGGCTTTTAACTGGGTTAAGCCCAGATCCA
GCTCTTTAGCGAGTTGTGCG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MEMNAMLELHWLKTFVTLAECKHFGKAAAALHMTQPNVSLHIKQLEQNTRVKLIERNPFRLTQAGFRLLESSQKTLMELQ
VCQADLNAINDLSQGTLTIAASDIISRLLLIQPFQLFKAEFPGIDFSLLNTTSSQASELVTNAEADLGFVIAQKESQPLH
FTELQQIKWCALGDNLQLWQQSQASHDMPHAERPTLILLGHDTRTRELLDPALPTLNLPRYRIMEVGSVDAQIDWAEAGF
GVAIVPEFSIYTKTHLKSKVTPLPQFPSTSLGYIVRQNQILSKAIKQLLHWVNQEIIRTQGS

Sequences:

>Translated_302_residues
MEMNAMLELHWLKTFVTLAECKHFGKAAAALHMTQPNVSLHIKQLEQNTRVKLIERNPFRLTQAGFRLLESSQKTLMELQ
VCQADLNAINDLSQGTLTIAASDIISRLLLIQPFQLFKAEFPGIDFSLLNTTSSQASELVTNAEADLGFVIAQKESQPLH
FTELQQIKWCALGDNLQLWQQSQASHDMPHAERPTLILLGHDTRTRELLDPALPTLNLPRYRIMEVGSVDAQIDWAEAGF
GVAIVPEFSIYTKTHLKSKVTPLPQFPSTSLGYIVRQNQILSKAIKQLLHWVNQEIIRTQGS
>Mature_302_residues
MEMNAMLELHWLKTFVTLAECKHFGKAAAALHMTQPNVSLHIKQLEQNTRVKLIERNPFRLTQAGFRLLESSQKTLMELQ
VCQADLNAINDLSQGTLTIAASDIISRLLLIQPFQLFKAEFPGIDFSLLNTTSSQASELVTNAEADLGFVIAQKESQPLH
FTELQQIKWCALGDNLQLWQQSQASHDMPHAERPTLILLGHDTRTRELLDPALPTLNLPRYRIMEVGSVDAQIDWAEAGF
GVAIVPEFSIYTKTHLKSKVTPLPQFPSTSLGYIVRQNQILSKAIKQLLHWVNQEIIRTQGS

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=293, Percent_Identity=26.2798634812287, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788748, Length=309, Percent_Identity=26.8608414239482, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI145693105, Length=295, Percent_Identity=23.3898305084746, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789204, Length=244, Percent_Identity=26.2295081967213, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790208, Length=251, Percent_Identity=27.0916334661355, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34015; Mature: 34015

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMNAMLELHWLKTFVTLAECKHFGKAAAALHMTQPNVSLHIKQLEQNTRVKLIERNPFR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEECCCCCCEEEEECCCCH
LTQAGFRLLESSQKTLMELQVCQADLNAINDLSQGTLTIAASDIISRLLLIQPFQLFKAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCHHHHHHH
FPGIDFSLLNTTSSQASELVTNAEADLGFVIAQKESQPLHFTELQQIKWCALGDNLQLWQ
CCCCCEEEECCCHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHEEEEEECCCHHHHH
QSQASHDMPHAERPTLILLGHDTRTRELLDPALPTLNLPRYRIMEVGSVDAQIDWAEAGF
HHHHCCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCCEEEEEECCCCCEEEHHCCCC
GVAIVPEFSIYTKTHLKSKVTPLPQFPSTSLGYIVRQNQILSKAIKQLLHWVNQEIIRTQ
CEEEECCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GS
CC
>Mature Secondary Structure
MEMNAMLELHWLKTFVTLAECKHFGKAAAALHMTQPNVSLHIKQLEQNTRVKLIERNPFR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCEEEEEECCCCCCEEEEECCCCH
LTQAGFRLLESSQKTLMELQVCQADLNAINDLSQGTLTIAASDIISRLLLIQPFQLFKAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHCCHHHHHHH
FPGIDFSLLNTTSSQASELVTNAEADLGFVIAQKESQPLHFTELQQIKWCALGDNLQLWQ
CCCCCEEEECCCHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHEEEEEECCCHHHHH
QSQASHDMPHAERPTLILLGHDTRTRELLDPALPTLNLPRYRIMEVGSVDAQIDWAEAGF
HHHHCCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCCEEEEEECCCCCEEEHHCCCC
GVAIVPEFSIYTKTHLKSKVTPLPQFPSTSLGYIVRQNQILSKAIKQLLHWVNQEIIRTQ
CEEEECCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GS
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]