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The map label for this gene is copS [H]

Identifier: 116696123

GI number: 116696123

Start: 2475553

End: 2476932

Strand: Direct

Name: copS [H]

Synonym: H16_B2187

Alternate gene names: 116696123

Gene position: 2475553-2476932 (Clockwise)

Preceding gene: 116696122

Following gene: 116696125

Centisome position: 85.0

GC content: 68.77

Gene sequence:

>1380_bases
ATGAAGGTCCGGATGTCGCTGACGGCACGGCTCACCATCCTGTTCTCGCTGTCGTCGGCCGCGGTGCTGCTGGGGCTGGG
CGTGCTGATCTGGCTGGCGATCGACAATCATTTCGCCGACGAGGACTACGCCGTGCTGGGCGACAACGTGCGGCTGATCC
AGAAGATCGCGGGCGAAGGCCCGGCGGCGTCGCTGGCGCAACGACTGGGCCCGGTGCTGGAACACCATGCCGGATTCCTG
GCCGAAGTGCGCGCCGCGGACGGCAAGCGCCTGTATGCCACGCAGGACTTCGACTTCGGCATGGCCCTGGCCGCCGCCGC
GCAACTGCCGGCGCAGCGGCATGCCTTCACCTGGGAACAGGGTGGCCAGACCTACCGCGGCATGCGTGCGCTGGCGCAGG
TGCCGCCCGGACAGCCGGGGCCGCTGCAGGTCGTGGTCGGCATGGACACGGCACTGCATGCCCACTTCATGCACGCCTTC
CGCCAGTCGCTGGCCTTCTACGCCGCGCTGGCCGCGCTGGCGAGCGGGCTGCTGGGCTGGTGGGCCGCGCGCCGCGGGCT
CTCGCCATTGCGCACCATGGCCTCGCGCGCGCGCACTGTCACCGCGCACAAGCTCGACGAGCGCATGCCGGTCGATGCCG
TGCCGGTGGAAATGGCCGACCTGGCCGCGACGCTCAACGCCATGCTGGAACGCCTGCAGCGCGATTTCGCGCGCCTGTCG
GAGTTCTCATCGGACCTGGCGCACGAGCTGCGCACGCCGATCACCAACCTGATGACGCAAACCCAGGTGGTGCTGTCGCA
GCCGCGCGATGCGGACAAGTACCGCGACGTGCTGGCGTCCAACGTGGAAGAGCTGCAGCGGCTGTCGCGCATGGTGTCGG
ACATGCTCTACCTGGCGAAGATGGAGCACGGCATCACCCTGCCGAACGCCGAGCCGATCGAGGTCGCTGATGAGGTCGCT
GCGCTGTTCGATTTCTACGATGCGTTGGCTGAGGACAAGGGTGTGCGCATGGCCGTGCGCGGCAGTGGCCGCATCACCGG
AGACCGGCTGATGCTGCGGCGGGCGCTGAGCAACCTGCTGTCGAATGCGCTGCGGCATACGCCGGCGGGCAAGGGCATTG
TGGTGGAGATCTTGCCCGCTGCCGAAGGGGTGACGGTGGTCGTCGAGAACGAAGGCGAGACCATCCGGCCTGAACTGCTG
CCCTCGCTGTTTGACCGGTTCTTCCGCGCGGACAAGTCGCGGGCGCGGCCCGAGTCCGATGGTGCGGGGCTGGGGCTGGG
GCTGGCGATCACGCAGGCGATTGTGGCTGCGCATGGCGGGGGCATTGGAGTGGAGTCGGAGGGGGGGCGGACGCGCTTTG
TCCTGACGTTCAGGGCGTAG

Upstream 100 bases:

>100_bases
TGCGCGCGAAGATCGACGATGAGTTCGAGCCCAAGCTGATCCAGACCGTGCGCGGCATGGGCTATGTGCTGGAAGCCCCC
GAGGCAGCGGAGAACGCTGA

Downstream 100 bases:

>100_bases
GGAGTGAGGGAGACTGCGCCGTGCCAGCGCTGATCGCATCCGCCGGCAACCCAGGCAGCATGGCGCGTATCGCGGGGACG
AGCTCCCGCGTGAGCACCGT

Product: signal transduction histidine kinase, copper sensor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
MKVRMSLTARLTILFSLSSAAVLLGLGVLIWLAIDNHFADEDYAVLGDNVRLIQKIAGEGPAASLAQRLGPVLEHHAGFL
AEVRAADGKRLYATQDFDFGMALAAAAQLPAQRHAFTWEQGGQTYRGMRALAQVPPGQPGPLQVVVGMDTALHAHFMHAF
RQSLAFYAALAALASGLLGWWAARRGLSPLRTMASRARTVTAHKLDERMPVDAVPVEMADLAATLNAMLERLQRDFARLS
EFSSDLAHELRTPITNLMTQTQVVLSQPRDADKYRDVLASNVEELQRLSRMVSDMLYLAKMEHGITLPNAEPIEVADEVA
ALFDFYDALAEDKGVRMAVRGSGRITGDRLMLRRALSNLLSNALRHTPAGKGIVVEILPAAEGVTVVVENEGETIRPELL
PSLFDRFFRADKSRARPESDGAGLGLGLAITQAIVAAHGGGIGVESEGGRTRFVLTFRA

Sequences:

>Translated_459_residues
MKVRMSLTARLTILFSLSSAAVLLGLGVLIWLAIDNHFADEDYAVLGDNVRLIQKIAGEGPAASLAQRLGPVLEHHAGFL
AEVRAADGKRLYATQDFDFGMALAAAAQLPAQRHAFTWEQGGQTYRGMRALAQVPPGQPGPLQVVVGMDTALHAHFMHAF
RQSLAFYAALAALASGLLGWWAARRGLSPLRTMASRARTVTAHKLDERMPVDAVPVEMADLAATLNAMLERLQRDFARLS
EFSSDLAHELRTPITNLMTQTQVVLSQPRDADKYRDVLASNVEELQRLSRMVSDMLYLAKMEHGITLPNAEPIEVADEVA
ALFDFYDALAEDKGVRMAVRGSGRITGDRLMLRRALSNLLSNALRHTPAGKGIVVEILPAAEGVTVVVENEGETIRPELL
PSLFDRFFRADKSRARPESDGAGLGLGLAITQAIVAAHGGGIGVESEGGRTRFVLTFRA
>Mature_459_residues
MKVRMSLTARLTILFSLSSAAVLLGLGVLIWLAIDNHFADEDYAVLGDNVRLIQKIAGEGPAASLAQRLGPVLEHHAGFL
AEVRAADGKRLYATQDFDFGMALAAAAQLPAQRHAFTWEQGGQTYRGMRALAQVPPGQPGPLQVVVGMDTALHAHFMHAF
RQSLAFYAALAALASGLLGWWAARRGLSPLRTMASRARTVTAHKLDERMPVDAVPVEMADLAATLNAMLERLQRDFARLS
EFSSDLAHELRTPITNLMTQTQVVLSQPRDADKYRDVLASNVEELQRLSRMVSDMLYLAKMEHGITLPNAEPIEVADEVA
ALFDFYDALAEDKGVRMAVRGSGRITGDRLMLRRALSNLLSNALRHTPAGKGIVVEILPAAEGVTVVVENEGETIRPELL
PSLFDRFFRADKSRARPESDGAGLGLGLAITQAIVAAHGGGIGVESEGGRTRFVLTFRA

Specific function: Member of the two-component regulatory system CusS/CusR. Copper ion sensor. Could also be a silver ion sensor. Probably activates CusR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=484, Percent_Identity=35.9504132231405, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI1788279, Length=305, Percent_Identity=32.1311475409836, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI1786600, Length=214, Percent_Identity=33.1775700934579, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1790346, Length=263, Percent_Identity=28.5171102661597, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1789403, Length=300, Percent_Identity=30.3333333333333, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788393, Length=228, Percent_Identity=27.1929824561404, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790551, Length=301, Percent_Identity=25.5813953488372, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787894, Length=312, Percent_Identity=27.5641025641026, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1789149, Length=320, Percent_Identity=25.3125, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI48994928, Length=237, Percent_Identity=27.0042194092827, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI145693157, Length=224, Percent_Identity=27.6785714285714, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1787374, Length=291, Percent_Identity=24.0549828178694, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1786912, Length=212, Percent_Identity=27.3584905660377, Blast_Score=65, Evalue=9e-12,
Organism=Escherichia coli, GI1788549, Length=222, Percent_Identity=26.1261261261261, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49759; Mature: 49759

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVRMSLTARLTILFSLSSAAVLLGLGVLIWLAIDNHFADEDYAVLGDNVRLIQKIAGEG
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHCCC
PAASLAQRLGPVLEHHAGFLAEVRAADGKRLYATQDFDFGMALAAAAQLPAQRHAFTWEQ
CHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCHHHCCCCHHC
GGQTYRGMRALAQVPPGQPGPLQVVVGMDTALHAHFMHAFRQSLAFYAALAALASGLLGW
CCCHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WAARRGLSPLRTMASRARTVTAHKLDERMPVDAVPVEMADLAATLNAMLERLQRDFARLS
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EFSSDLAHELRTPITNLMTQTQVVLSQPRDADKYRDVLASNVEELQRLSRMVSDMLYLAK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MEHGITLPNAEPIEVADEVAALFDFYDALAEDKGVRMAVRGSGRITGDRLMLRRALSNLL
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
SNALRHTPAGKGIVVEILPAAEGVTVVVENEGETIRPELLPSLFDRFFRADKSRARPESD
HHHHHCCCCCCCEEEEEEECCCCEEEEEECCCCEECHHHHHHHHHHHHHCCHHHCCCCCC
GAGLGLGLAITQAIVAAHGGGIGVESEGGRTRFVLTFRA
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MKVRMSLTARLTILFSLSSAAVLLGLGVLIWLAIDNHFADEDYAVLGDNVRLIQKIAGEG
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHCCC
PAASLAQRLGPVLEHHAGFLAEVRAADGKRLYATQDFDFGMALAAAAQLPAQRHAFTWEQ
CHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCHHHCCCCHHC
GGQTYRGMRALAQVPPGQPGPLQVVVGMDTALHAHFMHAFRQSLAFYAALAALASGLLGW
CCCHHHHHHHHHHCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WAARRGLSPLRTMASRARTVTAHKLDERMPVDAVPVEMADLAATLNAMLERLQRDFARLS
HHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
EFSSDLAHELRTPITNLMTQTQVVLSQPRDADKYRDVLASNVEELQRLSRMVSDMLYLAK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MEHGITLPNAEPIEVADEVAALFDFYDALAEDKGVRMAVRGSGRITGDRLMLRRALSNLL
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHH
SNALRHTPAGKGIVVEILPAAEGVTVVVENEGETIRPELLPSLFDRFFRADKSRARPESD
HHHHHCCCCCCCEEEEEEECCCCEEEEEECCCCEECHHHHHHHHHHHHHCCHHHCCCCCC
GAGLGLGLAITQAIVAAHGGGIGVESEGGRTRFVLTFRA
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]