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The map label for this gene is copR [H]

Identifier: 116696122

GI number: 116696122

Start: 2474861

End: 2475556

Strand: Direct

Name: copR [H]

Synonym: H16_B2186

Alternate gene names: 116696122

Gene position: 2474861-2475556 (Clockwise)

Preceding gene: 116696117

Following gene: 116696123

Centisome position: 84.97

GC content: 68.39

Gene sequence:

>696_bases
GTGAAACTGCTAGTGGTGGAGGACGAGTCCAAGACCGGCGAATACCTGCGCCAGGGGCTGACCGAGGCGGGCTTTGTCGT
CGACCTGGTGGCCAACGGGCTGGACGGCCAGCATCTGGCGATGACCGAGCCCTATGACCTGGTCATCCTGGACGTGATGC
TGCCGGACGTAGATGGCTGGCGCATCGTGCAGGCGCTGCGCGCGGCGGAGATCGCCGTGCCGGTGCTGTTCCTGACCGCG
CGCGACAGCGTGGCCGACCGCGTCAAGGGGCTGGAGCTGGGTGCGGACGACTACCTGGTCAAGCCCTTCGCCTTTTCCGA
GCTGCTCGCGCGGGTGCGCACGCTGCTGCGCCGGGGCACGGCGCAGATGGCGCTGGACCGCATCCAGGTGGCCGACCTGG
TGCTGGACCTGGGCCGCCGCCGGGCCACGCGCGCCGGGCGCCGCATCACGCTGACCAGCAAGGAGTTCGCCTTGCTGGAA
CTGCTGGCGCGCCGCCGCGGCGAAGTGCTGCCGCGCTCCTTGATCGCCTCGCAGGTGTGGGACATGAACTTCGACAGCGA
CAGCAATGTCATCGACGTCGCCATCCGGCGCCTGCGCGCGAAGATCGACGATGAGTTCGAGCCCAAGCTGATCCAGACCG
TGCGCGGCATGGGCTATGTGCTGGAAGCCCCCGAGGCAGCGGAGAACGCTGAATGA

Upstream 100 bases:

>100_bases
ACATGACATTGCGGTAATCTTCCGGTCATGTTGGCGCCCGCGTTGCCGGCGTAGAGTTGCCGGACCCTGCCCAAAGGGCC
GATCGATCAAGGAAAGTGCT

Downstream 100 bases:

>100_bases
AGGTCCGGATGTCGCTGACGGCACGGCTCACCATCCTGTTCTCGCTGTCGTCGGCCGCGGTGCTGCTGGGGCTGGGCGTG
CTGATCTGGCTGGCGATCGA

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MKLLVVEDESKTGEYLRQGLTEAGFVVDLVANGLDGQHLAMTEPYDLVILDVMLPDVDGWRIVQALRAAEIAVPVLFLTA
RDSVADRVKGLELGADDYLVKPFAFSELLARVRTLLRRGTAQMALDRIQVADLVLDLGRRRATRAGRRITLTSKEFALLE
LLARRRGEVLPRSLIASQVWDMNFDSDSNVIDVAIRRLRAKIDDEFEPKLIQTVRGMGYVLEAPEAAENAE

Sequences:

>Translated_231_residues
MKLLVVEDESKTGEYLRQGLTEAGFVVDLVANGLDGQHLAMTEPYDLVILDVMLPDVDGWRIVQALRAAEIAVPVLFLTA
RDSVADRVKGLELGADDYLVKPFAFSELLARVRTLLRRGTAQMALDRIQVADLVLDLGRRRATRAGRRITLTSKEFALLE
LLARRRGEVLPRSLIASQVWDMNFDSDSNVIDVAIRRLRAKIDDEFEPKLIQTVRGMGYVLEAPEAAENAE
>Mature_231_residues
MKLLVVEDESKTGEYLRQGLTEAGFVVDLVANGLDGQHLAMTEPYDLVILDVMLPDVDGWRIVQALRAAEIAVPVLFLTA
RDSVADRVKGLELGADDYLVKPFAFSELLARVRTLLRRGTAQMALDRIQVADLVLDLGRRRATRAGRRITLTSKEFALLE
LLARRRGEVLPRSLIASQVWDMNFDSDSNVIDVAIRRLRAKIDDEFEPKLIQTVRGMGYVLEAPEAAENAE

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=71.6814159292035, Blast_Score=334, Evalue=3e-93,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=56.0538116591928, Blast_Score=250, Evalue=6e-68,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=44.3438914027149, Blast_Score=176, Evalue=1e-45,
Organism=Escherichia coli, GI1790552, Length=229, Percent_Identity=39.7379912663755, Blast_Score=151, Evalue=3e-38,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=38.7665198237885, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=34.6846846846847, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1790860, Length=227, Percent_Identity=38.3259911894273, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=35.2678571428571, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=34.841628959276, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=37.7272727272727, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=38.5964912280702, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=32.3144104803493, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI145693140, Length=238, Percent_Identity=31.9327731092437, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=29.5154185022026, Blast_Score=94, Evalue=7e-21,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=32.7102803738318, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=34.2105263157895, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25787; Mature: 25787

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLVVEDESKTGEYLRQGLTEAGFVVDLVANGLDGQHLAMTEPYDLVILDVMLPDVDGW
CEEEEEECCCCHHHHHHHCCCCCCHHHHHHHCCCCCCEEEECCCCCEEEEEEECCCCCHH
RIVQALRAAEIAVPVLFLTARDSVADRVKGLELGADDYLVKPFAFSELLARVRTLLRRGT
HHHHHHHHHHHHHHHHEEECCHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHCCH
AQMALDRIQVADLVLDLGRRRATRAGRRITLTSKEFALLELLARRRGEVLPRSLIASQVW
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHH
DMNFDSDSNVIDVAIRRLRAKIDDEFEPKLIQTVRGMGYVLEAPEAAENAE
CCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEECCCCCCCCC
>Mature Secondary Structure
MKLLVVEDESKTGEYLRQGLTEAGFVVDLVANGLDGQHLAMTEPYDLVILDVMLPDVDGW
CEEEEEECCCCHHHHHHHCCCCCCHHHHHHHCCCCCCEEEECCCCCEEEEEEECCCCCHH
RIVQALRAAEIAVPVLFLTARDSVADRVKGLELGADDYLVKPFAFSELLARVRTLLRRGT
HHHHHHHHHHHHHHHHEEECCHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHCCH
AQMALDRIQVADLVLDLGRRRATRAGRRITLTSKEFALLELLARRRGEVLPRSLIASQVW
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCCHHHHHHHHHH
DMNFDSDSNVIDVAIRRLRAKIDDEFEPKLIQTVRGMGYVLEAPEAAENAE
CCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]