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The map label for this gene is lrp [H]

Identifier: 116695309

GI number: 116695309

Start: 1527740

End: 1528195

Strand: Direct

Name: lrp [H]

Synonym: H16_B1366

Alternate gene names: 116695309

Gene position: 1527740-1528195 (Clockwise)

Preceding gene: 116695307

Following gene: 116695311

Centisome position: 52.45

GC content: 64.25

Gene sequence:

>456_bases
GTGCTGGATCGCACGGACAAGGCCATCCTGCGCGCCTTGCAGCGCGATGCGTCCATCTCCAACCTGGCCCTGGCGGGCAA
GGTCAGCCTCAGCCCGCCCGCATGCCTGCGCCGCGTGGAACGCCTGAAAGCGGATGGCCTGATCCGCGGCGTCGTGGCGC
TGCTGAACCCGGCTCCCCTGGACGCGGGGATGCTGGTCATCATCGGGGTCGTGCTGGACCGGTCCACGCCCGAGTCCTTC
GCCGCCTTTGAGAAAGCGGCGCAGAAGGTATCAGGCTGTATGGAATGCCATGAAGTCACCGGCGAGTTCGACTACATCAT
GATGCTCAGGACCAAGGACAGCGAGAGCTTCAACCGCCTCCACGCGGAGCAGTTGCTCTACCTGCCGGGCGTGCGGCAGA
TTCGCTCGTTCATGGTGCTCAAGCAGGTGCTGTCGACGACGCAGTTTCCGATTTGA

Upstream 100 bases:

>100_bases
TAGACAGCAAGCACCCAGAAATTCTCTTTATTTCGTAGAAATGGCAACAAGCAGAATAAAATTTCGTTCGAAATCCGAGA
CCTCCGCACAGCCCGCGCCG

Downstream 100 bases:

>100_bases
GGATCGGGCTGGATCCGGCTGCGCGGGCGAAGAGAGGAGACAGGGAGGGGAATTCGGGGCCTGGGCGAAGCAGGAACCCC
GGCGCCGTTGCTGCCGGGGT

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 151; Mature: 151

Protein sequence:

>151_residues
MLDRTDKAILRALQRDASISNLALAGKVSLSPPACLRRVERLKADGLIRGVVALLNPAPLDAGMLVIIGVVLDRSTPESF
AAFEKAAQKVSGCMECHEVTGEFDYIMMLRTKDSESFNRLHAEQLLYLPGVRQIRSFMVLKQVLSTTQFPI

Sequences:

>Translated_151_residues
MLDRTDKAILRALQRDASISNLALAGKVSLSPPACLRRVERLKADGLIRGVVALLNPAPLDAGMLVIIGVVLDRSTPESF
AAFEKAAQKVSGCMECHEVTGEFDYIMMLRTKDSESFNRLHAEQLLYLPGVRQIRSFMVLKQVLSTTQFPI
>Mature_151_residues
MLDRTDKAILRALQRDASISNLALAGKVSLSPPACLRRVERLKADGLIRGVVALLNPAPLDAGMLVIIGVVLDRSTPESF
AAFEKAAQKVSGCMECHEVTGEFDYIMMLRTKDSESFNRLHAEQLLYLPGVRQIRSFMVLKQVLSTTQFPI

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=150, Percent_Identity=44, Blast_Score=140, Evalue=5e-35,
Organism=Escherichia coli, GI87081742, Length=151, Percent_Identity=28.476821192053, Blast_Score=88, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 16673; Mature: 16673

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDRTDKAILRALQRDASISNLALAGKVSLSPPACLRRVERLKADGLIRGVVALLNPAPL
CCCCHHHHHHHHHHHCCCHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DAGMLVIIGVVLDRSTPESFAAFEKAAQKVSGCMECHEVTGEFDYIMMLRTKDSESFNRL
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHH
HAEQLLYLPGVRQIRSFMVLKQVLSTTQFPI
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLDRTDKAILRALQRDASISNLALAGKVSLSPPACLRRVERLKADGLIRGVVALLNPAPL
CCCCHHHHHHHHHHHCCCHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DAGMLVIIGVVLDRSTPESFAAFEKAAQKVSGCMECHEVTGEFDYIMMLRTKDSESFNRL
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHH
HAEQLLYLPGVRQIRSFMVLKQVLSTTQFPI
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]