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The map label for this gene is acrC8 [H]

Identifier: 116694532

GI number: 116694532

Start: 651732

End: 652973

Strand: Direct

Name: acrC8 [H]

Synonym: H16_B0581

Alternate gene names: 116694532

Gene position: 651732-652973 (Clockwise)

Preceding gene: 116694531

Following gene: 116694533

Centisome position: 22.38

GC content: 72.54

Gene sequence:

>1242_bases
GTGCCGCCGCCGGCGGGCGCGACGCTGACCCTGGCGCAGGCGCGCCTGGACGCACTGCGCTGCAACCGCGACATCATCGC
CGCCCGCCGCGGCGTCGAAGCCAGCCAGGCGGACATACAGATCGCTTCGCAGCGGCCCAATCCCGTGCTGAGCCTGGGCG
TGACCAATATCAACCCGCATGCCGGCATCGGCTCGGGCAACCTGCGCAGCAAGACCGTGGACTCTACCCTGCGCGTGGAC
CAGCTGATCGAGACCGCCAACAAGGGCGGCCTGCGCGTGGACGCCGCGCGCAAGGCCAGCGCGGCCGCCGGCGAAGTGGT
GCAGGCGGTGGTGGCGCAGCAGAGCGCCGCGGCGGAGCAGGCTTTTTATGACGCGGTGGTCAGCCAGGAGCGCGTGGCGG
TGTTCAAGGAGATGCTGGCGCTCTACGACCGCACGCGCCAGGCCAGCGAGACCCGCCTGAAGGCCGGCGACGTCTCGCGC
GCCGACGTGACCAAGCTGCAGCTAGACGCGCTGCGCGCGCAGAGCGACATGCGCCAGGCCATGACCGACCACGCGCGCGA
CAAGGCCCAGCTGGCGCAGGCCATGGGCGTGCCCGGCACGCTTGCCGGCAACCGGCTGGTGGCGGACTGGCCGCCGCTGG
ATACGCCCGTGCCGCAGGTCGATCCCGACACATTGCAGCGCCGCCCCGACGTAACTGCGGCCGAGGCCCGCCTGGCCGCG
GCCGCCGCCGCGCGCGACCTGGCGCGCGCCGGCCGCGTGCCCGACGTGACCGTCGGCGCGCAGGCTGAGCACTATCCGGT
TTCCGCCACCAATACCAACGGCAGCGGCAACAGCTACGGCGTGTTCCTGACGATCCCGCTGTACGTGCGCCACAGCAACG
GCGGCGAGGCCCGCCGCGCCGAGGTGGACTACTACGCCGCGCTGGACGACCGCAACCGCGTGCTGCTGGAAGCCGGCAAT
GAGATGGAACGGCTGCGCAGCCAGCTCGAAGCCGCGCGCCAGTCACTGCGGCAGATGCGCGACGACGTGCTGCCCGCCGC
CGAAAGCGTGGCCGGCAGCGCCGAGTTTGCCTACGGCAAGGGCGCCACCGGCGTGCTCGACCTGCTCGATGCCCGCCGCG
CGCTGCGCCAGACCCGGCTCGATTCCGTCAGCGCCCAGGGCGATTACGCCAAGGCCCTGTCGGCCTACCGCGCCGCGCTG
CAGACCTCCACGACCGGCACTGCGACAAGCTCGCGTCCCTGA

Upstream 100 bases:

>100_bases
GCTACTGGGGGTTCTGGCCCGGCCCGCGGCAATCCTTGCCGCCGAAGGCCCCGCCGATCCGCTTCCTTCCGCTGATTCCG
CAGATGCTGCCGGTCCTTGC

Downstream 100 bases:

>100_bases
ACCGCAGTCCCAGCGAATCCAATGCACTCCCTCCTGTCACGCATGTCCCGCCGCATGTCTTCCGTCCATTTCCCCGCCGG
CCTGCCCGCACGGTTTGCTG

Product: cation/multidrug efflux system outer membrane porin

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MPPPAGATLTLAQARLDALRCNRDIIAARRGVEASQADIQIASQRPNPVLSLGVTNINPHAGIGSGNLRSKTVDSTLRVD
QLIETANKGGLRVDAARKASAAAGEVVQAVVAQQSAAAEQAFYDAVVSQERVAVFKEMLALYDRTRQASETRLKAGDVSR
ADVTKLQLDALRAQSDMRQAMTDHARDKAQLAQAMGVPGTLAGNRLVADWPPLDTPVPQVDPDTLQRRPDVTAAEARLAA
AAAARDLARAGRVPDVTVGAQAEHYPVSATNTNGSGNSYGVFLTIPLYVRHSNGGEARRAEVDYYAALDDRNRVLLEAGN
EMERLRSQLEAARQSLRQMRDDVLPAAESVAGSAEFAYGKGATGVLDLLDARRALRQTRLDSVSAQGDYAKALSAYRAAL
QTSTTGTATSSRP

Sequences:

>Translated_413_residues
MPPPAGATLTLAQARLDALRCNRDIIAARRGVEASQADIQIASQRPNPVLSLGVTNINPHAGIGSGNLRSKTVDSTLRVD
QLIETANKGGLRVDAARKASAAAGEVVQAVVAQQSAAAEQAFYDAVVSQERVAVFKEMLALYDRTRQASETRLKAGDVSR
ADVTKLQLDALRAQSDMRQAMTDHARDKAQLAQAMGVPGTLAGNRLVADWPPLDTPVPQVDPDTLQRRPDVTAAEARLAA
AAAARDLARAGRVPDVTVGAQAEHYPVSATNTNGSGNSYGVFLTIPLYVRHSNGGEARRAEVDYYAALDDRNRVLLEAGN
EMERLRSQLEAARQSLRQMRDDVLPAAESVAGSAEFAYGKGATGVLDLLDARRALRQTRLDSVSAQGDYAKALSAYRAAL
QTSTTGTATSSRP
>Mature_412_residues
PPPAGATLTLAQARLDALRCNRDIIAARRGVEASQADIQIASQRPNPVLSLGVTNINPHAGIGSGNLRSKTVDSTLRVDQ
LIETANKGGLRVDAARKASAAAGEVVQAVVAQQSAAAEQAFYDAVVSQERVAVFKEMLALYDRTRQASETRLKAGDVSRA
DVTKLQLDALRAQSDMRQAMTDHARDKAQLAQAMGVPGTLAGNRLVADWPPLDTPVPQVDPDTLQRRPDVTAAEARLAAA
AAARDLARAGRVPDVTVGAQAEHYPVSATNTNGSGNSYGVFLTIPLYVRHSNGGEARRAEVDYYAALDDRNRVLLEAGNE
MERLRSQLEAARQSLRQMRDDVLPAAESVAGSAEFAYGKGATGVLDLLDARRALRQTRLDSVSAQGDYAKALSAYRAALQ
TSTTGTATSSRP

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 43888; Mature: 43756

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPPAGATLTLAQARLDALRCNRDIIAARRGVEASQADIQIASQRPNPVLSLGVTNINPH
CCCCCCCEEHHHHHHHHHHHCCHHHHHHHCCCCCCCCCEEEECCCCCCEEEEECCCCCCC
AGIGSGNLRSKTVDSTLRVDQLIETANKGGLRVDAARKASAAAGEVVQAVVAQQSAAAEQ
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
AFYDAVVSQERVAVFKEMLALYDRTRQASETRLKAGDVSRADVTKLQLDALRAQSDMRQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
MTDHARDKAQLAQAMGVPGTLAGNRLVADWPPLDTPVPQVDPDTLQRRPDVTAAEARLAA
HHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHH
AAAARDLARAGRVPDVTVGAQAEHYPVSATNTNGSGNSYGVFLTIPLYVRHSNGGEARRA
HHHHHHHHHHCCCCCEEECCCCCCCCCEECCCCCCCCCEEEEEEEEEEEEECCCCCCHHC
EVDYYAALDDRNRVLLEAGNEMERLRSQLEAARQSLRQMRDDVLPAAESVAGSAEFAYGK
CEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GATGVLDLLDARRALRQTRLDSVSAQGDYAKALSAYRAALQTSTTGTATSSRP
CCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PPPAGATLTLAQARLDALRCNRDIIAARRGVEASQADIQIASQRPNPVLSLGVTNINPH
CCCCCCEEHHHHHHHHHHHCCHHHHHHHCCCCCCCCCEEEECCCCCCEEEEECCCCCCC
AGIGSGNLRSKTVDSTLRVDQLIETANKGGLRVDAARKASAAAGEVVQAVVAQQSAAAEQ
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
AFYDAVVSQERVAVFKEMLALYDRTRQASETRLKAGDVSRADVTKLQLDALRAQSDMRQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
MTDHARDKAQLAQAMGVPGTLAGNRLVADWPPLDTPVPQVDPDTLQRRPDVTAAEARLAA
HHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHH
AAAARDLARAGRVPDVTVGAQAEHYPVSATNTNGSGNSYGVFLTIPLYVRHSNGGEARRA
HHHHHHHHHHCCCCCEEECCCCCCCCCEECCCCCCCCCEEEEEEEEEEEEECCCCCCHHC
EVDYYAALDDRNRVLLEAGNEMERLRSQLEAARQSLRQMRDDVLPAAESVAGSAEFAYGK
CEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
GATGVLDLLDARRALRQTRLDSVSAQGDYAKALSAYRAALQTSTTGTATSSRP
CCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]