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The map label for this gene is acdA [H]

Identifier: 116694348

GI number: 116694348

Start: 451729

End: 452946

Strand: Direct

Name: acdA [H]

Synonym: H16_B0395

Alternate gene names: 116694348

Gene position: 451729-452946 (Clockwise)

Preceding gene: 116694347

Following gene: 116694349

Centisome position: 15.51

GC content: 68.06

Gene sequence:

>1218_bases
ATGGATTTCGAGCCCGATCTCGGACTGGAGGCGTTCCGCCAGGAAGTACGGACTTTCCTGCGCGAGAGCCTGCCTGCCGA
CCTGGCCGGCAGGCCGCGCAGCGGCACTCGCTCTTCGCGCGCGGACCTGACTCGCTGGCAGGGCATCCTGAACCAGCGTG
GCTGGGGCGCACCGTCCTGGCCGAAAGAGCATGGCGGCACCGGCTGGTCGGTGCTGCAACGGCTAATCTTCGACGAGGAA
TGCGTGGCCGCCGGCGCCCCGTCGCCGGACACCGCCGCCCAGCGCCTGCTGGGACCGGTGCTGAACGCTTTCGGCACGCC
GGCGCAGCGCGCCGAGCATATCCCGCACATGCTGAGCGGCGAGCGCCAGTGGTGCCAGGGCTTCTCGGAGCCGGGTTCCG
GCTCCGACCTCGCCTCGCTGCGCACGCGCGCAGTCAGGGATGGCGACCACTATGTGGTCAACGGCCAGAAAATCTGGACC
ACCTGCGCCCACCGCGCCGACTGGATCTTCCTGCTGGTGCGCACCGATCCCGAGGCGAAGAAGCAGGCCGGCATCACCTT
CCTGCTGGTGGACATGAAGTCGCCCGGCATCACGGTGCGGCCGATCCGCAGCATCGACGGCTGCCACCACCTGAACGAGA
CCTTCTTCGAGGATGTCAGGGTGCCGGTGGCCAACCGCGTGGGCGAGGAAGGCGCCGGGTGGAGTATCACCAAGTTCCTG
CTCAACAACGAACACGCGACGGCCGCCGACCTGCCGATGCTGCGCCGCTACCTGACGCAGGTGCGCAATCTCGCCGCGCG
CAAGGATGTCAGCGGCCGCACGCTGGCGCAGCGGCACGAGTTTTCGCTGCGGCTGGCGCGCTTCGAGGCGGAGCTGAACG
CCATCGCCATGCTGGTGCAGCGCGTGGCGTCGATGGAGGAAGACCATAGTCCCGCTGCCCACGCGATGGGCTCCATGCTG
AAGATCCGCGGCACGGAACTGCAGCAGGCCATGAGCACCTTCCTGGTGGAAGCGCTGGGCGACTACGGCGCCGTGGCGTA
CCCGACGCTGGACGACGAGGGTGGCAACGGCCATGGCGACGAACGCGCCGAGCTGCCCATGCAGGACCTGGGCCGCGGCA
TCGCCAGCGAGATGTTCTTCCGGCGCGCCTCGACCATCTATGGCGGCACCAGCGAAGTCCAGCGGACCATCATCGCCAAG
TCGCTGTTCAATTTCTGA

Upstream 100 bases:

>100_bases
CCGATGCTCAAGAGTTCGTTCGTCCCGTTCGAGCTGTCGCGCGACATCTTCACCTGGGACCCGGTCTGACCGCGGATCAC
GGCTTCAAAGGAGCAATGCA

Downstream 100 bases:

>100_bases
AGGCAGTCACCGAGCATGAAATTCAACCTGAATGATGAGCAAGGCCTGCTGCGCGACAGCGTGCGGCGCTTTGTCGACAA
GGAATACGACCTCGCGGCGC

Product: Acyl-CoA dehydrogenase

Products: 6-carboxyhex-2-enoyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MDFEPDLGLEAFRQEVRTFLRESLPADLAGRPRSGTRSSRADLTRWQGILNQRGWGAPSWPKEHGGTGWSVLQRLIFDEE
CVAAGAPSPDTAAQRLLGPVLNAFGTPAQRAEHIPHMLSGERQWCQGFSEPGSGSDLASLRTRAVRDGDHYVVNGQKIWT
TCAHRADWIFLLVRTDPEAKKQAGITFLLVDMKSPGITVRPIRSIDGCHHLNETFFEDVRVPVANRVGEEGAGWSITKFL
LNNEHATAADLPMLRRYLTQVRNLAARKDVSGRTLAQRHEFSLRLARFEAELNAIAMLVQRVASMEEDHSPAAHAMGSML
KIRGTELQQAMSTFLVEALGDYGAVAYPTLDDEGGNGHGDERAELPMQDLGRGIASEMFFRRASTIYGGTSEVQRTIIAK
SLFNF

Sequences:

>Translated_405_residues
MDFEPDLGLEAFRQEVRTFLRESLPADLAGRPRSGTRSSRADLTRWQGILNQRGWGAPSWPKEHGGTGWSVLQRLIFDEE
CVAAGAPSPDTAAQRLLGPVLNAFGTPAQRAEHIPHMLSGERQWCQGFSEPGSGSDLASLRTRAVRDGDHYVVNGQKIWT
TCAHRADWIFLLVRTDPEAKKQAGITFLLVDMKSPGITVRPIRSIDGCHHLNETFFEDVRVPVANRVGEEGAGWSITKFL
LNNEHATAADLPMLRRYLTQVRNLAARKDVSGRTLAQRHEFSLRLARFEAELNAIAMLVQRVASMEEDHSPAAHAMGSML
KIRGTELQQAMSTFLVEALGDYGAVAYPTLDDEGGNGHGDERAELPMQDLGRGIASEMFFRRASTIYGGTSEVQRTIIAK
SLFNF
>Mature_405_residues
MDFEPDLGLEAFRQEVRTFLRESLPADLAGRPRSGTRSSRADLTRWQGILNQRGWGAPSWPKEHGGTGWSVLQRLIFDEE
CVAAGAPSPDTAAQRLLGPVLNAFGTPAQRAEHIPHMLSGERQWCQGFSEPGSGSDLASLRTRAVRDGDHYVVNGQKIWT
TCAHRADWIFLLVRTDPEAKKQAGITFLLVDMKSPGITVRPIRSIDGCHHLNETFFEDVRVPVANRVGEEGAGWSITKFL
LNNEHATAADLPMLRRYLTQVRNLAARKDVSGRTLAQRHEFSLRLARFEAELNAIAMLVQRVASMEEDHSPAAHAMGSML
KIRGTELQQAMSTFLVEALGDYGAVAYPTLDDEGGNGHGDERAELPMQDLGRGIASEMFFRRASTIYGGTSEVQRTIIAK
SLFNF

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI187960098, Length=415, Percent_Identity=27.2289156626506, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI4557231, Length=415, Percent_Identity=27.2289156626506, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI7656849, Length=369, Percent_Identity=26.8292682926829, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI4557233, Length=354, Percent_Identity=29.3785310734463, Blast_Score=111, Evalue=9e-25,
Organism=Homo sapiens, GI226958412, Length=410, Percent_Identity=27.0731707317073, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI4501859, Length=413, Percent_Identity=27.1186440677966, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI226958414, Length=361, Percent_Identity=27.4238227146814, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI4501857, Length=406, Percent_Identity=24.6305418719212, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI21361497, Length=272, Percent_Identity=27.9411764705882, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4557235, Length=323, Percent_Identity=28.4829721362229, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI76496475, Length=323, Percent_Identity=28.7925696594427, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI48976061, Length=272, Percent_Identity=27.2058823529412, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI211971008, Length=272, Percent_Identity=27.2058823529412, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI87081958, Length=178, Percent_Identity=29.7752808988764, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1786223, Length=260, Percent_Identity=27.3076923076923, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17570075, Length=415, Percent_Identity=26.7469879518072, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17534899, Length=360, Percent_Identity=28.6111111111111, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17569725, Length=358, Percent_Identity=26.8156424581006, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17533517, Length=418, Percent_Identity=23.9234449760766, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17506239, Length=416, Percent_Identity=26.9230769230769, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17508101, Length=370, Percent_Identity=27.2972972972973, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17538396, Length=406, Percent_Identity=25.3694581280788, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17551932, Length=285, Percent_Identity=25.6140350877193, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI32563615, Length=192, Percent_Identity=31.7708333333333, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17505929, Length=238, Percent_Identity=27.3109243697479, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71985184, Length=146, Percent_Identity=32.1917808219178, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71985192, Length=146, Percent_Identity=32.1917808219178, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71990804, Length=261, Percent_Identity=25.6704980842912, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71982178, Length=238, Percent_Identity=26.4705882352941, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356377, Length=367, Percent_Identity=28.0653950953678, Blast_Score=116, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24660351, Length=404, Percent_Identity=26.7326732673267, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24666513, Length=356, Percent_Identity=26.123595505618, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21355753, Length=406, Percent_Identity=25.3694581280788, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI281363737, Length=306, Percent_Identity=26.4705882352941, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646207, Length=405, Percent_Identity=26.1728395061728, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.1.62

Molecular weight: Translated: 44808; Mature: 44808

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFEPDLGLEAFRQEVRTFLRESLPADLAGRPRSGTRSSRADLTRWQGILNQRGWGAPSW
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
PKEHGGTGWSVLQRLIFDEECVAAGAPSPDTAAQRLLGPVLNAFGTPAQRAEHIPHMLSG
CHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCHHHHCC
ERQWCQGFSEPGSGSDLASLRTRAVRDGDHYVVNGQKIWTTCAHRADWIFLLVRTDPEAK
CHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEECCHHHHHHHHCCCCEEEEEEECCCHHH
KQAGITFLLVDMKSPGITVRPIRSIDGCHHLNETFFEDVRVPVANRVGEEGAGWSITKFL
HHCCCEEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHH
LNNEHATAADLPMLRRYLTQVRNLAARKDVSGRTLAQRHEFSLRLARFEAELNAIAMLVQ
HCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVASMEEDHSPAAHAMGSMLKIRGTELQQAMSTFLVEALGDYGAVAYPTLDDEGGNGHGD
HHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCC
ERAELPMQDLGRGIASEMFFRRASTIYGGTSEVQRTIIAKSLFNF
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDFEPDLGLEAFRQEVRTFLRESLPADLAGRPRSGTRSSRADLTRWQGILNQRGWGAPSW
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
PKEHGGTGWSVLQRLIFDEECVAAGAPSPDTAAQRLLGPVLNAFGTPAQRAEHIPHMLSG
CHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHCHHHHCC
ERQWCQGFSEPGSGSDLASLRTRAVRDGDHYVVNGQKIWTTCAHRADWIFLLVRTDPEAK
CHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEECCHHHHHHHHCCCCEEEEEEECCCHHH
KQAGITFLLVDMKSPGITVRPIRSIDGCHHLNETFFEDVRVPVANRVGEEGAGWSITKFL
HHCCCEEEEEECCCCCEEEEECHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHH
LNNEHATAADLPMLRRYLTQVRNLAARKDVSGRTLAQRHEFSLRLARFEAELNAIAMLVQ
HCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVASMEEDHSPAAHAMGSMLKIRGTELQQAMSTFLVEALGDYGAVAYPTLDDEGGNGHGD
HHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCC
ERAELPMQDLGRGIASEMFFRRASTIYGGTSEVQRTIIAKSLFNF
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pimeloyl-CoA; NAD+

Specific reaction: pimeloyl-CoA + NAD+ = 6-carboxyhex-2-enoyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]