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The map label for this gene is mmgC [H]

Identifier: 116694349

GI number: 116694349

Start: 452962

End: 454095

Strand: Direct

Name: mmgC [H]

Synonym: H16_B0396

Alternate gene names: 116694349

Gene position: 452962-454095 (Clockwise)

Preceding gene: 116694348

Following gene: 116694350

Centisome position: 15.55

GC content: 69.4

Gene sequence:

>1134_bases
ATGAAATTCAACCTGAATGATGAGCAAGGCCTGCTGCGCGACAGCGTGCGGCGCTTTGTCGACAAGGAATACGACCTCGC
GGCGCGCACGGCACGCCTGCGCAGCGGCGAGCCGTGCCATGCCGGCCATTGGCGCACCTTCGCCGATAACGGCTGGCTGG
CCGCGGCGCTGCCGGAAGCGGCGGGCGGACTGGGCGGCAATGTCATCGACATGGCGCTGATCAGCGCCGAGTTCGGCCGC
GGCCTGGTGATCGAGCCCTGGCTCGGCAGCGCCGTGCTGGCGCCGCAGACGGTGCTGGCAGGCGGCTCTGCGCTGCAACG
CGAAGCGCTGCTGCCCGCCGTGGCGGACGGCTCGCGCCGGCTGGCGCTGGCCTACAGCGAAAGCCAGTCGCGCGGCTTCG
CCGGCCCGGTCCTGACGCGCGCCATGCCGACGCAGGGCGGCTACACACTGCACGGCACCAAGACGCTGGTGCTGGGCGGC
TGCGACGCCGATGCGTTCGTGGTCTCGGCCGATGTGGCCGGTGTGGGCACCAGCCTGTTCGTGGTGCCGGCCGGAAAGGA
AGGCGTAAAGCGGCGCGCACTGCCGCTGCATGACGGCAGCTGGGCCGCCGAAGTGAGCTTCGACGGCGTCTTCGTTCCGG
CCGACGCGCTCCTGGGCGAGGCCGGCAACGGCGAGGCCGCGCTGCGCCAGGGCCTGGCGCATGGCACCGCCGCGCTGTGC
GCCGAACTGGTGGGCGCCATGGAGAAGGCCATCGAGATCACGGCGGAGTACCTGAAGGTGCGCAAGCAGTTCGGCGTGGC
GATCGGCAGCTTCCAGTCGCTGCAGCACCGGGTGTCGGACATGGCCGCCGAGATGGAAGTCGCCCGCTCGATGCTTTACG
TGCTGCTGGCAGCCATCGAAAACGACAGCCCCGACCTGGACCGCACCGTGTCGCAGGCCAAGAGCCTGGTGGTGCGCGCC
GCGCGCTTTGTGTGCGGACAGGCCATCCAGCTGCACGGCGGCATTGGCATGACCGAGGAATATCCAGTCGGCCATTACTT
CAAGCGCGCCGTCGTGGCGGACGCGCTGTTCGGCAATGCCGACATGCACGATGCGCGCAATGCCGAGGCATGGCAGGCAT
CCCTGACTGAATAG

Upstream 100 bases:

>100_bases
GTTCTTCCGGCGCGCCTCGACCATCTATGGCGGCACCAGCGAAGTCCAGCGGACCATCATCGCCAAGTCGCTGTTCAATT
TCTGAAGGCAGTCACCGAGC

Downstream 100 bases:

>100_bases
GAAGAGCAAGCATGAAGACCTACGAGAACATCGCCGATCTCCAGCCGCTGGTTGGAGAAGTCATCGGCACGAGCGAATGG
CTGGCGCTGGACCAGGCCCG

Product: Acyl-CoA dehydrogenase

Products: 6-carboxyhex-2-enoyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MKFNLNDEQGLLRDSVRRFVDKEYDLAARTARLRSGEPCHAGHWRTFADNGWLAAALPEAAGGLGGNVIDMALISAEFGR
GLVIEPWLGSAVLAPQTVLAGGSALQREALLPAVADGSRRLALAYSESQSRGFAGPVLTRAMPTQGGYTLHGTKTLVLGG
CDADAFVVSADVAGVGTSLFVVPAGKEGVKRRALPLHDGSWAAEVSFDGVFVPADALLGEAGNGEAALRQGLAHGTAALC
AELVGAMEKAIEITAEYLKVRKQFGVAIGSFQSLQHRVSDMAAEMEVARSMLYVLLAAIENDSPDLDRTVSQAKSLVVRA
ARFVCGQAIQLHGGIGMTEEYPVGHYFKRAVVADALFGNADMHDARNAEAWQASLTE

Sequences:

>Translated_377_residues
MKFNLNDEQGLLRDSVRRFVDKEYDLAARTARLRSGEPCHAGHWRTFADNGWLAAALPEAAGGLGGNVIDMALISAEFGR
GLVIEPWLGSAVLAPQTVLAGGSALQREALLPAVADGSRRLALAYSESQSRGFAGPVLTRAMPTQGGYTLHGTKTLVLGG
CDADAFVVSADVAGVGTSLFVVPAGKEGVKRRALPLHDGSWAAEVSFDGVFVPADALLGEAGNGEAALRQGLAHGTAALC
AELVGAMEKAIEITAEYLKVRKQFGVAIGSFQSLQHRVSDMAAEMEVARSMLYVLLAAIENDSPDLDRTVSQAKSLVVRA
ARFVCGQAIQLHGGIGMTEEYPVGHYFKRAVVADALFGNADMHDARNAEAWQASLTE
>Mature_377_residues
MKFNLNDEQGLLRDSVRRFVDKEYDLAARTARLRSGEPCHAGHWRTFADNGWLAAALPEAAGGLGGNVIDMALISAEFGR
GLVIEPWLGSAVLAPQTVLAGGSALQREALLPAVADGSRRLALAYSESQSRGFAGPVLTRAMPTQGGYTLHGTKTLVLGG
CDADAFVVSADVAGVGTSLFVVPAGKEGVKRRALPLHDGSWAAEVSFDGVFVPADALLGEAGNGEAALRQGLAHGTAALC
AELVGAMEKAIEITAEYLKVRKQFGVAIGSFQSLQHRVSDMAAEMEVARSMLYVLLAAIENDSPDLDRTVSQAKSLVVRA
ARFVCGQAIQLHGGIGMTEEYPVGHYFKRAVVADALFGNADMHDARNAEAWQASLTE

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=372, Percent_Identity=27.1505376344086, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI226958412, Length=368, Percent_Identity=26.6304347826087, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI7656849, Length=365, Percent_Identity=25.4794520547945, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI76496475, Length=363, Percent_Identity=28.3746556473829, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4557235, Length=363, Percent_Identity=28.3746556473829, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI226958414, Length=322, Percent_Identity=27.3291925465839, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI4501857, Length=371, Percent_Identity=24.7978436657682, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI4501859, Length=374, Percent_Identity=24.0641711229947, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI21361497, Length=323, Percent_Identity=25.6965944272446, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI4557231, Length=376, Percent_Identity=23.1382978723404, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI187960098, Length=383, Percent_Identity=23.4986945169713, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4503943, Length=296, Percent_Identity=27.027027027027, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI7669494, Length=290, Percent_Identity=27.9310344827586, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1786223, Length=369, Percent_Identity=26.0162601626016, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI87081958, Length=383, Percent_Identity=26.3707571801567, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17538396, Length=359, Percent_Identity=30.08356545961, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17508101, Length=374, Percent_Identity=25.4010695187166, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71985184, Length=313, Percent_Identity=27.4760383386581, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17506239, Length=328, Percent_Identity=25.609756097561, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71990804, Length=261, Percent_Identity=27.5862068965517, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17570075, Length=379, Percent_Identity=24.5382585751979, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17569725, Length=378, Percent_Identity=24.6031746031746, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71985192, Length=285, Percent_Identity=26.6666666666667, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17534899, Length=381, Percent_Identity=25.4593175853018, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17533517, Length=265, Percent_Identity=24.1509433962264, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17505929, Length=319, Percent_Identity=25.705329153605, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21355753, Length=376, Percent_Identity=28.1914893617021, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI21356377, Length=371, Percent_Identity=26.4150943396226, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI281363737, Length=352, Percent_Identity=27.2727272727273, Blast_Score=98, Evalue=9e-21,
Organism=Drosophila melanogaster, GI24666513, Length=380, Percent_Identity=23.1578947368421, Blast_Score=95, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24646207, Length=367, Percent_Identity=24.5231607629428, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.1.62

Molecular weight: Translated: 39775; Mature: 39775

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFNLNDEQGLLRDSVRRFVDKEYDLAARTARLRSGEPCHAGHWRTFADNGWLAAALPEA
CCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCEECCCCEEEEECCHH
AGGLGGNVIDMALISAEFGRGLVIEPWLGSAVLAPQTVLAGGSALQREALLPAVADGSRR
HCCCCCHHHHHHHHHHHHCCCEEECCCCCCCHHCCHHHHCCCHHHHHHHCCCHHCCCCCE
LALAYSESQSRGFAGPVLTRAMPTQGGYTLHGTKTLVLGGCDADAFVVSADVAGVGTSLF
EEEEECCCCCCCCCCHHHHHCCCCCCCEEEECCEEEEEECCCCCCEEEEECCCCCCCEEE
VVPAGKEGVKRRALPLHDGSWAAEVSFDGVFVPADALLGEAGNGEAALRQGLAHGTAALC
EEECCCHHHHHCCCCCCCCCEEEEEEECCEEECHHHHHCCCCCCHHHHHHHHHCCHHHHH
AELVGAMEKAIEITAEYLKVRKQFGVAIGSFQSLQHRVSDMAAEMEVARSMLYVLLAAIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NDSPDLDRTVSQAKSLVVRAARFVCGQAIQLHGGIGMTEEYPVGHYFKRAVVADALFGNA
CCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCC
DMHDARNAEAWQASLTE
CCCCCCCCHHHHHCCCC
>Mature Secondary Structure
MKFNLNDEQGLLRDSVRRFVDKEYDLAARTARLRSGEPCHAGHWRTFADNGWLAAALPEA
CCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCEECCCCEEEEECCHH
AGGLGGNVIDMALISAEFGRGLVIEPWLGSAVLAPQTVLAGGSALQREALLPAVADGSRR
HCCCCCHHHHHHHHHHHHCCCEEECCCCCCCHHCCHHHHCCCHHHHHHHCCCHHCCCCCE
LALAYSESQSRGFAGPVLTRAMPTQGGYTLHGTKTLVLGGCDADAFVVSADVAGVGTSLF
EEEEECCCCCCCCCCHHHHHCCCCCCCEEEECCEEEEEECCCCCCEEEEECCCCCCCEEE
VVPAGKEGVKRRALPLHDGSWAAEVSFDGVFVPADALLGEAGNGEAALRQGLAHGTAALC
EEECCCHHHHHCCCCCCCCCEEEEEEECCEEECHHHHHCCCCCCHHHHHHHHHCCHHHHH
AELVGAMEKAIEITAEYLKVRKQFGVAIGSFQSLQHRVSDMAAEMEVARSMLYVLLAAIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NDSPDLDRTVSQAKSLVVRAARFVCGQAIQLHGGIGMTEEYPVGHYFKRAVVADALFGNA
CCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCC
DMHDARNAEAWQASLTE
CCCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pimeloyl-CoA; NAD+

Specific reaction: pimeloyl-CoA + NAD+ = 6-carboxyhex-2-enoyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]