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The map label for this gene is pimC [H]

Identifier: 116694325

GI number: 116694325

Start: 419444

End: 420613

Strand: Direct

Name: pimC [H]

Synonym: H16_B0371

Alternate gene names: 116694325

Gene position: 419444-420613 (Clockwise)

Preceding gene: 116694324

Following gene: 116694326

Centisome position: 14.4

GC content: 66.07

Gene sequence:

>1170_bases
ATGGATCTTTGTCTGACTCCCTCCCAACTCGCATTCCGCGACGACGTGCGCGCCTTCATCGCGGCGCGCCTGCCTGCCGG
CATCCGCGAACGCCTGCGGCGCGGCATGCGTCCGCGCATGGAAGACAACGCCGTCTGGCATCAGACGCTCAACGAGCGCG
GCTGGGTGGCTCCGCACTGGCCGAAGAAATACGGCGGTGCCGGCCTCGGCGCCATCGAGCGCATCATCCTCACCGACGAG
CTGTATCGCGCCTGCGCCCCGCAGCCGCTGGTCATGAACATCAACATGCTCGGCACCTTGCTGCTGCGCTACGGCACCGA
GGCGCAGAAACAGTACTTCCTGCCGAAGCTGCTGGACATGAACGTGATCTTCTGCCAGGGCTTTTCGGAACCGAACTCGG
GTTCCGACCTGGCATCGCTGTCGACGCGTGCCCGCCGCGAGGGCGACCACTATGTGGTGGATGGACAGAAGATCTGGACG
TCGCATGCGCACCACGCCAACTGGATGTTCGCGCTGGTACGCACGGCGCAGTGCGAACGCAAGCAGGACGGCATCTCGTT
CATCCTGATCGACATGAAGAGCCCGGGCGTGTCGGTGCGCCCCATCATGACGATCGACGGCTACCACAACGTCAACGAGG
TGTTCTTCGACAGCGTCCGCGTGCCCGTCGAAAACCTGGTCGGCGAAGAGGGGCGGGGCTGGGCGTGCGCGAAGTACCTG
CTCGGCAACGAGCGCATCCACGTCGCCAACGTCGGCTTCTGCTGGGAGCGCCTGGACTACGCGCGCGAACTCGCCGCAGC
CACCCGCCAGGGGGACGGCTATCTGATCGACGACCCCCGGGTGCGCGCCGACCTGGCCCGCCTGGGAGCGGAAATCCGGG
CACTGGAACTGACGAACTGGCGCTTCCTGCTCGACCCCGACATCGAGCGCGCCAATCCCGGCTTCGCGTCCGTGCTCAAG
CTCAAGGGCTCGGAGATGGCGCAGGAGCTGACCACCCTGATCGCCGGCATTGCCGGGCCCGCGGGCGTGGAGCGCCATGC
GCTCGATACCGCCGTGCCCGATCCGATGGGCGCCGCCGTGTGGGGATACTTCTTCCATCGGGCCTCGACGATCTTCGGCG
GTTCCAGCGAAGTCCAGAAGGACATTCTTGCCAAGGCAACCCGGGGTTAA

Upstream 100 bases:

>100_bases
TGCCCGAAGGGCAGGGCGTCGTGGCCCTCGACGCCGTCGTGCAGACCGGCGCACCGGGCCTGCCCATTGCACACCCGCCT
GCCAAACAGGATTGATCGAC

Downstream 100 bases:

>100_bases
ATCATGAACTTCAATCTGAACGACGAGCAGCGCCAGCTTGCCGACAGCCTGTCACGCCTGCTGGCCGATCACTACAGCTT
CGAGAAGCGCCGTGCGTTGA

Product: pimeloyl-CoA dehydrogenase (large subunit)

Products: 6-carboxyhex-2-enoyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MDLCLTPSQLAFRDDVRAFIAARLPAGIRERLRRGMRPRMEDNAVWHQTLNERGWVAPHWPKKYGGAGLGAIERIILTDE
LYRACAPQPLVMNINMLGTLLLRYGTEAQKQYFLPKLLDMNVIFCQGFSEPNSGSDLASLSTRARREGDHYVVDGQKIWT
SHAHHANWMFALVRTAQCERKQDGISFILIDMKSPGVSVRPIMTIDGYHNVNEVFFDSVRVPVENLVGEEGRGWACAKYL
LGNERIHVANVGFCWERLDYARELAAATRQGDGYLIDDPRVRADLARLGAEIRALELTNWRFLLDPDIERANPGFASVLK
LKGSEMAQELTTLIAGIAGPAGVERHALDTAVPDPMGAAVWGYFFHRASTIFGGSSEVQKDILAKATRG

Sequences:

>Translated_389_residues
MDLCLTPSQLAFRDDVRAFIAARLPAGIRERLRRGMRPRMEDNAVWHQTLNERGWVAPHWPKKYGGAGLGAIERIILTDE
LYRACAPQPLVMNINMLGTLLLRYGTEAQKQYFLPKLLDMNVIFCQGFSEPNSGSDLASLSTRARREGDHYVVDGQKIWT
SHAHHANWMFALVRTAQCERKQDGISFILIDMKSPGVSVRPIMTIDGYHNVNEVFFDSVRVPVENLVGEEGRGWACAKYL
LGNERIHVANVGFCWERLDYARELAAATRQGDGYLIDDPRVRADLARLGAEIRALELTNWRFLLDPDIERANPGFASVLK
LKGSEMAQELTTLIAGIAGPAGVERHALDTAVPDPMGAAVWGYFFHRASTIFGGSSEVQKDILAKATRG
>Mature_389_residues
MDLCLTPSQLAFRDDVRAFIAARLPAGIRERLRRGMRPRMEDNAVWHQTLNERGWVAPHWPKKYGGAGLGAIERIILTDE
LYRACAPQPLVMNINMLGTLLLRYGTEAQKQYFLPKLLDMNVIFCQGFSEPNSGSDLASLSTRARREGDHYVVDGQKIWT
SHAHHANWMFALVRTAQCERKQDGISFILIDMKSPGVSVRPIMTIDGYHNVNEVFFDSVRVPVENLVGEEGRGWACAKYL
LGNERIHVANVGFCWERLDYARELAAATRQGDGYLIDDPRVRADLARLGAEIRALELTNWRFLLDPDIERANPGFASVLK
LKGSEMAQELTTLIAGIAGPAGVERHALDTAVPDPMGAAVWGYFFHRASTIFGGSSEVQKDILAKATRG

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=347, Percent_Identity=29.3948126801153, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI187960098, Length=389, Percent_Identity=23.9074550128535, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI4557231, Length=389, Percent_Identity=23.9074550128535, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI226958412, Length=234, Percent_Identity=28.6324786324786, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI4501859, Length=359, Percent_Identity=28.133704735376, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI226958414, Length=193, Percent_Identity=31.0880829015544, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI7656849, Length=263, Percent_Identity=28.1368821292776, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4557235, Length=220, Percent_Identity=30, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI76496475, Length=220, Percent_Identity=30, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI38505218, Length=196, Percent_Identity=33.1632653061224, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI48976061, Length=298, Percent_Identity=29.1946308724832, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI211971008, Length=298, Percent_Identity=29.1946308724832, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI21361497, Length=322, Percent_Identity=26.7080745341615, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI4501857, Length=392, Percent_Identity=21.9387755102041, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI7669494, Length=380, Percent_Identity=27.1052631578947, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4503943, Length=380, Percent_Identity=27.1052631578947, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI87081958, Length=250, Percent_Identity=25.2, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17570075, Length=406, Percent_Identity=25.8620689655172, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17534899, Length=263, Percent_Identity=28.8973384030418, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17569725, Length=344, Percent_Identity=24.4186046511628, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17506239, Length=300, Percent_Identity=29, Blast_Score=108, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17508101, Length=218, Percent_Identity=31.1926605504587, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17551932, Length=227, Percent_Identity=28.6343612334802, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17538396, Length=264, Percent_Identity=25.7575757575758, Blast_Score=101, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI17505929, Length=227, Percent_Identity=25.5506607929515, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI71985184, Length=156, Percent_Identity=37.1794871794872, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI32563615, Length=195, Percent_Identity=31.7948717948718, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17533517, Length=275, Percent_Identity=26.5454545454545, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71985192, Length=156, Percent_Identity=37.1794871794872, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71990804, Length=252, Percent_Identity=26.1904761904762, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71982178, Length=190, Percent_Identity=29.4736842105263, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17562446, Length=206, Percent_Identity=28.6407766990291, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21356377, Length=350, Percent_Identity=28.5714285714286, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24660351, Length=402, Percent_Identity=25.1243781094527, Blast_Score=108, Evalue=8e-24,
Organism=Drosophila melanogaster, GI24666513, Length=256, Percent_Identity=27.34375, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI281363737, Length=247, Percent_Identity=29.5546558704453, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24646207, Length=390, Percent_Identity=26.9230769230769, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21355753, Length=244, Percent_Identity=27.8688524590164, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19920834, Length=285, Percent_Identity=27.3684210526316, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.1.62

Molecular weight: Translated: 43420; Mature: 43420

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLCLTPSQLAFRDDVRAFIAARLPAGIRERLRRGMRPRMEDNAVWHQTLNERGWVAPHW
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCC
PKKYGGAGLGAIERIILTDELYRACAPQPLVMNINMLGTLLLRYGTEAQKQYFLPKLLDM
CHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCHHHHHHHCHHHHCC
NVIFCQGFSEPNSGSDLASLSTRARREGDHYVVDGQKIWTSHAHHANWMFALVRTAQCER
CEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEECCHHHHHCCCCHHHHHHHHHHHHHHHH
KQDGISFILIDMKSPGVSVRPIMTIDGYHNVNEVFFDSVRVPVENLVGEEGRGWACAKYL
HCCCCEEEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHCCCHHHHCCCCCCCHHHHHHH
LGNERIHVANVGFCWERLDYARELAAATRQGDGYLIDDPRVRADLARLGAEIRALELTNW
HCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCEEEEEEECE
RFLLDPDIERANPGFASVLKLKGSEMAQELTTLIAGIAGPAGVERHALDTAVPDPMGAAV
EEEECCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHH
WGYFFHRASTIFGGSSEVQKDILAKATRG
HHHHHHHHHHHCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MDLCLTPSQLAFRDDVRAFIAARLPAGIRERLRRGMRPRMEDNAVWHQTLNERGWVAPHW
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCC
PKKYGGAGLGAIERIILTDELYRACAPQPLVMNINMLGTLLLRYGTEAQKQYFLPKLLDM
CHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCHHHHHHHCHHHHCC
NVIFCQGFSEPNSGSDLASLSTRARREGDHYVVDGQKIWTSHAHHANWMFALVRTAQCER
CEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEECCHHHHHCCCCHHHHHHHHHHHHHHHH
KQDGISFILIDMKSPGVSVRPIMTIDGYHNVNEVFFDSVRVPVENLVGEEGRGWACAKYL
HCCCCEEEEEEECCCCCEEEEEEEECCCCCHHHHHHHHHCCCHHHHCCCCCCCHHHHHHH
LGNERIHVANVGFCWERLDYARELAAATRQGDGYLIDDPRVRADLARLGAEIRALELTNW
HCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHCCCEEEEEEECE
RFLLDPDIERANPGFASVLKLKGSEMAQELTTLIAGIAGPAGVERHALDTAVPDPMGAAV
EEEECCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHH
WGYFFHRASTIFGGSSEVQKDILAKATRG
HHHHHHHHHHHCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pimeloyl-CoA; NAD+

Specific reaction: pimeloyl-CoA + NAD+ = 6-carboxyhex-2-enoyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]