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The map label for this gene is folE [H]

Identifier: 113478001

GI number: 113478001

Start: 7095389

End: 7096027

Strand: Reverse

Name: folE [H]

Synonym: Tery_4616

Alternate gene names: 113478001

Gene position: 7096027-7095389 (Counterclockwise)

Preceding gene: 113478002

Following gene: 113477999

Centisome position: 91.56

GC content: 38.03

Gene sequence:

>639_bases
ATGAATTTACCAACAGTTCCAGATTTTGTTTCTCCCAATGACTTGAAAACGAAATATCAGACTTCGGTTACAGAAGCTGA
AATGGTGCAAGCGGTAAGAACTTTATTAATAGGACTAGGAGAAAACCCAGATCGAGAAGGGTTATTAGATACTCCTAAAC
GAGTGGTAAAAGCACTAAAATTTCTCACTTCAGGTTATAATCAATCTCTAGATGAACTGCTCAATGGAGCTGTTTTTAGT
GAAGATACCTCAGAGATGGTTTTAGTTCGAGATATCGATCTTTTTAGCTCTTGCGAGCATCATATTCTCCCTATTATTGG
TCGCGCTCATGTAGCATATATTCCCAATGGAAAAGTTATTGGGCTATCAAAAATTGCTCGAATTTGTGAAATGTATGCCC
GACGTTTACAAGTTCAAGAGCGTCTAACAGCACAAATAGCTGATGCACTTCAAGGGTTACTTAGACCTTTAGGTGTTGCT
GTAGTTGTTGAAGCAACTCATATGTGTATGGTCATGCGTGGAGTACAAAAAACTGGTTCTTGGACAACTACTAGCGCTAT
GCGTGGTGTTTTTGCTGATGACGTGAAAACTCGTCAAGAATTTATGAGTTTAATTAAACATAGTCATAATTTCCATTAG

Upstream 100 bases:

>100_bases
CATAAACACAGATAATAGTCCTTATAGTTCATCTAAACTTTATGAGGGAAAATATCTGTCAAACCGTTCAACAAAACATT
AAGCTTAAAGCCTTTCAACT

Downstream 100 bases:

>100_bases
TTTTTTTAAGTTAAGTGATGAACCCAAGTTAAGCGACAATAAGTAAAAGTTGCTTATTCAGGACTTATACAGAAATACTA
TATCTAGGGGGGTTAAAGGT

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I 2; GTP-CH-I 2 [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MNLPTVPDFVSPNDLKTKYQTSVTEAEMVQAVRTLLIGLGENPDREGLLDTPKRVVKALKFLTSGYNQSLDELLNGAVFS
EDTSEMVLVRDIDLFSSCEHHILPIIGRAHVAYIPNGKVIGLSKIARICEMYARRLQVQERLTAQIADALQGLLRPLGVA
VVVEATHMCMVMRGVQKTGSWTTTSAMRGVFADDVKTRQEFMSLIKHSHNFH

Sequences:

>Translated_212_residues
MNLPTVPDFVSPNDLKTKYQTSVTEAEMVQAVRTLLIGLGENPDREGLLDTPKRVVKALKFLTSGYNQSLDELLNGAVFS
EDTSEMVLVRDIDLFSSCEHHILPIIGRAHVAYIPNGKVIGLSKIARICEMYARRLQVQERLTAQIADALQGLLRPLGVA
VVVEATHMCMVMRGVQKTGSWTTTSAMRGVFADDVKTRQEFMSLIKHSHNFH
>Mature_212_residues
MNLPTVPDFVSPNDLKTKYQTSVTEAEMVQAVRTLLIGLGENPDREGLLDTPKRVVKALKFLTSGYNQSLDELLNGAVFS
EDTSEMVLVRDIDLFSSCEHHILPIIGRAHVAYIPNGKVIGLSKIARICEMYARRLQVQERLTAQIADALQGLLRPLGVA
VVVEATHMCMVMRGVQKTGSWTTTSAMRGVFADDVKTRQEFMSLIKHSHNFH

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=179, Percent_Identity=59.2178770949721, Blast_Score=234, Evalue=4e-62,
Organism=Homo sapiens, GI4503949, Length=179, Percent_Identity=59.2178770949721, Blast_Score=234, Evalue=4e-62,
Organism=Homo sapiens, GI66932970, Length=148, Percent_Identity=54.0540540540541, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI66932972, Length=139, Percent_Identity=56.8345323741007, Blast_Score=178, Evalue=4e-45,
Organism=Escherichia coli, GI1788476, Length=209, Percent_Identity=37.799043062201, Blast_Score=125, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17560486, Length=178, Percent_Identity=60.1123595505618, Blast_Score=233, Evalue=7e-62,
Organism=Saccharomyces cerevisiae, GI6321706, Length=176, Percent_Identity=60.7954545454545, Blast_Score=224, Evalue=5e-60,
Organism=Drosophila melanogaster, GI24656791, Length=196, Percent_Identity=56.6326530612245, Blast_Score=223, Evalue=9e-59,
Organism=Drosophila melanogaster, GI24656796, Length=196, Percent_Identity=56.6326530612245, Blast_Score=222, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24656782, Length=196, Percent_Identity=56.6326530612245, Blast_Score=222, Evalue=1e-58,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 23580; Mature: 23580

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLPTVPDFVSPNDLKTKYQTSVTEAEMVQAVRTLLIGLGENPDREGLLDTPKRVVKALK
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
FLTSGYNQSLDELLNGAVFSEDTSEMVLVRDIDLFSSCEHHILPIIGRAHVAYIPNGKVI
HHHCCCCHHHHHHHCCCCCCCCCCCEEEEECCHHHHCCCHHHHHHHCCCEEEECCCCCEE
GLSKIARICEMYARRLQVQERLTAQIADALQGLLRPLGVAVVVEATHMCMVMRGVQKTGS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
WTTTSAMRGVFADDVKTRQEFMSLIKHSHNFH
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNLPTVPDFVSPNDLKTKYQTSVTEAEMVQAVRTLLIGLGENPDREGLLDTPKRVVKALK
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHH
FLTSGYNQSLDELLNGAVFSEDTSEMVLVRDIDLFSSCEHHILPIIGRAHVAYIPNGKVI
HHHCCCCHHHHHHHCCCCCCCCCCCEEEEECCHHHHCCCHHHHHHHCCCEEEECCCCCEE
GLSKIARICEMYARRLQVQERLTAQIADALQGLLRPLGVAVVVEATHMCMVMRGVQKTGS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
WTTTSAMRGVFADDVKTRQEFMSLIKHSHNFH
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]