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The map label for this gene is pyrE [H]

Identifier: 113476085

GI number: 113476085

Start: 3788235

End: 3788861

Strand: Direct

Name: pyrE [H]

Synonym: Tery_2462

Alternate gene names: 113476085

Gene position: 3788235-3788861 (Clockwise)

Preceding gene: 113476082

Following gene: 113476090

Centisome position: 48.88

GC content: 34.61

Gene sequence:

>627_bases
ATGACAAACCAAATTAAATCTCTAAATTCATCATCTTTGGCTACTACTGATATAACAACTATTAGACAACAATTACTTGA
TCTTTTAAGTACATTAGCTTATCGTGAGGGAGACTTTATATTATCCTCTGGGCAAAGTAGCTCCTATTATATAAATGGTA
AGTACGTTACTCTTCATCCCCTAGGAGCTCTGATAATTGGCAGATTAATCTTGTCTATGTTACCTGAAGATACTCAAGGA
GTAGCTGGTTTAACATTAGGTGCTGATCCAATTGTCACTGCTGTTAGTGTGGTATCTGCTTATGAAAATCGTCCTATACC
AGCTTTAATTATCCGCAAACAAGCTAAAGGACATGGTACAATGTCTTACATTGAAGGGCCAAGATTAGATGATAATGCCA
AAGTAGTTGTTTTAGAAGATGTCGTGACAACTGGAGCATCAGCAATGATGGCAGTTCATCGACTGCGAGAGGCAGGTTAT
CAGGTTAATCATATTTTTTCTCTTGTTGATAGACAACAAGGTGCTCAAGAATTTTATCAAAAAGAAGGTATTTATTTTAA
GTCAATATTTACTGTCTCAGAATTACAAGAAAATCTCAAAAATATTAATGATAAAAATGACGACTAA

Upstream 100 bases:

>100_bases
ACAAGTCGAGGTTGTCCTCATATATTGACTTGGAACAGCCATTTATATCCTAATTAAAGGCTTAGTGGCCAACAGGTTAT
ACTTAAATGTTGCACTTGAT

Downstream 100 bases:

>100_bases
AGCAGATTTGAAAAACTCATAATGCTAGTTTTTATGAGAGAAAATTAGTTGAGTTATGATAATTGATTGCTTATTTATTT
TACATTTTTATTGAGAGAAA

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MTNQIKSLNSSSLATTDITTIRQQLLDLLSTLAYREGDFILSSGQSSSYYINGKYVTLHPLGALIIGRLILSMLPEDTQG
VAGLTLGADPIVTAVSVVSAYENRPIPALIIRKQAKGHGTMSYIEGPRLDDNAKVVVLEDVVTTGASAMMAVHRLREAGY
QVNHIFSLVDRQQGAQEFYQKEGIYFKSIFTVSELQENLKNINDKNDD

Sequences:

>Translated_208_residues
MTNQIKSLNSSSLATTDITTIRQQLLDLLSTLAYREGDFILSSGQSSSYYINGKYVTLHPLGALIIGRLILSMLPEDTQG
VAGLTLGADPIVTAVSVVSAYENRPIPALIIRKQAKGHGTMSYIEGPRLDDNAKVVVLEDVVTTGASAMMAVHRLREAGY
QVNHIFSLVDRQQGAQEFYQKEGIYFKSIFTVSELQENLKNINDKNDD
>Mature_207_residues
TNQIKSLNSSSLATTDITTIRQQLLDLLSTLAYREGDFILSSGQSSSYYINGKYVTLHPLGALIIGRLILSMLPEDTQGV
AGLTLGADPIVTAVSVVSAYENRPIPALIIRKQAKGHGTMSYIEGPRLDDNAKVVVLEDVVTTGASAMMAVHRLREAGYQ
VNHIFSLVDRQQGAQEFYQKEGIYFKSIFTVSELQENLKNINDKNDD

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Homo sapiens, GI4507835, Length=179, Percent_Identity=31.2849162011173, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17554964, Length=173, Percent_Identity=32.3699421965318, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17508631, Length=181, Percent_Identity=28.7292817679558, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI17933654, Length=182, Percent_Identity=29.6703296703297, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 22838; Mature: 22707

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNQIKSLNSSSLATTDITTIRQQLLDLLSTLAYREGDFILSSGQSSSYYINGKYVTLHP
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEECEEEEECH
LGALIIGRLILSMLPEDTQGVAGLTLGADPIVTAVSVVSAYENRPIPALIIRKQAKGHGT
HHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCC
MSYIEGPRLDDNAKVVVLEDVVTTGASAMMAVHRLREAGYQVNHIFSLVDRQQGAQEFYQ
HHHCCCCCCCCCCCEEEEHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
KEGIYFKSIFTVSELQENLKNINDKNDD
HCCCCHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TNQIKSLNSSSLATTDITTIRQQLLDLLSTLAYREGDFILSSGQSSSYYINGKYVTLHP
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEECEEEEECH
LGALIIGRLILSMLPEDTQGVAGLTLGADPIVTAVSVVSAYENRPIPALIIRKQAKGHGT
HHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCC
MSYIEGPRLDDNAKVVVLEDVVTTGASAMMAVHRLREAGYQVNHIFSLVDRQQGAQEFYQ
HHHCCCCCCCCCCCEEEEHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
KEGIYFKSIFTVSELQENLKNINDKNDD
HCCCCHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]