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The map label for this gene is lktA [H]

Identifier: 113475953

GI number: 113475953

Start: 3591690

End: 3592478

Strand: Direct

Name: lktA [H]

Synonym: Tery_2318

Alternate gene names: 113475953

Gene position: 3591690-3592478 (Clockwise)

Preceding gene: 113475949

Following gene: 113475954

Centisome position: 46.34

GC content: 38.53

Gene sequence:

>789_bases
ATGGTGACTGCAACAGAAGAAGGTATTTTTATTGGTACTACAGTTGATCTTTTTAGGCCACTTCTGAATAATACTAAAGG
TAATACTAGTGAAGGTTCTGGGGGTTCGTTCAAACTCCTAACAGATGAAGATGATGAGACCATTGGTTCAGCAGGATCAG
ATTCAATTAGCGGACTTAAGGGTAGAGACTCTATAGACGGCAGAGGTGGAAGAGATATAATTTATGGCAACGAGGGTAGT
GATACACTTTTGGGAAGAAGCGGCGATGATTCCCTATTTGGTAATCAAGGAAAGGATTCTTTGTTAGGGAATGAGGACCA
AGATATATTGTGGGGTGGTAAAGATAATGACTTTTTAGATGGAGATGATGATCAAGACACACTTTATGGAAATAGGGGGA
ATGATACTCTTTTTGGCAGTTTAGATGATGATTGTTTATACGGTGGTAAAGGTGATGACTGCTTAGTTGGAAGCGAAGGT
AATGACACTCTAGCAGGCGATCGCGACTCTGACACTTTAATAGGAGGTATTGGAAAAGATTTATTCATTATTTCTAAAAG
TACAGGTGGCCTGAGTGAATCAGAAGCAGATATTATTAATGATTATAATACTGATCAACGTGATAGAATTGGATTAATTG
ATAGTTTGAGACGTAGTGACCTGGATTTTTTGGACACAATAGTTGGTGAAAGAAATGGAACAGTTATTCGGTTGAGGAAT
GACCCAGAAGATTTTCTGGCAATAGTTATTGGAGTCGATGAAGAGGACCTTGACTTCATAACTATCTGA

Upstream 100 bases:

>100_bases
ATTGAAATTAATCAGACTTAACATCCACTAATAAAAAAATATAATGAAAAATATGTAAATACTAATTTCATTGGACAAAA
AAGTTATTTAGAAAAGCTTT

Downstream 100 bases:

>100_bases
GACAACATGATCACAAAAGATTAAGTTTGAAATAACAATATAATGCAAGGATTTCTCAATCTTAACAAACCATCGGGCAT
GACTTCCCATGACTGTGTAG

Product: hypothetical protein

Products: NA

Alternate protein names: Lkt [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MVTATEEGIFIGTTVDLFRPLLNNTKGNTSEGSGGSFKLLTDEDDETIGSAGSDSISGLKGRDSIDGRGGRDIIYGNEGS
DTLLGRSGDDSLFGNQGKDSLLGNEDQDILWGGKDNDFLDGDDDQDTLYGNRGNDTLFGSLDDDCLYGGKGDDCLVGSEG
NDTLAGDRDSDTLIGGIGKDLFIISKSTGGLSESEADIINDYNTDQRDRIGLIDSLRRSDLDFLDTIVGERNGTVIRLRN
DPEDFLAIVIGVDEEDLDFITI

Sequences:

>Translated_262_residues
MVTATEEGIFIGTTVDLFRPLLNNTKGNTSEGSGGSFKLLTDEDDETIGSAGSDSISGLKGRDSIDGRGGRDIIYGNEGS
DTLLGRSGDDSLFGNQGKDSLLGNEDQDILWGGKDNDFLDGDDDQDTLYGNRGNDTLFGSLDDDCLYGGKGDDCLVGSEG
NDTLAGDRDSDTLIGGIGKDLFIISKSTGGLSESEADIINDYNTDQRDRIGLIDSLRRSDLDFLDTIVGERNGTVIRLRN
DPEDFLAIVIGVDEEDLDFITI
>Mature_262_residues
MVTATEEGIFIGTTVDLFRPLLNNTKGNTSEGSGGSFKLLTDEDDETIGSAGSDSISGLKGRDSIDGRGGRDIIYGNEGS
DTLLGRSGDDSLFGNQGKDSLLGNEDQDILWGGKDNDFLDGDDDQDTLYGNRGNDTLFGSLDDDCLYGGKGDDCLVGSEG
NDTLAGDRDSDTLIGGIGKDLFIISKSTGGLSESEADIINDYNTDQRDRIGLIDSLRRSDLDFLDTIVGERNGTVIRLRN
DPEDFLAIVIGVDEEDLDFITI

Specific function: One of the virulence factors of A.actinomycetemcomitans might be a cytotoxin, possibly the membrane-bound hemolysin [H]

COG id: COG2931

COG function: function code Q; RTX toxins and related Ca2+-binding proteins

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein. Secreted (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: NA

Molecular weight: Translated: 27977; Mature: 27977

Theoretical pI: Translated: 3.73; Mature: 3.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTATEEGIFIGTTVDLFRPLLNNTKGNTSEGSGGSFKLLTDEDDETIGSAGSDSISGLK
CCCCCCCCEEEECHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
GRDSIDGRGGRDIIYGNEGSDTLLGRSGDDSLFGNQGKDSLLGNEDQDILWGGKDNDFLD
CCCCCCCCCCCEEEECCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCC
GDDDQDTLYGNRGNDTLFGSLDDDCLYGGKGDDCLVGSEGNDTLAGDRDSDTLIGGIGKD
CCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCEEEECCCCCCCCCCCCCCCEEECCCCE
LFIISKSTGGLSESEADIINDYNTDQRDRIGLIDSLRRSDLDFLDTIVGERNGTVIRLRN
EEEEECCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEECC
DPEDFLAIVIGVDEEDLDFITI
CCCCEEEEEEECCCCCCCEEEC
>Mature Secondary Structure
MVTATEEGIFIGTTVDLFRPLLNNTKGNTSEGSGGSFKLLTDEDDETIGSAGSDSISGLK
CCCCCCCCEEEECHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
GRDSIDGRGGRDIIYGNEGSDTLLGRSGDDSLFGNQGKDSLLGNEDQDILWGGKDNDFLD
CCCCCCCCCCCEEEECCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCC
GDDDQDTLYGNRGNDTLFGSLDDDCLYGGKGDDCLVGSEGNDTLAGDRDSDTLIGGIGKD
CCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCEEEECCCCCCCCCCCCCCCEEECCCCE
LFIISKSTGGLSESEADIINDYNTDQRDRIGLIDSLRRSDLDFLDTIVGERNGTVIRLRN
EEEEECCCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEECC
DPEDFLAIVIGVDEEDLDFITI
CCCCEEEEEEECCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2670940 [H]