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The map label for this gene is recQ [H]

Identifier: 113475263

GI number: 113475263

Start: 2402846

End: 2404927

Strand: Reverse

Name: recQ [H]

Synonym: Tery_1571

Alternate gene names: 113475263

Gene position: 2404927-2402846 (Counterclockwise)

Preceding gene: 113475266

Following gene: 113475262

Centisome position: 31.03

GC content: 33.96

Gene sequence:

>2082_bases
ATGATTCAAAAAGAAGCATTATCATTACTAAGGCGGGCTTTAAATAATTCCACAGCTGAATTTCGTGATGGTCAATGGGA
GGCTATTGCAGCTATTACGGAACATCAAAGCCGTCTTTTAGTTGTGCAACGTACTGGTTGGGGTAAAAGTTTTGTCTATT
TTTTAGCTACTCGTTTACTTAGGGATAAAGGTAAGGGTATTACTCTATTAATTTCCCCACTTTTAGCATTAATGCGAAAT
CAAATTGCTGCTGCCGAACGAATTGGAATTAGGGCTCAAACAATTAATTCTAGTAACAAGGAAGAATGGGAAAAAGTAGA
AAATAATTTAATGGTAGGAAAAGTAGATATTTTATTAATTTCTCCTGAAAGATTAGCTAATGAAAACTTCCGAGAAAATA
TTTTAATTTATATAGCTAAAAATATCGGCTTATTTGTAGTTGATGAAGCTCACTGTATTTCTGATTGGGGACATGATTTT
CGTCCTAATTATCGAAGAATTGCGAGAATTTTACAAGCCTTACCAAAAAATATTCCTGTGCTTGCTACTACTGCTACTGC
TAATAATCGAGTTGTGGATGATATTACTGTTCAACTAGGTGCAAATCTGAAAATATTTAGGGGTTTATTAACTAGAGATA
GCCTCCAATTACAAAATATTTATTTGCCATCTTATTGTGATCGTTTAGGATGGTTAGCAGAACATTTACCTAATATTCCT
GGCAGTGGAATTATTTACACTTTAACTGTGAGAGATACGGAAATAGTTGCTAATTGGTTGAAGTCTCAAGGAATAAATGT
AGCAGCTTATCATAGTAAGAAAAATACGGAAGAGAAAGAAGAATTAGAACAGCAATTATTGAATAATGAAATTAAAGCAT
TAATAGCAACTGTAGCTCTAGGAATGGGTTTTGATAAACCAGATTTAGGATTTGTTATTCATTATCAACGTCCTGGATCT
GTAGTACATTACTATCAACAAGTAGGTCGTGCTGGTAGGGCAGTAGAAAATGCCTATGGTATTCTTCTAAGTGGTGAAGA
AGATAAAGAAATTACTAATTATTTTATTAAAACTGCTTTTCCTCCAGAAGCTCATAATCAGGCAATTTTGGATGCATTAA
ATCAAGCTGAAGATGGTCTTTCTGTTCCAATGTTAGAGGAAAAGTTGAATCTTACTAATGGGCAAATAAATAAAGTTTTG
AAGTTATTATCTATCGAAACTCCATCCCCAATAAAAAAAATACAGTCAAAGTATTATGCTACCCCAATTAATTATCAAAC
GGACACAGAAAAAATAGCAAGATTGAATGAAATACGCCATCAAGAACAGGATCGAATGTTGGATTATATGCACAGTCAAG
AATGTTTAATGCAATTTCTGAGAAAAGAATTAGATGACCCAAATCCTAGCCCTTGTGGTAAATGTGCTATTTGCTTAGGA
AAACCACTTTTACCGGGGAATGTTTCCTCAAAGTTTGTGACAGAAGCTGTACAATTTTTACGAACTAGGGAACAAATTAT
TGAGACGAGGAAAGTCTGGCGGAAGAATGCTTTATTAACTTATAATTTAACAGGCAAAATATCTAAAGATTTACAAGCAG
AAATTGGGCGATCGCTTTCTATTTGGAATGATGCTGGTTGGGGCCAATTTGTTGAAAAAGGTAAGTATAAAGATAATCAT
TTTGAGGATAGCTTAGTTCAAGCTACATACGATATGATTCAACGTTGGCAGCCTCAACCTTTTCCCACTTGGGTTACTTG
TATTCCCTCTTTAACACATCCGGAACTTGTTCCTAATTTTGCTCAACGTCTTGCTAAAAAATTAGGTTTACCCTTTGTTC
CATGTATTATAAAAATTCGTCAGACTTCACTACAAAAAGACATGACTAATAGTTACCAACAAGCTCATAATTTAGATGGT
GCTTTTAAAGTTTATAATTGGGAGGGAATTAGGGGAAATGTATTTTTAGTAGACGATATTGTAGACTCAAGATGGACTTT
TACTGTTGTTGCGGCGCTTTTACGAAATGCTGGTTCTGGTAAAGTTTTTCCATTGGCTTTAGCAATAAATAGATTTAAAT
AA

Upstream 100 bases:

>100_bases
CAATCACGGGTCGTATTTAAGAGTTACTAAAGTATTTTAGCAAGGTTTTTCCCAAATTTACTCAACTTTTAAAAGCTGGG
TGTTTAATATAAAAATTAAT

Downstream 100 bases:

>100_bases
GGAACAAAGAAGACTGAGGTTGGGAGGTAAGCATTTAGCTTTTAGGTATTAGTTATTAGCTAGAATGAGGAGTTATTCTC
CCAGAAGAATTAAAAGTTTG

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 693; Mature: 693

Protein sequence:

>693_residues
MIQKEALSLLRRALNNSTAEFRDGQWEAIAAITEHQSRLLVVQRTGWGKSFVYFLATRLLRDKGKGITLLISPLLALMRN
QIAAAERIGIRAQTINSSNKEEWEKVENNLMVGKVDILLISPERLANENFRENILIYIAKNIGLFVVDEAHCISDWGHDF
RPNYRRIARILQALPKNIPVLATTATANNRVVDDITVQLGANLKIFRGLLTRDSLQLQNIYLPSYCDRLGWLAEHLPNIP
GSGIIYTLTVRDTEIVANWLKSQGINVAAYHSKKNTEEKEELEQQLLNNEIKALIATVALGMGFDKPDLGFVIHYQRPGS
VVHYYQQVGRAGRAVENAYGILLSGEEDKEITNYFIKTAFPPEAHNQAILDALNQAEDGLSVPMLEEKLNLTNGQINKVL
KLLSIETPSPIKKIQSKYYATPINYQTDTEKIARLNEIRHQEQDRMLDYMHSQECLMQFLRKELDDPNPSPCGKCAICLG
KPLLPGNVSSKFVTEAVQFLRTREQIIETRKVWRKNALLTYNLTGKISKDLQAEIGRSLSIWNDAGWGQFVEKGKYKDNH
FEDSLVQATYDMIQRWQPQPFPTWVTCIPSLTHPELVPNFAQRLAKKLGLPFVPCIIKIRQTSLQKDMTNSYQQAHNLDG
AFKVYNWEGIRGNVFLVDDIVDSRWTFTVVAALLRNAGSGKVFPLALAINRFK

Sequences:

>Translated_693_residues
MIQKEALSLLRRALNNSTAEFRDGQWEAIAAITEHQSRLLVVQRTGWGKSFVYFLATRLLRDKGKGITLLISPLLALMRN
QIAAAERIGIRAQTINSSNKEEWEKVENNLMVGKVDILLISPERLANENFRENILIYIAKNIGLFVVDEAHCISDWGHDF
RPNYRRIARILQALPKNIPVLATTATANNRVVDDITVQLGANLKIFRGLLTRDSLQLQNIYLPSYCDRLGWLAEHLPNIP
GSGIIYTLTVRDTEIVANWLKSQGINVAAYHSKKNTEEKEELEQQLLNNEIKALIATVALGMGFDKPDLGFVIHYQRPGS
VVHYYQQVGRAGRAVENAYGILLSGEEDKEITNYFIKTAFPPEAHNQAILDALNQAEDGLSVPMLEEKLNLTNGQINKVL
KLLSIETPSPIKKIQSKYYATPINYQTDTEKIARLNEIRHQEQDRMLDYMHSQECLMQFLRKELDDPNPSPCGKCAICLG
KPLLPGNVSSKFVTEAVQFLRTREQIIETRKVWRKNALLTYNLTGKISKDLQAEIGRSLSIWNDAGWGQFVEKGKYKDNH
FEDSLVQATYDMIQRWQPQPFPTWVTCIPSLTHPELVPNFAQRLAKKLGLPFVPCIIKIRQTSLQKDMTNSYQQAHNLDG
AFKVYNWEGIRGNVFLVDDIVDSRWTFTVVAALLRNAGSGKVFPLALAINRFK
>Mature_693_residues
MIQKEALSLLRRALNNSTAEFRDGQWEAIAAITEHQSRLLVVQRTGWGKSFVYFLATRLLRDKGKGITLLISPLLALMRN
QIAAAERIGIRAQTINSSNKEEWEKVENNLMVGKVDILLISPERLANENFRENILIYIAKNIGLFVVDEAHCISDWGHDF
RPNYRRIARILQALPKNIPVLATTATANNRVVDDITVQLGANLKIFRGLLTRDSLQLQNIYLPSYCDRLGWLAEHLPNIP
GSGIIYTLTVRDTEIVANWLKSQGINVAAYHSKKNTEEKEELEQQLLNNEIKALIATVALGMGFDKPDLGFVIHYQRPGS
VVHYYQQVGRAGRAVENAYGILLSGEEDKEITNYFIKTAFPPEAHNQAILDALNQAEDGLSVPMLEEKLNLTNGQINKVL
KLLSIETPSPIKKIQSKYYATPINYQTDTEKIARLNEIRHQEQDRMLDYMHSQECLMQFLRKELDDPNPSPCGKCAICLG
KPLLPGNVSSKFVTEAVQFLRTREQIIETRKVWRKNALLTYNLTGKISKDLQAEIGRSLSIWNDAGWGQFVEKGKYKDNH
FEDSLVQATYDMIQRWQPQPFPTWVTCIPSLTHPELVPNFAQRLAKKLGLPFVPCIIKIRQTSLQKDMTNSYQQAHNLDG
AFKVYNWEGIRGNVFLVDDIVDSRWTFTVVAALLRNAGSGKVFPLALAINRFK

Specific function: Probable DNA helicase. Required for DNA repair and intramolecular recombination; probably has overlapping function with recS (AC P50729). It probably acts to help generate ss-DNA from ds-DNA breaks [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm, nucleoid. Note=Localized throughout the nucleoid in the presence or absence of DNA double- strand breaks [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=338, Percent_Identity=36.6863905325444, Blast_Score=190, Evalue=5e-48,
Organism=Homo sapiens, GI14591902, Length=340, Percent_Identity=35.2941176470588, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI14591904, Length=340, Percent_Identity=35.2941176470588, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI148612816, Length=350, Percent_Identity=30.8571428571429, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI51242943, Length=350, Percent_Identity=30.8571428571429, Blast_Score=167, Evalue=5e-41,
Organism=Homo sapiens, GI51242947, Length=350, Percent_Identity=30.8571428571429, Blast_Score=166, Evalue=8e-41,
Organism=Homo sapiens, GI169218196, Length=341, Percent_Identity=31.3782991202346, Blast_Score=159, Evalue=9e-39,
Organism=Homo sapiens, GI110735439, Length=341, Percent_Identity=31.3782991202346, Blast_Score=159, Evalue=1e-38,
Organism=Homo sapiens, GI284005309, Length=365, Percent_Identity=30.1369863013699, Blast_Score=145, Evalue=1e-34,
Organism=Escherichia coli, GI48994977, Length=316, Percent_Identity=35.4430379746835, Blast_Score=187, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI32564293, Length=326, Percent_Identity=34.9693251533742, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI71987993, Length=348, Percent_Identity=34.7701149425287, Blast_Score=182, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI71987997, Length=348, Percent_Identity=34.7701149425287, Blast_Score=182, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17552866, Length=365, Percent_Identity=32.0547945205479, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI25145561, Length=340, Percent_Identity=32.9411764705882, Blast_Score=176, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6323844, Length=334, Percent_Identity=33.5329341317365, Blast_Score=177, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24646066, Length=333, Percent_Identity=33.9339339339339, Blast_Score=176, Evalue=7e-44,
Organism=Drosophila melanogaster, GI24664230, Length=324, Percent_Identity=33.641975308642, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI62472181, Length=324, Percent_Identity=33.641975308642, Blast_Score=161, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24664226, Length=324, Percent_Identity=33.3333333333333, Blast_Score=159, Evalue=5e-39,
Organism=Drosophila melanogaster, GI21358123, Length=343, Percent_Identity=32.3615160349854, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 78650; Mature: 78650

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: PS00690 DEAH_ATP_HELICASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQKEALSLLRRALNNSTAEFRDGQWEAIAAITEHQSRLLVVQRTGWGKSFVYFLATRLL
CCCHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHH
RDKGKGITLLISPLLALMRNQIAAAERIGIRAQTINSSNKEEWEKVENNLMVGKVDILLI
HHCCCCEEHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHCCEEEEEEEEEEE
SPERLANENFRENILIYIAKNIGLFVVDEAHCISDWGHDFRPNYRRIARILQALPKNIPV
CCHHHCCCCCCCCEEEEEECCCCEEEEECHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCE
LATTATANNRVVDDITVQLGANLKIFRGLLTRDSLQLQNIYLPSYCDRLGWLAEHLPNIP
EEEECCCCCCEEEEEEEEECCCHHHHHHHHHCCCHHHHEEECHHHHHHHHHHHHHCCCCC
GSGIIYTLTVRDTEIVANWLKSQGINVAAYHSKKNTEEKEELEQQLLNNEIKALIATVAL
CCCEEEEEEECHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GMGFDKPDLGFVIHYQRPGSVVHYYQQVGRAGRAVENAYGILLSGEEDKEITNYFIKTAF
HCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHCCC
PPEAHNQAILDALNQAEDGLSVPMLEEKLNLTNGQINKVLKLLSIETPSPIKKIQSKYYA
CCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCC
TPINYQTDTEKIARLNEIRHQEQDRMLDYMHSQECLMQFLRKELDDPNPSPCGKCAICLG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHC
KPLLPGNVSSKFVTEAVQFLRTREQIIETRKVWRKNALLTYNLTGKISKDLQAEIGRSLS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHCCCEE
IWNDAGWGQFVEKGKYKDNHFEDSLVQATYDMIQRWQPQPFPTWVTCIPSLTHPELVPNF
ECCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHH
AQRLAKKLGLPFVPCIIKIRQTSLQKDMTNSYQQAHNLDGAFKVYNWEGIRGNVFLVDDI
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEECC
VDSRWTFTVVAALLRNAGSGKVFPLALAINRFK
CCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCC
>Mature Secondary Structure
MIQKEALSLLRRALNNSTAEFRDGQWEAIAAITEHQSRLLVVQRTGWGKSFVYFLATRLL
CCCHHHHHHHHHHHCCCCCHHCCCCHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHH
RDKGKGITLLISPLLALMRNQIAAAERIGIRAQTINSSNKEEWEKVENNLMVGKVDILLI
HHCCCCEEHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHCCEEEEEEEEEEE
SPERLANENFRENILIYIAKNIGLFVVDEAHCISDWGHDFRPNYRRIARILQALPKNIPV
CCHHHCCCCCCCCEEEEEECCCCEEEEECHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCE
LATTATANNRVVDDITVQLGANLKIFRGLLTRDSLQLQNIYLPSYCDRLGWLAEHLPNIP
EEEECCCCCCEEEEEEEEECCCHHHHHHHHHCCCHHHHEEECHHHHHHHHHHHHHCCCCC
GSGIIYTLTVRDTEIVANWLKSQGINVAAYHSKKNTEEKEELEQQLLNNEIKALIATVAL
CCCEEEEEEECHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GMGFDKPDLGFVIHYQRPGSVVHYYQQVGRAGRAVENAYGILLSGEEDKEITNYFIKTAF
HCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHCCC
PPEAHNQAILDALNQAEDGLSVPMLEEKLNLTNGQINKVLKLLSIETPSPIKKIQSKYYA
CCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCC
TPINYQTDTEKIARLNEIRHQEQDRMLDYMHSQECLMQFLRKELDDPNPSPCGKCAICLG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHC
KPLLPGNVSSKFVTEAVQFLRTREQIIETRKVWRKNALLTYNLTGKISKDLQAEIGRSLS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHCCCEE
IWNDAGWGQFVEKGKYKDNHFEDSLVQATYDMIQRWQPQPFPTWVTCIPSLTHPELVPNF
ECCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHHH
AQRLAKKLGLPFVPCIIKIRQTSLQKDMTNSYQQAHNLDGAFKVYNWEGIRGNVFLVDDI
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEEECC
VDSRWTFTVVAALLRNAGSGKVFPLALAINRFK
CCCCHHHHHHHHHHHCCCCCCEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9642195 [H]