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The map label for this gene is strD [H]

Identifier: 113475230

GI number: 113475230

Start: 2333973

End: 2335067

Strand: Direct

Name: strD [H]

Synonym: Tery_1537

Alternate gene names: 113475230

Gene position: 2333973-2335067 (Clockwise)

Preceding gene: 113475228

Following gene: 113475231

Centisome position: 30.12

GC content: 31.78

Gene sequence:

>1095_bases
ATGAAAGCATTAATTCTCTCTGGTGGAAAAGGAACAAGATTACGTCCTCTTACTTATACAGGAACAAAACAATTAGTACC
AGTTGCTAATAAGCCTATTTTGTGGTACGGAATTGAGGGTATTATTGCAGCAGGTGTTACTGACATAGGAATTATTATTA
GTCCAGAAACGGGAGAAGAAGTACAAGAATTAACAGGAAACGGGGAAAAATTTGGAGGAAATATTACTTATATTCTCCAA
GATAAACCTGCTGGTTTAGCTCATGCTGTTAAAACTGCTCAACCATTTTTGGGAGATTCTCCTTTTATTATGTATCTCGG
AGATAATATTATTGAAAGTCAGTTAGGGAATTTTTTAGATACTTTTAAAAAGAAGCAACTAGATGCTTTGATTTTGCTAC
GTAAAGTTCCTAATCCTACTGCTTTTGGTGTGGCAAAAATAGATGATAATGGACGAGTATTAAGATTAGTTGAAAAGCCC
AAAGTTCCACCATCAGATTTAGCACTTGTAGGTGTATATTTATTTTCTAAAAAAATACATAATGCTATTGCTAATATTAA
ACCTTCAGAGAGAGGAGAATTAGAAATTACAGATGCTATTCAATATTTAATTGACCAACAAATTTCAGGTGAAGAACCTG
AAATTTCTGTAGAAGCAAGCATCTTAGAAGGTTGGTGGTTAGATACCGGTAAAAAAGATGATTTACTTAGTGCTAATCAA
ATTATTTTAGATACTCGTATAATTAAGTCAATAAATGGAGAAATAGATTCTAAAAGTAAAATTATAGGAAGGGTAAAAAT
GGGTAAAAATACAAAACTAATCAATAGTAGTGTTCGTGGTCCTGTAATTATAGGTGATAACTGTTACCTAGAAAATTGTT
TTATCGGTCCTTATAGTAGTATTGCTGATAATGTGACTTTAATTGATGTTGATATAGAACATAGTGTTATATTACAAGGA
GCAAAAATTATTGAAATTAATCAACGTATTGTTGATAGTTTACTCGGTCGTCGTGCTCAATTAATTAATGCTCCACAACA
TCCTAAAGCATTACGGTTTATGATTGGAGATGATAGTCAAATAGAATTAACATAG

Upstream 100 bases:

>100_bases
AAGTTACAATTGATTGTTAGTAAACCTTATGTTAAGCTGAAAAAAAAATAGCCCTAAAAAACATAAAATACTGCAAAAAT
CTCTAATCGAAAATATTAAT

Downstream 100 bases:

>100_bases
ATTATACTTTATAGCGCTTTTTATTTTGTTAAAAACTTTGTTTATGGGGAAGAGCTGTCTGCGGTAAAGGTTTGTAGAAC
ATGACTTATCAAAACAAACT

Product: glucose-1-phosphate thymidyltransferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 364; Mature: 364

Protein sequence:

>364_residues
MKALILSGGKGTRLRPLTYTGTKQLVPVANKPILWYGIEGIIAAGVTDIGIIISPETGEEVQELTGNGEKFGGNITYILQ
DKPAGLAHAVKTAQPFLGDSPFIMYLGDNIIESQLGNFLDTFKKKQLDALILLRKVPNPTAFGVAKIDDNGRVLRLVEKP
KVPPSDLALVGVYLFSKKIHNAIANIKPSERGELEITDAIQYLIDQQISGEEPEISVEASILEGWWLDTGKKDDLLSANQ
IILDTRIIKSINGEIDSKSKIIGRVKMGKNTKLINSSVRGPVIIGDNCYLENCFIGPYSSIADNVTLIDVDIEHSVILQG
AKIIEINQRIVDSLLGRRAQLINAPQHPKALRFMIGDDSQIELT

Sequences:

>Translated_364_residues
MKALILSGGKGTRLRPLTYTGTKQLVPVANKPILWYGIEGIIAAGVTDIGIIISPETGEEVQELTGNGEKFGGNITYILQ
DKPAGLAHAVKTAQPFLGDSPFIMYLGDNIIESQLGNFLDTFKKKQLDALILLRKVPNPTAFGVAKIDDNGRVLRLVEKP
KVPPSDLALVGVYLFSKKIHNAIANIKPSERGELEITDAIQYLIDQQISGEEPEISVEASILEGWWLDTGKKDDLLSANQ
IILDTRIIKSINGEIDSKSKIIGRVKMGKNTKLINSSVRGPVIIGDNCYLENCFIGPYSSIADNVTLIDVDIEHSVILQG
AKIIEINQRIVDSLLGRRAQLINAPQHPKALRFMIGDDSQIELT
>Mature_364_residues
MKALILSGGKGTRLRPLTYTGTKQLVPVANKPILWYGIEGIIAAGVTDIGIIISPETGEEVQELTGNGEKFGGNITYILQ
DKPAGLAHAVKTAQPFLGDSPFIMYLGDNIIESQLGNFLDTFKKKQLDALILLRKVPNPTAFGVAKIDDNGRVLRLVEKP
KVPPSDLALVGVYLFSKKIHNAIANIKPSERGELEITDAIQYLIDQQISGEEPEISVEASILEGWWLDTGKKDDLLSANQ
IILDTRIIKSINGEIDSKSKIIGRVKMGKNTKLINSSVRGPVIIGDNCYLENCFIGPYSSIADNVTLIDVDIEHSVILQG
AKIIEINQRIVDSLLGRRAQLINAPQHPKALRFMIGDDSQIELT

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=327, Percent_Identity=29.9694189602446, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI11761619, Length=327, Percent_Identity=29.9694189602446, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI31881779, Length=383, Percent_Identity=24.8041775456919, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI45447090, Length=383, Percent_Identity=24.8041775456919, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1790224, Length=243, Percent_Identity=38.2716049382716, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1788351, Length=243, Percent_Identity=37.037037037037, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1787488, Length=277, Percent_Identity=30.3249097472924, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1788355, Length=277, Percent_Identity=25.9927797833935, Blast_Score=89, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI133931050, Length=345, Percent_Identity=31.0144927536232, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6320148, Length=327, Percent_Identity=29.0519877675841, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21355443, Length=347, Percent_Identity=27.3775216138329, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24644084, Length=347, Percent_Identity=27.3775216138329, Blast_Score=113, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 39769; Mature: 39769

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALILSGGKGTRLRPLTYTGTKQLVPVANKPILWYGIEGIIAAGVTDIGIIISPETGEE
CCEEEEECCCCCEEEEEEECCCCEEEECCCCCEEEEEHHHHHHCCCCEEEEEECCCCCHH
VQELTGNGEKFGGNITYILQDKPAGLAHAVKTAQPFLGDSPFIMYLGDNIIESQLGNFLD
HHHHCCCCCEECCEEEEEEECCCCCHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHH
TFKKKQLDALILLRKVPNPTAFGVAKIDDNGRVLRLVEKPKVPPSDLALVGVYLFSKKIH
HHHHHHHHHEEEEECCCCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
NAIANIKPSERGELEITDAIQYLIDQQISGEEPEISVEASILEGWWLDTGKKDDLLSANQ
HHHHCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCE
IILDTRIIKSINGEIDSKSKIIGRVKMGKNTKLINSSVRGPVIIGDNCYLENCFIGPYSS
EEEHHHHHHHHCCCCCCCCCEEEEEEECCCCEEECCCCCCCEEECCCEEEEEEECCCCHH
IADNVTLIDVDIEHSVILQGAKIIEINQRIVDSLLGRRAQLINAPQHPKALRFMIGDDSQ
HHCCEEEEEEECCCEEEECCCEEEEHHHHHHHHHHCCHHHHCCCCCCCCEEEEEECCCCE
IELT
EEEC
>Mature Secondary Structure
MKALILSGGKGTRLRPLTYTGTKQLVPVANKPILWYGIEGIIAAGVTDIGIIISPETGEE
CCEEEEECCCCCEEEEEEECCCCEEEECCCCCEEEEEHHHHHHCCCCEEEEEECCCCCHH
VQELTGNGEKFGGNITYILQDKPAGLAHAVKTAQPFLGDSPFIMYLGDNIIESQLGNFLD
HHHHCCCCCEECCEEEEEEECCCCCHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHH
TFKKKQLDALILLRKVPNPTAFGVAKIDDNGRVLRLVEKPKVPPSDLALVGVYLFSKKIH
HHHHHHHHHEEEEECCCCCCEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
NAIANIKPSERGELEITDAIQYLIDQQISGEEPEISVEASILEGWWLDTGKKDDLLSANQ
HHHHCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCE
IILDTRIIKSINGEIDSKSKIIGRVKMGKNTKLINSSVRGPVIIGDNCYLENCFIGPYSS
EEEHHHHHHHHCCCCCCCCCEEEEEEECCCCEEECCCCCCCEEECCCEEEEEEECCCCHH
IADNVTLIDVDIEHSVILQGAKIIEINQRIVDSLLGRRAQLINAPQHPKALRFMIGDDSQ
HHCCEEEEEEECCCEEEECCCEEEEHHHHHHHHHHCCHHHHCCCCCCCCEEEEEECCCCE
IELT
EEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]