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The map label for this gene is thiED [H]

Identifier: 113474634

GI number: 113474634

Start: 1281381

End: 1282022

Strand: Direct

Name: thiED [H]

Synonym: Tery_0805

Alternate gene names: 113474634

Gene position: 1281381-1282022 (Clockwise)

Preceding gene: 113474632

Following gene: 113474637

Centisome position: 16.53

GC content: 40.34

Gene sequence:

>642_bases
ATGATCTCAAAAAATCTTTGGAAAAGTAATCAGGACTTAGCAACAGCTTGTTTGTGTCATCCTTTTGTACAAGGAATTGC
TAATGGTACACTACCGCAGAAAAGTTTTGCCTATTATGTAGGACAAGATGCCTTTTTCCTGAAAGCATTTGCCCGTGCTT
ACAGCATTGCTGCTGCTAAGTCTGACGAATGGAAAACATTTGAACTATTTCATACCCTTGCTGGTGGGGTGAAAGAAGAA
TTAGAATTGCATCAAACCTATGCTGCTAAATGGGGAGTAAATTTAGAAAATATTACCCCAGGGTTTGCCACACGGCGTTA
CACAGATTTTTTATTAGCAACGGCTTGGGGTAATAATATTGGGGCGATCGCTACAGCCATGACTCCTTGTATGCGGCTCT
ATGCTTTTTTGGGGCAACAGTTAGCCACACCAAAAATTCCAGAACACCAATATTCTCAATGGATCCGTACTTACAGCACT
CAGGAATTTTTACAGTTAGTGCAAAACCTAGAGAAAGTTACAGACCGCTACGCAGAGAATATTCAAGAAACAGAATCAAT
TTATTGTTATGCCATGGTCTGCGAACGAGATTTCTTTCAAGCAGCTTGGGAAATGGGAAAAGGAGCATACCGTATTCATT
AA

Upstream 100 bases:

>100_bases
TTAAATAAACTACTTTGGTTTGTAAGTGAGATGCTCAGACTATTAATTAATTTTCATCAAAGATATACTCATCCTCTCAT
ATACTCCATTAAAAAAAACT

Downstream 100 bases:

>100_bases
CCTTTCTTATCTATCAAAAAAATTAGCCCTCACCAAAACTTGAATGGAGTTTTCAAAATTAAAAACCCGTTCTGATGACA
ACAGAGACTGCAAAACAAAT

Product: TenA family transcription regulator

Products: NA

Alternate protein names: Thiamine-phosphate pyrophosphorylase; TMP pyrophosphorylase; TMP-PPase; Thiamine-phosphate synthase; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MISKNLWKSNQDLATACLCHPFVQGIANGTLPQKSFAYYVGQDAFFLKAFARAYSIAAAKSDEWKTFELFHTLAGGVKEE
LELHQTYAAKWGVNLENITPGFATRRYTDFLLATAWGNNIGAIATAMTPCMRLYAFLGQQLATPKIPEHQYSQWIRTYST
QEFLQLVQNLEKVTDRYAENIQETESIYCYAMVCERDFFQAAWEMGKGAYRIH

Sequences:

>Translated_213_residues
MISKNLWKSNQDLATACLCHPFVQGIANGTLPQKSFAYYVGQDAFFLKAFARAYSIAAAKSDEWKTFELFHTLAGGVKEE
LELHQTYAAKWGVNLENITPGFATRRYTDFLLATAWGNNIGAIATAMTPCMRLYAFLGQQLATPKIPEHQYSQWIRTYST
QEFLQLVQNLEKVTDRYAENIQETESIYCYAMVCERDFFQAAWEMGKGAYRIH
>Mature_213_residues
MISKNLWKSNQDLATACLCHPFVQGIANGTLPQKSFAYYVGQDAFFLKAFARAYSIAAAKSDEWKTFELFHTLAGGVKEE
LELHQTYAAKWGVNLENITPGFATRRYTDFLLATAWGNNIGAIATAMTPCMRLYAFLGQQLATPKIPEHQYSQWIRTYST
QEFLQLVQNLEKVTDRYAENIQETESIYCYAMVCERDFFQAAWEMGKGAYRIH

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0819

COG function: function code K; Putative transcription activator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the thiaminase-2 family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6324517, Length=197, Percent_Identity=27.4111675126904, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6325378, Length=198, Percent_Identity=25.7575757575758, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR016084
- InterPro:   IPR013749
- InterPro:   IPR004399
- InterPro:   IPR004305
- InterPro:   IPR022998
- InterPro:   IPR003733 [H]

Pfam domain/function: PF08543 Phos_pyr_kin; PF03070 TENA_THI-4; PF02581 TMP-TENI [H]

EC number: =2.5.1.3; =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 24319; Mature: 24319

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISKNLWKSNQDLATACLCHPFVQGIANGTLPQKSFAYYVGQDAFFLKAFARAYSIAAAK
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCC
SDEWKTFELFHTLAGGVKEELELHQTYAAKWGVNLENITPGFATRRYTDFLLATAWGNNI
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHCCCCH
GAIATAMTPCMRLYAFLGQQLATPKIPEHQYSQWIRTYSTQEFLQLVQNLEKVTDRYAEN
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
IQETESIYCYAMVCERDFFQAAWEMGKGAYRIH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MISKNLWKSNQDLATACLCHPFVQGIANGTLPQKSFAYYVGQDAFFLKAFARAYSIAAAK
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHCC
SDEWKTFELFHTLAGGVKEELELHQTYAAKWGVNLENITPGFATRRYTDFLLATAWGNNI
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHHHCCCCH
GAIATAMTPCMRLYAFLGQQLATPKIPEHQYSQWIRTYSTQEFLQLVQNLEKVTDRYAEN
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
IQETESIYCYAMVCERDFFQAAWEMGKGAYRIH
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]