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The map label for this gene is def [H]

Identifier: 113474637

GI number: 113474637

Start: 1284063

End: 1284626

Strand: Direct

Name: def [H]

Synonym: Tery_0808

Alternate gene names: 113474637

Gene position: 1284063-1284626 (Clockwise)

Preceding gene: 113474634

Following gene: 113474638

Centisome position: 16.57

GC content: 37.41

Gene sequence:

>564_bases
ATGGATTCTGAAATTATAGTTAACAAAGAAAAATTAGAAAACTCGCCTTTAGAAATATATTATTTAGGCGATCGCTCTTT
ACGCCAGTCAGCCAAGCGAGTCGCTAAAGTAGATAGTGATATGAGGAAACTAGTGCGAGAAATGCTCCAAACTATGTATA
CTGCTGATGGTATTGGTCTCGCTGCACCCCAGGTTAATGTCCAAAAGCAAGTTATTGTTATAGACTGTGAGCCTACTAAT
TCTGCTACTCCTCCTCTAGTTTTAATTAATCCTACAATTAAAAAGTACAGCAATGATATTTGTCTTTTCCAAGAAGGATG
TCTGAGTATTCCTGGGGTTTATTTGGATGTTCAACGTCCCTCAGAGATTGAAGTTGCCTATAAAGACGAAAATGGCCGTC
CTCAAACTCTTCAGGCTCAAGAATTATTATCTAGGGCAATTCAACATGAAATGGATCATCTTCAAGGTATCCTTTTTGTA
GACCGAGTAGAAAATAAATTGGCACTGAATGAAGAGTTGGCCAAGTATAAGTTTTCTGCCAAAGATGTTAGATCTATTGC
TTAA

Upstream 100 bases:

>100_bases
ATTAATTTTGATGATTTTTACTTTTTGAAAATATATATAATAGAAGGACAGGGCTTTAGAGCCTAATTATTGGTAAACAC
TTTGGTATTCTTAAAATTGT

Downstream 100 bases:

>100_bases
ATCTTTCCACATTAGGGGAAGTCATTTTAGTGATCAGCTAGCCTATACCGGAGAAAATGAGCTTTTCCCATACGCCTAGG
CAAATAGTTATCAGTTATTA

Product: peptide deformylase

Products: NA

Alternate protein names: PDF 1; Polypeptide deformylase 1 [H]

Number of amino acids: Translated: 187; Mature: 187

Protein sequence:

>187_residues
MDSEIIVNKEKLENSPLEIYYLGDRSLRQSAKRVAKVDSDMRKLVREMLQTMYTADGIGLAAPQVNVQKQVIVIDCEPTN
SATPPLVLINPTIKKYSNDICLFQEGCLSIPGVYLDVQRPSEIEVAYKDENGRPQTLQAQELLSRAIQHEMDHLQGILFV
DRVENKLALNEELAKYKFSAKDVRSIA

Sequences:

>Translated_187_residues
MDSEIIVNKEKLENSPLEIYYLGDRSLRQSAKRVAKVDSDMRKLVREMLQTMYTADGIGLAAPQVNVQKQVIVIDCEPTN
SATPPLVLINPTIKKYSNDICLFQEGCLSIPGVYLDVQRPSEIEVAYKDENGRPQTLQAQELLSRAIQHEMDHLQGILFV
DRVENKLALNEELAKYKFSAKDVRSIA
>Mature_187_residues
MDSEIIVNKEKLENSPLEIYYLGDRSLRQSAKRVAKVDSDMRKLVREMLQTMYTADGIGLAAPQVNVQKQVIVIDCEPTN
SATPPLVLINPTIKKYSNDICLFQEGCLSIPGVYLDVQRPSEIEVAYKDENGRPQTLQAQELLSRAIQHEMDHLQGILFV
DRVENKLALNEELAKYKFSAKDVRSIA

Specific function: Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions

COG id: COG0242

COG function: function code J; N-formylmethionyl-tRNA deformylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the polypeptide deformylase family [H]

Homologues:

Organism=Homo sapiens, GI11641243, Length=170, Percent_Identity=30.5882352941176, Blast_Score=91, Evalue=6e-19,
Organism=Escherichia coli, GI1789682, Length=147, Percent_Identity=41.4965986394558, Blast_Score=113, Evalue=9e-27,
Organism=Drosophila melanogaster, GI24645728, Length=160, Percent_Identity=29.375, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24645726, Length=160, Percent_Identity=27.5, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000181 [H]

Pfam domain/function: PF01327 Pep_deformylase [H]

EC number: =3.5.1.88 [H]

Molecular weight: Translated: 21136; Mature: 21136

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSEIIVNKEKLENSPLEIYYLGDRSLRQSAKRVAKVDSDMRKLVREMLQTMYTADGIGL
CCCCEEEEHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AAPQVNVQKQVIVIDCEPTNSATPPLVLINPTIKKYSNDICLFQEGCLSIPGVYLDVQRP
CCCCCCCCEEEEEEECCCCCCCCCCEEEECCCHHHHCCCEEEEECCCCCCCCEEEEECCC
SEIEVAYKDENGRPQTLQAQELLSRAIQHEMDHLQGILFVDRVENKLALNEELAKYKFSA
CEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHCCH
KDVRSIA
HHHHHCC
>Mature Secondary Structure
MDSEIIVNKEKLENSPLEIYYLGDRSLRQSAKRVAKVDSDMRKLVREMLQTMYTADGIGL
CCCCEEEEHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AAPQVNVQKQVIVIDCEPTNSATPPLVLINPTIKKYSNDICLFQEGCLSIPGVYLDVQRP
CCCCCCCCEEEEEEECCCCCCCCCCEEEECCCHHHHCCCEEEEECCCCCCCCEEEEECCC
SEIEVAYKDENGRPQTLQAQELLSRAIQHEMDHLQGILFVDRVENKLALNEELAKYKFSA
CEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHCCH
KDVRSIA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]