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The map label for this gene is ahpC [C]

Identifier: 113474135

GI number: 113474135

Start: 364533

End: 365132

Strand: Reverse

Name: ahpC [C]

Synonym: Tery_0235

Alternate gene names: 113474135

Gene position: 365132-364533 (Counterclockwise)

Preceding gene: 113474136

Following gene: 113474134

Centisome position: 4.71

GC content: 38.17

Gene sequence:

>600_bases
ATGACAGACGAATGCCTGCGTGTGGGCCAAAAGGCTCCGGATTTTACAGCTACAGCTGTAGTGGATCAGGAATTCGAGAC
AATTAAACTGTCTGATTATCGTGGTAAGTATGTAGTCTTGTTCTTCTATCCCTTGGATTTTACTTTTGTTTGCCCAACCG
AAATTACAGCGTTTAGCGATCGTTATAAAGAGTTTGAGTTACTTAACACTGAAATTTTAGGAGTTTCTGTGGACAGTGAA
TTTTCACATCTAGCTTGGATTCAAACAGATCGTAAGTCTGGAGGTATTGGGGATCTTAATTACCCCCTATTATCTGATAT
AAAGAAAGAAATTAGTACAGCCTACAATGTTTTAGATCTAGAGGCTGGTATTGCTCTGCGAGGATTATTTATTATTGATA
GAGAAGGTATTATCCAGCACGCAACTGTTAATAATTTTGCTTTTGGCCGCAATGTGGATGAAGCTATCCGCACTCTACAA
GCTATTCAATATGTACAAATTCACCCAAATGAAGTTTGTCCTGTGGGCTGGAAACCAGGGGATAAAACTATGAATTCTGA
TCCAATTAAGTCTAAAGAATTTTTTGCTGCTGTTTCATAA

Upstream 100 bases:

>100_bases
GTATCAGTAATTAAAACTCAAAGCTTTTAAAACTATTAGATTGAGATTAACTAATAGTAAAAAAAATTATCAACTCATTT
TAATTAAGGAGATAAAAATC

Downstream 100 bases:

>100_bases
ATTGTTTTAGCTACTGGAGAAAGTACTTCATAATTTCCAGAAATATTCACTCCAACACTATGGCTGAGATGTTTGACCTC
AAAGTGTTGGAGTTATAAAT

Product: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MTDECLRVGQKAPDFTATAVVDQEFETIKLSDYRGKYVVLFFYPLDFTFVCPTEITAFSDRYKEFELLNTEILGVSVDSE
FSHLAWIQTDRKSGGIGDLNYPLLSDIKKEISTAYNVLDLEAGIALRGLFIIDREGIIQHATVNNFAFGRNVDEAIRTLQ
AIQYVQIHPNEVCPVGWKPGDKTMNSDPIKSKEFFAAVS

Sequences:

>Translated_199_residues
MTDECLRVGQKAPDFTATAVVDQEFETIKLSDYRGKYVVLFFYPLDFTFVCPTEITAFSDRYKEFELLNTEILGVSVDSE
FSHLAWIQTDRKSGGIGDLNYPLLSDIKKEISTAYNVLDLEAGIALRGLFIIDREGIIQHATVNNFAFGRNVDEAIRTLQ
AIQYVQIHPNEVCPVGWKPGDKTMNSDPIKSKEFFAAVS
>Mature_198_residues
TDECLRVGQKAPDFTATAVVDQEFETIKLSDYRGKYVVLFFYPLDFTFVCPTEITAFSDRYKEFELLNTEILGVSVDSEF
SHLAWIQTDRKSGGIGDLNYPLLSDIKKEISTAYNVLDLEAGIALRGLFIIDREGIIQHATVNNFAFGRNVDEAIRTLQA
IQYVQIHPNEVCPVGWKPGDKTMNSDPIKSKEFFAAVS

Specific function: Reduces peroxides. May play an important role in eliminating peroxides generated during metabolism [H]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=196, Percent_Identity=59.1836734693878, Blast_Score=245, Evalue=2e-65,
Organism=Homo sapiens, GI4505591, Length=197, Percent_Identity=55.8375634517767, Blast_Score=234, Evalue=4e-62,
Organism=Homo sapiens, GI32455266, Length=197, Percent_Identity=55.8375634517767, Blast_Score=234, Evalue=4e-62,
Organism=Homo sapiens, GI32455264, Length=197, Percent_Identity=55.8375634517767, Blast_Score=234, Evalue=4e-62,
Organism=Homo sapiens, GI5802974, Length=192, Percent_Identity=56.25, Blast_Score=229, Evalue=1e-60,
Organism=Homo sapiens, GI32483377, Length=199, Percent_Identity=53.7688442211055, Blast_Score=226, Evalue=9e-60,
Organism=Homo sapiens, GI5453549, Length=189, Percent_Identity=53.968253968254, Blast_Score=222, Evalue=2e-58,
Organism=Homo sapiens, GI33188454, Length=114, Percent_Identity=57.0175438596491, Blast_Score=131, Evalue=4e-31,
Organism=Homo sapiens, GI4758638, Length=189, Percent_Identity=29.1005291005291, Blast_Score=75, Evalue=5e-14,
Organism=Escherichia coli, GI1786822, Length=177, Percent_Identity=36.1581920903955, Blast_Score=132, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI193204376, Length=188, Percent_Identity=55.3191489361702, Blast_Score=219, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI32565831, Length=188, Percent_Identity=55.3191489361702, Blast_Score=219, Evalue=7e-58,
Organism=Caenorhabditis elegans, GI17554494, Length=187, Percent_Identity=50.2673796791444, Blast_Score=206, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6323613, Length=193, Percent_Identity=49.740932642487, Blast_Score=190, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6320661, Length=188, Percent_Identity=51.063829787234, Blast_Score=187, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6319407, Length=185, Percent_Identity=30.8108108108108, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17738015, Length=194, Percent_Identity=57.2164948453608, Blast_Score=233, Evalue=5e-62,
Organism=Drosophila melanogaster, GI17157991, Length=193, Percent_Identity=54.9222797927461, Blast_Score=225, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24641739, Length=193, Percent_Identity=54.9222797927461, Blast_Score=225, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24656348, Length=189, Percent_Identity=55.5555555555556, Blast_Score=223, Evalue=9e-59,
Organism=Drosophila melanogaster, GI17864676, Length=189, Percent_Identity=55.5555555555556, Blast_Score=223, Evalue=9e-59,
Organism=Drosophila melanogaster, GI21357347, Length=190, Percent_Identity=51.5789473684211, Blast_Score=209, Evalue=1e-54,
Organism=Drosophila melanogaster, GI17975518, Length=189, Percent_Identity=34.3915343915344, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24652434, Length=189, Percent_Identity=34.3915343915344, Blast_Score=103, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24652436, Length=189, Percent_Identity=34.3915343915344, Blast_Score=103, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24581278, Length=200, Percent_Identity=28.5, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 22417; Mature: 22285

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDECLRVGQKAPDFTATAVVDQEFETIKLSDYRGKYVVLFFYPLDFTFVCPTEITAFSD
CCHHHHHHCCCCCCCEEEEEECCCCCEEEEECCCCCEEEEEEEECCEEEECCCHHHHHHH
RYKEFELLNTEILGVSVDSEFSHLAWIQTDRKSGGIGDLNYPLLSDIKKEISTAYNVLDL
HHHHHEEECEEEEEEEECCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHEEEE
EAGIALRGLFIIDREGIIQHATVNNFAFGRNVDEAIRTLQAIQYVQIHPNEVCPVGWKPG
CCCCEEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHEEEECCCCCCCCCCCCC
DKTMNSDPIKSKEFFAAVS
CCCCCCCCCCCCCEEEECC
>Mature Secondary Structure 
TDECLRVGQKAPDFTATAVVDQEFETIKLSDYRGKYVVLFFYPLDFTFVCPTEITAFSD
CHHHHHHCCCCCCCEEEEEECCCCCEEEEECCCCCEEEEEEEECCEEEECCCHHHHHHH
RYKEFELLNTEILGVSVDSEFSHLAWIQTDRKSGGIGDLNYPLLSDIKKEISTAYNVLDL
HHHHHEEECEEEEEEEECCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHEEEE
EAGIALRGLFIIDREGIIQHATVNNFAFGRNVDEAIRTLQAIQYVQIHPNEVCPVGWKPG
CCCCEEEEEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHHHHEEEECCCCCCCCCCCCC
DKTMNSDPIKSKEFFAAVS
CCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]