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The map label for this gene is preA [H]

Identifier: 113474063

GI number: 113474063

Start: 238306

End: 239277

Strand: Direct

Name: preA [H]

Synonym: Tery_0157

Alternate gene names: 113474063

Gene position: 238306-239277 (Clockwise)

Preceding gene: 113474060

Following gene: 113474065

Centisome position: 3.07

GC content: 38.99

Gene sequence:

>972_bases
ATGACCACTTCCACTCTCCTATTCTCTCCAGTAGAAGCAGACCTTCAACTGCTAACGAATAACTTAAAACAATTGGTAGG
TGCCCGTCACCCTATATTGTACGCGGCGGCAGAACACCTATTCCGCGTCAAGGGAAAGCGGATAAGACCAGCTATTGTCC
TATTAATTTCACGGACTACCATGCTAACGCAAGAAATTACTCCTAAACATCGTCGTTTAGCAGAAATTACAGAAATGATC
CACACTGCTAGCTTAGTTCACGATGACATAGTAGACGAATCAGAAATCCGTCGAGGCGTCCCTACCGTTCACAGTTTATT
TACTAATCGTATTGCGGTACTAGCTGGAGATTTTCTATTTGCTCAATCATCTTGGTACTTGGCCAACCTGGATAATCTAG
AAGTTGTGAAACTTCTTTCAAAAGTAATTATGGATCTTGCCGAAGGAGAAATTCAGCAAGGACTACATAGATTTAATACT
GATTTATCCATAGAAGCTTATCTAGAAAAGAGCTATTACAAGACATCTTCTCTAATTGCTAATAGTTCTAAAGCTGCAGC
TATTATTAGTGATGTCCCACCAGAAATAGTCCAAGATATGTACTACTATGGAAGATATATAGGTTTAGCATTCCAGATAG
TGGACGATATACTAGACTTTACCAGTGCTACAGAATCTCTGGGAAAACCTGCTTGTTCAGACCTCAAAAGTGGCAACTTG
ACAGCACCCACATTATATGCTTTGGAAGAAAAGCCTGCATTAGAAAAACTACTGGAAAGAGAATTAGCCCAAGATAGCGA
TTTAGAAGAAGCTATTCAATTGATTAAAAATAGCCGAGGTATTAAAAGGTCTCAAGAGTTGGCTACTAAATATGCCAAAA
TGGCTGTTGAACATTTACAATCTTTACCAGATTGTGATTCTCGTCAAGCTCTAATTAATCTTACTGACTATGTTTTAAGT
CGCCTGTCTTAG

Upstream 100 bases:

>100_bases
AGAATCAAGATTTTTAACTTTCCTATATCAAGGATGCTTAGCTTAGAATAGGAATATAATTTGTAAAATTTTGTTAACTT
GTAGCTTGATTGGTTAATCC

Downstream 100 bases:

>100_bases
CTTTTACTATTGTCCAATAATTAGTTAGTAATAATGAACGAATACTATTAATTAGTGTATGGCTAACAAACAATATTTAT
ATTGATACTAACTAGGGTTT

Product: trans-hexaprenyltranstransferase

Products: trans-polyisoprenyln-PP; pyrophosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MTTSTLLFSPVEADLQLLTNNLKQLVGARHPILYAAAEHLFRVKGKRIRPAIVLLISRTTMLTQEITPKHRRLAEITEMI
HTASLVHDDIVDESEIRRGVPTVHSLFTNRIAVLAGDFLFAQSSWYLANLDNLEVVKLLSKVIMDLAEGEIQQGLHRFNT
DLSIEAYLEKSYYKTSSLIANSSKAAAIISDVPPEIVQDMYYYGRYIGLAFQIVDDILDFTSATESLGKPACSDLKSGNL
TAPTLYALEEKPALEKLLERELAQDSDLEEAIQLIKNSRGIKRSQELATKYAKMAVEHLQSLPDCDSRQALINLTDYVLS
RLS

Sequences:

>Translated_323_residues
MTTSTLLFSPVEADLQLLTNNLKQLVGARHPILYAAAEHLFRVKGKRIRPAIVLLISRTTMLTQEITPKHRRLAEITEMI
HTASLVHDDIVDESEIRRGVPTVHSLFTNRIAVLAGDFLFAQSSWYLANLDNLEVVKLLSKVIMDLAEGEIQQGLHRFNT
DLSIEAYLEKSYYKTSSLIANSSKAAAIISDVPPEIVQDMYYYGRYIGLAFQIVDDILDFTSATESLGKPACSDLKSGNL
TAPTLYALEEKPALEKLLERELAQDSDLEEAIQLIKNSRGIKRSQELATKYAKMAVEHLQSLPDCDSRQALINLTDYVLS
RLS
>Mature_322_residues
TTSTLLFSPVEADLQLLTNNLKQLVGARHPILYAAAEHLFRVKGKRIRPAIVLLISRTTMLTQEITPKHRRLAEITEMIH
TASLVHDDIVDESEIRRGVPTVHSLFTNRIAVLAGDFLFAQSSWYLANLDNLEVVKLLSKVIMDLAEGEIQQGLHRFNTD
LSIEAYLEKSYYKTSSLIANSSKAAAIISDVPPEIVQDMYYYGRYIGLAFQIVDDILDFTSATESLGKPACSDLKSGNLT
APTLYALEEKPALEKLLERELAQDSDLEEAIQLIKNSRGIKRSQELATKYAKMAVEHLQSLPDCDSRQALINLTDYVLSR
LS

Specific function: Possible role in synthesis of the nonaprenyl side chain of plastoquinone or in synthesis of other prenyl chains such as undekaprenyl pyrophosphate [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=319, Percent_Identity=36.6771159874608, Blast_Score=218, Evalue=8e-57,
Organism=Homo sapiens, GI169808399, Length=324, Percent_Identity=28.3950617283951, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI4758430, Length=225, Percent_Identity=28, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI83700220, Length=225, Percent_Identity=28, Blast_Score=88, Evalue=9e-18,
Organism=Escherichia coli, GI1789578, Length=281, Percent_Identity=33.8078291814947, Blast_Score=173, Evalue=1e-44,
Organism=Escherichia coli, GI1786623, Length=225, Percent_Identity=30.6666666666667, Blast_Score=72, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17505681, Length=294, Percent_Identity=35.3741496598639, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6319475, Length=301, Percent_Identity=39.8671096345515, Blast_Score=220, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24651612, Length=316, Percent_Identity=36.0759493670886, Blast_Score=221, Evalue=5e-58,
Organism=Drosophila melanogaster, GI21356309, Length=349, Percent_Identity=27.2206303724928, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281365769, Length=238, Percent_Identity=25.2100840336134, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24660002, Length=238, Percent_Identity=25.2100840336134, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR014120
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: 2.5.1.- [C]

Molecular weight: Translated: 36149; Mature: 36018

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSTLLFSPVEADLQLLTNNLKQLVGARHPILYAAAEHLFRVKGKRIRPAIVLLISRTT
CCCCCCEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
MLTQEITPKHRRLAEITEMIHTASLVHDDIVDESEIRRGVPTVHSLFTNRIAVLAGDFLF
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHH
AQSSWYLANLDNLEVVKLLSKVIMDLAEGEIQQGLHRFNTDLSIEAYLEKSYYKTSSLIA
HCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
NSSKAAAIISDVPPEIVQDMYYYGRYIGLAFQIVDDILDFTSATESLGKPACSDLKSGNL
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCC
TAPTLYALEEKPALEKLLERELAQDSDLEEAIQLIKNSRGIKRSQELATKYAKMAVEHLQ
CCCHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
SLPDCDSRQALINLTDYVLSRLS
CCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TTSTLLFSPVEADLQLLTNNLKQLVGARHPILYAAAEHLFRVKGKRIRPAIVLLISRTT
CCCCCEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
MLTQEITPKHRRLAEITEMIHTASLVHDDIVDESEIRRGVPTVHSLFTNRIAVLAGDFLF
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHH
AQSSWYLANLDNLEVVKLLSKVIMDLAEGEIQQGLHRFNTDLSIEAYLEKSYYKTSSLIA
HCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
NSSKAAAIISDVPPEIVQDMYYYGRYIGLAFQIVDDILDFTSATESLGKPACSDLKSGNL
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCC
TAPTLYALEEKPALEKLLERELAQDSDLEEAIQLIKNSRGIKRSQELATKYAKMAVEHLQ
CCCHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
SLPDCDSRQALINLTDYVLSRLS
CCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: trans-polyisoprenyln-PP; Delta3-isopentenyl-PP [C]

Specific reaction: trans-polyisoprenyln-PP + Delta3-isopentenyl-PP = trans-polyisoprenyln-PP + pyrophosphate [C]

General reaction: Transferring alkyl or aryl groups, other than methyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]