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The map label for this gene is mleN [H]

Identifier: 110835566

GI number: 110835566

Start: 3058906

End: 3060252

Strand: Reverse

Name: mleN [H]

Synonym: ABO_2705

Alternate gene names: 110835566

Gene position: 3060252-3058906 (Counterclockwise)

Preceding gene: 110835567

Following gene: 110835565

Centisome position: 98.08

GC content: 55.09

Gene sequence:

>1347_bases
ATGGCCAACACACATAACCACGCTGTGCCCTCTGGGCGCGTTTGGCCGCTGCTCCCTTTGTTGTTTTTCCTGGTGGTGTT
TCTTGGTAGTGGCTTGTACTACACCGCTGCCGATACTGACTTTGCTTTCTACCAGATAAAGGCGCCAGTGGTGGCCATGG
TCGCTATTGTGTTGTCCATGTTGATGGCGCGATTGGCTGGGCAGCGATTAAATACCAGTGTGGAGCGCCTGGTGGCGGGG
ATCGGCCACCCCAACATTATTCTCATGTGTTTAGTGTTTCTGCTGGCCGGCGCCTTTGCCAGTGTCAGCGTTAGCATTGG
CAGTGTGGAGGCCACTGTCCAACTTGGCCTGAGCATTATTCCTTCCCAGTGGGTGCTGCCTGCCCTATTTCTGATCTCTG
CTTTTATAGCCACCGCCATGGGTACGTCCATGGGCACCATTGCGGCAACGGCTCCCATTGCGGTCGGCTTTACCGGCGCT
ACCGGGTTGCCCATGTCACTGGCGTTGGGCGCGGTGGTGGGTGGCGCCATGTTTGGCGATAACCTGTCGATGATCTCCGA
TACCACCATCGCGGCTACACGTAGCCAGGGTGTGTCGTTGAAGGACAAATTTCGGGTCAACATCTGGATTGCGGTGCCGG
CGGCCTTACTGACTCTGGGCTTGCTAATCGTATTGGGCGGTGGTGAGCACCAGGTAGAGAGCAAACCTTTTCAGGTTGCT
CTAGTGGTGCCTTACCTGTTGGTGTTTGGTTTGGCACTCAGCGGCCTTAATGTACTGGCGGTACTGATCATCGGTATTGT
CGCTGCAGGCGCCACCGGCATAGCGATGATGGACGATTATAATCTGGCCACCATGAACGGCGCGATCTATGAAGGCTTCC
AAGGCATGTTCGAGATCATGCTGTTGTCCATGTTGATTGGCGGCTTGTCTCAGCTGATGACCGACCAGGGCGGTACCCGC
TGGGTTATTGAGCGCATTCATGGCTTGACGCGCTGGCTTAGGCTGCCGTTGCAACGTGCCGGTGAAATGGGCATTGCCCT
GCTGGTGGTGTTTGCGAATGTGTTTGTGGCCAACAATACCGTGGCCATTGTGCTGACTGGGGAGATGGCCCGTGATATTG
CCACTGACCATGGTGTGGACTTGCGCCGTTCTGCCAGCATGCTGGATATTTTTTCCTGCGTGGTGCAAGGCTTAATTCCC
TATGGGGCGCAAGTGTTGCTGGCCTGCTCCATTGCCAAGCTTTCACCGTTGGCGTTAATCGGTTCTATCCATTATTGCTG
GGTTCTGGCCATTGTCGGCATTGTCGCGATCACCATTAACCGGCCTAGGTTGAATTTTGTAAAGTGA

Upstream 100 bases:

>100_bases
GGCCATTAATTGATTTTTTAATGGCACGTTAAGGCGGCTATCGACATGGCCTCGGAAGCTCTACACTGGGTCGATCATTG
GTTGATCGGGACGCCCCTAC

Downstream 100 bases:

>100_bases
CTAAAAATTAGACTTCAAAAAAATTTATTTTTTAAGGATAAATAACGTGGCAGGAACAAGTTTACTGATGTTGCTGGATG
ACATCGCCGCAGTGCTTGAT

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MANTHNHAVPSGRVWPLLPLLFFLVVFLGSGLYYTAADTDFAFYQIKAPVVAMVAIVLSMLMARLAGQRLNTSVERLVAG
IGHPNIILMCLVFLLAGAFASVSVSIGSVEATVQLGLSIIPSQWVLPALFLISAFIATAMGTSMGTIAATAPIAVGFTGA
TGLPMSLALGAVVGGAMFGDNLSMISDTTIAATRSQGVSLKDKFRVNIWIAVPAALLTLGLLIVLGGGEHQVESKPFQVA
LVVPYLLVFGLALSGLNVLAVLIIGIVAAGATGIAMMDDYNLATMNGAIYEGFQGMFEIMLLSMLIGGLSQLMTDQGGTR
WVIERIHGLTRWLRLPLQRAGEMGIALLVVFANVFVANNTVAIVLTGEMARDIATDHGVDLRRSASMLDIFSCVVQGLIP
YGAQVLLACSIAKLSPLALIGSIHYCWVLAIVGIVAITINRPRLNFVK

Sequences:

>Translated_448_residues
MANTHNHAVPSGRVWPLLPLLFFLVVFLGSGLYYTAADTDFAFYQIKAPVVAMVAIVLSMLMARLAGQRLNTSVERLVAG
IGHPNIILMCLVFLLAGAFASVSVSIGSVEATVQLGLSIIPSQWVLPALFLISAFIATAMGTSMGTIAATAPIAVGFTGA
TGLPMSLALGAVVGGAMFGDNLSMISDTTIAATRSQGVSLKDKFRVNIWIAVPAALLTLGLLIVLGGGEHQVESKPFQVA
LVVPYLLVFGLALSGLNVLAVLIIGIVAAGATGIAMMDDYNLATMNGAIYEGFQGMFEIMLLSMLIGGLSQLMTDQGGTR
WVIERIHGLTRWLRLPLQRAGEMGIALLVVFANVFVANNTVAIVLTGEMARDIATDHGVDLRRSASMLDIFSCVVQGLIP
YGAQVLLACSIAKLSPLALIGSIHYCWVLAIVGIVAITINRPRLNFVK
>Mature_447_residues
ANTHNHAVPSGRVWPLLPLLFFLVVFLGSGLYYTAADTDFAFYQIKAPVVAMVAIVLSMLMARLAGQRLNTSVERLVAGI
GHPNIILMCLVFLLAGAFASVSVSIGSVEATVQLGLSIIPSQWVLPALFLISAFIATAMGTSMGTIAATAPIAVGFTGAT
GLPMSLALGAVVGGAMFGDNLSMISDTTIAATRSQGVSLKDKFRVNIWIAVPAALLTLGLLIVLGGGEHQVESKPFQVAL
VVPYLLVFGLALSGLNVLAVLIIGIVAAGATGIAMMDDYNLATMNGAIYEGFQGMFEIMLLSMLIGGLSQLMTDQGGTRW
VIERIHGLTRWLRLPLQRAGEMGIALLVVFANVFVANNTVAIVLTGEMARDIATDHGVDLRRSASMLDIFSCVVQGLIPY
GAQVLLACSIAKLSPLALIGSIHYCWVLAIVGIVAITINRPRLNFVK

Specific function: Couples proton uptake and Na(+) efflux to the substrate- product malate/lactate antiport, in an electroneutral malate- 2H(+)/Na(+)-lactate exchange. Plays a role in supporting growth to high density on malate at reduced protonmotive force [H]

COG id: COG1757

COG function: function code C; Na+/H+ antiporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaC Na(+)/H(+) antiporter family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004770
- InterPro:   IPR018461 [H]

Pfam domain/function: PF03553 Na_H_antiporter [H]

EC number: NA

Molecular weight: Translated: 47196; Mature: 47065

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANTHNHAVPSGRVWPLLPLLFFLVVFLGSGLYYTAADTDFAFYQIKAPVVAMVAIVLSM
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEECHHHHHHHHHHHHH
LMARLAGQRLNTSVERLVAGIGHPNIILMCLVFLLAGAFASVSVSIGSVEATVQLGLSII
HHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHCCHHC
PSQWVLPALFLISAFIATAMGTSMGTIAATAPIAVGFTGATGLPMSLALGAVVGGAMFGD
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHCCC
NLSMISDTTIAATRSQGVSLKDKFRVNIWIAVPAALLTLGLLIVLGGGEHQVESKPFQVA
CCHHHCCCHHEEHHCCCCCCCCEEEEEEEEEHHHHHHHHHHHHEECCCCCCCCCCCEEEH
LVVPYLLVFGLALSGLNVLAVLIIGIVAAGATGIAMMDDYNLATMNGAIYEGFQGMFEIM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCHHHHHHHHHHHHH
LLSMLIGGLSQLMTDQGGTRWVIERIHGLTRWLRLPLQRAGEMGIALLVVFANVFVANNT
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCE
VAIVLTGEMARDIATDHGVDLRRSASMLDIFSCVVQGLIPYGAQVLLACSIAKLSPLALI
EEEEEECHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCHHHHH
GSIHYCWVLAIVGIVAITINRPRLNFVK
HHHHHHHHHHHHHHHHEEECCCCCCCCC
>Mature Secondary Structure 
ANTHNHAVPSGRVWPLLPLLFFLVVFLGSGLYYTAADTDFAFYQIKAPVVAMVAIVLSM
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEEECHHHHHHHHHHHHH
LMARLAGQRLNTSVERLVAGIGHPNIILMCLVFLLAGAFASVSVSIGSVEATVQLGLSII
HHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHCCHHC
PSQWVLPALFLISAFIATAMGTSMGTIAATAPIAVGFTGATGLPMSLALGAVVGGAMFGD
CCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHCCC
NLSMISDTTIAATRSQGVSLKDKFRVNIWIAVPAALLTLGLLIVLGGGEHQVESKPFQVA
CCHHHCCCHHEEHHCCCCCCCCEEEEEEEEEHHHHHHHHHHHHEECCCCCCCCCCCEEEH
LVVPYLLVFGLALSGLNVLAVLIIGIVAAGATGIAMMDDYNLATMNGAIYEGFQGMFEIM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEECCHHHHHHHHHHHHH
LLSMLIGGLSQLMTDQGGTRWVIERIHGLTRWLRLPLQRAGEMGIALLVVFANVFVANNT
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCE
VAIVLTGEMARDIATDHGVDLRRSASMLDIFSCVVQGLIPYGAQVLLACSIAKLSPLALI
EEEEEECHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCHHHHH
GSIHYCWVLAIVGIVAITINRPRLNFVK
HHHHHHHHHHHHHHHHEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 10903309 [H]