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The map label for this gene is rep [H]

Identifier: 110835399

GI number: 110835399

Start: 2877320

End: 2879341

Strand: Direct

Name: rep [H]

Synonym: ABO_2538

Alternate gene names: 110835399

Gene position: 2877320-2879341 (Clockwise)

Preceding gene: 110835393

Following gene: 110835407

Centisome position: 92.22

GC content: 55.69

Gene sequence:

>2022_bases
ATGAGCAAGCTTAACCCCCGCCAGCAGGAAGCCGTGGACTACGCGGACGGCCCTCTGTTAGTGCTGGCCGGTGCGGGCTC
CGGCAAAACCAGCGTGATCACCCGTAAGATCGCTTGGCTGATCCAGGAGCGGGGCATTCCGGCACGCCATATTGCAGCGG
TGACCTTTACCAACAAGGCTTCGCGGGAGATGAAAGAGCGGGTGCAACAGCTGGTCAGCCGTGACCTGACCCGGGGGCTG
ATTGTTTCCACCTTCCATAACCTGGGCTTGCGCATCCTCAAATCCGAGTTAAAAGCCTGCGGGCTGCGCAACGGTTTCTC
CATTCTGGACGGGGCGGACAGCAAGGAAATCCTCAAGGAAATTCTTCGCCAAGGTGAATCGGAACGGGACCTGGACGCGG
TGGATGTGATCCACAAACGCATTTCCAGCTGGAAAAACGCCCTGGTGCTACCCGAACAAGCAGTGAGCACTGCCGAAACC
GACGAAGACCTGCGCGCAGCCATGGCCTACAGTGGCTATGATCGTATGCTGCGGGTGTGTAATGCGGTGGACTTCGACGA
CCTGATCCTGATGCCCGCGCGCATGTTCCACGAGCAGCCACGCATTCTGGAAAAGTGGCGCAACCGTATTCAGTACCTGC
TGGTGGATGAATACCAGGATACCAACGGTGCTCAGTATGAAATGGTGAAAATGCTCACCCTACCGGAGGGCAAATTCACC
GTGGTGGGCGATGACGACCAGTCCATCTATGCCTGGCGCGGCGCCCGCCCGGAAAACCTGGCGCAGCTACAGGAAGACTG
GCCGACCCTGAAGGTGGTGAAGCTGGAACAGAATTACCGTTCCACCGGGCGCATTCTTAAAGCCGCCAACACCGTCATCG
CCAACAATCCCCACGAATTCGAGAAAAGCCTGTGGTCCGATTATGGTTACGGCGAACCGATCCGCTTTTCTGCTCTACGC
GATGAAGAGGCTGAAACCGAATGGATCGCCAGCGACATCTTTCACCGTCGCCTACAGAAAGGGTTGCAGTGGAAAGACTT
TGCCGTACTTTACCGTGGCAATTTCCAATCGCGTATTTTGGAAATGAAACTGCAAAGTCTGTCGATTCCCTACAAGGTAT
CCGGTGGCAAAAGTTTCTTCTCCCGCAGCGAAATTAAAGACCTGATGTGCTACTTGCGCCTGCTGGTCAATCCGGATGAC
GACAACGCTTTTCTACGTATCATCAACACGCCACGCCGGGAAATTGGCCCCGCCACACTGGAAAAACTGGCCACCTGGGC
ACTCAAGCGCGAGCAGGGTTTGTACCACGTGTGTGATGACTTCGCGCTCAGTGAGGTCATGAACCCGAAAGCCGCCGAGA
AGCTACAAAAGTTCAAGGCTTGGCTCGATGCCAAGCGGCAATTCTGCTTCGGCCAGAACAGCTTGCAAGCGGTGCAAGAA
CTCATCACCGACATGGATTATGAAGGTTGGTTGATGCAGAACGCCTCCAGCCCACGTATCGGCGAAAAGAATATCGAAAA
TATCTGGCAACTGGTGCGCAGCATTGAGCGCATGCTGGAAAAACAGGAAGACGACGAAGAAGGCGCCAGCGATCTGGAAT
CGGTGATCAAGAAGCTGGTGCTACTGGACATGCTCGAACAGCAGCAAGAAGAAGACGACTCCGACCGGGTGCAACTGATG
ACCCTGCACGCCTCCAAGGGTCTGGAATTTCCCCACGTCTACATGATGGGGGTGGAAGAAGAGTTCCTGCCCCACCGCAC
CAGCATTGAAGAAGACAACATCGTCGAAGAGCGCCGCCTCATGTACGTGGGCATCACCCGCGCCCGAGAAACCCTGGCCA
TGACTCAGGCGCTGACGCGCAAACAATACGGCGAGCGAATCGACACCACTGCCAGCCGCTTCGTGGATGAAATGCCGCAA
GATGACATCGACTATCTGGGCATCGGCATTCAGAAAGATGAAGCCAAAGAAGCGGAAGTGGCCGAAGCCAGCATTGCTAA
TCTTCGGGCGTTACTGGATTAG

Upstream 100 bases:

>100_bases
CCGTTACCAGTAAAACCGCCATGATAACCGACATAAGGTGCCGCGAGGGCATCACTGGTATCATAGCGGCCCGATTCCCG
CCCAGAGTTACCGGAGCCCT

Downstream 100 bases:

>100_bases
GTAACGCGGCACTGACACGGCAACACGAGCACGTTCTTTTTGTGCCAAATGCAAAGAGGCCGCGTTCCCGTCCGGGGCGC
GGCCTCTTTGCAATATAAAA

Product: ATP-dependent DNA helicase Rep

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 673; Mature: 672

Protein sequence:

>673_residues
MSKLNPRQQEAVDYADGPLLVLAGAGSGKTSVITRKIAWLIQERGIPARHIAAVTFTNKASREMKERVQQLVSRDLTRGL
IVSTFHNLGLRILKSELKACGLRNGFSILDGADSKEILKEILRQGESERDLDAVDVIHKRISSWKNALVLPEQAVSTAET
DEDLRAAMAYSGYDRMLRVCNAVDFDDLILMPARMFHEQPRILEKWRNRIQYLLVDEYQDTNGAQYEMVKMLTLPEGKFT
VVGDDDQSIYAWRGARPENLAQLQEDWPTLKVVKLEQNYRSTGRILKAANTVIANNPHEFEKSLWSDYGYGEPIRFSALR
DEEAETEWIASDIFHRRLQKGLQWKDFAVLYRGNFQSRILEMKLQSLSIPYKVSGGKSFFSRSEIKDLMCYLRLLVNPDD
DNAFLRIINTPRREIGPATLEKLATWALKREQGLYHVCDDFALSEVMNPKAAEKLQKFKAWLDAKRQFCFGQNSLQAVQE
LITDMDYEGWLMQNASSPRIGEKNIENIWQLVRSIERMLEKQEDDEEGASDLESVIKKLVLLDMLEQQQEEDDSDRVQLM
TLHASKGLEFPHVYMMGVEEEFLPHRTSIEEDNIVEERRLMYVGITRARETLAMTQALTRKQYGERIDTTASRFVDEMPQ
DDIDYLGIGIQKDEAKEAEVAEASIANLRALLD

Sequences:

>Translated_673_residues
MSKLNPRQQEAVDYADGPLLVLAGAGSGKTSVITRKIAWLIQERGIPARHIAAVTFTNKASREMKERVQQLVSRDLTRGL
IVSTFHNLGLRILKSELKACGLRNGFSILDGADSKEILKEILRQGESERDLDAVDVIHKRISSWKNALVLPEQAVSTAET
DEDLRAAMAYSGYDRMLRVCNAVDFDDLILMPARMFHEQPRILEKWRNRIQYLLVDEYQDTNGAQYEMVKMLTLPEGKFT
VVGDDDQSIYAWRGARPENLAQLQEDWPTLKVVKLEQNYRSTGRILKAANTVIANNPHEFEKSLWSDYGYGEPIRFSALR
DEEAETEWIASDIFHRRLQKGLQWKDFAVLYRGNFQSRILEMKLQSLSIPYKVSGGKSFFSRSEIKDLMCYLRLLVNPDD
DNAFLRIINTPRREIGPATLEKLATWALKREQGLYHVCDDFALSEVMNPKAAEKLQKFKAWLDAKRQFCFGQNSLQAVQE
LITDMDYEGWLMQNASSPRIGEKNIENIWQLVRSIERMLEKQEDDEEGASDLESVIKKLVLLDMLEQQQEEDDSDRVQLM
TLHASKGLEFPHVYMMGVEEEFLPHRTSIEEDNIVEERRLMYVGITRARETLAMTQALTRKQYGERIDTTASRFVDEMPQ
DDIDYLGIGIQKDEAKEAEVAEASIANLRALLD
>Mature_672_residues
SKLNPRQQEAVDYADGPLLVLAGAGSGKTSVITRKIAWLIQERGIPARHIAAVTFTNKASREMKERVQQLVSRDLTRGLI
VSTFHNLGLRILKSELKACGLRNGFSILDGADSKEILKEILRQGESERDLDAVDVIHKRISSWKNALVLPEQAVSTAETD
EDLRAAMAYSGYDRMLRVCNAVDFDDLILMPARMFHEQPRILEKWRNRIQYLLVDEYQDTNGAQYEMVKMLTLPEGKFTV
VGDDDQSIYAWRGARPENLAQLQEDWPTLKVVKLEQNYRSTGRILKAANTVIANNPHEFEKSLWSDYGYGEPIRFSALRD
EEAETEWIASDIFHRRLQKGLQWKDFAVLYRGNFQSRILEMKLQSLSIPYKVSGGKSFFSRSEIKDLMCYLRLLVNPDDD
NAFLRIINTPRREIGPATLEKLATWALKREQGLYHVCDDFALSEVMNPKAAEKLQKFKAWLDAKRQFCFGQNSLQAVQEL
ITDMDYEGWLMQNASSPRIGEKNIENIWQLVRSIERMLEKQEDDEEGASDLESVIKKLVLLDMLEQQQEEDDSDRVQLMT
LHASKGLEFPHVYMMGVEEEFLPHRTSIEEDNIVEERRLMYVGITRARETLAMTQALTRKQYGERIDTTASRFVDEMPQD
DIDYLGIGIQKDEAKEAEVAEASIANLRALLD

Specific function: Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction [H]

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI48994965, Length=674, Percent_Identity=51.9287833827893, Blast_Score=674, Evalue=0.0,
Organism=Escherichia coli, GI2367296, Length=647, Percent_Identity=37.5579598145286, Blast_Score=392, Evalue=1e-110,
Organism=Escherichia coli, GI1787196, Length=342, Percent_Identity=28.6549707602339, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6322369, Length=490, Percent_Identity=30, Blast_Score=190, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6324477, Length=678, Percent_Identity=22.4188790560472, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005752
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 77261; Mature: 77130

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKLNPRQQEAVDYADGPLLVLAGAGSGKTSVITRKIAWLIQERGIPARHIAAVTFTNKA
CCCCCCCHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHEEEEEECCHH
SREMKERVQQLVSRDLTRGLIVSTFHNLGLRILKSELKACGLRNGFSILDGADSKEILKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
ILRQGESERDLDAVDVIHKRISSWKNALVLPEQAVSTAETDEDLRAAMAYSGYDRMLRVC
HHHCCCCCCCHHHHHHHHHHHHHHHCEEECCHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
NAVDFDDLILMPARMFHEQPRILEKWRNRIQYLLVDEYQDTNGAQYEMVKMLTLPEGKFT
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEEECCCCCCCCCEEHEEEEECCCCCEE
VVGDDDQSIYAWRGARPENLAQLQEDWPTLKVVKLEQNYRSTGRILKAANTVIANNPHEF
EECCCCCCEEEECCCCHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCHHH
EKSLWSDYGYGEPIRFSALRDEEAETEWIASDIFHRRLQKGLQWKDFAVLYRGNFQSRIL
HHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHH
EMKLQSLSIPYKVSGGKSFFSRSEIKDLMCYLRLLVNPDDDNAFLRIINTPRREIGPATL
HHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHCCHHHH
EKLATWALKREQGLYHVCDDFALSEVMNPKAAEKLQKFKAWLDAKRQFCFGQNSLQAVQE
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LITDMDYEGWLMQNASSPRIGEKNIENIWQLVRSIERMLEKQEDDEEGASDLESVIKKLV
HHHCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LLDMLEQQQEEDDSDRVQLMTLHASKGLEFPHVYMMGVEEEFLPHRTSIEEDNIVEERRL
HHHHHHHHHCCCCCCCEEEEEEECCCCCCCCEEEEECCCHHHCCCCCCCCCCCHHHHHHH
MYVGITRARETLAMTQALTRKQYGERIDTTASRFVDEMPQDDIDYLGIGIQKDEAKEAEV
HEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCHHHHH
AEASIANLRALLD
HHHHHHHHHHHCC
>Mature Secondary Structure 
SKLNPRQQEAVDYADGPLLVLAGAGSGKTSVITRKIAWLIQERGIPARHIAAVTFTNKA
CCCCCCHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCHHHEEEEEECCHH
SREMKERVQQLVSRDLTRGLIVSTFHNLGLRILKSELKACGLRNGFSILDGADSKEILKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
ILRQGESERDLDAVDVIHKRISSWKNALVLPEQAVSTAETDEDLRAAMAYSGYDRMLRVC
HHHCCCCCCCHHHHHHHHHHHHHHHCEEECCHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
NAVDFDDLILMPARMFHEQPRILEKWRNRIQYLLVDEYQDTNGAQYEMVKMLTLPEGKFT
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHEEEEECCCCCCCCCEEHEEEEECCCCCEE
VVGDDDQSIYAWRGARPENLAQLQEDWPTLKVVKLEQNYRSTGRILKAANTVIANNPHEF
EECCCCCCEEEECCCCHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCHHH
EKSLWSDYGYGEPIRFSALRDEEAETEWIASDIFHRRLQKGLQWKDFAVLYRGNFQSRIL
HHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHH
EMKLQSLSIPYKVSGGKSFFSRSEIKDLMCYLRLLVNPDDDNAFLRIINTPRREIGPATL
HHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHCCHHHH
EKLATWALKREQGLYHVCDDFALSEVMNPKAAEKLQKFKAWLDAKRQFCFGQNSLQAVQE
HHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LITDMDYEGWLMQNASSPRIGEKNIENIWQLVRSIERMLEKQEDDEEGASDLESVIKKLV
HHHCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
LLDMLEQQQEEDDSDRVQLMTLHASKGLEFPHVYMMGVEEEFLPHRTSIEEDNIVEERRL
HHHHHHHHHCCCCCCCEEEEEEECCCCCCCCEEEEECCCHHHCCCCCCCCCCCHHHHHHH
MYVGITRARETLAMTQALTRKQYGERIDTTASRFVDEMPQDDIDYLGIGIQKDEAKEAEV
HEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCHHHHH
AEASIANLRALLD
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]