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The map label for this gene is hisA [H]

Identifier: 110835140

GI number: 110835140

Start: 2598714

End: 2599490

Strand: Reverse

Name: hisA [H]

Synonym: ABO_2279

Alternate gene names: 110835140

Gene position: 2599490-2598714 (Counterclockwise)

Preceding gene: 110835141

Following gene: 110835139

Centisome position: 83.31

GC content: 57.14

Gene sequence:

>777_bases
ATGCCGATTTCCATGAATTTAAATGAAGAGATTCTGATGTTACTGATTCCCGCCATCGATCTGAAAGACGGTAAATGTGT
ACGCCTTAAGCAAGGGCGGATGGAAGACGATACGGTGTTTTCCGAAGATCCGGTGGCCGTTGCCAGCCATTGGGTGGAGC
GGGGTGCCCGCCGCTTGCATTTGGTCGACTTGAATGGGGCCTTTGCCGGTGAGCCGGTGAACGGCGATATCGTCAAAGCG
ATTGCCAAGGCGCACCCGGATTTACCGATCCAGATTGGGGGTGGCATCCGCAGCCCGGAAATCATTCAGGCTTATCTAGA
TGCCGGGGTGCAGTGGGTGATCATCGGCACCAAGGCCGTGAATGAGCCGGCTTTCGTGAAAGCCATGTGCGAGCAGTTCC
CCGGCCACATTATCGTGGGTCTGGACGCGAAAGACGGCAAGGTGGCCACCGATGGCTGGGCCAATGTCACCGATGTGGAT
GTGATCGACCTGGCGAAACAATTCGAGAACGATGGCGTTTCGGCCATCGTCTACACCGACATCAGCCGTGATGGCATGTT
GCAGGGGGTGAATGTGGACGCCACTGTGCGCTTGGCCCAGTCCATGTCGATCCCGGTGATCGCTTCCGGCGGCATTACCA
ATCTTGATGACGTGCGCAACCTGTGTGCAGTGGCCGATCAGGGCATCAGTGGTGCTATCACGGGCCGTGCCATCTATGAG
AACACCCTGGACTTTGCCGATGGTCAGGCGTTGTCCGATGAGTTGAGCGGCGCCTGA

Upstream 100 bases:

>100_bases
TGTTGGAAAACTTCCTGCGCTGGCAGCCATAAAAGACAGCAGGCTTGCACGCTAGGGTTTCTCTCTACGGTGTTCGTATA
ACGGGCGCGGCGGGGGAGGG

Downstream 100 bases:

>100_bases
GCGCCGGGGACGTATTATGGGTTTAGCCAAACGCATTATTCCGTGTCTGGATGTGGACGCCGGCCGAGTGGTCAAGGGCG
TGCAATTCGTGGATATCCGT

Product: phosphoribosylformimino-5-aminoimidazolecarboxam ide ribotide

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MPISMNLNEEILMLLIPAIDLKDGKCVRLKQGRMEDDTVFSEDPVAVASHWVERGARRLHLVDLNGAFAGEPVNGDIVKA
IAKAHPDLPIQIGGGIRSPEIIQAYLDAGVQWVIIGTKAVNEPAFVKAMCEQFPGHIIVGLDAKDGKVATDGWANVTDVD
VIDLAKQFENDGVSAIVYTDISRDGMLQGVNVDATVRLAQSMSIPVIASGGITNLDDVRNLCAVADQGISGAITGRAIYE
NTLDFADGQALSDELSGA

Sequences:

>Translated_258_residues
MPISMNLNEEILMLLIPAIDLKDGKCVRLKQGRMEDDTVFSEDPVAVASHWVERGARRLHLVDLNGAFAGEPVNGDIVKA
IAKAHPDLPIQIGGGIRSPEIIQAYLDAGVQWVIIGTKAVNEPAFVKAMCEQFPGHIIVGLDAKDGKVATDGWANVTDVD
VIDLAKQFENDGVSAIVYTDISRDGMLQGVNVDATVRLAQSMSIPVIASGGITNLDDVRNLCAVADQGISGAITGRAIYE
NTLDFADGQALSDELSGA
>Mature_257_residues
PISMNLNEEILMLLIPAIDLKDGKCVRLKQGRMEDDTVFSEDPVAVASHWVERGARRLHLVDLNGAFAGEPVNGDIVKAI
AKAHPDLPIQIGGGIRSPEIIQAYLDAGVQWVIIGTKAVNEPAFVKAMCEQFPGHIIVGLDAKDGKVATDGWANVTDVDV
IDLAKQFENDGVSAIVYTDISRDGMLQGVNVDATVRLAQSMSIPVIASGGITNLDDVRNLCAVADQGISGAITGRAIYEN
TLDFADGQALSDELSGA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=237, Percent_Identity=35.0210970464135, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1788336, Length=247, Percent_Identity=24.6963562753036, Blast_Score=77, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 27404; Mature: 27272

Theoretical pI: Translated: 4.24; Mature: 4.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPISMNLNEEILMLLIPAIDLKDGKCVRLKQGRMEDDTVFSEDPVAVASHWVERGARRLH
CCCCCCCCHHEEEEEEECCCCCCCCEEEEECCCCCCCCEECCCCHHHHHHHHHCCCCEEE
LVDLNGAFAGEPVNGDIVKAIAKAHPDLPIQIGGGIRSPEIIQAYLDAGVQWVIIGTKAV
EEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCEEEEEECCCC
NEPAFVKAMCEQFPGHIIVGLDAKDGKVATDGWANVTDVDVIDLAKQFENDGVSAIVYTD
CCHHHHHHHHHHCCCEEEEEEECCCCEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEEE
ISRDGMLQGVNVDATVRLAQSMSIPVIASGGITNLDDVRNLCAVADQGISGAITGRAIYE
CCCCCCEECCCCCCEEEEHHHCCCCEEECCCCCCHHHHHHHHHHHCCCCCCEEECCCHHH
NTLDFADGQALSDELSGA
CCCCCCCCCHHHHHHCCC
>Mature Secondary Structure 
PISMNLNEEILMLLIPAIDLKDGKCVRLKQGRMEDDTVFSEDPVAVASHWVERGARRLH
CCCCCCCHHEEEEEEECCCCCCCCEEEEECCCCCCCCEECCCCHHHHHHHHHCCCCEEE
LVDLNGAFAGEPVNGDIVKAIAKAHPDLPIQIGGGIRSPEIIQAYLDAGVQWVIIGTKAV
EEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHCCCEEEEEECCCC
NEPAFVKAMCEQFPGHIIVGLDAKDGKVATDGWANVTDVDVIDLAKQFENDGVSAIVYTD
CCHHHHHHHHHHCCCEEEEEEECCCCEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEEE
ISRDGMLQGVNVDATVRLAQSMSIPVIASGGITNLDDVRNLCAVADQGISGAITGRAIYE
CCCCCCEECCCCCCEEEEHHHCCCCEEECCCCCCHHHHHHHHHHHCCCCCCEEECCCHHH
NTLDFADGQALSDELSGA
CCCCCCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA