Click here to switch to the map view.

The map label for this gene is glyA

Identifier: 110835037

GI number: 110835037

Start: 2484813

End: 2486069

Strand: Reverse

Name: glyA

Synonym: ABO_2176

Alternate gene names: 110835037

Gene position: 2486069-2484813 (Counterclockwise)

Preceding gene: 110835046

Following gene: 110835036

Centisome position: 79.68

GC content: 57.84

Gene sequence:

>1257_bases
ATGTTCCCGAAATCCATGTCCATCGCCGAGTTTGACCCGGAAATCAAGGCCGCTATTGAGGCCGAAGAAGTCCGCCAGGA
AGAGCATATCGAGCTGATCGCCTCTGAAAACTATGCCTCGCCAAGGGTTATGGAAGCCCAGGGCTCCGTACTGACCAACA
AGTACGCCGAGGGCTATCCGGGCAAGCGTTATTACGGCGGTTGCGAGAATGTGGACGTGGTTGAGCAGTTGGCTATCGAT
CGGGCCTGTGAGCTGTTCGGCGCGGATTGGGCCAATGTGCAGCCGCATTCCGGTTCCCAGGCCAATGGCGCGGTTTACAT
GGCTATGCTCAAGGCGGGCGATACCGTGTTAGGCATGAGCCTGGATGCCGGTGGCCACCTGACCCACGGTGCTAAGCCGA
ACTTCTCCGGTAAGACCTATAACGCGGTGCAGTATGGTCTGGACAACGAAACTGGGCTGATTGATTACGATCAGGTGGCG
TCTCTGGCCCGCGAGCACAAGCCGAAAATGATCGTGGCCGGCTTCTCTGCCTATTCGCAGATTGTCGACTGGCAGCGTTT
CCGTGACATCGCCGACGAAGTGGGTGCGATCCTGCTGGTGGACATGGCCCACGTGGCAGGTCTGGTTGCTGCGGGTGTGT
ACCCGAGCCCGGTAGGCATTGCGGATATCACCACGACCACTACCCACAAGACCCTAGGCGGCCCCCGTGGCGGTCTGATC
ATGGGTAAGGCCAGCGAAGAGATTCAGAAGAAGATCAACTCTGCTGTGTTTCCCGGTGGCCAGGGTGGCCCGTTGGAGCA
CGTGATCGCCGCTAAAGCGATTTGCTTCAAAGAAGCCATGCAGGACGACTTCAAGGGCTACCAGCAGCAGGTAGTGAAGA
ACGCCCAGGCCATGGCCGGTGTGTTCATCGAGCGTGGCTTTGATGTGGTTTCCAATGGCACCGAGAATCACCTGTTCCTG
CTTAGCTTGATCAAGCAGGACATTACCGGTAAAGATGCGGACGCCGCCTTGGGCCGCGCCAACATCACCGTGAACAAAAA
TGCTGTCCCCAACGATCCGCGCTCCCCGTTCGTTACCTCCGGCCTGCGTATCGGTTCCCCCTCCATCACCCGCCGTGGTT
TTGATGAAGCGGATGCCAAGGCGTTGGCTGGCTGGATCTGCGACATCCTCGAGAACATGGGTGATGAAGGCGTGATTGAG
CAGGTTAAAGGCAAGGTTAAAGAGATTTGTGCTCGCCTGCCGGTGTACGAGCGCTAA

Upstream 100 bases:

>100_bases
TGACCGGCCGGTTTCCATGAGCGGACTTCAAGTGCCAAAGCGGCTAGATTTGGGTAGAATACGCGCCCCTGAATCCACCA
CTGACTCCGTAGGGTAGCCC

Downstream 100 bases:

>100_bases
AAAAGCCGCAAGCAGCAATGCGGATAGATGTGCTCGTAGTTTGCCGTTTTGAGGGCCGCGACCGAATTTCGGTGGCGGCT
TTCTTGTCTCTGAAATCTCG

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MFPKSMSIAEFDPEIKAAIEAEEVRQEEHIELIASENYASPRVMEAQGSVLTNKYAEGYPGKRYYGGCENVDVVEQLAID
RACELFGADWANVQPHSGSQANGAVYMAMLKAGDTVLGMSLDAGGHLTHGAKPNFSGKTYNAVQYGLDNETGLIDYDQVA
SLAREHKPKMIVAGFSAYSQIVDWQRFRDIADEVGAILLVDMAHVAGLVAAGVYPSPVGIADITTTTTHKTLGGPRGGLI
MGKASEEIQKKINSAVFPGGQGGPLEHVIAAKAICFKEAMQDDFKGYQQQVVKNAQAMAGVFIERGFDVVSNGTENHLFL
LSLIKQDITGKDADAALGRANITVNKNAVPNDPRSPFVTSGLRIGSPSITRRGFDEADAKALAGWICDILENMGDEGVIE
QVKGKVKEICARLPVYER

Sequences:

>Translated_418_residues
MFPKSMSIAEFDPEIKAAIEAEEVRQEEHIELIASENYASPRVMEAQGSVLTNKYAEGYPGKRYYGGCENVDVVEQLAID
RACELFGADWANVQPHSGSQANGAVYMAMLKAGDTVLGMSLDAGGHLTHGAKPNFSGKTYNAVQYGLDNETGLIDYDQVA
SLAREHKPKMIVAGFSAYSQIVDWQRFRDIADEVGAILLVDMAHVAGLVAAGVYPSPVGIADITTTTTHKTLGGPRGGLI
MGKASEEIQKKINSAVFPGGQGGPLEHVIAAKAICFKEAMQDDFKGYQQQVVKNAQAMAGVFIERGFDVVSNGTENHLFL
LSLIKQDITGKDADAALGRANITVNKNAVPNDPRSPFVTSGLRIGSPSITRRGFDEADAKALAGWICDILENMGDEGVIE
QVKGKVKEICARLPVYER
>Mature_418_residues
MFPKSMSIAEFDPEIKAAIEAEEVRQEEHIELIASENYASPRVMEAQGSVLTNKYAEGYPGKRYYGGCENVDVVEQLAID
RACELFGADWANVQPHSGSQANGAVYMAMLKAGDTVLGMSLDAGGHLTHGAKPNFSGKTYNAVQYGLDNETGLIDYDQVA
SLAREHKPKMIVAGFSAYSQIVDWQRFRDIADEVGAILLVDMAHVAGLVAAGVYPSPVGIADITTTTTHKTLGGPRGGLI
MGKASEEIQKKINSAVFPGGQGGPLEHVIAAKAICFKEAMQDDFKGYQQQVVKNAQAMAGVFIERGFDVVSNGTENHLFL
LSLIKQDITGKDADAALGRANITVNKNAVPNDPRSPFVTSGLRIGSPSITRRGFDEADAKALAGWICDILENMGDEGVIE
QVKGKVKEICARLPVYER

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI19923315, Length=429, Percent_Identity=46.3869463869464, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI261862352, Length=429, Percent_Identity=46.3869463869464, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI261862350, Length=429, Percent_Identity=46.3869463869464, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI261862348, Length=429, Percent_Identity=46.3869463869464, Blast_Score=350, Evalue=1e-96,
Organism=Homo sapiens, GI261862346, Length=429, Percent_Identity=44.7552447552448, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI22547186, Length=432, Percent_Identity=43.75, Blast_Score=307, Evalue=1e-83,
Organism=Homo sapiens, GI22547189, Length=419, Percent_Identity=40.8114558472554, Blast_Score=272, Evalue=4e-73,
Organism=Escherichia coli, GI1788902, Length=417, Percent_Identity=71.462829736211, Blast_Score=607, Evalue=1e-175,
Organism=Caenorhabditis elegans, GI25144732, Length=400, Percent_Identity=43.75, Blast_Score=330, Evalue=7e-91,
Organism=Caenorhabditis elegans, GI25144729, Length=400, Percent_Identity=43.75, Blast_Score=330, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6319739, Length=404, Percent_Identity=45.2970297029703, Blast_Score=343, Evalue=3e-95,
Organism=Saccharomyces cerevisiae, GI6323087, Length=406, Percent_Identity=43.8423645320197, Blast_Score=329, Evalue=5e-91,
Organism=Drosophila melanogaster, GI24640005, Length=400, Percent_Identity=46.25, Blast_Score=352, Evalue=2e-97,
Organism=Drosophila melanogaster, GI221329721, Length=400, Percent_Identity=46.25, Blast_Score=352, Evalue=3e-97,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA_ALCBS (Q0VMH4)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_693896.1
- ProteinModelPortal:   Q0VMH4
- SMR:   Q0VMH4
- STRING:   Q0VMH4
- GeneID:   4212768
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_2176
- NMPDR:   fig|393595.12.peg.2176
- eggNOG:   COG0112
- HOGENOM:   HBG301263
- OMA:   ITHINDD
- PhylomeDB:   Q0VMH4
- BioCyc:   ABOR393595:ABO_2176-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 44941; Mature: 44941

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPKSMSIAEFDPEIKAAIEAEEVRQEEHIELIASENYASPRVMEAQGSVLTNKYAEGYP
CCCCCCCHHHCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCEEECCCCHHHHHHHCCCC
GKRYYGGCENVDVVEQLAIDRACELFGADWANVQPHSGSQANGAVYMAMLKAGDTVLGMS
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEE
LDAGGHLTHGAKPNFSGKTYNAVQYGLDNETGLIDYDQVASLAREHKPKMIVAGFSAYSQ
ECCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECHHHHHH
IVDWQRFRDIADEVGAILLVDMAHVAGLVAAGVYPSPVGIADITTTTTHKTLGGPRGGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECEECCCHHHCCCCCCCEE
MGKASEEIQKKINSAVFPGGQGGPLEHVIAAKAICFKEAMQDDFKGYQQQVVKNAQAMAG
ECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFIERGFDVVSNGTENHLFLLSLIKQDITGKDADAALGRANITVNKNAVPNDPRSPFVTS
HHHHCCCHHHCCCCCCHHHHHHHHHHHCCCCCHHHHCCCCEEEECCCCCCCCCCCCHHHC
GLRIGSPSITRRGFDEADAKALAGWICDILENMGDEGVIEQVKGKVKEICARLPVYER
CEEECCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MFPKSMSIAEFDPEIKAAIEAEEVRQEEHIELIASENYASPRVMEAQGSVLTNKYAEGYP
CCCCCCCHHHCCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCEEECCCCHHHHHHHCCCC
GKRYYGGCENVDVVEQLAIDRACELFGADWANVQPHSGSQANGAVYMAMLKAGDTVLGMS
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEE
LDAGGHLTHGAKPNFSGKTYNAVQYGLDNETGLIDYDQVASLAREHKPKMIVAGFSAYSQ
ECCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECHHHHHH
IVDWQRFRDIADEVGAILLVDMAHVAGLVAAGVYPSPVGIADITTTTTHKTLGGPRGGLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECEECCCHHHCCCCCCCEE
MGKASEEIQKKINSAVFPGGQGGPLEHVIAAKAICFKEAMQDDFKGYQQQVVKNAQAMAG
ECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFIERGFDVVSNGTENHLFLLSLIKQDITGKDADAALGRANITVNKNAVPNDPRSPFVTS
HHHHCCCHHHCCCCCCHHHHHHHHHHHCCCCCHHHHCCCCEEEECCCCCCCCCCCCHHHC
GLRIGSPSITRRGFDEADAKALAGWICDILENMGDEGVIEQVKGKVKEICARLPVYER
CEEECCCCHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA