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The map label for this gene is pcm

Identifier: 110834030

GI number: 110834030

Start: 1330096

End: 1330758

Strand: Direct

Name: pcm

Synonym: ABO_1169

Alternate gene names: 110834030

Gene position: 1330096-1330758 (Clockwise)

Preceding gene: 110834029

Following gene: 110834031

Centisome position: 42.63

GC content: 57.47

Gene sequence:

>663_bases
ATGGATATCCAACTCAGCGGCATCGGTATGACCTCTGCACGGACCCGGGATAGGTTAGTGCAGCGGCTGCGTGATGCCGG
TATCCAGGACGAGCGCGTACTGGACGCTATTCGTAATACACCTCGACATTTGTTTATCGAAGAAGCGCTGGCTCACCAGG
CCTATGACGATACCGCCTTGCCTATCGGCCATGGTCAGACCATCTCCCAGCCCTGGGTAGTGGCACGGATGACCGAGCTG
CTGATTGCCAAGGGCAAGCCCCGCAAGGTGCTAGAAATTGGCACTGGCTGTGGTTACCAAACAGCGGTGCTGGCGCCTTT
TTGCGACGAGCTTTATTCGGTGGAACGTATTCGCCCGTTACAGGATCTGGCACGCAAACGTCTGCTACAGCTGGGGCTGG
CCAAGGTCCAGCTCAAACATGCTGACGGTGGCTTCGGTTGGACAGCGGAGGCGCCATTCGATGCTATTCTTGCGGCCTGT
GCCCGCGTGGATATTCCTGAGGGTTTATTATCGCAGTTGGCAGATGGTGGCCGCCTGGTGATGCCTGTCGGCGGCGATCG
TCAGCAGGTTCTCACTGTGGTTGATCGTGACGGTGACCAGTTCCGTAGCCAAACGCTGGATTCGGTACGGTTTGTGCCTT
TTCAGCGCGGGGTGTTGAGGTAA

Upstream 100 bases:

>100_bases
CTGGCGTTTACGCTGCCCACAGGCGCTTTTGCCACGACAGTAATGGCAGAGCTTGTCAGTTCACCGGCTGACTGACTCGC
ATTGAGGCAAACGAACACAG

Downstream 100 bases:

>100_bases
GGTGGCCAAAAGCTACAAGGCGCGTTGAAGCTCGTTGTTTGCTTCTTCAGCGGTCGAGAAAATTCATTCCCACCCCGCAT
TGATGTGTGCAGCGTGATGC

Product: protein-L-isoaspartate(D-aspartate) O-methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MDIQLSGIGMTSARTRDRLVQRLRDAGIQDERVLDAIRNTPRHLFIEEALAHQAYDDTALPIGHGQTISQPWVVARMTEL
LIAKGKPRKVLEIGTGCGYQTAVLAPFCDELYSVERIRPLQDLARKRLLQLGLAKVQLKHADGGFGWTAEAPFDAILAAC
ARVDIPEGLLSQLADGGRLVMPVGGDRQQVLTVVDRDGDQFRSQTLDSVRFVPFQRGVLR

Sequences:

>Translated_220_residues
MDIQLSGIGMTSARTRDRLVQRLRDAGIQDERVLDAIRNTPRHLFIEEALAHQAYDDTALPIGHGQTISQPWVVARMTEL
LIAKGKPRKVLEIGTGCGYQTAVLAPFCDELYSVERIRPLQDLARKRLLQLGLAKVQLKHADGGFGWTAEAPFDAILAAC
ARVDIPEGLLSQLADGGRLVMPVGGDRQQVLTVVDRDGDQFRSQTLDSVRFVPFQRGVLR
>Mature_220_residues
MDIQLSGIGMTSARTRDRLVQRLRDAGIQDERVLDAIRNTPRHLFIEEALAHQAYDDTALPIGHGQTISQPWVVARMTEL
LIAKGKPRKVLEIGTGCGYQTAVLAPFCDELYSVERIRPLQDLARKRLLQLGLAKVQLKHADGGFGWTAEAPFDAILAAC
ARVDIPEGLLSQLADGGRLVMPVGGDRQQVLTVVDRDGDQFRSQTLDSVRFVPFQRGVLR

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family

Homologues:

Organism=Homo sapiens, GI226530908, Length=216, Percent_Identity=29.6296296296296, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI1789100, Length=210, Percent_Identity=51.9047619047619, Blast_Score=194, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI71983477, Length=217, Percent_Identity=28.110599078341, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI193207222, Length=214, Percent_Identity=27.1028037383178, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17981723, Length=217, Percent_Identity=30.8755760368664, Blast_Score=78, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PIMT_ALCBS (Q0VQD1)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_692889.1
- ProteinModelPortal:   Q0VQD1
- SMR:   Q0VQD1
- STRING:   Q0VQD1
- GeneID:   4212444
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_1169
- NMPDR:   fig|393595.12.peg.1180
- eggNOG:   COG2518
- HOGENOM:   HBG699907
- OMA:   YSVERIR
- PhylomeDB:   Q0VQD1
- BioCyc:   ABOR393595:ABO_1169-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00090
- InterPro:   IPR000682
- PANTHER:   PTHR11579
- TIGRFAMs:   TIGR00080

Pfam domain/function: PF01135 PCMT

EC number: =2.1.1.77

Molecular weight: Translated: 24321; Mature: 24321

Theoretical pI: Translated: 8.08; Mature: 8.08

Prosite motif: PS01279 PCMT

Important sites: ACT_SITE 69-69

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIQLSGIGMTSARTRDRLVQRLRDAGIQDERVLDAIRNTPRHLFIEEALAHQAYDDTAL
CCEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC
PIGHGQTISQPWVVARMTELLIAKGKPRKVLEIGTGCGYQTAVLAPFCDELYSVERIRPL
CCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHH
QDLARKRLLQLGLAKVQLKHADGGFGWTAEAPFDAILAACARVDIPEGLLSQLADGGRLV
HHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCEEE
MPVGGDRQQVLTVVDRDGDQFRSQTLDSVRFVPFQRGVLR
EECCCCHHHEEEEECCCCHHHHHHHHHHHHCCHHHCCCCC
>Mature Secondary Structure
MDIQLSGIGMTSARTRDRLVQRLRDAGIQDERVLDAIRNTPRHLFIEEALAHQAYDDTAL
CCEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCC
PIGHGQTISQPWVVARMTELLIAKGKPRKVLEIGTGCGYQTAVLAPFCDELYSVERIRPL
CCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCHH
QDLARKRLLQLGLAKVQLKHADGGFGWTAEAPFDAILAACARVDIPEGLLSQLADGGRLV
HHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCCEEE
MPVGGDRQQVLTVVDRDGDQFRSQTLDSVRFVPFQRGVLR
EECCCCHHHEEEEECCCCHHHHHHHHHHHHCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA