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The map label for this gene is kdsA-1 [H]

Identifier: 110834024

GI number: 110834024

Start: 1325287

End: 1326135

Strand: Direct

Name: kdsA-1 [H]

Synonym: ABO_1163

Alternate gene names: 110834024

Gene position: 1325287-1326135 (Clockwise)

Preceding gene: 110834023

Following gene: 110834025

Centisome position: 42.48

GC content: 55.83

Gene sequence:

>849_bases
GTGAGTAGCCAGAAGACCATTCATCTAAATGGGCTGGAATTCGCCAATGACAAGCCCATGGCCTTGTTTGGTGGCATGAA
TGTGTTGGAATCCCGGGACCTGGCCATGCAGGTGGCCGAGGCGTATGCCGAGGCGACCAGCAAGCTGAACATGCCTTGGG
TATTCAAGGCCAGTTTCGACAAGGCCAACCGGTCTTCGCTTAGCTCCTACCGGGGGCCGGGGATGGAAGAAGGGCTGAAA
ATCTTCGAGGAAGTAAAGAAGACGTTTAACTGCCCGTTGATCACCGACGTGCACGAGCCTGGCCAAGCAGGGCCGGTGGC
AGAAGTGGTCGATATTATTCAGTTGCCGGCCTTCTTGGCACGGCAGACGGATCTGGTGGTGGCTATGGCAAAGACCGGCG
CCATCATCAATATCAAGAAACCCCAGTTCCTAGCACCTCACGAAATGTCGCATATCTTGCACAAGTGTGAGGATGCCGGA
AACGATCAGCTGATTCTTTGCGAGCGTGGGTCTAGCTTTGGGTACAACAACCTAGTGGTGGACATGCTCGGCTTTGGCAT
CATGAAGCAGTTTAACTATCCGGTCTTTTTCGATGTGACTCATGCCTTGCAGAAGCCGGGAGGTAGGGCCGACAGTGCTG
ATGGTCGCCGCGCCCAAGTCGCTGAATTGGGCCGCGCTGGCATCAGTCAGGGCATCGCCGGACTGTTCCTTGAAGCCCAC
CCGGACCCGGATAACGCGAAATGCGATGGCCCCTGCGCCCTGCGACTGGATCGCCTAGAGCCATTCCTCGCACAGATGCA
AGCCCTGGATAATACCGTAAAGGCACTGCCTGCCTTCGAAAATAACTGA

Upstream 100 bases:

>100_bases
CCCTGAGTTCACTTCCACCCCTCGTGACGGTCACGGTTTGTTCAAAGGTTATGTGGCCGCCGCCCTGGCGGAACAAAAGG
CCCACAAGGAGACGTGACCC

Downstream 100 bases:

>100_bases
TTTGAGTTTGGAGATTTACCGACATGTCCAAGATCGTTGACATCAAGGCCCGCGAAATTCTGGATTCCCGTGGCAACCCG
ACCATCGAAGCTGATGTGAT

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase 1; KDO-8-phosphate synthase 1; KDO 8-P synthase 1; KDOPS 1; Phospho-2-dehydro-3-deoxyoctonate aldolase 1 [H]

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MSSQKTIHLNGLEFANDKPMALFGGMNVLESRDLAMQVAEAYAEATSKLNMPWVFKASFDKANRSSLSSYRGPGMEEGLK
IFEEVKKTFNCPLITDVHEPGQAGPVAEVVDIIQLPAFLARQTDLVVAMAKTGAIINIKKPQFLAPHEMSHILHKCEDAG
NDQLILCERGSSFGYNNLVVDMLGFGIMKQFNYPVFFDVTHALQKPGGRADSADGRRAQVAELGRAGISQGIAGLFLEAH
PDPDNAKCDGPCALRLDRLEPFLAQMQALDNTVKALPAFENN

Sequences:

>Translated_282_residues
MSSQKTIHLNGLEFANDKPMALFGGMNVLESRDLAMQVAEAYAEATSKLNMPWVFKASFDKANRSSLSSYRGPGMEEGLK
IFEEVKKTFNCPLITDVHEPGQAGPVAEVVDIIQLPAFLARQTDLVVAMAKTGAIINIKKPQFLAPHEMSHILHKCEDAG
NDQLILCERGSSFGYNNLVVDMLGFGIMKQFNYPVFFDVTHALQKPGGRADSADGRRAQVAELGRAGISQGIAGLFLEAH
PDPDNAKCDGPCALRLDRLEPFLAQMQALDNTVKALPAFENN
>Mature_281_residues
SSQKTIHLNGLEFANDKPMALFGGMNVLESRDLAMQVAEAYAEATSKLNMPWVFKASFDKANRSSLSSYRGPGMEEGLKI
FEEVKKTFNCPLITDVHEPGQAGPVAEVVDIIQLPAFLARQTDLVVAMAKTGAIINIKKPQFLAPHEMSHILHKCEDAGN
DQLILCERGSSFGYNNLVVDMLGFGIMKQFNYPVFFDVTHALQKPGGRADSADGRRAQVAELGRAGISQGIAGLFLEAHP
DPDNAKCDGPCALRLDRLEPFLAQMQALDNTVKALPAFENN

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=281, Percent_Identity=63.7010676156584, Blast_Score=377, Evalue=1e-106,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 30766; Mature: 30634

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSQKTIHLNGLEFANDKPMALFGGMNVLESRDLAMQVAEAYAEATSKLNMPWVFKASFD
CCCCCEEEECCCEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCC
KANRSSLSSYRGPGMEEGLKIFEEVKKTFNCPLITDVHEPGQAGPVAEVVDIIQLPAFLA
CCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHH
RQTDLVVAMAKTGAIINIKKPQFLAPHEMSHILHKCEDAGNDQLILCERGSSFGYNNLVV
CCCCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHH
DMLGFGIMKQFNYPVFFDVTHALQKPGGRADSADGRRAQVAELGRAGISQGIAGLFLEAH
HHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCHHEEEEEEC
PDPDNAKCDGPCALRLDRLEPFLAQMQALDNTVKALPAFENN
CCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SSQKTIHLNGLEFANDKPMALFGGMNVLESRDLAMQVAEAYAEATSKLNMPWVFKASFD
CCCCEEEECCCEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCC
KANRSSLSSYRGPGMEEGLKIFEEVKKTFNCPLITDVHEPGQAGPVAEVVDIIQLPAFLA
CCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHH
RQTDLVVAMAKTGAIINIKKPQFLAPHEMSHILHKCEDAGNDQLILCERGSSFGYNNLVV
CCCCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHH
DMLGFGIMKQFNYPVFFDVTHALQKPGGRADSADGRRAQVAELGRAGISQGIAGLFLEAH
HHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCHHEEEEEEC
PDPDNAKCDGPCALRLDRLEPFLAQMQALDNTVKALPAFENN
CCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]