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The map label for this gene is pyrG

Identifier: 110834023

GI number: 110834023

Start: 1323646

End: 1325283

Strand: Direct

Name: pyrG

Synonym: ABO_1162

Alternate gene names: 110834023

Gene position: 1323646-1325283 (Clockwise)

Preceding gene: 110834022

Following gene: 110834024

Centisome position: 42.42

GC content: 54.58

Gene sequence:

>1638_bases
ATGTCTCGTTTCATCTTTGTCACCGGCGGTGTGGTGTCGTCTCTGGGGAAGGGGATTACCTCTGCGTCCCTGGCCACCCT
GTTGGAAGCCCGCGGTCTCAACGTGACCCTGATTAAAATGGATCCTTATATTAATGTGGATCCCGGTACCATGAGCCCTT
ACCAGCATGGTGAGGTATTTGTGACTGAAGATGGCGCCGAAACCGATCTGGATTTGGGTCATTACGAGCGTTTTATTCGC
ACTCGCTTGAACCGCCGCAACAGCTTTACGACTGGTCGTGTGTATCAGCACGTGCTGGATAAAGAGCGTCGAGGTGAATA
CCTCGGTGCCACCGTGCAAGTCATTCCCCATATCACCGATGAGATCAAACTTAAGATTCGCGAAGGCGCCGGTGATGCGG
ATGTGGCTATCGTAGAAATTGGTGGTACCGCGGGCGATATTGAATCTCTGCCTTTCCTGGAAGCAGCCCGTCAGATGCGT
GTTGAATTGGGCTCTAGCCAGTCCTTACTGGTGCATCTGACCTTGGTGCCTTATATCGCCACCGCCGGCGAGATCAAGAC
TAAGCCGACCCAGCACTCCGTGAAAGAGCTACGCTCCATCGGCCTGCAACCGGATATTCTGGTGTGCCGTGCGGATGACC
CGATTCCGCAGAGTGCCCGTGAAAAAATTGCCTTGTTTACCAATGTGGAAGCGCGGGCGGTGATTTCCTCACCGGACTGC
AAGACCATTTATCAGGTGCCGCGGGGTATGCACGAGCAGGGCCTGGATGCCATCGTGGTAGAAAAATTCGGCCTGGACCT
GCCGGAACCGGATCTCGGTGAATGGGACCGTGTGGTGGAAGCTCAGTTGAACCCGGAGCACGAAGTCACTGTCGGCATGG
TCGGCAAGTACATTGAACTGGTTGATGCTTACAAATCGCTCAATGAAGCGTTGATCCATGCAGGTATCAGCAACCGTGCC
AAGGTCAATATCCTTTATCTGGATGCAGAAGATATCGAGCGCGACGGCACCGGTGTGCTGGAAAGTCTCGACGCGATTCT
GGTGCCCGGCGGTTTCGGCGACCGGGGTACGGAAGGCAAGATTGCCGCGATCCGTTATGCTCGTGAGAATAAGGTGCCCT
ATCTGGGTATTTGTCTTGGTATGCAATTGGCGGTGATTGAATATGCTCGCCATGTGGCGGGGATTGAAAAAGCGCATTCA
TCTGAGCTTAACCCAAACACCCCGGACCCGGTGGTGGGCCTGATTACCGAATGGATCACCGAAGACGGGCAGAAGGAACT
GCGTTCGGCGGATTCTGACCTGGGTGGTACCATGCGTTTGGGTGGTCAGGAGTGTGTACTTGAAGCTGATAGCCGTGCTG
CTGAGTGTTATGGCAGCACGCATATCGTAGAGCGTCATCGCCACCGTTATGAGGTGAATAACAACTACTTGCCGCAGTTG
GAAGCGGCAGGTTTGAAAATTGTTGGCCGTTCCGCGGATGGTGAGCTTGTGGAAGTGATTGAAGTGGGCGACCACCCGTG
GTTTGTGGCTTGTCAGTTCCACCCTGAGTTCACTTCCACCCCTCGTGACGGTCACGGTTTGTTCAAAGGTTATGTGGCCG
CCGCCCTGGCGGAACAAAAGGCCCACAAGGAGACGTGA

Upstream 100 bases:

>100_bases
AAAACTCCTTGCCCGTCTGTAACGTGCAGGGTGTTTTTTTTATGGGGGTCGGTACACTTTGACGATGGTGCTATTAACCC
ACTAGCGATCTGGTGAGTGC

Downstream 100 bases:

>100_bases
CCCGTGAGTAGCCAGAAGACCATTCATCTAAATGGGCTGGAATTCGCCAATGACAAGCCCATGGCCTTGTTTGGTGGCAT
GAATGTGTTGGAATCCCGGG

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MSRFIFVTGGVVSSLGKGITSASLATLLEARGLNVTLIKMDPYINVDPGTMSPYQHGEVFVTEDGAETDLDLGHYERFIR
TRLNRRNSFTTGRVYQHVLDKERRGEYLGATVQVIPHITDEIKLKIREGAGDADVAIVEIGGTAGDIESLPFLEAARQMR
VELGSSQSLLVHLTLVPYIATAGEIKTKPTQHSVKELRSIGLQPDILVCRADDPIPQSAREKIALFTNVEARAVISSPDC
KTIYQVPRGMHEQGLDAIVVEKFGLDLPEPDLGEWDRVVEAQLNPEHEVTVGMVGKYIELVDAYKSLNEALIHAGISNRA
KVNILYLDAEDIERDGTGVLESLDAILVPGGFGDRGTEGKIAAIRYARENKVPYLGICLGMQLAVIEYARHVAGIEKAHS
SELNPNTPDPVVGLITEWITEDGQKELRSADSDLGGTMRLGGQECVLEADSRAAECYGSTHIVERHRHRYEVNNNYLPQL
EAAGLKIVGRSADGELVEVIEVGDHPWFVACQFHPEFTSTPRDGHGLFKGYVAAALAEQKAHKET

Sequences:

>Translated_545_residues
MSRFIFVTGGVVSSLGKGITSASLATLLEARGLNVTLIKMDPYINVDPGTMSPYQHGEVFVTEDGAETDLDLGHYERFIR
TRLNRRNSFTTGRVYQHVLDKERRGEYLGATVQVIPHITDEIKLKIREGAGDADVAIVEIGGTAGDIESLPFLEAARQMR
VELGSSQSLLVHLTLVPYIATAGEIKTKPTQHSVKELRSIGLQPDILVCRADDPIPQSAREKIALFTNVEARAVISSPDC
KTIYQVPRGMHEQGLDAIVVEKFGLDLPEPDLGEWDRVVEAQLNPEHEVTVGMVGKYIELVDAYKSLNEALIHAGISNRA
KVNILYLDAEDIERDGTGVLESLDAILVPGGFGDRGTEGKIAAIRYARENKVPYLGICLGMQLAVIEYARHVAGIEKAHS
SELNPNTPDPVVGLITEWITEDGQKELRSADSDLGGTMRLGGQECVLEADSRAAECYGSTHIVERHRHRYEVNNNYLPQL
EAAGLKIVGRSADGELVEVIEVGDHPWFVACQFHPEFTSTPRDGHGLFKGYVAAALAEQKAHKET
>Mature_544_residues
SRFIFVTGGVVSSLGKGITSASLATLLEARGLNVTLIKMDPYINVDPGTMSPYQHGEVFVTEDGAETDLDLGHYERFIRT
RLNRRNSFTTGRVYQHVLDKERRGEYLGATVQVIPHITDEIKLKIREGAGDADVAIVEIGGTAGDIESLPFLEAARQMRV
ELGSSQSLLVHLTLVPYIATAGEIKTKPTQHSVKELRSIGLQPDILVCRADDPIPQSAREKIALFTNVEARAVISSPDCK
TIYQVPRGMHEQGLDAIVVEKFGLDLPEPDLGEWDRVVEAQLNPEHEVTVGMVGKYIELVDAYKSLNEALIHAGISNRAK
VNILYLDAEDIERDGTGVLESLDAILVPGGFGDRGTEGKIAAIRYARENKVPYLGICLGMQLAVIEYARHVAGIEKAHSS
ELNPNTPDPVVGLITEWITEDGQKELRSADSDLGGTMRLGGQECVLEADSRAAECYGSTHIVERHRHRYEVNNNYLPQLE
AAGLKIVGRSADGELVEVIEVGDHPWFVACQFHPEFTSTPRDGHGLFKGYVAAALAEQKAHKET

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=559, Percent_Identity=43.8282647584973, Blast_Score=474, Evalue=1e-134,
Organism=Homo sapiens, GI28559085, Length=566, Percent_Identity=43.1095406360424, Blast_Score=472, Evalue=1e-133,
Organism=Homo sapiens, GI28559083, Length=566, Percent_Identity=43.1095406360424, Blast_Score=472, Evalue=1e-133,
Organism=Homo sapiens, GI221316689, Length=566, Percent_Identity=43.1095406360424, Blast_Score=472, Evalue=1e-133,
Organism=Escherichia coli, GI1789142, Length=539, Percent_Identity=65.8627087198516, Blast_Score=725, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25148299, Length=615, Percent_Identity=38.8617886178862, Blast_Score=410, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6319432, Length=568, Percent_Identity=39.7887323943662, Blast_Score=425, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6322563, Length=572, Percent_Identity=40.3846153846154, Blast_Score=422, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24664469, Length=559, Percent_Identity=43.8282647584973, Blast_Score=450, Evalue=1e-126,
Organism=Drosophila melanogaster, GI21357815, Length=504, Percent_Identity=42.0634920634921, Blast_Score=376, Evalue=1e-104,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_ALCBS (Q0VQD8)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_692882.1
- ProteinModelPortal:   Q0VQD8
- SMR:   Q0VQD8
- STRING:   Q0VQD8
- GeneID:   4211642
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_1162
- NMPDR:   fig|393595.12.peg.1173
- eggNOG:   COG0504
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- PhylomeDB:   Q0VQD8
- ProtClustDB:   PRK05380
- BioCyc:   ABOR393595:ABO_1162-MONOMER
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 59687; Mature: 59556

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 378-378 ACT_SITE 514-514 ACT_SITE 516-516

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFIFVTGGVVSSLGKGITSASLATLLEARGLNVTLIKMDPYINVDPGTMSPYQHGEVF
CCEEEEEECHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFIRTRLNRRNSFTTGRVYQHVLDKERRGEYLGATVQVIPHITD
EECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCC
EIKLKIREGAGDADVAIVEIGGTAGDIESLPFLEAARQMRVELGSSQSLLVHLTLVPYIA
EEEEEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEHHHHH
TAGEIKTKPTQHSVKELRSIGLQPDILVCRADDPIPQSAREKIALFTNVEARAVISSPDC
CCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHEEEEECCCEEEEECCCCH
KTIYQVPRGMHEQGLDAIVVEKFGLDLPEPDLGEWDRVVEAQLNPEHEVTVGMVGKYIEL
HHHHHHCCCHHHHCCCEEEEHHHCCCCCCCCCCCHHHHHHHCCCCCCEEEHHHHHHHHHH
VDAYKSLNEALIHAGISNRAKVNILYLDAEDIERDGTGVLESLDAILVPGGFGDRGTEGK
HHHHHHHHHHHHHCCCCCCEEEEEEEEEHHHHCCCCCHHHHCCCEEEECCCCCCCCCCCC
IAAIRYARENKVPYLGICLGMQLAVIEYARHVAGIEKAHSSELNPNTPDPVVGLITEWIT
EEEEEEHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
EDGQKELRSADSDLGGTMRLGGQECVLEADSRAAECYGSTHIVERHRHRYEVNNNYLPQL
CCCHHHHHHCCCCCCCEEEECCCEEEEECCCCHHHHCCCHHHHHHHHHHEECCCCCCCCC
EAAGLKIVGRSADGELVEVIEVGDHPWFVACQFHPEFTSTPRDGHGLFKGYVAAALAEQK
CCCCEEEEECCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
AHKET
HCCCC
>Mature Secondary Structure 
SRFIFVTGGVVSSLGKGITSASLATLLEARGLNVTLIKMDPYINVDPGTMSPYQHGEVF
CEEEEEECHHHHHHCCCCHHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTEDGAETDLDLGHYERFIRTRLNRRNSFTTGRVYQHVLDKERRGEYLGATVQVIPHITD
EECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCC
EIKLKIREGAGDADVAIVEIGGTAGDIESLPFLEAARQMRVELGSSQSLLVHLTLVPYIA
EEEEEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEHHHHH
TAGEIKTKPTQHSVKELRSIGLQPDILVCRADDPIPQSAREKIALFTNVEARAVISSPDC
CCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHEEEEECCCEEEEECCCCH
KTIYQVPRGMHEQGLDAIVVEKFGLDLPEPDLGEWDRVVEAQLNPEHEVTVGMVGKYIEL
HHHHHHCCCHHHHCCCEEEEHHHCCCCCCCCCCCHHHHHHHCCCCCCEEEHHHHHHHHHH
VDAYKSLNEALIHAGISNRAKVNILYLDAEDIERDGTGVLESLDAILVPGGFGDRGTEGK
HHHHHHHHHHHHHCCCCCCEEEEEEEEEHHHHCCCCCHHHHCCCEEEECCCCCCCCCCCC
IAAIRYARENKVPYLGICLGMQLAVIEYARHVAGIEKAHSSELNPNTPDPVVGLITEWIT
EEEEEEHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
EDGQKELRSADSDLGGTMRLGGQECVLEADSRAAECYGSTHIVERHRHRYEVNNNYLPQL
CCCHHHHHHCCCCCCCEEEECCCEEEEECCCCHHHHCCCHHHHHHHHHHEECCCCCCCCC
EAAGLKIVGRSADGELVEVIEVGDHPWFVACQFHPEFTSTPRDGHGLFKGYVAAALAEQK
CCCCEEEEECCCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHH
AHKET
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA