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The map label for this gene is eno

Identifier: 110834025

GI number: 110834025

Start: 1326159

End: 1327451

Strand: Direct

Name: eno

Synonym: ABO_1164

Alternate gene names: 110834025

Gene position: 1326159-1327451 (Clockwise)

Preceding gene: 110834024

Following gene: 110834026

Centisome position: 42.5

GC content: 54.68

Gene sequence:

>1293_bases
ATGTCCAAGATCGTTGACATCAAGGCCCGCGAAATTCTGGATTCCCGTGGCAACCCGACCATCGAAGCTGATGTGATTCT
CGAGTCCGGCGCTAGTGGCAGTGCCTGTGCACCCAGCGGTGCCTCTACCGGTTCGCGCGAAGCGCTGGAACTGCGTGACG
GTGACAAGTCCCGCTATCTGGGCAAGGGCGTCACCAAGGCAGTAGGCAATGTGAACTCTGCTATTCGTGAGCTGCTGGTG
GGCATGGAGGTGTCCGATCAAAAGGCGCTGGACCAGGCCATGCTGGATGCCGATGGTACCGAGAACAAGGGTAACCTGGG
CGCCAATGCCATCCTGGCGGTGTCTTTGGCTGCGGCTAAGGCCGCGGCAGTGGATCAGGGCAAGCCTCTCTACGAGTACA
TCTCTGACCTGCAAGACGATGACAACGAATACTCCCTGCCAGTACCCATGATGAACATCATCAATGGTGGTGAGCATGCC
GATAACAATGTGGACATTCAGGAATTCATGATCCAGCCGGTGGGCGCGCCCACTGTGGCCGAAGCGATCCGATACGGTGC
AGAAATCTTTCACGCCCTGAAAGGGGTGCTTAAGAAGCGTGGCCTAAATACCGCGGTAGGCGATGAAGGCGGTTTTGCGC
CTAATTTGCCGAGTAACGAAGCGGCGCTGGAAGCGATTATGGAAGCCATCGAAATCGCGGGCTATAAGGCCGGTGATGAC
GTGACTCTGGCGCTTGACTGTGCAGCCAGCGAATTCTACAAGGATGGCAAGTATGTGTTGGCCGGCGAAGACCGCAGCAT
GAATTCTGAAGAGTTTGCCGATTATCTGGCTGAGCTGTGCGATCGCTATCCGATCATTTCCATTGAAGATGGCATGGACG
AGTCTGACTGGGATGGCTGGAAAATTCTCACTGAAAAGCTGGGCAAAAAAGTTCAGTTGGTCGGTGATGATTTGTTCGTG
ACCAACACCCGTATTCTGCAGCGTGGCATTGACGAGAAAGTGGCGAACTCCATTCTTATCAAATTCAACCAGATCGGTTC
TCTTACCGAAACCTTGGATGCCATCAAGATGGCCAAGGATGCCGGCTACACTGCGGTCATTTCTCATCGCAGTGGTGAAA
CTGCGGACACCACCATTGCGGACTTGGCTGTGGCTACGGCTGCAGGGCAGATCAAGACAGGCTCCTTGTGCCGTTCTGAT
CGAGTGGCCAAGTACAACCGTTTGATTCGCATTGAACAAGAGCTGGGGCGTGCTGCGTACCATGGCCGTAAAGAGTTCAA
GCTGCTCGGCTAA

Upstream 100 bases:

>100_bases
GCCTAGAGCCATTCCTCGCACAGATGCAAGCCCTGGATAATACCGTAAAGGCACTGCCTGCCTTCGAAAATAACTGATTT
GAGTTTGGAGATTTACCGAC

Downstream 100 bases:

>100_bases
GTGATGCCAGCGTCCAAGGGCAAATCCAGCGCCAGCAATCACCAAGGCAATGCCACAGGGCTGACACGACAACTGTCTCC
TGGTAGGCAAATTGTGTTGG

Product: enolase

Products: NA

Alternate protein names: 2-phospho-D-glycerate hydro-lyase; 2-phosphoglycerate dehydratase

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MSKIVDIKAREILDSRGNPTIEADVILESGASGSACAPSGASTGSREALELRDGDKSRYLGKGVTKAVGNVNSAIRELLV
GMEVSDQKALDQAMLDADGTENKGNLGANAILAVSLAAAKAAAVDQGKPLYEYISDLQDDDNEYSLPVPMMNIINGGEHA
DNNVDIQEFMIQPVGAPTVAEAIRYGAEIFHALKGVLKKRGLNTAVGDEGGFAPNLPSNEAALEAIMEAIEIAGYKAGDD
VTLALDCAASEFYKDGKYVLAGEDRSMNSEEFADYLAELCDRYPIISIEDGMDESDWDGWKILTEKLGKKVQLVGDDLFV
TNTRILQRGIDEKVANSILIKFNQIGSLTETLDAIKMAKDAGYTAVISHRSGETADTTIADLAVATAAGQIKTGSLCRSD
RVAKYNRLIRIEQELGRAAYHGRKEFKLLG

Sequences:

>Translated_430_residues
MSKIVDIKAREILDSRGNPTIEADVILESGASGSACAPSGASTGSREALELRDGDKSRYLGKGVTKAVGNVNSAIRELLV
GMEVSDQKALDQAMLDADGTENKGNLGANAILAVSLAAAKAAAVDQGKPLYEYISDLQDDDNEYSLPVPMMNIINGGEHA
DNNVDIQEFMIQPVGAPTVAEAIRYGAEIFHALKGVLKKRGLNTAVGDEGGFAPNLPSNEAALEAIMEAIEIAGYKAGDD
VTLALDCAASEFYKDGKYVLAGEDRSMNSEEFADYLAELCDRYPIISIEDGMDESDWDGWKILTEKLGKKVQLVGDDLFV
TNTRILQRGIDEKVANSILIKFNQIGSLTETLDAIKMAKDAGYTAVISHRSGETADTTIADLAVATAAGQIKTGSLCRSD
RVAKYNRLIRIEQELGRAAYHGRKEFKLLG
>Mature_429_residues
SKIVDIKAREILDSRGNPTIEADVILESGASGSACAPSGASTGSREALELRDGDKSRYLGKGVTKAVGNVNSAIRELLVG
MEVSDQKALDQAMLDADGTENKGNLGANAILAVSLAAAKAAAVDQGKPLYEYISDLQDDDNEYSLPVPMMNIINGGEHAD
NNVDIQEFMIQPVGAPTVAEAIRYGAEIFHALKGVLKKRGLNTAVGDEGGFAPNLPSNEAALEAIMEAIEIAGYKAGDDV
TLALDCAASEFYKDGKYVLAGEDRSMNSEEFADYLAELCDRYPIISIEDGMDESDWDGWKILTEKLGKKVQLVGDDLFVT
NTRILQRGIDEKVANSILIKFNQIGSLTETLDAIKMAKDAGYTAVISHRSGETADTTIADLAVATAAGQIKTGSLCRSDR
VAKYNRLIRIEQELGRAAYHGRKEFKLLG

Specific function: Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis

COG id: COG0148

COG function: function code G; Enolase

Gene ontology:

Cell location: Cytoplasm. Secreted. Cell surface. Note=Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the bacterial ce

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enolase family

Homologues:

Organism=Homo sapiens, GI4503571, Length=433, Percent_Identity=51.0392609699769, Blast_Score=417, Evalue=1e-117,
Organism=Homo sapiens, GI5803011, Length=433, Percent_Identity=51.5011547344111, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI301897477, Length=428, Percent_Identity=51.6355140186916, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI301897469, Length=428, Percent_Identity=51.6355140186916, Blast_Score=411, Evalue=1e-115,
Organism=Homo sapiens, GI301897479, Length=426, Percent_Identity=47.4178403755869, Blast_Score=359, Evalue=3e-99,
Organism=Homo sapiens, GI169201331, Length=347, Percent_Identity=27.9538904899135, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI169201757, Length=347, Percent_Identity=27.9538904899135, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI239744207, Length=347, Percent_Identity=27.9538904899135, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1789141, Length=429, Percent_Identity=72.027972027972, Blast_Score=610, Evalue=1e-176,
Organism=Caenorhabditis elegans, GI71995829, Length=434, Percent_Identity=51.8433179723502, Blast_Score=427, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17536383, Length=434, Percent_Identity=51.8433179723502, Blast_Score=426, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI32563855, Length=193, Percent_Identity=46.1139896373057, Blast_Score=185, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6324974, Length=435, Percent_Identity=48.2758620689655, Blast_Score=390, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6324969, Length=435, Percent_Identity=48.2758620689655, Blast_Score=390, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6323985, Length=434, Percent_Identity=47.926267281106, Blast_Score=386, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6321693, Length=434, Percent_Identity=47.926267281106, Blast_Score=382, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6321968, Length=434, Percent_Identity=48.1566820276498, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24580918, Length=431, Percent_Identity=49.1879350348028, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24580916, Length=431, Percent_Identity=49.1879350348028, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24580920, Length=431, Percent_Identity=49.1879350348028, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24580914, Length=431, Percent_Identity=49.1879350348028, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI281360527, Length=431, Percent_Identity=49.1879350348028, Blast_Score=384, Evalue=1e-107,
Organism=Drosophila melanogaster, GI17137654, Length=431, Percent_Identity=49.1879350348028, Blast_Score=384, Evalue=1e-107,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase,

Swissprot (AC and ID): ENO_ALCBS (Q0VQD6)

Other databases:

- EMBL:   AM286690
- RefSeq:   YP_692884.1
- ProteinModelPortal:   Q0VQD6
- SMR:   Q0VQD6
- STRING:   Q0VQD6
- GeneID:   4213348
- GenomeReviews:   AM286690_GR
- KEGG:   abo:ABO_1164
- NMPDR:   fig|393595.12.peg.1175
- eggNOG:   COG0148
- HOGENOM:   HBG726599
- OMA:   DIAVGTN
- PhylomeDB:   Q0VQD6
- BioCyc:   ABOR393595:ABO_1164-MONOMER
- GO:   GO:0006096
- HAMAP:   MF_00318
- InterPro:   IPR000941
- InterPro:   IPR020810
- InterPro:   IPR020809
- InterPro:   IPR020811
- PIRSF:   PIRSF001400
- PRINTS:   PR00148
- TIGRFAMs:   TIGR01060

Pfam domain/function: PF00113 Enolase_C; PF03952 Enolase_N

EC number: =4.2.1.11

Molecular weight: Translated: 46032; Mature: 45901

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: PS00164 ENOLASE

Important sites: ACT_SITE 209-209 ACT_SITE 341-341 BINDING 159-159 BINDING 168-168 BINDING 289-289 BINDING 316-316 BINDING 341-341 BINDING 392-392

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIVDIKAREILDSRGNPTIEADVILESGASGSACAPSGASTGSREALELRDGDKSRYL
CCCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCHHHH
GKGVTKAVGNVNSAIRELLVGMEVSDQKALDQAMLDADGTENKGNLGANAILAVSLAAAK
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
AAAVDQGKPLYEYISDLQDDDNEYSLPVPMMNIINGGEHADNNVDIQEFMIQPVGAPTVA
HHHHCCCCHHHHHHHHHCCCCCCEECCCCHHHHHCCCCCCCCCCCHHHHHHCCCCCHHHH
EAIRYGAEIFHALKGVLKKRGLNTAVGDEGGFAPNLPSNEAALEAIMEAIEIAGYKAGDD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
VTLALDCAASEFYKDGKYVLAGEDRSMNSEEFADYLAELCDRYPIISIEDGMDESDWDGW
EEEEEEHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHH
KILTEKLGKKVQLVGDDLFVTNTRILQRGIDEKVANSILIKFNQIGSLTETLDAIKMAKD
HHHHHHCCCEEEEECCCEEEEHHHHHHHCHHHHHHHHHEEEHHHHCCHHHHHHHHHHHHC
AGYTAVISHRSGETADTTIADLAVATAAGQIKTGSLCRSDRVAKYNRLIRIEQELGRAAY
CCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HGRKEFKLLG
CCCCCEEECC
>Mature Secondary Structure 
SKIVDIKAREILDSRGNPTIEADVILESGASGSACAPSGASTGSREALELRDGDKSRYL
CCCCCHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCHHHH
GKGVTKAVGNVNSAIRELLVGMEVSDQKALDQAMLDADGTENKGNLGANAILAVSLAAAK
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
AAAVDQGKPLYEYISDLQDDDNEYSLPVPMMNIINGGEHADNNVDIQEFMIQPVGAPTVA
HHHHCCCCHHHHHHHHHCCCCCCEECCCCHHHHHCCCCCCCCCCCHHHHHHCCCCCHHHH
EAIRYGAEIFHALKGVLKKRGLNTAVGDEGGFAPNLPSNEAALEAIMEAIEIAGYKAGDD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
VTLALDCAASEFYKDGKYVLAGEDRSMNSEEFADYLAELCDRYPIISIEDGMDESDWDGW
EEEEEEHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCHH
KILTEKLGKKVQLVGDDLFVTNTRILQRGIDEKVANSILIKFNQIGSLTETLDAIKMAKD
HHHHHHCCCEEEEECCCEEEEHHHHHHHCHHHHHHHHHEEEHHHHCCHHHHHHHHHHHHC
AGYTAVISHRSGETADTTIADLAVATAAGQIKTGSLCRSDRVAKYNRLIRIEQELGRAAY
CCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HGRKEFKLLG
CCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA